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P11235

- HN_MUMPM

UniProt

P11235 - HN_MUMPM

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Protein

Hemagglutinin-neuraminidase

Gene
HN
Organism
Mumps virus (strain Miyahara vaccine) (MuV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiMumps virus (strain Miyahara vaccine) (MuV)
Taxonomic identifieri11171 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002331: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Intravirion Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini56 – 582527Virion surface Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Hemagglutinin-neuraminidasePRO_0000142603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi329 – 3291N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi464 – 4641N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi507 – 5071N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP11235.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi541 – 5444Poly-Thr

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P11235-1 [UniParc]FASTAAdd to Basket

« Hide

MEPSKLFTMS DNATFAPGPV INAADKKTFR TCFRILVLSV QAVTLILVIV    50
TLGELVRMIN DQGLSNQLSS IADKIRESAT MIASAVGVMN QVIHGVTVSL 100
PLQIEGNQNQ LLSTLATICT GKKQVSNCST NIPLVNDLRF INGINKFIIE 150
DYATHDFSIG HPLNMPSFIP TATSPNGCTR IPSFSLGKTH WCYTHNVINA 200
NCKDHTSSNQ YISMGILVQT ASGYPMFKTL KIQYLSDGLN RKSCSIATVP 250
DGCAMYCYVS TQLETDDYAG SSPPTQKLTL LFYNDTVTER TISPTGLEGN 300
WATLVPGVGS GIYFENKLIF PAYGGVLPNS SLGVKSAREF FRPVNPYNPC 350
SGPQQDLDQR ALRSYFPSYF SNRRVQSAFL VCAWNQILVT NCELVVPSNN 400
QTLMGAEGRV LLINNRLLYY QRSTSWWPYE LLYEISFTFT NSGQSSVNMS 450
WIPIYSFTRP GSGNCSGENV CPTACVSGVY LDPWPLTPYS HQSGINRNFY 500
FTGALLNSST TRVNPTLYVS ALNNLKVLAP YGNQGLFASY TTTTCFQDTG 550
DASVYCVYIM ELASNIVGEF QILPVLTRLT IT 582
Length:582
Mass (Da):64,044
Last modified:July 1, 1989 - v1
Checksum:i9902600339625499
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15284 mRNA. Translation: CAA33358.1.
AB040874 Genomic RNA. Translation: BAA94390.1.
PIRiA34054. HNNZMM.
RefSeqiNP_054713.1. NC_002200.1.

Genome annotation databases

GeneIDi1489765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15284 mRNA. Translation: CAA33358.1 .
AB040874 Genomic RNA. Translation: BAA94390.1 .
PIRi A34054. HNNZMM.
RefSeqi NP_054713.1. NC_002200.1.

3D structure databases

ProteinModelPortali P11235.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1489765.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the haemagglutinin-neuraminidase gene of mumps virus (Miyahara strain)."
    Takeuchi K., Tanabayashi K., Hishiyama M., Yamada A., Sugiura A.
    Nucleic Acids Res. 17:5840-5840(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence."
    Okazaki K., Tanabayashi K., Takeuchi K., Hishiyama M., Okazaki K., Yamada A.
    Virology 188:926-930(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_MUMPM
AccessioniPrimary (citable) accession number: P11235
Secondary accession number(s): Q783V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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