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Protein

Arylamine N-acetyltransferase 2

Gene

NAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Catalytic activityi

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Acyl-thioester intermediate1
Binding sitei103Coenzyme A1 Publication1
Binding sitei104Coenzyme A; via amide nitrogen1 Publication1
Active sitei1071
Active sitei1221
Binding sitei208Coenzyme A1 Publication1
Binding sitei214Coenzyme A1 Publication1
Binding sitei287Coenzyme A1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS08090-MONOMER.
BRENDAi2.3.1.5. 2681.
ReactomeiR-HSA-156582. Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylamine N-acetyltransferase 2 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 2
N-acetyltransferase type 2
Short name:
NAT-2
Polymorphic arylamine N-acetyltransferase
Short name:
PNAT
Gene namesi
Name:NAT2
Synonyms:AAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7646. NAT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10.
MalaCardsiNAT2.
MIMi243400. phenotype.
Orphaneti240887. Isoniazid toxicity.
PharmGKBiPA18.

Chemistry databases

ChEMBLiCHEMBL2194.
DrugBankiDB00316. Acetaminophen.
DB01068. Clonazepam.
DB00250. Dapsone.
DB04953. Ezogabine.
DB00951. Isoniazid.
DB01015. Sulfamethoxazole.

Polymorphism and mutation databases

BioMutaiNAT2.
DMDMi114238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079051 – 290Arylamine N-acetyltransferase 2Add BLAST290

Proteomic databases

MaxQBiP11245.
PaxDbiP11245.
PeptideAtlasiP11245.
PRIDEiP11245.

PTM databases

iPTMnetiP11245.
PhosphoSitePlusiP11245.

Expressioni

Gene expression databases

BgeeiENSG00000156006.
CleanExiHS_NAT2.
ExpressionAtlasiP11245. baseline and differential.
GenevisibleiP11245. HS.

Organism-specific databases

HPAiHPA043704.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATMQ133152EBI-9057228,EBI-495465
RAD51Q066094EBI-9057228,EBI-297202

Protein-protein interaction databases

BioGridi106528. 20 interactors.
IntActiP11245. 16 interactors.
STRINGi9606.ENSP00000286479.

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 9Combined sources8
Helixi21 – 34Combined sources14
Helixi40 – 43Combined sources4
Helixi52 – 59Combined sources8
Helixi68 – 82Combined sources15
Beta strandi85 – 95Combined sources11
Helixi96 – 98Combined sources3
Beta strandi107 – 114Combined sources8
Beta strandi117 – 121Combined sources5
Helixi127 – 129Combined sources3
Beta strandi142 – 144Combined sources3
Beta strandi149 – 155Combined sources7
Beta strandi158 – 164Combined sources7
Beta strandi167 – 171Combined sources5
Helixi173 – 175Combined sources3
Beta strandi185 – 192Combined sources8
Helixi199 – 202Combined sources4
Helixi203 – 211Combined sources9
Helixi216 – 219Combined sources4
Beta strandi222 – 226Combined sources5
Beta strandi228 – 235Combined sources8
Beta strandi238 – 247Combined sources10
Beta strandi250 – 257Combined sources8
Helixi260 – 269Combined sources10
Beta strandi285 – 288Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PFRX-ray1.92A/B2-290[»]
ProteinModelPortaliP11245.
SMRiP11245.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11245.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 107Substrate bindingCurated2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
HOVERGENiHBG000165.
InParanoidiP11245.
KOiK00622.
OrthoDBiEOG091G0CO6.
PhylomeDBiP11245.
TreeFamiTF106311.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.

Sequencei

Sequence statusi: Complete.

P11245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL
60 70 80 90 100
GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK
110 120 130 140 150
YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF
160 170 180 190 200
CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE
210 220 230 240 250
DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT
260 270 280 290
DLVEFKTLTE EEVEEVLKNI FKISLGRNLV PKPGDGSLTI
Length:290
Mass (Da):33,542
Last modified:July 1, 1989 - v1
Checksum:i63EE3BC2107F12B9
GO

Sequence cautioni

The sequence AAK51711 differs from that shown. Reason: Frameshift at position 287.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6Y → D in CAG28559 (Ref. 13) Curated1
Sequence conflicti30H → T AA sequence (PubMed:2924904).Curated1
Sequence conflicti286G → R in AAG34181 (Ref. 9) Curated1

Polymorphismi

Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIMi:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01885324L → I.2 PublicationsCorresponds to variant rs45477599dbSNPEnsembl.1
Natural variantiVAR_00460864R → Q in allele NAT2*14A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14D, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G; a slow acetylator. 4 PublicationsCorresponds to variant rs1801279dbSNPEnsembl.1
Natural variantiVAR_00907564R → W in allele NAT2*19. Corresponds to variant rs1805158dbSNPEnsembl.1
Natural variantiVAR_004609114I → T in allele NAT2*5A, allele NAT2*5B, allele NAT2*5C, allele NAT2*5D, allele NAT2*5E, allele NAT2*5F, allele NAT2*14B and allele NAT2*14E; a slow acetylator. 8 PublicationsCorresponds to variant rs1801280dbSNPEnsembl.1
Natural variantiVAR_020385122D → N.1 PublicationCorresponds to variant rs4986996dbSNPEnsembl.1
Natural variantiVAR_046905135L → V.Corresponds to variant rs12720065dbSNPEnsembl.1
Natural variantiVAR_020386137L → F.1 PublicationCorresponds to variant rs4986997dbSNPEnsembl.1
Natural variantiVAR_009076145Q → P in allele NAT2*17. 1 Publication1
Natural variantiVAR_028781193T → M.1 Publication1
Natural variantiVAR_004610197R → Q in allele NAT2*5E, allele NAT2*6A, allele NAT2*6B, allele NAT2*6C, allele NAT2*6D and allele NAT2*14D; a slow acetylator. 5 PublicationsCorresponds to variant rs1799930dbSNPEnsembl.1
Natural variantiVAR_028782208Y → H.1 PublicationCorresponds to variant rs56387565dbSNPEnsembl.1
Natural variantiVAR_018854228P → L.1 PublicationCorresponds to variant rs45518335dbSNPEnsembl.1
Natural variantiVAR_004611268K → R in allele NAT2*5B, allele NAT2*5C, allele NAT2*5F, allele NAT2*6C, allele NAT2*12A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G. 8 PublicationsCorresponds to variant rs1208dbSNPEnsembl.1
Natural variantiVAR_061368280V → M.Corresponds to variant rs56393504dbSNPEnsembl.1
Natural variantiVAR_009077282K → T in allele NAT2*18. 1 PublicationCorresponds to variant rs56054745dbSNPEnsembl.1
Natural variantiVAR_004612286G → E in allele NAT2*7A and allele NAT2*7B; a slow acetylator. 4 PublicationsCorresponds to variant rs1799931dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14672 Genomic DNA. Translation: CAA32802.1.
D90040 mRNA. Translation: BAA14094.1.
D90042 mRNA. Translation: BAA14096.1.
D10870 Genomic DNA. Translation: BAA01640.1.
D10871 Genomic DNA. Translation: BAA01641.1.
D10872 Genomic DNA. Translation: BAA01642.1.
U23052 Genomic DNA. Translation: AAA64584.1.
U23434 Genomic DNA. Translation: AAA64585.1.
DQ305496 Genomic DNA. Translation: ABC26032.1.
DQ305497 Genomic DNA. Translation: ABC26033.1.
DQ305498 Genomic DNA. Translation: ABC26034.1.
DQ305499 Genomic DNA. Translation: ABC26035.1.
DQ305500 Genomic DNA. Translation: ABC26036.1.
DQ305501 Genomic DNA. Translation: ABC26037.1.
DQ305502 Genomic DNA. Translation: ABC26038.1.
DQ305503 Genomic DNA. Translation: ABC26039.1.
DQ305504 Genomic DNA. Translation: ABC26040.1.
DQ305505 Genomic DNA. Translation: ABC26041.1.
DQ305506 Genomic DNA. Translation: ABC26042.1.
DQ305507 Genomic DNA. Translation: ABC26043.1.
DQ305508 Genomic DNA. Translation: ABC26044.1.
DQ305509 Genomic DNA. Translation: ABC26045.1.
DQ305510 Genomic DNA. Translation: ABC26046.1.
DQ305511 Genomic DNA. Translation: ABC26047.1.
DQ305512 Genomic DNA. Translation: ABC26048.1.
DQ305513 Genomic DNA. Translation: ABC26049.1.
DQ305514 Genomic DNA. Translation: ABC26050.1.
DQ305515 Genomic DNA. Translation: ABC26051.1.
DQ305516 Genomic DNA. Translation: ABC26052.1.
DQ305517 Genomic DNA. Translation: ABC26053.1.
DQ305518 Genomic DNA. Translation: ABC26054.1.
DQ305519 Genomic DNA. Translation: ABC26055.1.
DQ305520 Genomic DNA. Translation: ABC26056.1.
DQ305521 Genomic DNA. Translation: ABC26057.1.
DQ305522 Genomic DNA. Translation: ABC26058.1.
DQ305523 Genomic DNA. Translation: ABC26059.1.
DQ305524 Genomic DNA. Translation: ABC26060.1.
DQ305525 Genomic DNA. Translation: ABC26061.1.
DQ305526 Genomic DNA. Translation: ABC26062.1.
DQ305527 Genomic DNA. Translation: ABC26063.1.
DQ305528 Genomic DNA. Translation: ABC26064.1.
DQ305529 Genomic DNA. Translation: ABC26065.1.
DQ305530 Genomic DNA. Translation: ABC26066.1.
DQ305531 Genomic DNA. Translation: ABC26067.1.
DQ305532 Genomic DNA. Translation: ABC26068.1.
DQ305533 Genomic DNA. Translation: ABC26069.1.
DQ305534 Genomic DNA. Translation: ABC26070.1.
DQ305535 Genomic DNA. Translation: ABC26071.1.
DQ305536 Genomic DNA. Translation: ABC26072.1.
DQ305537 Genomic DNA. Translation: ABC26073.1.
DQ305538 Genomic DNA. Translation: ABC26074.1.
DQ305539 Genomic DNA. Translation: ABC26075.1.
DQ305540 Genomic DNA. Translation: ABC26076.1.
DQ305541 Genomic DNA. Translation: ABC26077.1.
DQ305542 Genomic DNA. Translation: ABC26078.1.
DQ305543 Genomic DNA. Translation: ABC26079.1.
DQ305544 Genomic DNA. Translation: ABC26080.1.
DQ305545 Genomic DNA. Translation: ABC26081.1.
DQ305546 Genomic DNA. Translation: ABC26082.1.
DQ305547 Genomic DNA. Translation: ABC26083.1.
DQ305548 Genomic DNA. Translation: ABC26084.1.
DQ305549 Genomic DNA. Translation: ABC26085.1.
DQ305550 Genomic DNA. Translation: ABC26086.1.
DQ305551 Genomic DNA. Translation: ABC26087.1.
DQ305552 Genomic DNA. Translation: ABC26088.1.
DQ305553 Genomic DNA. Translation: ABC26089.1.
DQ305554 Genomic DNA. Translation: ABC26090.1.
DQ305555 Genomic DNA. Translation: ABC26091.1.
DQ305556 Genomic DNA. Translation: ABC26092.1.
DQ305557 Genomic DNA. Translation: ABC26093.1.
DQ305558 Genomic DNA. Translation: ABC26094.1.
DQ305559 Genomic DNA. Translation: ABC26095.1.
DQ305560 Genomic DNA. Translation: ABC26096.1.
DQ305561 Genomic DNA. Translation: ABC26097.1.
DQ305562 Genomic DNA. Translation: ABC26098.1.
DQ305563 Genomic DNA. Translation: ABC26099.1.
DQ305564 Genomic DNA. Translation: ABC26100.1.
DQ305565 Genomic DNA. Translation: ABC26101.1.
DQ305566 Genomic DNA. Translation: ABC26102.1.
DQ305567 Genomic DNA. Translation: ABC26103.1.
DQ305568 Genomic DNA. Translation: ABC26104.1.
DQ305569 Genomic DNA. Translation: ABC26105.1.
DQ305570 Genomic DNA. Translation: ABC26106.1.
DQ305571 Genomic DNA. Translation: ABC26107.1.
DQ305572 Genomic DNA. Translation: ABC26108.1.
DQ305573 Genomic DNA. Translation: ABC26109.1.
DQ305574 Genomic DNA. Translation: ABC26110.1.
DQ305575 Genomic DNA. Translation: ABC26111.1.
DQ305576 Genomic DNA. Translation: ABC26112.1.
DQ305577 Genomic DNA. Translation: ABC26113.1.
DQ305578 Genomic DNA. Translation: ABC26114.1.
DQ305579 Genomic DNA. Translation: ABC26115.1.
DQ305580 Genomic DNA. Translation: ABC26116.1.
DQ305581 Genomic DNA. Translation: ABC26117.1.
DQ305582 Genomic DNA. Translation: ABC26118.1.
DQ305583 Genomic DNA. Translation: ABC26119.1.
DQ305584 Genomic DNA. Translation: ABC26120.1.
DQ305585 Genomic DNA. Translation: ABC26121.1.
DQ305586 Genomic DNA. Translation: ABC26122.1.
DQ305587 Genomic DNA. Translation: ABC26123.1.
DQ305588 Genomic DNA. Translation: ABC26124.1.
DQ305589 Genomic DNA. Translation: ABC26125.1.
DQ305590 Genomic DNA. Translation: ABC26126.1.
DQ305591 Genomic DNA. Translation: ABC26127.1.
DQ305592 Genomic DNA. Translation: ABC26128.1.
DQ305593 Genomic DNA. Translation: ABC26129.1.
DQ305594 Genomic DNA. Translation: ABC26130.1.
DQ305595 Genomic DNA. Translation: ABC26131.1.
DQ305596 Genomic DNA. Translation: ABC26132.1.
DQ305597 Genomic DNA. Translation: ABC26133.1.
DQ305598 Genomic DNA. Translation: ABC26134.1.
DQ305599 Genomic DNA. Translation: ABC26135.1.
DQ305600 Genomic DNA. Translation: ABC26136.1.
DQ305601 Genomic DNA. Translation: ABC26137.1.
DQ305602 Genomic DNA. Translation: ABC26138.1.
DQ305603 Genomic DNA. Translation: ABC26139.1.
DQ305604 Genomic DNA. Translation: ABC26140.1.
DQ305605 Genomic DNA. Translation: ABC26141.1.
DQ305606 Genomic DNA. Translation: ABC26142.1.
DQ305607 Genomic DNA. Translation: ABC26143.1.
DQ305608 Genomic DNA. Translation: ABC26144.1.
DQ305609 Genomic DNA. Translation: ABC26145.1.
DQ305610 Genomic DNA. Translation: ABC26146.1.
DQ305611 Genomic DNA. Translation: ABC26147.1.
DQ305612 Genomic DNA. Translation: ABC26148.1.
DQ305613 Genomic DNA. Translation: ABC26149.1.
DQ305614 Genomic DNA. Translation: ABC26150.1.
DQ305615 Genomic DNA. Translation: ABC26151.1.
DQ305616 Genomic DNA. Translation: ABC26152.1.
DQ305617 Genomic DNA. Translation: ABC26153.1.
DQ305618 Genomic DNA. Translation: ABC26154.1.
DQ305619 Genomic DNA. Translation: ABC26155.1.
DQ305620 Genomic DNA. Translation: ABC26156.1.
DQ305621 Genomic DNA. Translation: ABC26157.1.
DQ305622 Genomic DNA. Translation: ABC26158.1.
DQ305623 Genomic DNA. Translation: ABC26159.1.
DQ305624 Genomic DNA. Translation: ABC26160.1.
DQ305625 Genomic DNA. Translation: ABC26161.1.
DQ305626 Genomic DNA. Translation: ABC26162.1.
DQ305627 Genomic DNA. Translation: ABC26163.1.
DQ305628 Genomic DNA. Translation: ABC26164.1.
DQ305629 Genomic DNA. Translation: ABC26165.1.
DQ305630 Genomic DNA. Translation: ABC26166.1.
DQ305631 Genomic DNA. Translation: ABC26167.1.
DQ305632 Genomic DNA. Translation: ABC26168.1.
DQ305633 Genomic DNA. Translation: ABC26169.1.
DQ305634 Genomic DNA. Translation: ABC26170.1.
DQ305635 Genomic DNA. Translation: ABC26171.1.
DQ305636 Genomic DNA. Translation: ABC26172.1.
DQ305637 Genomic DNA. Translation: ABC26173.1.
DQ305638 Genomic DNA. Translation: ABC26174.1.
DQ305639 Genomic DNA. Translation: ABC26175.1.
DQ305640 Genomic DNA. Translation: ABC26176.1.
DQ305641 Genomic DNA. Translation: ABC26177.1.
DQ305642 Genomic DNA. Translation: ABC26178.1.
DQ305643 Genomic DNA. Translation: ABC26179.1.
DQ305644 Genomic DNA. Translation: ABC26180.1.
DQ305645 Genomic DNA. Translation: ABC26181.1.
DQ305646 Genomic DNA. Translation: ABC26182.1.
DQ305647 Genomic DNA. Translation: ABC26183.1.
DQ305648 Genomic DNA. Translation: ABC26184.1.
DQ305649 Genomic DNA. Translation: ABC26185.1.
DQ305650 Genomic DNA. Translation: ABC26186.1.
DQ305651 Genomic DNA. Translation: ABC26187.1.
DQ305652 Genomic DNA. Translation: ABC26188.1.
DQ305653 Genomic DNA. Translation: ABC26189.1.
DQ305654 Genomic DNA. Translation: ABC26190.1.
DQ305655 Genomic DNA. Translation: ABC26191.1.
U53473 Genomic DNA. Translation: AAA98976.1.
AF042740 Genomic DNA. Translation: AAC03773.1.
AF055874 Genomic DNA. Translation: AAC14117.1.
AF055875 Genomic DNA. Translation: AAC14118.1.
AF320309 Genomic DNA. Translation: AAG34181.1.
AF348074 Genomic DNA. Translation: AAK51710.1.
AF348075 Genomic DNA. Translation: AAK51711.1. Frameshift.
AY230251 Genomic DNA. Translation: AAO73561.1.
AY230252 Genomic DNA. Translation: AAO73562.1.
CR407631 mRNA. Translation: CAG28559.1.
AY331807 Genomic DNA. Translation: AAP81164.1.
AC025062 Genomic DNA. No translation available.
AC120051 Genomic DNA. No translation available.
BC015878 mRNA. Translation: AAH15878.1.
BC067218 mRNA. Translation: AAH67218.1.
M75163 Genomic DNA. Translation: AAA59906.1.
CCDSiCCDS6008.1.
PIRiB34585.
S02788.
RefSeqiNP_000006.2. NM_000015.2.
XP_016868427.1. XM_017012938.1.
UniGeneiHs.2.

Genome annotation databases

EnsembliENST00000286479; ENSP00000286479; ENSG00000156006.
GeneIDi10.
KEGGihsa:10.
UCSCiuc003wyw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NAT

NAT alleles

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14672 Genomic DNA. Translation: CAA32802.1.
D90040 mRNA. Translation: BAA14094.1.
D90042 mRNA. Translation: BAA14096.1.
D10870 Genomic DNA. Translation: BAA01640.1.
D10871 Genomic DNA. Translation: BAA01641.1.
D10872 Genomic DNA. Translation: BAA01642.1.
U23052 Genomic DNA. Translation: AAA64584.1.
U23434 Genomic DNA. Translation: AAA64585.1.
DQ305496 Genomic DNA. Translation: ABC26032.1.
DQ305497 Genomic DNA. Translation: ABC26033.1.
DQ305498 Genomic DNA. Translation: ABC26034.1.
DQ305499 Genomic DNA. Translation: ABC26035.1.
DQ305500 Genomic DNA. Translation: ABC26036.1.
DQ305501 Genomic DNA. Translation: ABC26037.1.
DQ305502 Genomic DNA. Translation: ABC26038.1.
DQ305503 Genomic DNA. Translation: ABC26039.1.
DQ305504 Genomic DNA. Translation: ABC26040.1.
DQ305505 Genomic DNA. Translation: ABC26041.1.
DQ305506 Genomic DNA. Translation: ABC26042.1.
DQ305507 Genomic DNA. Translation: ABC26043.1.
DQ305508 Genomic DNA. Translation: ABC26044.1.
DQ305509 Genomic DNA. Translation: ABC26045.1.
DQ305510 Genomic DNA. Translation: ABC26046.1.
DQ305511 Genomic DNA. Translation: ABC26047.1.
DQ305512 Genomic DNA. Translation: ABC26048.1.
DQ305513 Genomic DNA. Translation: ABC26049.1.
DQ305514 Genomic DNA. Translation: ABC26050.1.
DQ305515 Genomic DNA. Translation: ABC26051.1.
DQ305516 Genomic DNA. Translation: ABC26052.1.
DQ305517 Genomic DNA. Translation: ABC26053.1.
DQ305518 Genomic DNA. Translation: ABC26054.1.
DQ305519 Genomic DNA. Translation: ABC26055.1.
DQ305520 Genomic DNA. Translation: ABC26056.1.
DQ305521 Genomic DNA. Translation: ABC26057.1.
DQ305522 Genomic DNA. Translation: ABC26058.1.
DQ305523 Genomic DNA. Translation: ABC26059.1.
DQ305524 Genomic DNA. Translation: ABC26060.1.
DQ305525 Genomic DNA. Translation: ABC26061.1.
DQ305526 Genomic DNA. Translation: ABC26062.1.
DQ305527 Genomic DNA. Translation: ABC26063.1.
DQ305528 Genomic DNA. Translation: ABC26064.1.
DQ305529 Genomic DNA. Translation: ABC26065.1.
DQ305530 Genomic DNA. Translation: ABC26066.1.
DQ305531 Genomic DNA. Translation: ABC26067.1.
DQ305532 Genomic DNA. Translation: ABC26068.1.
DQ305533 Genomic DNA. Translation: ABC26069.1.
DQ305534 Genomic DNA. Translation: ABC26070.1.
DQ305535 Genomic DNA. Translation: ABC26071.1.
DQ305536 Genomic DNA. Translation: ABC26072.1.
DQ305537 Genomic DNA. Translation: ABC26073.1.
DQ305538 Genomic DNA. Translation: ABC26074.1.
DQ305539 Genomic DNA. Translation: ABC26075.1.
DQ305540 Genomic DNA. Translation: ABC26076.1.
DQ305541 Genomic DNA. Translation: ABC26077.1.
DQ305542 Genomic DNA. Translation: ABC26078.1.
DQ305543 Genomic DNA. Translation: ABC26079.1.
DQ305544 Genomic DNA. Translation: ABC26080.1.
DQ305545 Genomic DNA. Translation: ABC26081.1.
DQ305546 Genomic DNA. Translation: ABC26082.1.
DQ305547 Genomic DNA. Translation: ABC26083.1.
DQ305548 Genomic DNA. Translation: ABC26084.1.
DQ305549 Genomic DNA. Translation: ABC26085.1.
DQ305550 Genomic DNA. Translation: ABC26086.1.
DQ305551 Genomic DNA. Translation: ABC26087.1.
DQ305552 Genomic DNA. Translation: ABC26088.1.
DQ305553 Genomic DNA. Translation: ABC26089.1.
DQ305554 Genomic DNA. Translation: ABC26090.1.
DQ305555 Genomic DNA. Translation: ABC26091.1.
DQ305556 Genomic DNA. Translation: ABC26092.1.
DQ305557 Genomic DNA. Translation: ABC26093.1.
DQ305558 Genomic DNA. Translation: ABC26094.1.
DQ305559 Genomic DNA. Translation: ABC26095.1.
DQ305560 Genomic DNA. Translation: ABC26096.1.
DQ305561 Genomic DNA. Translation: ABC26097.1.
DQ305562 Genomic DNA. Translation: ABC26098.1.
DQ305563 Genomic DNA. Translation: ABC26099.1.
DQ305564 Genomic DNA. Translation: ABC26100.1.
DQ305565 Genomic DNA. Translation: ABC26101.1.
DQ305566 Genomic DNA. Translation: ABC26102.1.
DQ305567 Genomic DNA. Translation: ABC26103.1.
DQ305568 Genomic DNA. Translation: ABC26104.1.
DQ305569 Genomic DNA. Translation: ABC26105.1.
DQ305570 Genomic DNA. Translation: ABC26106.1.
DQ305571 Genomic DNA. Translation: ABC26107.1.
DQ305572 Genomic DNA. Translation: ABC26108.1.
DQ305573 Genomic DNA. Translation: ABC26109.1.
DQ305574 Genomic DNA. Translation: ABC26110.1.
DQ305575 Genomic DNA. Translation: ABC26111.1.
DQ305576 Genomic DNA. Translation: ABC26112.1.
DQ305577 Genomic DNA. Translation: ABC26113.1.
DQ305578 Genomic DNA. Translation: ABC26114.1.
DQ305579 Genomic DNA. Translation: ABC26115.1.
DQ305580 Genomic DNA. Translation: ABC26116.1.
DQ305581 Genomic DNA. Translation: ABC26117.1.
DQ305582 Genomic DNA. Translation: ABC26118.1.
DQ305583 Genomic DNA. Translation: ABC26119.1.
DQ305584 Genomic DNA. Translation: ABC26120.1.
DQ305585 Genomic DNA. Translation: ABC26121.1.
DQ305586 Genomic DNA. Translation: ABC26122.1.
DQ305587 Genomic DNA. Translation: ABC26123.1.
DQ305588 Genomic DNA. Translation: ABC26124.1.
DQ305589 Genomic DNA. Translation: ABC26125.1.
DQ305590 Genomic DNA. Translation: ABC26126.1.
DQ305591 Genomic DNA. Translation: ABC26127.1.
DQ305592 Genomic DNA. Translation: ABC26128.1.
DQ305593 Genomic DNA. Translation: ABC26129.1.
DQ305594 Genomic DNA. Translation: ABC26130.1.
DQ305595 Genomic DNA. Translation: ABC26131.1.
DQ305596 Genomic DNA. Translation: ABC26132.1.
DQ305597 Genomic DNA. Translation: ABC26133.1.
DQ305598 Genomic DNA. Translation: ABC26134.1.
DQ305599 Genomic DNA. Translation: ABC26135.1.
DQ305600 Genomic DNA. Translation: ABC26136.1.
DQ305601 Genomic DNA. Translation: ABC26137.1.
DQ305602 Genomic DNA. Translation: ABC26138.1.
DQ305603 Genomic DNA. Translation: ABC26139.1.
DQ305604 Genomic DNA. Translation: ABC26140.1.
DQ305605 Genomic DNA. Translation: ABC26141.1.
DQ305606 Genomic DNA. Translation: ABC26142.1.
DQ305607 Genomic DNA. Translation: ABC26143.1.
DQ305608 Genomic DNA. Translation: ABC26144.1.
DQ305609 Genomic DNA. Translation: ABC26145.1.
DQ305610 Genomic DNA. Translation: ABC26146.1.
DQ305611 Genomic DNA. Translation: ABC26147.1.
DQ305612 Genomic DNA. Translation: ABC26148.1.
DQ305613 Genomic DNA. Translation: ABC26149.1.
DQ305614 Genomic DNA. Translation: ABC26150.1.
DQ305615 Genomic DNA. Translation: ABC26151.1.
DQ305616 Genomic DNA. Translation: ABC26152.1.
DQ305617 Genomic DNA. Translation: ABC26153.1.
DQ305618 Genomic DNA. Translation: ABC26154.1.
DQ305619 Genomic DNA. Translation: ABC26155.1.
DQ305620 Genomic DNA. Translation: ABC26156.1.
DQ305621 Genomic DNA. Translation: ABC26157.1.
DQ305622 Genomic DNA. Translation: ABC26158.1.
DQ305623 Genomic DNA. Translation: ABC26159.1.
DQ305624 Genomic DNA. Translation: ABC26160.1.
DQ305625 Genomic DNA. Translation: ABC26161.1.
DQ305626 Genomic DNA. Translation: ABC26162.1.
DQ305627 Genomic DNA. Translation: ABC26163.1.
DQ305628 Genomic DNA. Translation: ABC26164.1.
DQ305629 Genomic DNA. Translation: ABC26165.1.
DQ305630 Genomic DNA. Translation: ABC26166.1.
DQ305631 Genomic DNA. Translation: ABC26167.1.
DQ305632 Genomic DNA. Translation: ABC26168.1.
DQ305633 Genomic DNA. Translation: ABC26169.1.
DQ305634 Genomic DNA. Translation: ABC26170.1.
DQ305635 Genomic DNA. Translation: ABC26171.1.
DQ305636 Genomic DNA. Translation: ABC26172.1.
DQ305637 Genomic DNA. Translation: ABC26173.1.
DQ305638 Genomic DNA. Translation: ABC26174.1.
DQ305639 Genomic DNA. Translation: ABC26175.1.
DQ305640 Genomic DNA. Translation: ABC26176.1.
DQ305641 Genomic DNA. Translation: ABC26177.1.
DQ305642 Genomic DNA. Translation: ABC26178.1.
DQ305643 Genomic DNA. Translation: ABC26179.1.
DQ305644 Genomic DNA. Translation: ABC26180.1.
DQ305645 Genomic DNA. Translation: ABC26181.1.
DQ305646 Genomic DNA. Translation: ABC26182.1.
DQ305647 Genomic DNA. Translation: ABC26183.1.
DQ305648 Genomic DNA. Translation: ABC26184.1.
DQ305649 Genomic DNA. Translation: ABC26185.1.
DQ305650 Genomic DNA. Translation: ABC26186.1.
DQ305651 Genomic DNA. Translation: ABC26187.1.
DQ305652 Genomic DNA. Translation: ABC26188.1.
DQ305653 Genomic DNA. Translation: ABC26189.1.
DQ305654 Genomic DNA. Translation: ABC26190.1.
DQ305655 Genomic DNA. Translation: ABC26191.1.
U53473 Genomic DNA. Translation: AAA98976.1.
AF042740 Genomic DNA. Translation: AAC03773.1.
AF055874 Genomic DNA. Translation: AAC14117.1.
AF055875 Genomic DNA. Translation: AAC14118.1.
AF320309 Genomic DNA. Translation: AAG34181.1.
AF348074 Genomic DNA. Translation: AAK51710.1.
AF348075 Genomic DNA. Translation: AAK51711.1. Frameshift.
AY230251 Genomic DNA. Translation: AAO73561.1.
AY230252 Genomic DNA. Translation: AAO73562.1.
CR407631 mRNA. Translation: CAG28559.1.
AY331807 Genomic DNA. Translation: AAP81164.1.
AC025062 Genomic DNA. No translation available.
AC120051 Genomic DNA. No translation available.
BC015878 mRNA. Translation: AAH15878.1.
BC067218 mRNA. Translation: AAH67218.1.
M75163 Genomic DNA. Translation: AAA59906.1.
CCDSiCCDS6008.1.
PIRiB34585.
S02788.
RefSeqiNP_000006.2. NM_000015.2.
XP_016868427.1. XM_017012938.1.
UniGeneiHs.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PFRX-ray1.92A/B2-290[»]
ProteinModelPortaliP11245.
SMRiP11245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106528. 20 interactors.
IntActiP11245. 16 interactors.
STRINGi9606.ENSP00000286479.

Chemistry databases

ChEMBLiCHEMBL2194.
DrugBankiDB00316. Acetaminophen.
DB01068. Clonazepam.
DB00250. Dapsone.
DB04953. Ezogabine.
DB00951. Isoniazid.
DB01015. Sulfamethoxazole.

PTM databases

iPTMnetiP11245.
PhosphoSitePlusiP11245.

Polymorphism and mutation databases

BioMutaiNAT2.
DMDMi114238.

Proteomic databases

MaxQBiP11245.
PaxDbiP11245.
PeptideAtlasiP11245.
PRIDEiP11245.

Protocols and materials databases

DNASUi10.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286479; ENSP00000286479; ENSG00000156006.
GeneIDi10.
KEGGihsa:10.
UCSCiuc003wyw.2. human.

Organism-specific databases

CTDi10.
DisGeNETi10.
GeneCardsiNAT2.
HGNCiHGNC:7646. NAT2.
HPAiHPA043704.
MalaCardsiNAT2.
MIMi243400. phenotype.
612182. gene.
neXtProtiNX_P11245.
Orphaneti240887. Isoniazid toxicity.
PharmGKBiPA18.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
HOVERGENiHBG000165.
InParanoidiP11245.
KOiK00622.
OrthoDBiEOG091G0CO6.
PhylomeDBiP11245.
TreeFamiTF106311.

Enzyme and pathway databases

BioCyciZFISH:HS08090-MONOMER.
BRENDAi2.3.1.5. 2681.
ReactomeiR-HSA-156582. Acetylation.

Miscellaneous databases

EvolutionaryTraceiP11245.
GeneWikiiN-acetyltransferase_2.
GenomeRNAii10.
PROiP11245.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156006.
CleanExiHS_NAT2.
ExpressionAtlasiP11245. baseline and differential.
GenevisibleiP11245. HS.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.
ProtoNetiSearch...

Entry informationi

Entry nameiARY2_HUMAN
AccessioniPrimary (citable) accession number: P11245
Secondary accession number(s): O43637
, O60654, O60655, Q13146, Q16697, Q2MLE4, Q2MLF5, Q2MLG8, Q2MLJ6, Q2MLK4, Q2MLK6, Q2MLN7, Q6LET4, Q86XS0, Q86XS1, Q96KY8, Q96T64, Q96T65, Q9H220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.