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P11231

- VP2_ROTHW

UniProt

P11231 - VP2_ROTHW

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain Human/United States/Wa/1974 G1-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus A (strain Human/United States/Wa/1974 G1-P1A[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) (RV-A)
    Taxonomic identifieri10962 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000006581: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 890890Inner capsid protein VP2PRO_0000149533Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 100100Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni404 – 42421HydrophobicBy similarityAdd
    BLAST
    Regioni432 – 45221HydrophobicBy similarityAdd
    BLAST
    Regioni546 – 56722Leucine-zipper 1Sequence AnalysisAdd
    BLAST
    Regioni675 – 69622Leucine-zipper 2Sequence AnalysisAdd
    BLAST

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P11231-1 [UniParc]FASTAAdd to Basket

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    MAYRKRGAKR ENLPQQNERL QEKEIEKDVD VTMENKNNNR KQQLSDKVLS    50
    QKEEIITDAQ DDIKIAGEIK KSSKEESKQL LEILKTKEDH QKEIQYEILQ 100
    KTIPTFESKE SILKKLEDIR PEQAKKQMKL FRIFEPKQLP IYRANGEKEL 150
    RNRWYWKLKK DTLPDGDYDV REYFLNLYDQ ILIEMPDYLL LKDMAVENKN 200
    SRDAGKVVDS ETANICDAIF QDEETEGVVR RFIADMRQQV QADRNIVNYP 250
    SILHPIDHAF NEYFLNHQLV EPLNNEIIFN YIPERIRNDV NYILNMDMNL 300
    PSTARYIRPN LLQDRLNLHD NFESLWDTIT TSNYILARSV VPDLKEKELV 350
    STEAQIQKMS QDLQLEALTI QSETQFLAGI NSQAANDCFK TLIAAMLSQR 400
    TMSLDFVTTN YMSLISGMWL LTVIPNDMFL RESLVACELA IINTIVYPAF 450
    GMQRMHYRNG DPQTPFQIAE QQIQNFQVAN WLHFINNNRF RQVVIDGVLN 500
    QTLNDNIRNG QVINQLMEAL MQLSRQQFPT MPVDYKRSIQ RGILLLSNRL 550
    GQLVDLTRLV SYNYETLMAC VTMNMQHVQT LTTEKLQLTS VTSLCMLIGN 600
    TTVIPSPQTL FHYYNINVNF HSNYNERIND AVAIITAANR LNLYQKKMKS 650
    IVEDFLKRLQ IFDVPRVPDD QMYRLRDRLR LLPVERRRLD IFNLILMNME 700
    QIERASDKIA QGVIIAYRDM QLERDEMYGY VNIARNLDGY QQINLEELMR 750
    TGDYGQITNM LLNNQPVALV GALPFVTDSS VISLIAKLDA TVFAQIVKLR 800
    KVDTLKPILY KINSDSNDFY LVANYDWIPT STTKVYKQVP QPFDFRASMH 850
    MLTSNLTFTV YSDLLSFVSA DTVEPINAVA FDNMRIMNEL 890
    Length:890
    Mass (Da):103,751
    Last modified:July 1, 1989 - v1
    Checksum:i0E0933ED56EB4295
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14942 Genomic RNA. Translation: CAA33074.1.
    PIRiA34008. P2XRWA.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14942 Genomic RNA. Translation: CAA33074.1 .
    PIRi A34008. P2XRWA.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a subgroup specificity associated with the rotavirus inner capsid protein VP2."
      McDonald S.M., Patton J.T.
      J. Virol. 82:2752-2764(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Nucleotide sequence of genomic segment 2 of the human rotavirus Wa."
      Ernst H., Duhl J.A.
      Nucleic Acids Res. 17:4382-4382(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTHW
    AccessioniPrimary (citable) accession number: P11231
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3