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Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

Cox5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:Cox5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620607. Cox5a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37Mitochondrion1 PublicationAdd BLAST37
ChainiPRO_000000610238 – 146Cytochrome c oxidase subunit 5A, mitochondrialAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83N6-acetyllysineBy similarity1
Modified residuei109N6-acetyllysineBy similarity1
Modified residuei137PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11240.
PRIDEiP11240.

2D gel databases

UCD-2DPAGEiP11240.

PTM databases

iPTMnetiP11240.
PhosphoSitePlusiP11240.

Expressioni

Tissue specificityi

Expressed in the head of epididymal sperm but not in testicular sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000018816.
GenevisibleiP11240. RN.

Interactioni

Subunit structurei

Interacts with AFG1L.By similarity

Protein-protein interaction databases

CORUMiP11240.
IntActiP11240. 1 interactor.
STRINGi10116.ENSRNOP00000025525.

Structurei

3D structure databases

ProteinModelPortaliP11240.
SMRiP11240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4077. Eukaryota.
ENOG4111MPD. LUCA.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP11240.
KOiK02264.
OMAiLNNCFAH.
OrthoDBiEOG091G0FVR.
PhylomeDBiP11240.
TreeFamiTF105062.

Family and domain databases

CDDicd00923. Cyt_c_Oxidase_Va. 1 hit.
Gene3Di1.25.40.40. 1 hit.
InterProiView protein in InterPro
IPR003204. Cyt_c_oxidase_su5A/6.
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiView protein in Pfam
PF02284. COX5A. 1 hit.
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAALRRCT AAAAARGLLH PVSAPSPAAA VCSIRCYSHG SHETDEEFDA
60 70 80 90 100
RWVTYFNKPD IDAWELRKGM NTLVGYDLVP EPKIIDAALR ACRRLNDFAS
110 120 130 140
AVRILEVVKD KAGPHKEIYP YVIQELRPTL NELGISTPEE LGLDKV
Length:146
Mass (Da):16,130
Last modified:July 1, 1989 - v1
Checksum:i8F6AE081BDD6010F
GO

Mass spectrometryi

Molecular mass is 12420 Da from positions 38 - 146. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15030 mRNA. Translation: CAA33134.1.
PIRiS04592.
RefSeqiNP_665726.1. NM_145783.1.
UniGeneiRn.11077.

Genome annotation databases

EnsembliENSRNOT00000025525; ENSRNOP00000025525; ENSRNOG00000018816.
GeneIDi252934.
KEGGirno:252934.
UCSCiRGD:620607. rat.

Similar proteinsi

Entry informationi

Entry nameiCOX5A_RAT
AccessioniPrimary (citable) accession number: P11240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 27, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families