P11245 (ARY2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylamine N-acetyltransferase 2
EC=2.3.1.5

Alternative name(s):
Arylamide acetylase 2
N-acetyltransferase type 2
Short name=NAT-2
Polymorphic arylamine N-acetyltransferase
Short name=PNAT

Gene names

Name:	NAT2
Synonyms:	AAC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm.
Polymorphism	Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.
Sequence caution	The sequence AAK51711.1 differs from that shown. Reason: Frameshift at position 287.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Acyltransferase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	small molecule metabolic process Traceable author statement. Source: Reactome xenobiotic metabolic process Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	arylamine N-acetyltransferase activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 290

290

Arylamine N-acetyltransferase 2

PRO_0000107905

Regions

Region

106 – 107

2

Substrate binding Probable

Sites

Active site

68

1

Acyl-thioester intermediate

Active site

107

1

Active site

122

1

Binding site

103

1

Coenzyme A

Binding site

104

1

Coenzyme A; via amide nitrogen

Binding site

208

1

Coenzyme A

Binding site

214

1

Coenzyme A

Binding site

287

1

Coenzyme A

Amino acid modifications

Modified residue

246

1

Phosphotyrosine By similarity

Natural variations

Natural variant

24

1

L → I. Ref.6 Ref.14
Corresponds to variant rs45477599 [ dbSNP | Ensembl ].

VAR_018853

Natural variant

64

1

R → Q in allele NAT2*14A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14D, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G; a slow acetylator. Ref.5 Ref.6 Ref.8 Ref.14
Corresponds to variant rs1801279 [ dbSNP | Ensembl ].

VAR_004608

Natural variant

64

1

R → W in allele NAT2*19.
Corresponds to variant rs1805158 [ dbSNP | Ensembl ].

VAR_009075

Natural variant

114

1

I → T in allele NAT2*5A, allele NAT2*5B, allele NAT2*5C, allele NAT2*5D, allele NAT2*5E, allele NAT2*5F, allele NAT2*14B and allele NAT2*14E; a slow acetylator. Ref.5 Ref.6 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14
Corresponds to variant rs1801280 [ dbSNP | Ensembl ].

VAR_004609

Natural variant

122

1

D → N. Ref.12
Corresponds to variant rs4986996 [ dbSNP | Ensembl ].

VAR_020385

Natural variant

135

1

L → V.
Corresponds to variant rs12720065 [ dbSNP | Ensembl ].

VAR_046905

Natural variant

137

1

L → F. Ref.12
Corresponds to variant rs4986997 [ dbSNP | Ensembl ].

VAR_020386

Natural variant

145

1

Q → P in allele NAT2*17. Ref.22

VAR_009076

Natural variant

193

1

T → M. Ref.6

VAR_028781

Natural variant

197

1

R → Q in allele NAT2*5E, allele NAT2*6A, allele NAT2*6B, allele NAT2*6C, allele NAT2*6D and allele NAT2*14D; a slow acetylator. Ref.4 Ref.6 Ref.8 Ref.14 Ref.16
Corresponds to variant rs1799930 [ dbSNP | Ensembl ].

VAR_004610

Natural variant

208

1

Y → H. Ref.6
Corresponds to variant rs56387565 [ dbSNP | Ensembl ].

VAR_028782

Natural variant

228

1

P → L. Ref.14
Corresponds to variant rs45518335 [ dbSNP | Ensembl ].

VAR_018854

Natural variant

268

1

K → R in allele NAT2*5B, allele NAT2*5C, allele NAT2*5F, allele NAT2*6C, allele NAT2*12A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G. Ref.5 Ref.6 Ref.7 Ref.8 Ref.10 Ref.11 Ref.12 Ref.14
Corresponds to variant rs1208 [ dbSNP | Ensembl ].

VAR_004611

Natural variant

280

1

V → M.
Corresponds to variant rs56393504 [ dbSNP | Ensembl ].

VAR_061368

Natural variant

282

1

K → T in allele NAT2*18. Ref.22
Corresponds to variant rs56054745 [ dbSNP | Ensembl ].

VAR_009077

Natural variant

286

1

G → E in allele NAT2*7A and allele NAT2*7B; a slow acetylator. Ref.3 Ref.4 Ref.6 Ref.14
Corresponds to variant rs1799931 [ dbSNP | Ensembl ].

VAR_004612

Experimental info

Sequence conflict

6

1

Y → D in CAG28559. Ref.13

Sequence conflict

30

1

H → T AA sequence Ref.18

Sequence conflict

286

1

G → R in AAG34181. Ref.9

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

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.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

290

Helix Strand Turn

Details...

Helix

2 – 9

8

Helix

21 – 34

14

Helix

40 – 43

4

Helix

52 – 59

8

Helix

68 – 82

15

Beta strand

85 – 95

11

Helix

96 – 98

3

Beta strand

107 – 114

8

Beta strand

117 – 121

5

Helix

127 – 129

3

Beta strand

142 – 144

3

Beta strand

149 – 155

7

Beta strand

158 – 164

7

Beta strand

167 – 171

5

Helix

173 – 175

3

Beta strand

185 – 192

8

Helix

199 – 202

4

Helix

203 – 211

9

Helix

216 – 219

4

Beta strand

222 – 226

5

Beta strand

228 – 235

8

Beta strand

238 – 247

10

Beta strand

250 – 257

8

Helix

260 – 269

10

Beta strand

285 – 288

4

Sequences

	Sequence		Length	Mass (Da)
	P11245 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 63EE3BC2107F12B9	FASTA	290	33,542
	10 20 30 40 50 60 MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL GLEAIFDHIV 70 80 90 100 110 120 RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK YSTGMVHLLL QVTIDGRNYI 130 140 150 160 170 180 VDAGSGSSSQ MWQPLELISG KDQPQVPCIF CLTEERGIWY LDQIRREQYI TNKEFLNSHL 190 200 210 220 230 240 LPKKKHQKIY LFTLEPRTIE DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT 250 260 270 280 290 YRKFNYKDNT DLVEFKTLTE EEVEEVLKNI FKISLGRNLV PKPGDGSLTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation." Grant D.M., Blum M., Demierre A., Meyer U.A. Nucleic Acids Res. 17:3978-3978(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression." Blum M., Grant D.M., McBride W., Heim M., Meyer U.A. DNA Cell Biol. 9:193-203(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver." Ohsako S., Deguchi T. J. Biol. Chem. 265:4630-4634(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-286. Tissue: Liver.
[4]	"Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver." Deguchi T. J. Biol. Chem. 267:18140-18147(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT2*6D), VARIANTS GLN-197 AND GLU-286. Tissue: Liver.
[5]	"Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles." Ferguson R.J., Doll M.A., Rustan T.D., Gray K., Hein D.W. Drug Metab. Dispos. 22:371-376(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES NAT2*5C AND NAT2*14), VARIANTS GLN-64; THR-114 AND ARG-268.
[6]	"Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes." Patin E., Barreiro L.B., Sabeti P.C., Austerlitz F., Luca F., Sajantila A., Behar D.M., Semino O., Sakuntabhai A., Guiso N., Gicquel B., McElreavey K., Harding R.M., Heyer E., Quintana-Murci L. Am. J. Hum. Genet. 78:423-436(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-24; GLN-64; THR-114; MET-193; GLN-197; HIS-208; ARG-268 AND GLU-286.
[7]	Doll M.A., Satran S.L., Hein D.W. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT2*12A), VARIANT ARG-268.
[8]	Leff M.A., Doll M.A., Feng Y., Fretland A.J., Hein D.W. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES NAT2*5D; NAT2*6D; NAT2*14G), VARIANTS GLN-64; THR-114; GLN-197 AND ARG-268.
[9]	"A novel linkage of two NAT2 mutations." Banerjee M., Anitha A. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-114.
[10]	"A novel allele showing linkage with 282, 341, 481, 803 point mutations in the NAT2 gene." Pillai A.A., Banerjee M. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114 AND ARG-268.
[11]	"A novel NAT2 allele with point mutations 341, 481, 803, 859 in the ethnic populations of Kerala." Pillai A.A., Banerjee M. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114 AND ARG-268.
[12]	Doll M.A., Zang Y., Yeager M., Welch R., Chanock S., Hein D.W. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114; ASN-122; PHE-137 AND ARG-268.
[13]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[14]	NIEHS SNPs program Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-24; GLN-64; THR-114; GLN-197; LEU-228; ARG-268 AND GLU-286.
[15]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[16]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-197. Tissue: Liver.
[17]	"Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases." Ebisawa T., Deguchi T. Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
[18]	"Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver." Grant D.M., Lottspeich F., Meyer U.A. FEBS Lett. 244:203-207(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 18-33 AND 189-197.
[19]	"Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases." Wu H., Dombrovsky L., Tempel W., Martin F., Loppnau P., Goodfellow G.H., Grant D.M., Plotnikov A.N. J. Biol. Chem. 282:30189-30197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) IN COMPLEX WITH COENZYME A.
[20]	"Diverse point mutations in the human gene for polymorphic N-acetyltransferase." Vatsis K.P., Martell K.J., Weber W.W. Proc. Natl. Acad. Sci. U.S.A. 88:6333-6337(1991) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS.
[21]	"The structure and characteristics of a fourth allele of polymorphic N-acetyltransferase gene found in the Japanese population." Abe M., Deguchi T., Suzuki T. Biochem. Biophys. Res. Commun. 191:811-816(1993) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS.
[22]	"Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene." Lin H.J., Han C.Y., Lin B.K., Hardy S. Pharmacogenetics 4:125-134(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS NAT2*17 PRO-145 AND NAT2*18 THR-282.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NAT

NAT alleles

NIEHS-SNPs

SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X14672 Genomic DNA. Translation: CAA32802.1.
D90040 mRNA. Translation: BAA14094.1.
D90042 mRNA. Translation: BAA14096.1.
D10870 Genomic DNA. Translation: BAA01640.1.
D10871 Genomic DNA. Translation: BAA01641.1.
D10872 Genomic DNA. Translation: BAA01642.1.
U23052 Genomic DNA. Translation: AAA64584.1.
U23434 Genomic DNA. Translation: AAA64585.1.
DQ305496 Genomic DNA. Translation: ABC26032.1.
DQ305497 Genomic DNA. Translation: ABC26033.1.
DQ305498 Genomic DNA. Translation: ABC26034.1.
DQ305499 Genomic DNA. Translation: ABC26035.1.
DQ305500 Genomic DNA. Translation: ABC26036.1.
DQ305501 Genomic DNA. Translation: ABC26037.1.
DQ305502 Genomic DNA. Translation: ABC26038.1.
DQ305503 Genomic DNA. Translation: ABC26039.1.
DQ305504 Genomic DNA. Translation: ABC26040.1.
DQ305505 Genomic DNA. Translation: ABC26041.1.
DQ305506 Genomic DNA. Translation: ABC26042.1.
DQ305507 Genomic DNA. Translation: ABC26043.1.
DQ305508 Genomic DNA. Translation: ABC26044.1.
DQ305509 Genomic DNA. Translation: ABC26045.1.
DQ305510 Genomic DNA. Translation: ABC26046.1.
DQ305511 Genomic DNA. Translation: ABC26047.1.
DQ305512 Genomic DNA. Translation: ABC26048.1.
DQ305513 Genomic DNA. Translation: ABC26049.1.
DQ305514 Genomic DNA. Translation: ABC26050.1.
DQ305515 Genomic DNA. Translation: ABC26051.1.
DQ305516 Genomic DNA. Translation: ABC26052.1.
DQ305517 Genomic DNA. Translation: ABC26053.1.
DQ305518 Genomic DNA. Translation: ABC26054.1.
DQ305519 Genomic DNA. Translation: ABC26055.1.
DQ305520 Genomic DNA. Translation: ABC26056.1.
DQ305521 Genomic DNA. Translation: ABC26057.1.
DQ305522 Genomic DNA. Translation: ABC26058.1.
DQ305523 Genomic DNA. Translation: ABC26059.1.
DQ305524 Genomic DNA. Translation: ABC26060.1.
DQ305525 Genomic DNA. Translation: ABC26061.1.
DQ305526 Genomic DNA. Translation: ABC26062.1.
DQ305527 Genomic DNA. Translation: ABC26063.1.
DQ305528 Genomic DNA. Translation: ABC26064.1.
DQ305529 Genomic DNA. Translation: ABC26065.1.
DQ305530 Genomic DNA. Translation: ABC26066.1.
DQ305531 Genomic DNA. Translation: ABC26067.1.
DQ305532 Genomic DNA. Translation: ABC26068.1.
DQ305533 Genomic DNA. Translation: ABC26069.1.
DQ305534 Genomic DNA. Translation: ABC26070.1.
DQ305535 Genomic DNA. Translation: ABC26071.1.
DQ305536 Genomic DNA. Translation: ABC26072.1.
DQ305537 Genomic DNA. Translation: ABC26073.1.
DQ305538 Genomic DNA. Translation: ABC26074.1.
DQ305539 Genomic DNA. Translation: ABC26075.1.
DQ305540 Genomic DNA. Translation: ABC26076.1.
DQ305541 Genomic DNA. Translation: ABC26077.1.
DQ305542 Genomic DNA. Translation: ABC26078.1.
DQ305543 Genomic DNA. Translation: ABC26079.1.
DQ305544 Genomic DNA. Translation: ABC26080.1.
DQ305545 Genomic DNA. Translation: ABC26081.1.
DQ305546 Genomic DNA. Translation: ABC26082.1.
DQ305547 Genomic DNA. Translation: ABC26083.1.
DQ305548 Genomic DNA. Translation: ABC26084.1.
DQ305549 Genomic DNA. Translation: ABC26085.1.
DQ305550 Genomic DNA. Translation: ABC26086.1.
DQ305551 Genomic DNA. Translation: ABC26087.1.
DQ305552 Genomic DNA. Translation: ABC26088.1.
DQ305553 Genomic DNA. Translation: ABC26089.1.
DQ305554 Genomic DNA. Translation: ABC26090.1.
DQ305555 Genomic DNA. Translation: ABC26091.1.
DQ305556 Genomic DNA. Translation: ABC26092.1.
DQ305557 Genomic DNA. Translation: ABC26093.1.
DQ305558 Genomic DNA. Translation: ABC26094.1.
DQ305559 Genomic DNA. Translation: ABC26095.1.
DQ305560 Genomic DNA. Translation: ABC26096.1.
DQ305561 Genomic DNA. Translation: ABC26097.1.
DQ305562 Genomic DNA. Translation: ABC26098.1.
DQ305563 Genomic DNA. Translation: ABC26099.1.
DQ305564 Genomic DNA. Translation: ABC26100.1.
DQ305565 Genomic DNA. Translation: ABC26101.1.
DQ305566 Genomic DNA. Translation: ABC26102.1.
DQ305567 Genomic DNA. Translation: ABC26103.1.
DQ305568 Genomic DNA. Translation: ABC26104.1.
DQ305569 Genomic DNA. Translation: ABC26105.1.
DQ305570 Genomic DNA. Translation: ABC26106.1.
DQ305571 Genomic DNA. Translation: ABC26107.1.
DQ305572 Genomic DNA. Translation: ABC26108.1.
DQ305573 Genomic DNA. Translation: ABC26109.1.
DQ305574 Genomic DNA. Translation: ABC26110.1.
DQ305575 Genomic DNA. Translation: ABC26111.1.
DQ305576 Genomic DNA. Translation: ABC26112.1.
DQ305577 Genomic DNA. Translation: ABC26113.1.
DQ305578 Genomic DNA. Translation: ABC26114.1.
DQ305579 Genomic DNA. Translation: ABC26115.1.
DQ305580 Genomic DNA. Translation: ABC26116.1.
DQ305581 Genomic DNA. Translation: ABC26117.1.
DQ305582 Genomic DNA. Translation: ABC26118.1.
DQ305583 Genomic DNA. Translation: ABC26119.1.
DQ305584 Genomic DNA. Translation: ABC26120.1.
DQ305585 Genomic DNA. Translation: ABC26121.1.
DQ305586 Genomic DNA. Translation: ABC26122.1.
DQ305587 Genomic DNA. Translation: ABC26123.1.
DQ305588 Genomic DNA. Translation: ABC26124.1.
DQ305589 Genomic DNA. Translation: ABC26125.1.
DQ305590 Genomic DNA. Translation: ABC26126.1.
DQ305591 Genomic DNA. Translation: ABC26127.1.
DQ305592 Genomic DNA. Translation: ABC26128.1.
DQ305593 Genomic DNA. Translation: ABC26129.1.
DQ305594 Genomic DNA. Translation: ABC26130.1.
DQ305595 Genomic DNA. Translation: ABC26131.1.
DQ305596 Genomic DNA. Translation: ABC26132.1.
DQ305597 Genomic DNA. Translation: ABC26133.1.
DQ305598 Genomic DNA. Translation: ABC26134.1.
DQ305599 Genomic DNA. Translation: ABC26135.1.
DQ305600 Genomic DNA. Translation: ABC26136.1.
DQ305601 Genomic DNA. Translation: ABC26137.1.
DQ305602 Genomic DNA. Translation: ABC26138.1.
DQ305603 Genomic DNA. Translation: ABC26139.1.
DQ305604 Genomic DNA. Translation: ABC26140.1.
DQ305605 Genomic DNA. Translation: ABC26141.1.
DQ305606 Genomic DNA. Translation: ABC26142.1.
DQ305607 Genomic DNA. Translation: ABC26143.1.
DQ305608 Genomic DNA. Translation: ABC26144.1.
DQ305609 Genomic DNA. Translation: ABC26145.1.
DQ305610 Genomic DNA. Translation: ABC26146.1.
DQ305611 Genomic DNA. Translation: ABC26147.1.
DQ305612 Genomic DNA. Translation: ABC26148.1.
DQ305613 Genomic DNA. Translation: ABC26149.1.
DQ305614 Genomic DNA. Translation: ABC26150.1.
DQ305615 Genomic DNA. Translation: ABC26151.1.
DQ305616 Genomic DNA. Translation: ABC26152.1.
DQ305617 Genomic DNA. Translation: ABC26153.1.
DQ305618 Genomic DNA. Translation: ABC26154.1.
DQ305619 Genomic DNA. Translation: ABC26155.1.
DQ305620 Genomic DNA. Translation: ABC26156.1.
DQ305621 Genomic DNA. Translation: ABC26157.1.
DQ305622 Genomic DNA. Translation: ABC26158.1.
DQ305623 Genomic DNA. Translation: ABC26159.1.
DQ305624 Genomic DNA. Translation: ABC26160.1.
DQ305625 Genomic DNA. Translation: ABC26161.1.
DQ305626 Genomic DNA. Translation: ABC26162.1.
DQ305627 Genomic DNA. Translation: ABC26163.1.
DQ305628 Genomic DNA. Translation: ABC26164.1.
DQ305629 Genomic DNA. Translation: ABC26165.1.
DQ305630 Genomic DNA. Translation: ABC26166.1.
DQ305631 Genomic DNA. Translation: ABC26167.1.
DQ305632 Genomic DNA. Translation: ABC26168.1.
DQ305633 Genomic DNA. Translation: ABC26169.1.
DQ305634 Genomic DNA. Translation: ABC26170.1.
DQ305635 Genomic DNA. Translation: ABC26171.1.
DQ305636 Genomic DNA. Translation: ABC26172.1.
DQ305637 Genomic DNA. Translation: ABC26173.1.
DQ305638 Genomic DNA. Translation: ABC26174.1.
DQ305639 Genomic DNA. Translation: ABC26175.1.
DQ305640 Genomic DNA. Translation: ABC26176.1.
DQ305641 Genomic DNA. Translation: ABC26177.1.
DQ305642 Genomic DNA. Translation: ABC26178.1.
DQ305643 Genomic DNA. Translation: ABC26179.1.
DQ305644 Genomic DNA. Translation: ABC26180.1.
DQ305645 Genomic DNA. Translation: ABC26181.1.
DQ305646 Genomic DNA. Translation: ABC26182.1.
DQ305647 Genomic DNA. Translation: ABC26183.1.
DQ305648 Genomic DNA. Translation: ABC26184.1.
DQ305649 Genomic DNA. Translation: ABC26185.1.
DQ305650 Genomic DNA. Translation: ABC26186.1.
DQ305651 Genomic DNA. Translation: ABC26187.1.
DQ305652 Genomic DNA. Translation: ABC26188.1.
DQ305653 Genomic DNA. Translation: ABC26189.1.
DQ305654 Genomic DNA. Translation: ABC26190.1.
DQ305655 Genomic DNA. Translation: ABC26191.1.
U53473 Genomic DNA. Translation: AAA98976.1.
AF042740 Genomic DNA. Translation: AAC03773.1.
AF055874 Genomic DNA. Translation: AAC14117.1.
AF055875 Genomic DNA. Translation: AAC14118.1.
AF320309 Genomic DNA. Translation: AAG34181.1.
AF348074 Genomic DNA. Translation: AAK51710.1.
AF348075 Genomic DNA. Translation: AAK51711.1. Frameshift.
AY230251 Genomic DNA. Translation: AAO73561.1.
AY230252 Genomic DNA. Translation: AAO73562.1.
CR407631 mRNA. Translation: CAG28559.1.
AY331807 Genomic DNA. Translation: AAP81164.1.
AC025062 Genomic DNA. No translation available.
AC120051 Genomic DNA. No translation available.
BC015878 mRNA. Translation: AAH15878.1.
BC067218 mRNA. Translation: AAH67218.1.
M75163 Genomic DNA. Translation: AAA59906.1.

IPI

IPI00004421.

PIR

B34585.
S02788.

RefSeq

NP_000006.2. NM_000015.2.

UniGene

Hs.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2PFR	X-ray	1.92	A/B	2-290	[»]

ProteinModelPortal

P11245.

ModBase

Search...

PTM databases

PhosphoSite

P11245.

Polymorphism databases

DMDM

114238.

Proteomic databases

PaxDb

P11245.

PRIDE

P11245.

Protocols and materials databases

DNASU

10.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000286479; ENSP00000286479; ENSG00000156006.

GeneID

10.

KEGG

hsa:10.

Organism-specific databases

CTD

10.

GeneCards

GC08P018250.

HGNC

HGNC:7646. NAT2.

HPA

HPA043704.

MIM

243400. phenotype.
612182. gene.

neXtProt

NX_P11245.

Orphanet

240887. Isoniazide toxicity.
240975. Susceptibility to adverse reaction due to isoniazide treatment.

PharmGKB

PA18.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG2162.

HOVERGEN

HBG000165.

InParanoid

P11245.

KO

K00622.

OrthoDB

EOG4JDH7B.

Enzyme and pathway databases

BRENDA

2.3.1.5. 2681.

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

P11245.

Bgee

P11245.

CleanEx

HS_NAT2.

Genevestigator

P11245.

GermOnline

ENSG00000156006. Homo sapiens.

Family and domain databases

InterPro

IPR001447. Arylamine_N-AcTrfase.
[Graphical view]

PANTHER

PTHR11786. PTHR11786. 1 hit.

Pfam

PF00797. Acetyltransf_2. 1 hit.
[Graphical view]

PRINTS

PR01543. ANATRNSFRASE.

ProtoNet

Search...

Other

BindingDB

P11245.

ChEMBL

CHEMBL2194.

EvolutionaryTrace

P11245.

GenomeRNAi

10.

NextBio

17.

SOURCE

Search...

Entry information

Entry name

ARY2_HUMAN

Accession

Primary (citable) accession number: P11245
Secondary accession number(s): O43637 , O60654, O60655, Q13146, Q16697, Q2MLE4, Q2MLF5, Q2MLG8, Q2MLJ6, Q2MLK4, Q2MLK6, Q2MLN7, Q6LET4, Q86XS0, Q86XS1, Q96KY8, Q96T64, Q96T65, Q9H220

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 133 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.