P11246 (ARY2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylamine N-acetyltransferase 2
EC=2.3.1.5

Alternative name(s):
Arylamide acetylase 2
N-acetyltransferase type 2
Short name=NAT-2
Polymorphic arylamine N-acetyltransferase
Short name=PNAT

Gene names

Name:	NAT2
Synonyms:	AAC2

Organism

Oryctolagus cuniculus (Rabbit) [Complete proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Arylamine N-acetyltransferase 2		PRO_0000107914
Regions
	Region	106 – 107	2	Substrate binding By similarity
Sites
	Active site	68	1	Acyl-thioester intermediate By similarity
	Active site	107	1	By similarity
	Active site	122	1	By similarity
	Binding site	103	1	Coenzyme A By similarity
	Binding site	104	1	Coenzyme A; via amide nitrogen By similarity
	Binding site	208	1	Coenzyme A By similarity
	Binding site	214	1	Coenzyme A By similarity
	Binding site	287	1	Coenzyme A By similarity
Amino acid modifications
	Modified residue	246	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P11246 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: CF0ECBED398C352A	FASTA	290	33,649
	10 20 30 40 50 60 MDIEAYYQRI GYKNPRNKLD LESLTDIFQH QIRTVPYENL SIHCGESMEL DLEAIFDQIV 70 80 90 100 110 120 RRNRGGWCLQ VNYLLYWALT TTGFETTMLG GFVYGSNNDK YSTGMIHLIV QVTINGRNYI 130 140 150 160 170 180 VDAGFGRSYQ MWQPVELISG KDQPQVPSIF RLREEGETWY LDQIRRQQHV PDQEFLNSEL 190 200 210 220 230 240 LEKKIYQKLY CFTLQPRTIE EFESANTYLQ ESPSSVFLDK SICSLQTPEG VHCLVGLTLT 250 260 270 280 290 SRTYNYKENT DLVEFKVLTE EEVEGVLKTI FNISLGKKLV SKNGHLSFTI

References

[1]	"Nucleotide sequence of a full-length cDNA for arylamine N-acetyltransferase from rabbit liver." Blum M., Grant D.M., Demierre A., Meyer U.A. Nucleic Acids Res. 17:3589-3589(1989) [PubMed: 2726493] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: New Zealand white. Tissue: Liver.
[2]	"Nucleotide sequence of rabbit NAT2 encoding polymorphic liver arylamine N-acetyltransferase (NAT)." Blum M., Heim M., Meyer U.A. Nucleic Acids Res. 18:5295-5295(1990) [PubMed: 2402461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: New Zealand white.
[3]	"Molecular and genetic analyses of arylamine N-acetyltransferase polymorphism of rabbit liver." Sasaki Y., Ohsako S., Deguchi T. J. Biol. Chem. 266:13243-13250(1991) [PubMed: 2071601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: New Zealand white. Tissue: Liver.
[4]	"Purification, physicochemical, and kinetic properties of liver acetyl-CoA:arylamine N-acetyltransferase from rapid acetylator rabbits." Andres H.H., Vogel R.S., Tarr G.E., Johnson L., Weber W.W. Mol. Pharmacol. 31:446-456(1987) [PubMed: 3574290] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14673 mRNA. Translation: CAA32803.1. X53767 Genomic DNA. Translation: CAA37786.1. D10109 Genomic DNA. Translation: BAA00990.1. D10111 mRNA. Translation: BAA00991.1.
PIR	XYRBPR. A39870.
RefSeq	NP_001075655.1. NM_001082186.1.
UniGene	Ocu.1527.
3D structure databases
ProteinModelPortal	P11246.
SMR	P11246. Positions 2-290.
ModBase	Search...
Protein-protein interaction databases
STRING	P11246.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100008974.
Organism-specific databases
CTD	10.
Phylogenomic databases
HOVERGEN	HBG000165.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProtoNet	Search...

Entry information

Entry name

ARY2_RABIT

Accession

Primary (citable) accession number: P11246

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 16, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program