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Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

Cox5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:Cox5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620607. Cox5a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion1 PublicationAdd
BLAST
Chaini38 – 146109Cytochrome c oxidase subunit 5A, mitochondrialPRO_0000006102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831N6-acetyllysineBy similarity
Modified residuei109 – 1091N6-acetyllysineBy similarity
Modified residuei137 – 1371PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11240.
PRIDEiP11240.

2D gel databases

UCD-2DPAGEP11240.

PTM databases

iPTMnetiP11240.
PhosphoSiteiP11240.

Expressioni

Tissue specificityi

Expressed in the head of epididymal sperm but not in testicular sperm (at protein level).1 Publication

Gene expression databases

GenevisibleiP11240. RN.

Interactioni

Protein-protein interaction databases

IntActiP11240. 1 interaction.
STRINGi10116.ENSRNOP00000025525.

Structurei

3D structure databases

ProteinModelPortaliP11240.
SMRiP11240. Positions 38-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4077. Eukaryota.
ENOG4111MPD. LUCA.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP11240.
KOiK02264.
OMAiSARCYSH.
OrthoDBiEOG74J99R.
PhylomeDBiP11240.
TreeFamiTF105062.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAALRRCT AAAAARGLLH PVSAPSPAAA VCSIRCYSHG SHETDEEFDA
60 70 80 90 100
RWVTYFNKPD IDAWELRKGM NTLVGYDLVP EPKIIDAALR ACRRLNDFAS
110 120 130 140
AVRILEVVKD KAGPHKEIYP YVIQELRPTL NELGISTPEE LGLDKV
Length:146
Mass (Da):16,130
Last modified:July 1, 1989 - v1
Checksum:i8F6AE081BDD6010F
GO

Mass spectrometryi

Molecular mass is 12420 Da from positions 38 - 146. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15030 mRNA. Translation: CAA33134.1.
PIRiS04592.
RefSeqiNP_665726.1. NM_145783.1.
UniGeneiRn.11077.

Genome annotation databases

EnsembliENSRNOT00000025525; ENSRNOP00000025525; ENSRNOG00000018816.
GeneIDi252934.
KEGGirno:252934.
UCSCiRGD:620607. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15030 mRNA. Translation: CAA33134.1.
PIRiS04592.
RefSeqiNP_665726.1. NM_145783.1.
UniGeneiRn.11077.

3D structure databases

ProteinModelPortaliP11240.
SMRiP11240. Positions 38-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11240. 1 interaction.
STRINGi10116.ENSRNOP00000025525.

PTM databases

iPTMnetiP11240.
PhosphoSiteiP11240.

2D gel databases

UCD-2DPAGEP11240.

Proteomic databases

PaxDbiP11240.
PRIDEiP11240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025525; ENSRNOP00000025525; ENSRNOG00000018816.
GeneIDi252934.
KEGGirno:252934.
UCSCiRGD:620607. rat.

Organism-specific databases

CTDi9377.
RGDi620607. Cox5a.

Phylogenomic databases

eggNOGiKOG4077. Eukaryota.
ENOG4111MPD. LUCA.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP11240.
KOiK02264.
OMAiSARCYSH.
OrthoDBiEOG74J99R.
PhylomeDBiP11240.
TreeFamiTF105062.

Enzyme and pathway databases

ReactomeiR-RNO-5628897. TP53 Regulates Metabolic Genes.
R-RNO-611105. Respiratory electron transport.

Miscellaneous databases

NextBioi624104.
PROiP11240.

Gene expression databases

GenevisibleiP11240. RN.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of cDNA encoding subunit Va from rat heart cytochrome c oxidase."
    Droste M., Schon E., Kadenbach B.
    Nucleic Acids Res. 17:4375-4375(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Heart.
  2. "Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform."
    Schaegger H., Noack H., Halangk W., Brandt U., von Jagow G.
    Eur. J. Biochem. 230:235-241(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 38-47.
    Strain: Wistar.
    Tissue: Liver.
  3. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 94-103, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  4. "Differential proteomics leads to identification of domain specific epididymal sperm proteins."
    Suryawanshi A.R., Khan S.A., Gajbhiye R.K., Gurav M.Y., Khole V.V.
    J. Androl. 32:240-259(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Strain: Holtzman.
    Tissue: Sperm.

Entry informationi

Entry nameiCOX5A_RAT
AccessioniPrimary (citable) accession number: P11240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.