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P11247

- PERM_MOUSE

UniProt

P11247 - PERM_MOUSE

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Protein

Myeloperoxidase

Gene
Mpo
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity By similarity.

Catalytic activityi

Cl- + H2O2 + H+ = HClO + H2O.
Cl- + H2O2 = HOCl + 2 H2O.

Cofactori

Binds 1 calcium ion per monomer By similarity.
Binds 1 heme B (iron-protoporphyrin IX) group covalently per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei234 – 2341Heme (covalent; via 3 links) By similarity
Active sitei235 – 2351Proton acceptor By similarity
Metal bindingi236 – 2361Calcium By similarity
Metal bindingi308 – 3081Calcium By similarity
Metal bindingi310 – 3101Calcium; via carbonyl oxygen By similarity
Metal bindingi312 – 3121Calcium By similarity
Metal bindingi314 – 3141Calcium By similarity
Sitei379 – 3791Transition state stabilizer By similarity
Binding sitei382 – 3821Heme (covalent; via 3 links) By similarity
Binding sitei383 – 3831Heme (covalent; via 3 links) By similarity
Metal bindingi476 – 4761Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. heparin binding Source: Ensembl
  3. metal ion binding Source: UniProtKB-KW
  4. peroxidase activity Source: MGI

GO - Biological processi

  1. aging Source: Ensembl
  2. defense response to fungus Source: MGI
  3. hydrogen peroxide catabolic process Source: MGI
  4. hypochlorous acid biosynthetic process Source: MGI
  5. low-density lipoprotein particle remodeling Source: Ensembl
  6. negative regulation of growth of symbiont in host Source: MGI
  7. removal of superoxide radicals Source: MGI
  8. respiratory burst involved in defense response Source: MGI
  9. response to food Source: Ensembl
  10. response to lipopolysaccharide Source: Ensembl
  11. response to mechanical stimulus Source: Ensembl
  12. response to yeast Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3344. MmMPO.

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloperoxidase (EC:1.11.2.2)
Short name:
MPO
Cleaved into the following 2 chains:
Gene namesi
Name:Mpo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:97137. Mpo.

Subcellular locationi

GO - Cellular componenti

  1. azurophil granule Source: UniProtKB
  2. extracellular space Source: Ensembl
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Propeptidei16 – 138123 Reviewed predictionPRO_0000023657Add
BLAST
Chaini139 – 718580MyeloperoxidasePRO_0000023658Add
BLAST
Chaini139 – 252114Myeloperoxidase light chainPRO_0000023659Add
BLAST
Chaini253 – 718466Myeloperoxidase heavy chainPRO_0000023660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi141 ↔ 154 By similarity
Disulfide bondi255 ↔ 265 By similarity
Disulfide bondi259 ↔ 283 By similarity
Modified residuei290 – 2901Cysteine sulfenic acid (-SOH) By similarity
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi329 – 3291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi361 ↔ 372 By similarity
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi580 ↔ 637 By similarity
Disulfide bondi678 ↔ 704 By similarity
Glycosylationi711 – 7111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Oxidation

Proteomic databases

PaxDbiP11247.
PRIDEiP11247.

PTM databases

PhosphoSiteiP11247.

Expressioni

Gene expression databases

ArrayExpressiP11247.
BgeeiP11247.
CleanExiMM_MPO.
GenevestigatoriP11247.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103563.

Structurei

3D structure databases

ProteinModelPortaliP11247.
SMRiP11247. Positions 131-717.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG262194.
GeneTreeiENSGT00550000074325.
HOGENOMiHOG000016084.
HOVERGENiHBG000071.
InParanoidiQ5NCP1.
KOiK10789.
OMAiQDKYRTI.
OrthoDBiEOG7M0NQW.
TreeFamiTF314316.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
InterProiIPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR029609. MPO.
[Graphical view]
PANTHERiPTHR11475:SF46. PTHR11475:SF46. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11247-1 [UniParc]FASTAAdd to Basket

« Hide

MKLLLALAGL LAPLAMLQTS NGATPALLGE VENSVVLSCM EEAKQLVDRA    50
YKERRESIKR SLQSGSASPT ELLFYFKQPV AGTRTAVRAA DYLHVALDLL 100
KRKLQPLWPR PFNVTDVLTP AQLNLLSVSS GCAYQDVRVT CPPNDKYRTI 150
TGHCNNRRSP TLGASNRAFV RWLPAEYEDG VSMPFGWTPG VNRNGFKVPL 200
ARQVSNAIVR FPNDQLTKDQ ERALMFMQWG QFLDHDITLT PEPATRFSFF 250
TGLNCETSCL QQPPCFPLKI PPNDPRIKNQ KDCIPFFRSC PACTRNNITI 300
RNQINALTSF VDASGVYGSE DPLARKLRNL TNQLGLLAIN TRFQDNGRAL 350
MPFDSLHDDP CLLTNRSARI PCFLAGDMRS SEMPELTSMH TLFVREHNRL 400
ATQLKRLNPR WNGEKLYQEA RKIVGAMVQI ITYRDYLPLV LGPAAMKKYL 450
PQYRSYNDSV DPRIANVFTN AFRYGHTLIQ PFMFRLNNQY RPTGPNPRVP 500
LSKVFFASWR VVLEGGIDPI LRGLMATPAK LNRQNQIVVD EIRERLFEQV 550
MRIGLDLPAL NMQRSRDHGL PGYNAWRRFC GLPQPSTVGE LGTVLKNLEL 600
ARKLMAQYGT PNNIDIWMGG VSEPLEPNGR VGQLLACLIG TQFRKLRDGD 650
RFWWENPGVF SKQQRQALAS ISLPRIICDN TGITTVSKNN IFMSNTYPRD 700
FVSCNTLPKL NLTSWKET 718
Length:718
Mass (Da):81,182
Last modified:July 27, 2011 - v2
Checksum:iE6763BE528E2ED83
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611S → T in CAA33373. 1 Publication
Sequence conflicti61 – 611S → T in CAA33439. 1 Publication
Sequence conflicti138 – 1381R → G in CAA33373. 1 Publication
Sequence conflicti138 – 1381R → G in CAA33439. 1 Publication
Sequence conflicti339 – 3391I → V in CAA33373. 1 Publication
Sequence conflicti339 – 3391I → V in CAA33439. 1 Publication
Sequence conflicti494 – 4952GP → AA in CAA33373. 1 Publication
Sequence conflicti494 – 4952GP → AA in CAA33439. 1 Publication
Sequence conflicti676 – 6761I → L in CAA33373. 1 Publication
Sequence conflicti676 – 6761I → L in CAA33439. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15313 mRNA. Translation: CAA33373.1.
X15378 Genomic DNA. Translation: CAA33439.1.
AL604022 Genomic DNA. Translation: CAI35961.1.
CCDSiCCDS25217.1.
PIRiS06068.
RefSeqiNP_034954.2. NM_010824.2.
XP_006532467.1. XM_006532404.1.
XP_006532468.1. XM_006532405.1.
UniGeneiMm.4668.

Genome annotation databases

EnsembliENSMUST00000020779; ENSMUSP00000020779; ENSMUSG00000009350.
ENSMUST00000121303; ENSMUSP00000112837; ENSMUSG00000009350.
GeneIDi17523.
KEGGimmu:17523.
UCSCiuc011ycc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15313 mRNA. Translation: CAA33373.1 .
X15378 Genomic DNA. Translation: CAA33439.1 .
AL604022 Genomic DNA. Translation: CAI35961.1 .
CCDSi CCDS25217.1.
PIRi S06068.
RefSeqi NP_034954.2. NM_010824.2.
XP_006532467.1. XM_006532404.1.
XP_006532468.1. XM_006532405.1.
UniGenei Mm.4668.

3D structure databases

ProteinModelPortali P11247.
SMRi P11247. Positions 131-717.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000103563.

Chemistry

ChEMBLi CHEMBL2440.

Protein family/group databases

PeroxiBasei 3344. MmMPO.

PTM databases

PhosphoSitei P11247.

Proteomic databases

PaxDbi P11247.
PRIDEi P11247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020779 ; ENSMUSP00000020779 ; ENSMUSG00000009350 .
ENSMUST00000121303 ; ENSMUSP00000112837 ; ENSMUSG00000009350 .
GeneIDi 17523.
KEGGi mmu:17523.
UCSCi uc011ycc.1. mouse.

Organism-specific databases

CTDi 4353.
MGIi MGI:97137. Mpo.

Phylogenomic databases

eggNOGi NOG262194.
GeneTreei ENSGT00550000074325.
HOGENOMi HOG000016084.
HOVERGENi HBG000071.
InParanoidi Q5NCP1.
KOi K10789.
OMAi QDKYRTI.
OrthoDBi EOG7M0NQW.
TreeFami TF314316.

Miscellaneous databases

ChiTaRSi MPO. mouse.
NextBioi 292132.
PROi P11247.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11247.
Bgeei P11247.
CleanExi MM_MPO.
Genevestigatori P11247.

Family and domain databases

Gene3Di 1.10.640.10. 2 hits.
InterProi IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR029609. MPO.
[Graphical view ]
PANTHERi PTHR11475:SF46. PTHR11475:SF46. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS00435. PEROXIDASE_1. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPERM_MOUSE
AccessioniPrimary (citable) accession number: P11247
Secondary accession number(s): Q5NCP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi