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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini. VP2 is required for the replicase activity of VP1 polymerase. Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles. May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2UniRule annotation
OrganismiRotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
Taxonomic identifieri10962 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000006581 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, T=2 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001495331 – 890Inner capsid protein VP2Add BLAST890

Post-translational modificationi

Sumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins seems to have a positive role on viral replication.UniRule annotation

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiP11231

Interactioni

Subunit structurei

Homodecamer; each decamer is made up of two conformers of VP2, called VP2A and VP2B. Interacts with a VP1-VP3 complex. Interacts with the intermediate capsid protein VP6. Interacts with NSP5. Interacts (via N-terminus) with NSP2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei232Interaction with the intermediate capsid protein VP6UniRule annotation1
Sitei236Interaction with the intermediate capsid protein VP6UniRule annotation1
Sitei849Interaction with the intermediate capsid protein VP6UniRule annotation1
Sitei851Interaction with the intermediate capsid protein VP6UniRule annotation1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 885-fold hub; involved in the encapsidation of VP1 and VP3UniRule annotationAdd BLAST88
Regioni404 – 424HydrophobicUniRule annotationAdd BLAST21
Regioni432 – 452HydrophobicUniRule annotationAdd BLAST21

Domaini

The N-terminus binds RNA. It is necessary for encapsidation of VP1 and VP3. The N-termini of 10 VP2 molecules form a cylindrical hub underneath each 5-fold axis of the inner capsid.UniRule annotation

Sequence similaritiesi

Belongs to the rotavirus VP2 family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

OrthoDBiVOG0900001T

Family and domain databases

HAMAPiMF_04123 Rota_VP2, 1 hit
MF_04127 Rota_VP2_A, 1 hit
InterProiView protein in InterPro
IPR007779 Rotavirus_VP2
PfamiView protein in Pfam
PF05087 Rota_VP2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008866 Rota_VP2, 1 hit

Sequencei

Sequence statusi: Complete.

P11231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYRKRGAKR ENLPQQNERL QEKEIEKDVD VTMENKNNNR KQQLSDKVLS
60 70 80 90 100
QKEEIITDAQ DDIKIAGEIK KSSKEESKQL LEILKTKEDH QKEIQYEILQ
110 120 130 140 150
KTIPTFESKE SILKKLEDIR PEQAKKQMKL FRIFEPKQLP IYRANGEKEL
160 170 180 190 200
RNRWYWKLKK DTLPDGDYDV REYFLNLYDQ ILIEMPDYLL LKDMAVENKN
210 220 230 240 250
SRDAGKVVDS ETANICDAIF QDEETEGVVR RFIADMRQQV QADRNIVNYP
260 270 280 290 300
SILHPIDHAF NEYFLNHQLV EPLNNEIIFN YIPERIRNDV NYILNMDMNL
310 320 330 340 350
PSTARYIRPN LLQDRLNLHD NFESLWDTIT TSNYILARSV VPDLKEKELV
360 370 380 390 400
STEAQIQKMS QDLQLEALTI QSETQFLAGI NSQAANDCFK TLIAAMLSQR
410 420 430 440 450
TMSLDFVTTN YMSLISGMWL LTVIPNDMFL RESLVACELA IINTIVYPAF
460 470 480 490 500
GMQRMHYRNG DPQTPFQIAE QQIQNFQVAN WLHFINNNRF RQVVIDGVLN
510 520 530 540 550
QTLNDNIRNG QVINQLMEAL MQLSRQQFPT MPVDYKRSIQ RGILLLSNRL
560 570 580 590 600
GQLVDLTRLV SYNYETLMAC VTMNMQHVQT LTTEKLQLTS VTSLCMLIGN
610 620 630 640 650
TTVIPSPQTL FHYYNINVNF HSNYNERIND AVAIITAANR LNLYQKKMKS
660 670 680 690 700
IVEDFLKRLQ IFDVPRVPDD QMYRLRDRLR LLPVERRRLD IFNLILMNME
710 720 730 740 750
QIERASDKIA QGVIIAYRDM QLERDEMYGY VNIARNLDGY QQINLEELMR
760 770 780 790 800
TGDYGQITNM LLNNQPVALV GALPFVTDSS VISLIAKLDA TVFAQIVKLR
810 820 830 840 850
KVDTLKPILY KINSDSNDFY LVANYDWIPT STTKVYKQVP QPFDFRASMH
860 870 880 890
MLTSNLTFTV YSDLLSFVSA DTVEPINAVA FDNMRIMNEL
Length:890
Mass (Da):103,751
Last modified:July 1, 1989 - v1
Checksum:i0E0933ED56EB4295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14942 Genomic RNA Translation: CAA33074.1
PIRiA34008 P2XRWA

Similar proteinsi

Entry informationi

Entry nameiVP2_ROTHW
AccessioniPrimary (citable) accession number: P11231
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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