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P11235 (HN_MUMPM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase
EC=3.2.1.18
Gene names
Name:HN
OrganismMumps virus (strain Miyahara vaccine) (MuV) [Reference proteome]
Taxonomic identifier11171 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Rubulavirus ›
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Hemagglutinin-neuraminidase
PRO_0000142603

Regions

Topological domain1 – 3434Intravirion Potential
Transmembrane35 – 5521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain56 – 582527Virion surface Potential
Compositional bias541 – 5444Poly-Thr

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...); by host Potential
Glycosylation2841N-linked (GlcNAc...); by host Potential
Glycosylation3291N-linked (GlcNAc...); by host Potential
Glycosylation4001N-linked (GlcNAc...); by host Potential
Glycosylation4481N-linked (GlcNAc...); by host Potential
Glycosylation4641N-linked (GlcNAc...); by host Potential
Glycosylation5071N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P11235 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 9902600339625499

FASTA58264,044
        10         20         30         40         50         60 
MEPSKLFTMS DNATFAPGPV INAADKKTFR TCFRILVLSV QAVTLILVIV TLGELVRMIN 

        70         80         90        100        110        120 
DQGLSNQLSS IADKIRESAT MIASAVGVMN QVIHGVTVSL PLQIEGNQNQ LLSTLATICT 

       130        140        150        160        170        180 
GKKQVSNCST NIPLVNDLRF INGINKFIIE DYATHDFSIG HPLNMPSFIP TATSPNGCTR 

       190        200        210        220        230        240 
IPSFSLGKTH WCYTHNVINA NCKDHTSSNQ YISMGILVQT ASGYPMFKTL KIQYLSDGLN 

       250        260        270        280        290        300 
RKSCSIATVP DGCAMYCYVS TQLETDDYAG SSPPTQKLTL LFYNDTVTER TISPTGLEGN 

       310        320        330        340        350        360 
WATLVPGVGS GIYFENKLIF PAYGGVLPNS SLGVKSAREF FRPVNPYNPC SGPQQDLDQR 

       370        380        390        400        410        420 
ALRSYFPSYF SNRRVQSAFL VCAWNQILVT NCELVVPSNN QTLMGAEGRV LLINNRLLYY 

       430        440        450        460        470        480 
QRSTSWWPYE LLYEISFTFT NSGQSSVNMS WIPIYSFTRP GSGNCSGENV CPTACVSGVY 

       490        500        510        520        530        540 
LDPWPLTPYS HQSGINRNFY FTGALLNSST TRVNPTLYVS ALNNLKVLAP YGNQGLFASY 

       550        560        570        580 
TTTTCFQDTG DASVYCVYIM ELASNIVGEF QILPVLTRLT IT

« Hide

References

[1]"Cloning and sequencing of the haemagglutinin-neuraminidase gene of mumps virus (Miyahara strain)."
Takeuchi K., Tanabayashi K., Hishiyama M., Yamada A., Sugiura A.
Nucleic Acids Res. 17:5840-5840(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence."
Okazaki K., Tanabayashi K., Takeuchi K., Hishiyama M., Okazaki K., Yamada A.
Virology 188:926-930(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X15284 mRNA. Translation: CAA33358.1.
AB040874 Genomic RNA. Translation: BAA94390.1.
PIRHNNZMM. A34054.
RefSeqNP_054713.1. NC_002200.1.

3D structure databases

ProteinModelPortalP11235.
ModBaseSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1489765.

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. Sialidase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_MUMPM
AccessionPrimary (citable) accession number: P11235
Secondary accession number(s): Q783V7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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