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P11245

- ARY2_HUMAN

UniProt

P11245 - ARY2_HUMAN

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Protein

Arylamine N-acetyltransferase 2

Gene
NAT2, AAC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Catalytic activityi

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Acyl-thioester intermediate
Binding sitei103 – 1031Coenzyme A
Binding sitei104 – 1041Coenzyme A; via amide nitrogen
Active sitei107 – 1071
Active sitei122 – 1221
Binding sitei208 – 2081Coenzyme A
Binding sitei214 – 2141Coenzyme A
Binding sitei287 – 2871Coenzyme A

GO - Molecular functioni

  1. arylamine N-acetyltransferase activity Source: ProtInc

GO - Biological processi

  1. small molecule metabolic process Source: Reactome
  2. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.5. 2681.
ReactomeiREACT_6732. Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylamine N-acetyltransferase 2 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 2
N-acetyltransferase type 2
Short name:
NAT-2
Polymorphic arylamine N-acetyltransferase
Short name:
PNAT
Gene namesi
Name:NAT2
Synonyms:AAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:7646. NAT2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

MIMi243400. phenotype.
Orphaneti240887. Isoniazid toxicity.
240975. Susceptibility to adverse reaction due to isoniazide treatment.
PharmGKBiPA18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Arylamine N-acetyltransferase 2PRO_0000107905Add
BLAST

Proteomic databases

MaxQBiP11245.
PaxDbiP11245.
PRIDEiP11245.

PTM databases

PhosphoSiteiP11245.

Expressioni

Gene expression databases

ArrayExpressiP11245.
BgeeiP11245.
CleanExiHS_NAT2.
GenevestigatoriP11245.

Organism-specific databases

HPAiHPA043704.

Interactioni

Protein-protein interaction databases

BioGridi106528. 1 interaction.

Structurei

Secondary structure

1
290
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 98
Helixi21 – 3414
Helixi40 – 434
Helixi52 – 598
Helixi68 – 8215
Beta strandi85 – 9511
Helixi96 – 983
Beta strandi107 – 1148
Beta strandi117 – 1215
Helixi127 – 1293
Beta strandi142 – 1443
Beta strandi149 – 1557
Beta strandi158 – 1647
Beta strandi167 – 1715
Helixi173 – 1753
Beta strandi185 – 1928
Helixi199 – 2024
Helixi203 – 2119
Helixi216 – 2194
Beta strandi222 – 2265
Beta strandi228 – 2358
Beta strandi238 – 24710
Beta strandi250 – 2578
Helixi260 – 26910
Beta strandi285 – 2884

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PFRX-ray1.92A/B2-290[»]
ProteinModelPortaliP11245.
SMRiP11245. Positions 2-290.

Miscellaneous databases

EvolutionaryTraceiP11245.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072Substrate binding Inferred

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2162.
HOVERGENiHBG000165.
InParanoidiP11245.
KOiK00622.
OrthoDBiEOG7BP83H.
PhylomeDBiP11245.
TreeFamiTF106311.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.

Sequencei

Sequence statusi: Complete.

P11245-1 [UniParc]FASTAAdd to Basket

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MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL    50
GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK 100
YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF 150
CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE 200
DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT 250
DLVEFKTLTE EEVEEVLKNI FKISLGRNLV PKPGDGSLTI 290
Length:290
Mass (Da):33,542
Last modified:July 1, 1989 - v1
Checksum:i63EE3BC2107F12B9
GO

Sequence cautioni

The sequence AAK51711.1 differs from that shown. Reason: Frameshift at position 287.

Polymorphismi

Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIMi:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241L → I.2 Publications
Corresponds to variant rs45477599 [ dbSNP | Ensembl ].
VAR_018853
Natural varianti64 – 641R → Q in allele NAT2*14A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14D, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G; a slow acetylator. 4 Publications
Corresponds to variant rs1801279 [ dbSNP | Ensembl ].
VAR_004608
Natural varianti64 – 641R → W in allele NAT2*19.
Corresponds to variant rs1805158 [ dbSNP | Ensembl ].
VAR_009075
Natural varianti114 – 1141I → T in allele NAT2*5A, allele NAT2*5B, allele NAT2*5C, allele NAT2*5D, allele NAT2*5E, allele NAT2*5F, allele NAT2*14B and allele NAT2*14E; a slow acetylator. 8 Publications
Corresponds to variant rs1801280 [ dbSNP | Ensembl ].
VAR_004609
Natural varianti122 – 1221D → N.1 Publication
Corresponds to variant rs4986996 [ dbSNP | Ensembl ].
VAR_020385
Natural varianti135 – 1351L → V.
Corresponds to variant rs12720065 [ dbSNP | Ensembl ].
VAR_046905
Natural varianti137 – 1371L → F.1 Publication
Corresponds to variant rs4986997 [ dbSNP | Ensembl ].
VAR_020386
Natural varianti145 – 1451Q → P in allele NAT2*17. 1 Publication
VAR_009076
Natural varianti193 – 1931T → M.1 Publication
VAR_028781
Natural varianti197 – 1971R → Q in allele NAT2*5E, allele NAT2*6A, allele NAT2*6B, allele NAT2*6C, allele NAT2*6D and allele NAT2*14D; a slow acetylator. 5 Publications
Corresponds to variant rs1799930 [ dbSNP | Ensembl ].
VAR_004610
Natural varianti208 – 2081Y → H.1 Publication
Corresponds to variant rs56387565 [ dbSNP | Ensembl ].
VAR_028782
Natural varianti228 – 2281P → L.1 Publication
Corresponds to variant rs45518335 [ dbSNP | Ensembl ].
VAR_018854
Natural varianti268 – 2681K → R in allele NAT2*5B, allele NAT2*5C, allele NAT2*5F, allele NAT2*6C, allele NAT2*12A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G. 8 Publications
Corresponds to variant rs1208 [ dbSNP | Ensembl ].
VAR_004611
Natural varianti280 – 2801V → M.
Corresponds to variant rs56393504 [ dbSNP | Ensembl ].
VAR_061368
Natural varianti282 – 2821K → T in allele NAT2*18. 1 Publication
Corresponds to variant rs56054745 [ dbSNP | Ensembl ].
VAR_009077
Natural varianti286 – 2861G → E in allele NAT2*7A and allele NAT2*7B; a slow acetylator. 4 Publications
Corresponds to variant rs1799931 [ dbSNP | Ensembl ].
VAR_004612

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61Y → D in CAG28559. 1 Publication
Sequence conflicti30 – 301H → T AA sequence 1 Publication
Sequence conflicti286 – 2861G → R in AAG34181. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14672 Genomic DNA. Translation: CAA32802.1.
D90040 mRNA. Translation: BAA14094.1.
D90042 mRNA. Translation: BAA14096.1.
D10870 Genomic DNA. Translation: BAA01640.1.
D10871 Genomic DNA. Translation: BAA01641.1.
D10872 Genomic DNA. Translation: BAA01642.1.
U23052 Genomic DNA. Translation: AAA64584.1.
U23434 Genomic DNA. Translation: AAA64585.1.
DQ305496 Genomic DNA. Translation: ABC26032.1.
DQ305497 Genomic DNA. Translation: ABC26033.1.
DQ305498 Genomic DNA. Translation: ABC26034.1.
DQ305499 Genomic DNA. Translation: ABC26035.1.
DQ305500 Genomic DNA. Translation: ABC26036.1.
DQ305501 Genomic DNA. Translation: ABC26037.1.
DQ305502 Genomic DNA. Translation: ABC26038.1.
DQ305503 Genomic DNA. Translation: ABC26039.1.
DQ305504 Genomic DNA. Translation: ABC26040.1.
DQ305505 Genomic DNA. Translation: ABC26041.1.
DQ305506 Genomic DNA. Translation: ABC26042.1.
DQ305507 Genomic DNA. Translation: ABC26043.1.
DQ305508 Genomic DNA. Translation: ABC26044.1.
DQ305509 Genomic DNA. Translation: ABC26045.1.
DQ305510 Genomic DNA. Translation: ABC26046.1.
DQ305511 Genomic DNA. Translation: ABC26047.1.
DQ305512 Genomic DNA. Translation: ABC26048.1.
DQ305513 Genomic DNA. Translation: ABC26049.1.
DQ305514 Genomic DNA. Translation: ABC26050.1.
DQ305515 Genomic DNA. Translation: ABC26051.1.
DQ305516 Genomic DNA. Translation: ABC26052.1.
DQ305517 Genomic DNA. Translation: ABC26053.1.
DQ305518 Genomic DNA. Translation: ABC26054.1.
DQ305519 Genomic DNA. Translation: ABC26055.1.
DQ305520 Genomic DNA. Translation: ABC26056.1.
DQ305521 Genomic DNA. Translation: ABC26057.1.
DQ305522 Genomic DNA. Translation: ABC26058.1.
DQ305523 Genomic DNA. Translation: ABC26059.1.
DQ305524 Genomic DNA. Translation: ABC26060.1.
DQ305525 Genomic DNA. Translation: ABC26061.1.
DQ305526 Genomic DNA. Translation: ABC26062.1.
DQ305527 Genomic DNA. Translation: ABC26063.1.
DQ305528 Genomic DNA. Translation: ABC26064.1.
DQ305529 Genomic DNA. Translation: ABC26065.1.
DQ305530 Genomic DNA. Translation: ABC26066.1.
DQ305531 Genomic DNA. Translation: ABC26067.1.
DQ305532 Genomic DNA. Translation: ABC26068.1.
DQ305533 Genomic DNA. Translation: ABC26069.1.
DQ305534 Genomic DNA. Translation: ABC26070.1.
DQ305535 Genomic DNA. Translation: ABC26071.1.
DQ305536 Genomic DNA. Translation: ABC26072.1.
DQ305537 Genomic DNA. Translation: ABC26073.1.
DQ305538 Genomic DNA. Translation: ABC26074.1.
DQ305539 Genomic DNA. Translation: ABC26075.1.
DQ305540 Genomic DNA. Translation: ABC26076.1.
DQ305541 Genomic DNA. Translation: ABC26077.1.
DQ305542 Genomic DNA. Translation: ABC26078.1.
DQ305543 Genomic DNA. Translation: ABC26079.1.
DQ305544 Genomic DNA. Translation: ABC26080.1.
DQ305545 Genomic DNA. Translation: ABC26081.1.
DQ305546 Genomic DNA. Translation: ABC26082.1.
DQ305547 Genomic DNA. Translation: ABC26083.1.
DQ305548 Genomic DNA. Translation: ABC26084.1.
DQ305549 Genomic DNA. Translation: ABC26085.1.
DQ305550 Genomic DNA. Translation: ABC26086.1.
DQ305551 Genomic DNA. Translation: ABC26087.1.
DQ305552 Genomic DNA. Translation: ABC26088.1.
DQ305553 Genomic DNA. Translation: ABC26089.1.
DQ305554 Genomic DNA. Translation: ABC26090.1.
DQ305555 Genomic DNA. Translation: ABC26091.1.
DQ305556 Genomic DNA. Translation: ABC26092.1.
DQ305557 Genomic DNA. Translation: ABC26093.1.
DQ305558 Genomic DNA. Translation: ABC26094.1.
DQ305559 Genomic DNA. Translation: ABC26095.1.
DQ305560 Genomic DNA. Translation: ABC26096.1.
DQ305561 Genomic DNA. Translation: ABC26097.1.
DQ305562 Genomic DNA. Translation: ABC26098.1.
DQ305563 Genomic DNA. Translation: ABC26099.1.
DQ305564 Genomic DNA. Translation: ABC26100.1.
DQ305565 Genomic DNA. Translation: ABC26101.1.
DQ305566 Genomic DNA. Translation: ABC26102.1.
DQ305567 Genomic DNA. Translation: ABC26103.1.
DQ305568 Genomic DNA. Translation: ABC26104.1.
DQ305569 Genomic DNA. Translation: ABC26105.1.
DQ305570 Genomic DNA. Translation: ABC26106.1.
DQ305571 Genomic DNA. Translation: ABC26107.1.
DQ305572 Genomic DNA. Translation: ABC26108.1.
DQ305573 Genomic DNA. Translation: ABC26109.1.
DQ305574 Genomic DNA. Translation: ABC26110.1.
DQ305575 Genomic DNA. Translation: ABC26111.1.
DQ305576 Genomic DNA. Translation: ABC26112.1.
DQ305577 Genomic DNA. Translation: ABC26113.1.
DQ305578 Genomic DNA. Translation: ABC26114.1.
DQ305579 Genomic DNA. Translation: ABC26115.1.
DQ305580 Genomic DNA. Translation: ABC26116.1.
DQ305581 Genomic DNA. Translation: ABC26117.1.
DQ305582 Genomic DNA. Translation: ABC26118.1.
DQ305583 Genomic DNA. Translation: ABC26119.1.
DQ305584 Genomic DNA. Translation: ABC26120.1.
DQ305585 Genomic DNA. Translation: ABC26121.1.
DQ305586 Genomic DNA. Translation: ABC26122.1.
DQ305587 Genomic DNA. Translation: ABC26123.1.
DQ305588 Genomic DNA. Translation: ABC26124.1.
DQ305589 Genomic DNA. Translation: ABC26125.1.
DQ305590 Genomic DNA. Translation: ABC26126.1.
DQ305591 Genomic DNA. Translation: ABC26127.1.
DQ305592 Genomic DNA. Translation: ABC26128.1.
DQ305593 Genomic DNA. Translation: ABC26129.1.
DQ305594 Genomic DNA. Translation: ABC26130.1.
DQ305595 Genomic DNA. Translation: ABC26131.1.
DQ305596 Genomic DNA. Translation: ABC26132.1.
DQ305597 Genomic DNA. Translation: ABC26133.1.
DQ305598 Genomic DNA. Translation: ABC26134.1.
DQ305599 Genomic DNA. Translation: ABC26135.1.
DQ305600 Genomic DNA. Translation: ABC26136.1.
DQ305601 Genomic DNA. Translation: ABC26137.1.
DQ305602 Genomic DNA. Translation: ABC26138.1.
DQ305603 Genomic DNA. Translation: ABC26139.1.
DQ305604 Genomic DNA. Translation: ABC26140.1.
DQ305605 Genomic DNA. Translation: ABC26141.1.
DQ305606 Genomic DNA. Translation: ABC26142.1.
DQ305607 Genomic DNA. Translation: ABC26143.1.
DQ305608 Genomic DNA. Translation: ABC26144.1.
DQ305609 Genomic DNA. Translation: ABC26145.1.
DQ305610 Genomic DNA. Translation: ABC26146.1.
DQ305611 Genomic DNA. Translation: ABC26147.1.
DQ305612 Genomic DNA. Translation: ABC26148.1.
DQ305613 Genomic DNA. Translation: ABC26149.1.
DQ305614 Genomic DNA. Translation: ABC26150.1.
DQ305615 Genomic DNA. Translation: ABC26151.1.
DQ305616 Genomic DNA. Translation: ABC26152.1.
DQ305617 Genomic DNA. Translation: ABC26153.1.
DQ305618 Genomic DNA. Translation: ABC26154.1.
DQ305619 Genomic DNA. Translation: ABC26155.1.
DQ305620 Genomic DNA. Translation: ABC26156.1.
DQ305621 Genomic DNA. Translation: ABC26157.1.
DQ305622 Genomic DNA. Translation: ABC26158.1.
DQ305623 Genomic DNA. Translation: ABC26159.1.
DQ305624 Genomic DNA. Translation: ABC26160.1.
DQ305625 Genomic DNA. Translation: ABC26161.1.
DQ305626 Genomic DNA. Translation: ABC26162.1.
DQ305627 Genomic DNA. Translation: ABC26163.1.
DQ305628 Genomic DNA. Translation: ABC26164.1.
DQ305629 Genomic DNA. Translation: ABC26165.1.
DQ305630 Genomic DNA. Translation: ABC26166.1.
DQ305631 Genomic DNA. Translation: ABC26167.1.
DQ305632 Genomic DNA. Translation: ABC26168.1.
DQ305633 Genomic DNA. Translation: ABC26169.1.
DQ305634 Genomic DNA. Translation: ABC26170.1.
DQ305635 Genomic DNA. Translation: ABC26171.1.
DQ305636 Genomic DNA. Translation: ABC26172.1.
DQ305637 Genomic DNA. Translation: ABC26173.1.
DQ305638 Genomic DNA. Translation: ABC26174.1.
DQ305639 Genomic DNA. Translation: ABC26175.1.
DQ305640 Genomic DNA. Translation: ABC26176.1.
DQ305641 Genomic DNA. Translation: ABC26177.1.
DQ305642 Genomic DNA. Translation: ABC26178.1.
DQ305643 Genomic DNA. Translation: ABC26179.1.
DQ305644 Genomic DNA. Translation: ABC26180.1.
DQ305645 Genomic DNA. Translation: ABC26181.1.
DQ305646 Genomic DNA. Translation: ABC26182.1.
DQ305647 Genomic DNA. Translation: ABC26183.1.
DQ305648 Genomic DNA. Translation: ABC26184.1.
DQ305649 Genomic DNA. Translation: ABC26185.1.
DQ305650 Genomic DNA. Translation: ABC26186.1.
DQ305651 Genomic DNA. Translation: ABC26187.1.
DQ305652 Genomic DNA. Translation: ABC26188.1.
DQ305653 Genomic DNA. Translation: ABC26189.1.
DQ305654 Genomic DNA. Translation: ABC26190.1.
DQ305655 Genomic DNA. Translation: ABC26191.1.
U53473 Genomic DNA. Translation: AAA98976.1.
AF042740 Genomic DNA. Translation: AAC03773.1.
AF055874 Genomic DNA. Translation: AAC14117.1.
AF055875 Genomic DNA. Translation: AAC14118.1.
AF320309 Genomic DNA. Translation: AAG34181.1.
AF348074 Genomic DNA. Translation: AAK51710.1.
AF348075 Genomic DNA. Translation: AAK51711.1. Frameshift.
AY230251 Genomic DNA. Translation: AAO73561.1.
AY230252 Genomic DNA. Translation: AAO73562.1.
CR407631 mRNA. Translation: CAG28559.1.
AY331807 Genomic DNA. Translation: AAP81164.1.
AC025062 Genomic DNA. No translation available.
AC120051 Genomic DNA. No translation available.
BC015878 mRNA. Translation: AAH15878.1.
BC067218 mRNA. Translation: AAH67218.1.
M75163 Genomic DNA. Translation: AAA59906.1.
CCDSiCCDS6008.1.
PIRiB34585.
S02788.
RefSeqiNP_000006.2. NM_000015.2.
UniGeneiHs.2.

Genome annotation databases

EnsembliENST00000286479; ENSP00000286479; ENSG00000156006.
GeneIDi10.
KEGGihsa:10.

Polymorphism databases

DMDMi114238.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NAT

NAT alleles

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14672 Genomic DNA. Translation: CAA32802.1 .
D90040 mRNA. Translation: BAA14094.1 .
D90042 mRNA. Translation: BAA14096.1 .
D10870 Genomic DNA. Translation: BAA01640.1 .
D10871 Genomic DNA. Translation: BAA01641.1 .
D10872 Genomic DNA. Translation: BAA01642.1 .
U23052 Genomic DNA. Translation: AAA64584.1 .
U23434 Genomic DNA. Translation: AAA64585.1 .
DQ305496 Genomic DNA. Translation: ABC26032.1 .
DQ305497 Genomic DNA. Translation: ABC26033.1 .
DQ305498 Genomic DNA. Translation: ABC26034.1 .
DQ305499 Genomic DNA. Translation: ABC26035.1 .
DQ305500 Genomic DNA. Translation: ABC26036.1 .
DQ305501 Genomic DNA. Translation: ABC26037.1 .
DQ305502 Genomic DNA. Translation: ABC26038.1 .
DQ305503 Genomic DNA. Translation: ABC26039.1 .
DQ305504 Genomic DNA. Translation: ABC26040.1 .
DQ305505 Genomic DNA. Translation: ABC26041.1 .
DQ305506 Genomic DNA. Translation: ABC26042.1 .
DQ305507 Genomic DNA. Translation: ABC26043.1 .
DQ305508 Genomic DNA. Translation: ABC26044.1 .
DQ305509 Genomic DNA. Translation: ABC26045.1 .
DQ305510 Genomic DNA. Translation: ABC26046.1 .
DQ305511 Genomic DNA. Translation: ABC26047.1 .
DQ305512 Genomic DNA. Translation: ABC26048.1 .
DQ305513 Genomic DNA. Translation: ABC26049.1 .
DQ305514 Genomic DNA. Translation: ABC26050.1 .
DQ305515 Genomic DNA. Translation: ABC26051.1 .
DQ305516 Genomic DNA. Translation: ABC26052.1 .
DQ305517 Genomic DNA. Translation: ABC26053.1 .
DQ305518 Genomic DNA. Translation: ABC26054.1 .
DQ305519 Genomic DNA. Translation: ABC26055.1 .
DQ305520 Genomic DNA. Translation: ABC26056.1 .
DQ305521 Genomic DNA. Translation: ABC26057.1 .
DQ305522 Genomic DNA. Translation: ABC26058.1 .
DQ305523 Genomic DNA. Translation: ABC26059.1 .
DQ305524 Genomic DNA. Translation: ABC26060.1 .
DQ305525 Genomic DNA. Translation: ABC26061.1 .
DQ305526 Genomic DNA. Translation: ABC26062.1 .
DQ305527 Genomic DNA. Translation: ABC26063.1 .
DQ305528 Genomic DNA. Translation: ABC26064.1 .
DQ305529 Genomic DNA. Translation: ABC26065.1 .
DQ305530 Genomic DNA. Translation: ABC26066.1 .
DQ305531 Genomic DNA. Translation: ABC26067.1 .
DQ305532 Genomic DNA. Translation: ABC26068.1 .
DQ305533 Genomic DNA. Translation: ABC26069.1 .
DQ305534 Genomic DNA. Translation: ABC26070.1 .
DQ305535 Genomic DNA. Translation: ABC26071.1 .
DQ305536 Genomic DNA. Translation: ABC26072.1 .
DQ305537 Genomic DNA. Translation: ABC26073.1 .
DQ305538 Genomic DNA. Translation: ABC26074.1 .
DQ305539 Genomic DNA. Translation: ABC26075.1 .
DQ305540 Genomic DNA. Translation: ABC26076.1 .
DQ305541 Genomic DNA. Translation: ABC26077.1 .
DQ305542 Genomic DNA. Translation: ABC26078.1 .
DQ305543 Genomic DNA. Translation: ABC26079.1 .
DQ305544 Genomic DNA. Translation: ABC26080.1 .
DQ305545 Genomic DNA. Translation: ABC26081.1 .
DQ305546 Genomic DNA. Translation: ABC26082.1 .
DQ305547 Genomic DNA. Translation: ABC26083.1 .
DQ305548 Genomic DNA. Translation: ABC26084.1 .
DQ305549 Genomic DNA. Translation: ABC26085.1 .
DQ305550 Genomic DNA. Translation: ABC26086.1 .
DQ305551 Genomic DNA. Translation: ABC26087.1 .
DQ305552 Genomic DNA. Translation: ABC26088.1 .
DQ305553 Genomic DNA. Translation: ABC26089.1 .
DQ305554 Genomic DNA. Translation: ABC26090.1 .
DQ305555 Genomic DNA. Translation: ABC26091.1 .
DQ305556 Genomic DNA. Translation: ABC26092.1 .
DQ305557 Genomic DNA. Translation: ABC26093.1 .
DQ305558 Genomic DNA. Translation: ABC26094.1 .
DQ305559 Genomic DNA. Translation: ABC26095.1 .
DQ305560 Genomic DNA. Translation: ABC26096.1 .
DQ305561 Genomic DNA. Translation: ABC26097.1 .
DQ305562 Genomic DNA. Translation: ABC26098.1 .
DQ305563 Genomic DNA. Translation: ABC26099.1 .
DQ305564 Genomic DNA. Translation: ABC26100.1 .
DQ305565 Genomic DNA. Translation: ABC26101.1 .
DQ305566 Genomic DNA. Translation: ABC26102.1 .
DQ305567 Genomic DNA. Translation: ABC26103.1 .
DQ305568 Genomic DNA. Translation: ABC26104.1 .
DQ305569 Genomic DNA. Translation: ABC26105.1 .
DQ305570 Genomic DNA. Translation: ABC26106.1 .
DQ305571 Genomic DNA. Translation: ABC26107.1 .
DQ305572 Genomic DNA. Translation: ABC26108.1 .
DQ305573 Genomic DNA. Translation: ABC26109.1 .
DQ305574 Genomic DNA. Translation: ABC26110.1 .
DQ305575 Genomic DNA. Translation: ABC26111.1 .
DQ305576 Genomic DNA. Translation: ABC26112.1 .
DQ305577 Genomic DNA. Translation: ABC26113.1 .
DQ305578 Genomic DNA. Translation: ABC26114.1 .
DQ305579 Genomic DNA. Translation: ABC26115.1 .
DQ305580 Genomic DNA. Translation: ABC26116.1 .
DQ305581 Genomic DNA. Translation: ABC26117.1 .
DQ305582 Genomic DNA. Translation: ABC26118.1 .
DQ305583 Genomic DNA. Translation: ABC26119.1 .
DQ305584 Genomic DNA. Translation: ABC26120.1 .
DQ305585 Genomic DNA. Translation: ABC26121.1 .
DQ305586 Genomic DNA. Translation: ABC26122.1 .
DQ305587 Genomic DNA. Translation: ABC26123.1 .
DQ305588 Genomic DNA. Translation: ABC26124.1 .
DQ305589 Genomic DNA. Translation: ABC26125.1 .
DQ305590 Genomic DNA. Translation: ABC26126.1 .
DQ305591 Genomic DNA. Translation: ABC26127.1 .
DQ305592 Genomic DNA. Translation: ABC26128.1 .
DQ305593 Genomic DNA. Translation: ABC26129.1 .
DQ305594 Genomic DNA. Translation: ABC26130.1 .
DQ305595 Genomic DNA. Translation: ABC26131.1 .
DQ305596 Genomic DNA. Translation: ABC26132.1 .
DQ305597 Genomic DNA. Translation: ABC26133.1 .
DQ305598 Genomic DNA. Translation: ABC26134.1 .
DQ305599 Genomic DNA. Translation: ABC26135.1 .
DQ305600 Genomic DNA. Translation: ABC26136.1 .
DQ305601 Genomic DNA. Translation: ABC26137.1 .
DQ305602 Genomic DNA. Translation: ABC26138.1 .
DQ305603 Genomic DNA. Translation: ABC26139.1 .
DQ305604 Genomic DNA. Translation: ABC26140.1 .
DQ305605 Genomic DNA. Translation: ABC26141.1 .
DQ305606 Genomic DNA. Translation: ABC26142.1 .
DQ305607 Genomic DNA. Translation: ABC26143.1 .
DQ305608 Genomic DNA. Translation: ABC26144.1 .
DQ305609 Genomic DNA. Translation: ABC26145.1 .
DQ305610 Genomic DNA. Translation: ABC26146.1 .
DQ305611 Genomic DNA. Translation: ABC26147.1 .
DQ305612 Genomic DNA. Translation: ABC26148.1 .
DQ305613 Genomic DNA. Translation: ABC26149.1 .
DQ305614 Genomic DNA. Translation: ABC26150.1 .
DQ305615 Genomic DNA. Translation: ABC26151.1 .
DQ305616 Genomic DNA. Translation: ABC26152.1 .
DQ305617 Genomic DNA. Translation: ABC26153.1 .
DQ305618 Genomic DNA. Translation: ABC26154.1 .
DQ305619 Genomic DNA. Translation: ABC26155.1 .
DQ305620 Genomic DNA. Translation: ABC26156.1 .
DQ305621 Genomic DNA. Translation: ABC26157.1 .
DQ305622 Genomic DNA. Translation: ABC26158.1 .
DQ305623 Genomic DNA. Translation: ABC26159.1 .
DQ305624 Genomic DNA. Translation: ABC26160.1 .
DQ305625 Genomic DNA. Translation: ABC26161.1 .
DQ305626 Genomic DNA. Translation: ABC26162.1 .
DQ305627 Genomic DNA. Translation: ABC26163.1 .
DQ305628 Genomic DNA. Translation: ABC26164.1 .
DQ305629 Genomic DNA. Translation: ABC26165.1 .
DQ305630 Genomic DNA. Translation: ABC26166.1 .
DQ305631 Genomic DNA. Translation: ABC26167.1 .
DQ305632 Genomic DNA. Translation: ABC26168.1 .
DQ305633 Genomic DNA. Translation: ABC26169.1 .
DQ305634 Genomic DNA. Translation: ABC26170.1 .
DQ305635 Genomic DNA. Translation: ABC26171.1 .
DQ305636 Genomic DNA. Translation: ABC26172.1 .
DQ305637 Genomic DNA. Translation: ABC26173.1 .
DQ305638 Genomic DNA. Translation: ABC26174.1 .
DQ305639 Genomic DNA. Translation: ABC26175.1 .
DQ305640 Genomic DNA. Translation: ABC26176.1 .
DQ305641 Genomic DNA. Translation: ABC26177.1 .
DQ305642 Genomic DNA. Translation: ABC26178.1 .
DQ305643 Genomic DNA. Translation: ABC26179.1 .
DQ305644 Genomic DNA. Translation: ABC26180.1 .
DQ305645 Genomic DNA. Translation: ABC26181.1 .
DQ305646 Genomic DNA. Translation: ABC26182.1 .
DQ305647 Genomic DNA. Translation: ABC26183.1 .
DQ305648 Genomic DNA. Translation: ABC26184.1 .
DQ305649 Genomic DNA. Translation: ABC26185.1 .
DQ305650 Genomic DNA. Translation: ABC26186.1 .
DQ305651 Genomic DNA. Translation: ABC26187.1 .
DQ305652 Genomic DNA. Translation: ABC26188.1 .
DQ305653 Genomic DNA. Translation: ABC26189.1 .
DQ305654 Genomic DNA. Translation: ABC26190.1 .
DQ305655 Genomic DNA. Translation: ABC26191.1 .
U53473 Genomic DNA. Translation: AAA98976.1 .
AF042740 Genomic DNA. Translation: AAC03773.1 .
AF055874 Genomic DNA. Translation: AAC14117.1 .
AF055875 Genomic DNA. Translation: AAC14118.1 .
AF320309 Genomic DNA. Translation: AAG34181.1 .
AF348074 Genomic DNA. Translation: AAK51710.1 .
AF348075 Genomic DNA. Translation: AAK51711.1 . Frameshift.
AY230251 Genomic DNA. Translation: AAO73561.1 .
AY230252 Genomic DNA. Translation: AAO73562.1 .
CR407631 mRNA. Translation: CAG28559.1 .
AY331807 Genomic DNA. Translation: AAP81164.1 .
AC025062 Genomic DNA. No translation available.
AC120051 Genomic DNA. No translation available.
BC015878 mRNA. Translation: AAH15878.1 .
BC067218 mRNA. Translation: AAH67218.1 .
M75163 Genomic DNA. Translation: AAA59906.1 .
CCDSi CCDS6008.1.
PIRi B34585.
S02788.
RefSeqi NP_000006.2. NM_000015.2.
UniGenei Hs.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PFR X-ray 1.92 A/B 2-290 [» ]
ProteinModelPortali P11245.
SMRi P11245. Positions 2-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106528. 1 interaction.

Chemistry

BindingDBi P11245.
ChEMBLi CHEMBL2194.

PTM databases

PhosphoSitei P11245.

Polymorphism databases

DMDMi 114238.

Proteomic databases

MaxQBi P11245.
PaxDbi P11245.
PRIDEi P11245.

Protocols and materials databases

DNASUi 10.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286479 ; ENSP00000286479 ; ENSG00000156006 .
GeneIDi 10.
KEGGi hsa:10.

Organism-specific databases

CTDi 10.
GeneCardsi GC08P018250.
HGNCi HGNC:7646. NAT2.
HPAi HPA043704.
MIMi 243400. phenotype.
612182. gene.
neXtProti NX_P11245.
Orphaneti 240887. Isoniazid toxicity.
240975. Susceptibility to adverse reaction due to isoniazide treatment.
PharmGKBi PA18.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2162.
HOVERGENi HBG000165.
InParanoidi P11245.
KOi K00622.
OrthoDBi EOG7BP83H.
PhylomeDBi P11245.
TreeFami TF106311.

Enzyme and pathway databases

BRENDAi 2.3.1.5. 2681.
Reactomei REACT_6732. Acetylation.

Miscellaneous databases

EvolutionaryTracei P11245.
GeneWikii N-acetyltransferase_2.
GenomeRNAii 10.
NextBioi 17.
PROi P11245.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11245.
Bgeei P11245.
CleanExi HS_NAT2.
Genevestigatori P11245.

Family and domain databases

InterProi IPR001447. Arylamine_N-AcTrfase.
[Graphical view ]
PANTHERi PTHR11786. PTHR11786. 1 hit.
Pfami PF00797. Acetyltransf_2. 1 hit.
[Graphical view ]
PRINTSi PR01543. ANATRNSFRASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation."
    Grant D.M., Blum M., Demierre A., Meyer U.A.
    Nucleic Acids Res. 17:3978-3978(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression."
    Blum M., Grant D.M., McBride W., Heim M., Meyer U.A.
    DNA Cell Biol. 9:193-203(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver."
    Ohsako S., Deguchi T.
    J. Biol. Chem. 265:4630-4634(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-286.
    Tissue: Liver.
  4. "Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver."
    Deguchi T.
    J. Biol. Chem. 267:18140-18147(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT2*6D), VARIANTS GLN-197 AND GLU-286.
    Tissue: Liver.
  5. "Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles."
    Ferguson R.J., Doll M.A., Rustan T.D., Gray K., Hein D.W.
    Drug Metab. Dispos. 22:371-376(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES NAT2*5C AND NAT2*14), VARIANTS GLN-64; THR-114 AND ARG-268.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-24; GLN-64; THR-114; MET-193; GLN-197; HIS-208; ARG-268 AND GLU-286.
  7. Doll M.A., Satran S.L., Hein D.W.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT2*12A), VARIANT ARG-268.
  8. Leff M.A., Doll M.A., Feng Y., Fretland A.J., Hein D.W.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES NAT2*5D; NAT2*6D; NAT2*14G), VARIANTS GLN-64; THR-114; GLN-197 AND ARG-268.
  9. "A novel linkage of two NAT2 mutations."
    Banerjee M., Anitha A.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-114.
  10. "A novel allele showing linkage with 282, 341, 481, 803 point mutations in the NAT2 gene."
    Pillai A.A., Banerjee M.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114 AND ARG-268.
  11. "A novel NAT2 allele with point mutations 341, 481, 803, 859 in the ethnic populations of Kerala."
    Pillai A.A., Banerjee M.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114 AND ARG-268.
  12. Doll M.A., Zang Y., Yeager M., Welch R., Chanock S., Hein D.W.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114; ASN-122; PHE-137 AND ARG-268.
  13. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  14. NIEHS SNPs program
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-24; GLN-64; THR-114; GLN-197; LEU-228; ARG-268 AND GLU-286.
  15. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  16. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-197.
    Tissue: Liver.
  17. "Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases."
    Ebisawa T., Deguchi T.
    Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
  18. "Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver."
    Grant D.M., Lottspeich F., Meyer U.A.
    FEBS Lett. 244:203-207(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-33 AND 189-197.
  19. "Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases."
    Wu H., Dombrovsky L., Tempel W., Martin F., Loppnau P., Goodfellow G.H., Grant D.M., Plotnikov A.N.
    J. Biol. Chem. 282:30189-30197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) IN COMPLEX WITH COENZYME A.
  20. "Diverse point mutations in the human gene for polymorphic N-acetyltransferase."
    Vatsis K.P., Martell K.J., Weber W.W.
    Proc. Natl. Acad. Sci. U.S.A. 88:6333-6337(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS.
  21. "The structure and characteristics of a fourth allele of polymorphic N-acetyltransferase gene found in the Japanese population."
    Abe M., Deguchi T., Suzuki T.
    Biochem. Biophys. Res. Commun. 191:811-816(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS.
  22. "Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene."
    Lin H.J., Han C.Y., Lin B.K., Hardy S.
    Pharmacogenetics 4:125-134(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS NAT2*17 PRO-145 AND NAT2*18 THR-282.

Entry informationi

Entry nameiARY2_HUMAN
AccessioniPrimary (citable) accession number: P11245
Secondary accession number(s): O43637
, O60654, O60655, Q13146, Q16697, Q2MLE4, Q2MLF5, Q2MLG8, Q2MLJ6, Q2MLK4, Q2MLK6, Q2MLN7, Q6LET4, Q86XS0, Q86XS1, Q96KY8, Q96T64, Q96T65, Q9H220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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