Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P11245

- ARY2_HUMAN

UniProt

P11245 - ARY2_HUMAN

Protein

Arylamine N-acetyltransferase 2

Gene

NAT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

    Catalytic activityi

    Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Acyl-thioester intermediate
    Binding sitei103 – 1031Coenzyme A1 Publication
    Binding sitei104 – 1041Coenzyme A; via amide nitrogen1 Publication
    Active sitei107 – 1071
    Active sitei122 – 1221
    Binding sitei208 – 2081Coenzyme A1 Publication
    Binding sitei214 – 2141Coenzyme A1 Publication
    Binding sitei287 – 2871Coenzyme A1 Publication

    GO - Molecular functioni

    1. arylamine N-acetyltransferase activity Source: ProtInc

    GO - Biological processi

    1. small molecule metabolic process Source: Reactome
    2. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.3.1.5. 2681.
    ReactomeiREACT_6732. Acetylation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arylamine N-acetyltransferase 2 (EC:2.3.1.5)
    Alternative name(s):
    Arylamide acetylase 2
    N-acetyltransferase type 2
    Short name:
    NAT-2
    Polymorphic arylamine N-acetyltransferase
    Short name:
    PNAT
    Gene namesi
    Name:NAT2
    Synonyms:AAC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7646. NAT2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    MIMi243400. phenotype.
    Orphaneti240887. Isoniazid toxicity.
    240975. Susceptibility to adverse reaction due to isoniazide treatment.
    PharmGKBiPA18.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Arylamine N-acetyltransferase 2PRO_0000107905Add
    BLAST

    Proteomic databases

    MaxQBiP11245.
    PaxDbiP11245.
    PRIDEiP11245.

    PTM databases

    PhosphoSiteiP11245.

    Expressioni

    Gene expression databases

    ArrayExpressiP11245.
    BgeeiP11245.
    CleanExiHS_NAT2.
    GenevestigatoriP11245.

    Organism-specific databases

    HPAiHPA043704.

    Interactioni

    Protein-protein interaction databases

    BioGridi106528. 1 interaction.

    Structurei

    Secondary structure

    1
    290
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 98
    Helixi21 – 3414
    Helixi40 – 434
    Helixi52 – 598
    Helixi68 – 8215
    Beta strandi85 – 9511
    Helixi96 – 983
    Beta strandi107 – 1148
    Beta strandi117 – 1215
    Helixi127 – 1293
    Beta strandi142 – 1443
    Beta strandi149 – 1557
    Beta strandi158 – 1647
    Beta strandi167 – 1715
    Helixi173 – 1753
    Beta strandi185 – 1928
    Helixi199 – 2024
    Helixi203 – 2119
    Helixi216 – 2194
    Beta strandi222 – 2265
    Beta strandi228 – 2358
    Beta strandi238 – 24710
    Beta strandi250 – 2578
    Helixi260 – 26910
    Beta strandi285 – 2884

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PFRX-ray1.92A/B2-290[»]
    ProteinModelPortaliP11245.
    SMRiP11245. Positions 2-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11245.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni106 – 1072Substrate bindingCurated

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2162.
    HOVERGENiHBG000165.
    InParanoidiP11245.
    KOiK00622.
    OrthoDBiEOG7BP83H.
    PhylomeDBiP11245.
    TreeFamiTF106311.

    Family and domain databases

    InterProiIPR001447. Arylamine_N-AcTrfase.
    [Graphical view]
    PANTHERiPTHR11786. PTHR11786. 1 hit.
    PfamiPF00797. Acetyltransf_2. 1 hit.
    [Graphical view]
    PRINTSiPR01543. ANATRNSFRASE.

    Sequencei

    Sequence statusi: Complete.

    P11245-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL    50
    GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK 100
    YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF 150
    CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE 200
    DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT 250
    DLVEFKTLTE EEVEEVLKNI FKISLGRNLV PKPGDGSLTI 290
    Length:290
    Mass (Da):33,542
    Last modified:July 1, 1989 - v1
    Checksum:i63EE3BC2107F12B9
    GO

    Sequence cautioni

    The sequence AAK51711.1 differs from that shown. Reason: Frameshift at position 287.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61Y → D in CAG28559. 1 PublicationCurated
    Sequence conflicti30 – 301H → T AA sequence (PubMed:2924904)Curated
    Sequence conflicti286 – 2861G → R in AAG34181. 1 PublicationCurated

    Polymorphismi

    Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIMi:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241L → I.2 Publications
    Corresponds to variant rs45477599 [ dbSNP | Ensembl ].
    VAR_018853
    Natural varianti64 – 641R → Q in allele NAT2*14A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14D, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G; a slow acetylator. 4 Publications
    Corresponds to variant rs1801279 [ dbSNP | Ensembl ].
    VAR_004608
    Natural varianti64 – 641R → W in allele NAT2*19.
    Corresponds to variant rs1805158 [ dbSNP | Ensembl ].
    VAR_009075
    Natural varianti114 – 1141I → T in allele NAT2*5A, allele NAT2*5B, allele NAT2*5C, allele NAT2*5D, allele NAT2*5E, allele NAT2*5F, allele NAT2*14B and allele NAT2*14E; a slow acetylator. 8 Publications
    Corresponds to variant rs1801280 [ dbSNP | Ensembl ].
    VAR_004609
    Natural varianti122 – 1221D → N.1 Publication
    Corresponds to variant rs4986996 [ dbSNP | Ensembl ].
    VAR_020385
    Natural varianti135 – 1351L → V.
    Corresponds to variant rs12720065 [ dbSNP | Ensembl ].
    VAR_046905
    Natural varianti137 – 1371L → F.1 Publication
    Corresponds to variant rs4986997 [ dbSNP | Ensembl ].
    VAR_020386
    Natural varianti145 – 1451Q → P in allele NAT2*17. 1 Publication
    VAR_009076
    Natural varianti193 – 1931T → M.1 Publication
    VAR_028781
    Natural varianti197 – 1971R → Q in allele NAT2*5E, allele NAT2*6A, allele NAT2*6B, allele NAT2*6C, allele NAT2*6D and allele NAT2*14D; a slow acetylator. 5 Publications
    Corresponds to variant rs1799930 [ dbSNP | Ensembl ].
    VAR_004610
    Natural varianti208 – 2081Y → H.1 Publication
    Corresponds to variant rs56387565 [ dbSNP | Ensembl ].
    VAR_028782
    Natural varianti228 – 2281P → L.1 Publication
    Corresponds to variant rs45518335 [ dbSNP | Ensembl ].
    VAR_018854
    Natural varianti268 – 2681K → R in allele NAT2*5B, allele NAT2*5C, allele NAT2*5F, allele NAT2*6C, allele NAT2*12A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G. 8 Publications
    Corresponds to variant rs1208 [ dbSNP | Ensembl ].
    VAR_004611
    Natural varianti280 – 2801V → M.
    Corresponds to variant rs56393504 [ dbSNP | Ensembl ].
    VAR_061368
    Natural varianti282 – 2821K → T in allele NAT2*18. 1 Publication
    Corresponds to variant rs56054745 [ dbSNP | Ensembl ].
    VAR_009077
    Natural varianti286 – 2861G → E in allele NAT2*7A and allele NAT2*7B; a slow acetylator. 4 Publications
    Corresponds to variant rs1799931 [ dbSNP | Ensembl ].
    VAR_004612

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14672 Genomic DNA. Translation: CAA32802.1.
    D90040 mRNA. Translation: BAA14094.1.
    D90042 mRNA. Translation: BAA14096.1.
    D10870 Genomic DNA. Translation: BAA01640.1.
    D10871 Genomic DNA. Translation: BAA01641.1.
    D10872 Genomic DNA. Translation: BAA01642.1.
    U23052 Genomic DNA. Translation: AAA64584.1.
    U23434 Genomic DNA. Translation: AAA64585.1.
    DQ305496 Genomic DNA. Translation: ABC26032.1.
    DQ305497 Genomic DNA. Translation: ABC26033.1.
    DQ305498 Genomic DNA. Translation: ABC26034.1.
    DQ305499 Genomic DNA. Translation: ABC26035.1.
    DQ305500 Genomic DNA. Translation: ABC26036.1.
    DQ305501 Genomic DNA. Translation: ABC26037.1.
    DQ305502 Genomic DNA. Translation: ABC26038.1.
    DQ305503 Genomic DNA. Translation: ABC26039.1.
    DQ305504 Genomic DNA. Translation: ABC26040.1.
    DQ305505 Genomic DNA. Translation: ABC26041.1.
    DQ305506 Genomic DNA. Translation: ABC26042.1.
    DQ305507 Genomic DNA. Translation: ABC26043.1.
    DQ305508 Genomic DNA. Translation: ABC26044.1.
    DQ305509 Genomic DNA. Translation: ABC26045.1.
    DQ305510 Genomic DNA. Translation: ABC26046.1.
    DQ305511 Genomic DNA. Translation: ABC26047.1.
    DQ305512 Genomic DNA. Translation: ABC26048.1.
    DQ305513 Genomic DNA. Translation: ABC26049.1.
    DQ305514 Genomic DNA. Translation: ABC26050.1.
    DQ305515 Genomic DNA. Translation: ABC26051.1.
    DQ305516 Genomic DNA. Translation: ABC26052.1.
    DQ305517 Genomic DNA. Translation: ABC26053.1.
    DQ305518 Genomic DNA. Translation: ABC26054.1.
    DQ305519 Genomic DNA. Translation: ABC26055.1.
    DQ305520 Genomic DNA. Translation: ABC26056.1.
    DQ305521 Genomic DNA. Translation: ABC26057.1.
    DQ305522 Genomic DNA. Translation: ABC26058.1.
    DQ305523 Genomic DNA. Translation: ABC26059.1.
    DQ305524 Genomic DNA. Translation: ABC26060.1.
    DQ305525 Genomic DNA. Translation: ABC26061.1.
    DQ305526 Genomic DNA. Translation: ABC26062.1.
    DQ305527 Genomic DNA. Translation: ABC26063.1.
    DQ305528 Genomic DNA. Translation: ABC26064.1.
    DQ305529 Genomic DNA. Translation: ABC26065.1.
    DQ305530 Genomic DNA. Translation: ABC26066.1.
    DQ305531 Genomic DNA. Translation: ABC26067.1.
    DQ305532 Genomic DNA. Translation: ABC26068.1.
    DQ305533 Genomic DNA. Translation: ABC26069.1.
    DQ305534 Genomic DNA. Translation: ABC26070.1.
    DQ305535 Genomic DNA. Translation: ABC26071.1.
    DQ305536 Genomic DNA. Translation: ABC26072.1.
    DQ305537 Genomic DNA. Translation: ABC26073.1.
    DQ305538 Genomic DNA. Translation: ABC26074.1.
    DQ305539 Genomic DNA. Translation: ABC26075.1.
    DQ305540 Genomic DNA. Translation: ABC26076.1.
    DQ305541 Genomic DNA. Translation: ABC26077.1.
    DQ305542 Genomic DNA. Translation: ABC26078.1.
    DQ305543 Genomic DNA. Translation: ABC26079.1.
    DQ305544 Genomic DNA. Translation: ABC26080.1.
    DQ305545 Genomic DNA. Translation: ABC26081.1.
    DQ305546 Genomic DNA. Translation: ABC26082.1.
    DQ305547 Genomic DNA. Translation: ABC26083.1.
    DQ305548 Genomic DNA. Translation: ABC26084.1.
    DQ305549 Genomic DNA. Translation: ABC26085.1.
    DQ305550 Genomic DNA. Translation: ABC26086.1.
    DQ305551 Genomic DNA. Translation: ABC26087.1.
    DQ305552 Genomic DNA. Translation: ABC26088.1.
    DQ305553 Genomic DNA. Translation: ABC26089.1.
    DQ305554 Genomic DNA. Translation: ABC26090.1.
    DQ305555 Genomic DNA. Translation: ABC26091.1.
    DQ305556 Genomic DNA. Translation: ABC26092.1.
    DQ305557 Genomic DNA. Translation: ABC26093.1.
    DQ305558 Genomic DNA. Translation: ABC26094.1.
    DQ305559 Genomic DNA. Translation: ABC26095.1.
    DQ305560 Genomic DNA. Translation: ABC26096.1.
    DQ305561 Genomic DNA. Translation: ABC26097.1.
    DQ305562 Genomic DNA. Translation: ABC26098.1.
    DQ305563 Genomic DNA. Translation: ABC26099.1.
    DQ305564 Genomic DNA. Translation: ABC26100.1.
    DQ305565 Genomic DNA. Translation: ABC26101.1.
    DQ305566 Genomic DNA. Translation: ABC26102.1.
    DQ305567 Genomic DNA. Translation: ABC26103.1.
    DQ305568 Genomic DNA. Translation: ABC26104.1.
    DQ305569 Genomic DNA. Translation: ABC26105.1.
    DQ305570 Genomic DNA. Translation: ABC26106.1.
    DQ305571 Genomic DNA. Translation: ABC26107.1.
    DQ305572 Genomic DNA. Translation: ABC26108.1.
    DQ305573 Genomic DNA. Translation: ABC26109.1.
    DQ305574 Genomic DNA. Translation: ABC26110.1.
    DQ305575 Genomic DNA. Translation: ABC26111.1.
    DQ305576 Genomic DNA. Translation: ABC26112.1.
    DQ305577 Genomic DNA. Translation: ABC26113.1.
    DQ305578 Genomic DNA. Translation: ABC26114.1.
    DQ305579 Genomic DNA. Translation: ABC26115.1.
    DQ305580 Genomic DNA. Translation: ABC26116.1.
    DQ305581 Genomic DNA. Translation: ABC26117.1.
    DQ305582 Genomic DNA. Translation: ABC26118.1.
    DQ305583 Genomic DNA. Translation: ABC26119.1.
    DQ305584 Genomic DNA. Translation: ABC26120.1.
    DQ305585 Genomic DNA. Translation: ABC26121.1.
    DQ305586 Genomic DNA. Translation: ABC26122.1.
    DQ305587 Genomic DNA. Translation: ABC26123.1.
    DQ305588 Genomic DNA. Translation: ABC26124.1.
    DQ305589 Genomic DNA. Translation: ABC26125.1.
    DQ305590 Genomic DNA. Translation: ABC26126.1.
    DQ305591 Genomic DNA. Translation: ABC26127.1.
    DQ305592 Genomic DNA. Translation: ABC26128.1.
    DQ305593 Genomic DNA. Translation: ABC26129.1.
    DQ305594 Genomic DNA. Translation: ABC26130.1.
    DQ305595 Genomic DNA. Translation: ABC26131.1.
    DQ305596 Genomic DNA. Translation: ABC26132.1.
    DQ305597 Genomic DNA. Translation: ABC26133.1.
    DQ305598 Genomic DNA. Translation: ABC26134.1.
    DQ305599 Genomic DNA. Translation: ABC26135.1.
    DQ305600 Genomic DNA. Translation: ABC26136.1.
    DQ305601 Genomic DNA. Translation: ABC26137.1.
    DQ305602 Genomic DNA. Translation: ABC26138.1.
    DQ305603 Genomic DNA. Translation: ABC26139.1.
    DQ305604 Genomic DNA. Translation: ABC26140.1.
    DQ305605 Genomic DNA. Translation: ABC26141.1.
    DQ305606 Genomic DNA. Translation: ABC26142.1.
    DQ305607 Genomic DNA. Translation: ABC26143.1.
    DQ305608 Genomic DNA. Translation: ABC26144.1.
    DQ305609 Genomic DNA. Translation: ABC26145.1.
    DQ305610 Genomic DNA. Translation: ABC26146.1.
    DQ305611 Genomic DNA. Translation: ABC26147.1.
    DQ305612 Genomic DNA. Translation: ABC26148.1.
    DQ305613 Genomic DNA. Translation: ABC26149.1.
    DQ305614 Genomic DNA. Translation: ABC26150.1.
    DQ305615 Genomic DNA. Translation: ABC26151.1.
    DQ305616 Genomic DNA. Translation: ABC26152.1.
    DQ305617 Genomic DNA. Translation: ABC26153.1.
    DQ305618 Genomic DNA. Translation: ABC26154.1.
    DQ305619 Genomic DNA. Translation: ABC26155.1.
    DQ305620 Genomic DNA. Translation: ABC26156.1.
    DQ305621 Genomic DNA. Translation: ABC26157.1.
    DQ305622 Genomic DNA. Translation: ABC26158.1.
    DQ305623 Genomic DNA. Translation: ABC26159.1.
    DQ305624 Genomic DNA. Translation: ABC26160.1.
    DQ305625 Genomic DNA. Translation: ABC26161.1.
    DQ305626 Genomic DNA. Translation: ABC26162.1.
    DQ305627 Genomic DNA. Translation: ABC26163.1.
    DQ305628 Genomic DNA. Translation: ABC26164.1.
    DQ305629 Genomic DNA. Translation: ABC26165.1.
    DQ305630 Genomic DNA. Translation: ABC26166.1.
    DQ305631 Genomic DNA. Translation: ABC26167.1.
    DQ305632 Genomic DNA. Translation: ABC26168.1.
    DQ305633 Genomic DNA. Translation: ABC26169.1.
    DQ305634 Genomic DNA. Translation: ABC26170.1.
    DQ305635 Genomic DNA. Translation: ABC26171.1.
    DQ305636 Genomic DNA. Translation: ABC26172.1.
    DQ305637 Genomic DNA. Translation: ABC26173.1.
    DQ305638 Genomic DNA. Translation: ABC26174.1.
    DQ305639 Genomic DNA. Translation: ABC26175.1.
    DQ305640 Genomic DNA. Translation: ABC26176.1.
    DQ305641 Genomic DNA. Translation: ABC26177.1.
    DQ305642 Genomic DNA. Translation: ABC26178.1.
    DQ305643 Genomic DNA. Translation: ABC26179.1.
    DQ305644 Genomic DNA. Translation: ABC26180.1.
    DQ305645 Genomic DNA. Translation: ABC26181.1.
    DQ305646 Genomic DNA. Translation: ABC26182.1.
    DQ305647 Genomic DNA. Translation: ABC26183.1.
    DQ305648 Genomic DNA. Translation: ABC26184.1.
    DQ305649 Genomic DNA. Translation: ABC26185.1.
    DQ305650 Genomic DNA. Translation: ABC26186.1.
    DQ305651 Genomic DNA. Translation: ABC26187.1.
    DQ305652 Genomic DNA. Translation: ABC26188.1.
    DQ305653 Genomic DNA. Translation: ABC26189.1.
    DQ305654 Genomic DNA. Translation: ABC26190.1.
    DQ305655 Genomic DNA. Translation: ABC26191.1.
    U53473 Genomic DNA. Translation: AAA98976.1.
    AF042740 Genomic DNA. Translation: AAC03773.1.
    AF055874 Genomic DNA. Translation: AAC14117.1.
    AF055875 Genomic DNA. Translation: AAC14118.1.
    AF320309 Genomic DNA. Translation: AAG34181.1.
    AF348074 Genomic DNA. Translation: AAK51710.1.
    AF348075 Genomic DNA. Translation: AAK51711.1. Frameshift.
    AY230251 Genomic DNA. Translation: AAO73561.1.
    AY230252 Genomic DNA. Translation: AAO73562.1.
    CR407631 mRNA. Translation: CAG28559.1.
    AY331807 Genomic DNA. Translation: AAP81164.1.
    AC025062 Genomic DNA. No translation available.
    AC120051 Genomic DNA. No translation available.
    BC015878 mRNA. Translation: AAH15878.1.
    BC067218 mRNA. Translation: AAH67218.1.
    M75163 Genomic DNA. Translation: AAA59906.1.
    CCDSiCCDS6008.1.
    PIRiB34585.
    S02788.
    RefSeqiNP_000006.2. NM_000015.2.
    UniGeneiHs.2.

    Genome annotation databases

    EnsembliENST00000286479; ENSP00000286479; ENSG00000156006.
    GeneIDi10.
    KEGGihsa:10.

    Polymorphism databases

    DMDMi114238.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    NAT

    NAT alleles

    NIEHS-SNPs
    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14672 Genomic DNA. Translation: CAA32802.1 .
    D90040 mRNA. Translation: BAA14094.1 .
    D90042 mRNA. Translation: BAA14096.1 .
    D10870 Genomic DNA. Translation: BAA01640.1 .
    D10871 Genomic DNA. Translation: BAA01641.1 .
    D10872 Genomic DNA. Translation: BAA01642.1 .
    U23052 Genomic DNA. Translation: AAA64584.1 .
    U23434 Genomic DNA. Translation: AAA64585.1 .
    DQ305496 Genomic DNA. Translation: ABC26032.1 .
    DQ305497 Genomic DNA. Translation: ABC26033.1 .
    DQ305498 Genomic DNA. Translation: ABC26034.1 .
    DQ305499 Genomic DNA. Translation: ABC26035.1 .
    DQ305500 Genomic DNA. Translation: ABC26036.1 .
    DQ305501 Genomic DNA. Translation: ABC26037.1 .
    DQ305502 Genomic DNA. Translation: ABC26038.1 .
    DQ305503 Genomic DNA. Translation: ABC26039.1 .
    DQ305504 Genomic DNA. Translation: ABC26040.1 .
    DQ305505 Genomic DNA. Translation: ABC26041.1 .
    DQ305506 Genomic DNA. Translation: ABC26042.1 .
    DQ305507 Genomic DNA. Translation: ABC26043.1 .
    DQ305508 Genomic DNA. Translation: ABC26044.1 .
    DQ305509 Genomic DNA. Translation: ABC26045.1 .
    DQ305510 Genomic DNA. Translation: ABC26046.1 .
    DQ305511 Genomic DNA. Translation: ABC26047.1 .
    DQ305512 Genomic DNA. Translation: ABC26048.1 .
    DQ305513 Genomic DNA. Translation: ABC26049.1 .
    DQ305514 Genomic DNA. Translation: ABC26050.1 .
    DQ305515 Genomic DNA. Translation: ABC26051.1 .
    DQ305516 Genomic DNA. Translation: ABC26052.1 .
    DQ305517 Genomic DNA. Translation: ABC26053.1 .
    DQ305518 Genomic DNA. Translation: ABC26054.1 .
    DQ305519 Genomic DNA. Translation: ABC26055.1 .
    DQ305520 Genomic DNA. Translation: ABC26056.1 .
    DQ305521 Genomic DNA. Translation: ABC26057.1 .
    DQ305522 Genomic DNA. Translation: ABC26058.1 .
    DQ305523 Genomic DNA. Translation: ABC26059.1 .
    DQ305524 Genomic DNA. Translation: ABC26060.1 .
    DQ305525 Genomic DNA. Translation: ABC26061.1 .
    DQ305526 Genomic DNA. Translation: ABC26062.1 .
    DQ305527 Genomic DNA. Translation: ABC26063.1 .
    DQ305528 Genomic DNA. Translation: ABC26064.1 .
    DQ305529 Genomic DNA. Translation: ABC26065.1 .
    DQ305530 Genomic DNA. Translation: ABC26066.1 .
    DQ305531 Genomic DNA. Translation: ABC26067.1 .
    DQ305532 Genomic DNA. Translation: ABC26068.1 .
    DQ305533 Genomic DNA. Translation: ABC26069.1 .
    DQ305534 Genomic DNA. Translation: ABC26070.1 .
    DQ305535 Genomic DNA. Translation: ABC26071.1 .
    DQ305536 Genomic DNA. Translation: ABC26072.1 .
    DQ305537 Genomic DNA. Translation: ABC26073.1 .
    DQ305538 Genomic DNA. Translation: ABC26074.1 .
    DQ305539 Genomic DNA. Translation: ABC26075.1 .
    DQ305540 Genomic DNA. Translation: ABC26076.1 .
    DQ305541 Genomic DNA. Translation: ABC26077.1 .
    DQ305542 Genomic DNA. Translation: ABC26078.1 .
    DQ305543 Genomic DNA. Translation: ABC26079.1 .
    DQ305544 Genomic DNA. Translation: ABC26080.1 .
    DQ305545 Genomic DNA. Translation: ABC26081.1 .
    DQ305546 Genomic DNA. Translation: ABC26082.1 .
    DQ305547 Genomic DNA. Translation: ABC26083.1 .
    DQ305548 Genomic DNA. Translation: ABC26084.1 .
    DQ305549 Genomic DNA. Translation: ABC26085.1 .
    DQ305550 Genomic DNA. Translation: ABC26086.1 .
    DQ305551 Genomic DNA. Translation: ABC26087.1 .
    DQ305552 Genomic DNA. Translation: ABC26088.1 .
    DQ305553 Genomic DNA. Translation: ABC26089.1 .
    DQ305554 Genomic DNA. Translation: ABC26090.1 .
    DQ305555 Genomic DNA. Translation: ABC26091.1 .
    DQ305556 Genomic DNA. Translation: ABC26092.1 .
    DQ305557 Genomic DNA. Translation: ABC26093.1 .
    DQ305558 Genomic DNA. Translation: ABC26094.1 .
    DQ305559 Genomic DNA. Translation: ABC26095.1 .
    DQ305560 Genomic DNA. Translation: ABC26096.1 .
    DQ305561 Genomic DNA. Translation: ABC26097.1 .
    DQ305562 Genomic DNA. Translation: ABC26098.1 .
    DQ305563 Genomic DNA. Translation: ABC26099.1 .
    DQ305564 Genomic DNA. Translation: ABC26100.1 .
    DQ305565 Genomic DNA. Translation: ABC26101.1 .
    DQ305566 Genomic DNA. Translation: ABC26102.1 .
    DQ305567 Genomic DNA. Translation: ABC26103.1 .
    DQ305568 Genomic DNA. Translation: ABC26104.1 .
    DQ305569 Genomic DNA. Translation: ABC26105.1 .
    DQ305570 Genomic DNA. Translation: ABC26106.1 .
    DQ305571 Genomic DNA. Translation: ABC26107.1 .
    DQ305572 Genomic DNA. Translation: ABC26108.1 .
    DQ305573 Genomic DNA. Translation: ABC26109.1 .
    DQ305574 Genomic DNA. Translation: ABC26110.1 .
    DQ305575 Genomic DNA. Translation: ABC26111.1 .
    DQ305576 Genomic DNA. Translation: ABC26112.1 .
    DQ305577 Genomic DNA. Translation: ABC26113.1 .
    DQ305578 Genomic DNA. Translation: ABC26114.1 .
    DQ305579 Genomic DNA. Translation: ABC26115.1 .
    DQ305580 Genomic DNA. Translation: ABC26116.1 .
    DQ305581 Genomic DNA. Translation: ABC26117.1 .
    DQ305582 Genomic DNA. Translation: ABC26118.1 .
    DQ305583 Genomic DNA. Translation: ABC26119.1 .
    DQ305584 Genomic DNA. Translation: ABC26120.1 .
    DQ305585 Genomic DNA. Translation: ABC26121.1 .
    DQ305586 Genomic DNA. Translation: ABC26122.1 .
    DQ305587 Genomic DNA. Translation: ABC26123.1 .
    DQ305588 Genomic DNA. Translation: ABC26124.1 .
    DQ305589 Genomic DNA. Translation: ABC26125.1 .
    DQ305590 Genomic DNA. Translation: ABC26126.1 .
    DQ305591 Genomic DNA. Translation: ABC26127.1 .
    DQ305592 Genomic DNA. Translation: ABC26128.1 .
    DQ305593 Genomic DNA. Translation: ABC26129.1 .
    DQ305594 Genomic DNA. Translation: ABC26130.1 .
    DQ305595 Genomic DNA. Translation: ABC26131.1 .
    DQ305596 Genomic DNA. Translation: ABC26132.1 .
    DQ305597 Genomic DNA. Translation: ABC26133.1 .
    DQ305598 Genomic DNA. Translation: ABC26134.1 .
    DQ305599 Genomic DNA. Translation: ABC26135.1 .
    DQ305600 Genomic DNA. Translation: ABC26136.1 .
    DQ305601 Genomic DNA. Translation: ABC26137.1 .
    DQ305602 Genomic DNA. Translation: ABC26138.1 .
    DQ305603 Genomic DNA. Translation: ABC26139.1 .
    DQ305604 Genomic DNA. Translation: ABC26140.1 .
    DQ305605 Genomic DNA. Translation: ABC26141.1 .
    DQ305606 Genomic DNA. Translation: ABC26142.1 .
    DQ305607 Genomic DNA. Translation: ABC26143.1 .
    DQ305608 Genomic DNA. Translation: ABC26144.1 .
    DQ305609 Genomic DNA. Translation: ABC26145.1 .
    DQ305610 Genomic DNA. Translation: ABC26146.1 .
    DQ305611 Genomic DNA. Translation: ABC26147.1 .
    DQ305612 Genomic DNA. Translation: ABC26148.1 .
    DQ305613 Genomic DNA. Translation: ABC26149.1 .
    DQ305614 Genomic DNA. Translation: ABC26150.1 .
    DQ305615 Genomic DNA. Translation: ABC26151.1 .
    DQ305616 Genomic DNA. Translation: ABC26152.1 .
    DQ305617 Genomic DNA. Translation: ABC26153.1 .
    DQ305618 Genomic DNA. Translation: ABC26154.1 .
    DQ305619 Genomic DNA. Translation: ABC26155.1 .
    DQ305620 Genomic DNA. Translation: ABC26156.1 .
    DQ305621 Genomic DNA. Translation: ABC26157.1 .
    DQ305622 Genomic DNA. Translation: ABC26158.1 .
    DQ305623 Genomic DNA. Translation: ABC26159.1 .
    DQ305624 Genomic DNA. Translation: ABC26160.1 .
    DQ305625 Genomic DNA. Translation: ABC26161.1 .
    DQ305626 Genomic DNA. Translation: ABC26162.1 .
    DQ305627 Genomic DNA. Translation: ABC26163.1 .
    DQ305628 Genomic DNA. Translation: ABC26164.1 .
    DQ305629 Genomic DNA. Translation: ABC26165.1 .
    DQ305630 Genomic DNA. Translation: ABC26166.1 .
    DQ305631 Genomic DNA. Translation: ABC26167.1 .
    DQ305632 Genomic DNA. Translation: ABC26168.1 .
    DQ305633 Genomic DNA. Translation: ABC26169.1 .
    DQ305634 Genomic DNA. Translation: ABC26170.1 .
    DQ305635 Genomic DNA. Translation: ABC26171.1 .
    DQ305636 Genomic DNA. Translation: ABC26172.1 .
    DQ305637 Genomic DNA. Translation: ABC26173.1 .
    DQ305638 Genomic DNA. Translation: ABC26174.1 .
    DQ305639 Genomic DNA. Translation: ABC26175.1 .
    DQ305640 Genomic DNA. Translation: ABC26176.1 .
    DQ305641 Genomic DNA. Translation: ABC26177.1 .
    DQ305642 Genomic DNA. Translation: ABC26178.1 .
    DQ305643 Genomic DNA. Translation: ABC26179.1 .
    DQ305644 Genomic DNA. Translation: ABC26180.1 .
    DQ305645 Genomic DNA. Translation: ABC26181.1 .
    DQ305646 Genomic DNA. Translation: ABC26182.1 .
    DQ305647 Genomic DNA. Translation: ABC26183.1 .
    DQ305648 Genomic DNA. Translation: ABC26184.1 .
    DQ305649 Genomic DNA. Translation: ABC26185.1 .
    DQ305650 Genomic DNA. Translation: ABC26186.1 .
    DQ305651 Genomic DNA. Translation: ABC26187.1 .
    DQ305652 Genomic DNA. Translation: ABC26188.1 .
    DQ305653 Genomic DNA. Translation: ABC26189.1 .
    DQ305654 Genomic DNA. Translation: ABC26190.1 .
    DQ305655 Genomic DNA. Translation: ABC26191.1 .
    U53473 Genomic DNA. Translation: AAA98976.1 .
    AF042740 Genomic DNA. Translation: AAC03773.1 .
    AF055874 Genomic DNA. Translation: AAC14117.1 .
    AF055875 Genomic DNA. Translation: AAC14118.1 .
    AF320309 Genomic DNA. Translation: AAG34181.1 .
    AF348074 Genomic DNA. Translation: AAK51710.1 .
    AF348075 Genomic DNA. Translation: AAK51711.1 . Frameshift.
    AY230251 Genomic DNA. Translation: AAO73561.1 .
    AY230252 Genomic DNA. Translation: AAO73562.1 .
    CR407631 mRNA. Translation: CAG28559.1 .
    AY331807 Genomic DNA. Translation: AAP81164.1 .
    AC025062 Genomic DNA. No translation available.
    AC120051 Genomic DNA. No translation available.
    BC015878 mRNA. Translation: AAH15878.1 .
    BC067218 mRNA. Translation: AAH67218.1 .
    M75163 Genomic DNA. Translation: AAA59906.1 .
    CCDSi CCDS6008.1.
    PIRi B34585.
    S02788.
    RefSeqi NP_000006.2. NM_000015.2.
    UniGenei Hs.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PFR X-ray 1.92 A/B 2-290 [» ]
    ProteinModelPortali P11245.
    SMRi P11245. Positions 2-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106528. 1 interaction.

    Chemistry

    BindingDBi P11245.
    ChEMBLi CHEMBL2194.

    PTM databases

    PhosphoSitei P11245.

    Polymorphism databases

    DMDMi 114238.

    Proteomic databases

    MaxQBi P11245.
    PaxDbi P11245.
    PRIDEi P11245.

    Protocols and materials databases

    DNASUi 10.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286479 ; ENSP00000286479 ; ENSG00000156006 .
    GeneIDi 10.
    KEGGi hsa:10.

    Organism-specific databases

    CTDi 10.
    GeneCardsi GC08P018250.
    HGNCi HGNC:7646. NAT2.
    HPAi HPA043704.
    MIMi 243400. phenotype.
    612182. gene.
    neXtProti NX_P11245.
    Orphaneti 240887. Isoniazid toxicity.
    240975. Susceptibility to adverse reaction due to isoniazide treatment.
    PharmGKBi PA18.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2162.
    HOVERGENi HBG000165.
    InParanoidi P11245.
    KOi K00622.
    OrthoDBi EOG7BP83H.
    PhylomeDBi P11245.
    TreeFami TF106311.

    Enzyme and pathway databases

    BRENDAi 2.3.1.5. 2681.
    Reactomei REACT_6732. Acetylation.

    Miscellaneous databases

    EvolutionaryTracei P11245.
    GeneWikii N-acetyltransferase_2.
    GenomeRNAii 10.
    NextBioi 17.
    PROi P11245.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11245.
    Bgeei P11245.
    CleanExi HS_NAT2.
    Genevestigatori P11245.

    Family and domain databases

    InterProi IPR001447. Arylamine_N-AcTrfase.
    [Graphical view ]
    PANTHERi PTHR11786. PTHR11786. 1 hit.
    Pfami PF00797. Acetyltransf_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01543. ANATRNSFRASE.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation."
      Grant D.M., Blum M., Demierre A., Meyer U.A.
      Nucleic Acids Res. 17:3978-3978(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression."
      Blum M., Grant D.M., McBride W., Heim M., Meyer U.A.
      DNA Cell Biol. 9:193-203(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver."
      Ohsako S., Deguchi T.
      J. Biol. Chem. 265:4630-4634(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-286.
      Tissue: Liver.
    4. "Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver."
      Deguchi T.
      J. Biol. Chem. 267:18140-18147(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT2*6D), VARIANTS GLN-197 AND GLU-286.
      Tissue: Liver.
    5. "Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles."
      Ferguson R.J., Doll M.A., Rustan T.D., Gray K., Hein D.W.
      Drug Metab. Dispos. 22:371-376(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES NAT2*5C AND NAT2*14), VARIANTS GLN-64; THR-114 AND ARG-268.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-24; GLN-64; THR-114; MET-193; GLN-197; HIS-208; ARG-268 AND GLU-286.
    7. Doll M.A., Satran S.L., Hein D.W.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT2*12A), VARIANT ARG-268.
    8. Leff M.A., Doll M.A., Feng Y., Fretland A.J., Hein D.W.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES NAT2*5D; NAT2*6D; NAT2*14G), VARIANTS GLN-64; THR-114; GLN-197 AND ARG-268.
    9. "A novel linkage of two NAT2 mutations."
      Banerjee M., Anitha A.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-114.
    10. "A novel allele showing linkage with 282, 341, 481, 803 point mutations in the NAT2 gene."
      Pillai A.A., Banerjee M.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114 AND ARG-268.
    11. "A novel NAT2 allele with point mutations 341, 481, 803, 859 in the ethnic populations of Kerala."
      Pillai A.A., Banerjee M.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114 AND ARG-268.
    12. Doll M.A., Zang Y., Yeager M., Welch R., Chanock S., Hein D.W.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-114; ASN-122; PHE-137 AND ARG-268.
    13. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    14. NIEHS SNPs program
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-24; GLN-64; THR-114; GLN-197; LEU-228; ARG-268 AND GLU-286.
    15. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    16. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-197.
      Tissue: Liver.
    17. "Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases."
      Ebisawa T., Deguchi T.
      Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
    18. "Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver."
      Grant D.M., Lottspeich F., Meyer U.A.
      FEBS Lett. 244:203-207(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-33 AND 189-197.
    19. "Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases."
      Wu H., Dombrovsky L., Tempel W., Martin F., Loppnau P., Goodfellow G.H., Grant D.M., Plotnikov A.N.
      J. Biol. Chem. 282:30189-30197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) IN COMPLEX WITH COENZYME A.
    20. "Diverse point mutations in the human gene for polymorphic N-acetyltransferase."
      Vatsis K.P., Martell K.J., Weber W.W.
      Proc. Natl. Acad. Sci. U.S.A. 88:6333-6337(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS.
    21. "The structure and characteristics of a fourth allele of polymorphic N-acetyltransferase gene found in the Japanese population."
      Abe M., Deguchi T., Suzuki T.
      Biochem. Biophys. Res. Commun. 191:811-816(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS.
    22. "Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene."
      Lin H.J., Han C.Y., Lin B.K., Hardy S.
      Pharmacogenetics 4:125-134(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS NAT2*17 PRO-145 AND NAT2*18 THR-282.

    Entry informationi

    Entry nameiARY2_HUMAN
    AccessioniPrimary (citable) accession number: P11245
    Secondary accession number(s): O43637
    , O60654, O60655, Q13146, Q16697, Q2MLE4, Q2MLF5, Q2MLG8, Q2MLJ6, Q2MLK4, Q2MLK6, Q2MLN7, Q6LET4, Q86XS0, Q86XS1, Q96KY8, Q96T64, Q96T65, Q9H220
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3