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P11229

- ACM1_HUMAN

UniProt

P11229 - ACM1_HUMAN

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Protein
Muscarinic acetylcholine receptor M1
Gene
CHRM1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functioni

  1. G-protein coupled acetylcholine receptor activity Source: ProtInc
  2. drug binding Source: Ensembl
  3. phosphatidylinositol phospholipase C activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled acetylcholine receptor signaling pathway Source: ProtInc
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. cell proliferation Source: ProtInc
  4. cellular protein modification process Source: ProtInc
  5. cognition Source: InterPro
  6. nervous system development Source: ProtInc
  7. neuromuscular synaptic transmission Source: Ensembl
  8. phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: ProtInc
  9. positive regulation of cell proliferation Source: ProtInc
  10. positive regulation of intracellular protein transport Source: Ensembl
  11. positive regulation of ion transport Source: MGI
  12. protein kinase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  13. regulation of locomotion Source: Ensembl
  14. saliva secretion Source: InterPro
  15. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16943. Muscarinic acetylcholine receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M1
Gene namesi
Name:CHRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1950. CHRM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed prediction
Add
BLAST
Transmembranei25 – 4723Helical; Name=1; By similarity
Add
BLAST
Topological domaini48 – 6114Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Name=2; By similarity
Add
BLAST
Topological domaini83 – 9917Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12122Helical; Name=3; By similarity
Add
BLAST
Topological domaini122 – 14120Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei142 – 16423Helical; Name=4; By similarity
Add
BLAST
Topological domaini165 – 18622Extracellular Reviewed prediction
Add
BLAST
Transmembranei187 – 20923Helical; Name=5; By similarity
Add
BLAST
Topological domaini210 – 366157Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei367 – 38721Helical; Name=6; By similarity
Add
BLAST
Topological domaini388 – 40114Extracellular Reviewed prediction
Add
BLAST
Transmembranei402 – 42120Helical; Name=7; By similarity
Add
BLAST
Topological domaini422 – 46039Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. asymmetric synapse Source: Ensembl
  2. axon terminus Source: Ensembl
  3. cell junction Source: UniProtKB-KW
  4. dendrite Source: Ensembl
  5. integral component of plasma membrane Source: ProtInc
  6. membrane Source: ProtInc
  7. plasma membrane Source: Reactome
  8. postsynaptic density Source: Ensembl
  9. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Muscarinic acetylcholine receptor M1
PRO_0000069015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) Inferred
Glycosylationi12 – 121N-linked (GlcNAc...) Inferred
Disulfide bondi98 ↔ 178 By similarity
Modified residuei428 – 4281Phosphothreonine Reviewed prediction
Modified residuei451 – 4511Phosphoserine Reviewed prediction
Modified residuei455 – 4551Phosphothreonine Reviewed prediction
Modified residuei457 – 4571Phosphoserine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11229.
PRIDEiP11229.

PTM databases

PhosphoSiteiP11229.

Expressioni

Gene expression databases

ArrayExpressiP11229.
BgeeiP11229.
CleanExiHS_CHRM1.
GenevestigatoriP11229.

Organism-specific databases

HPAiCAB022366.
HPA014101.

Interactioni

Subunit structurei

Interacts with GPRASP2.1 Publication

Protein-protein interaction databases

BioGridi107550. 4 interactions.
IntActiP11229. 5 interactions.
MINTiMINT-7970464.
STRINGi9606.ENSP00000306490.

Structurei

3D structure databases

ProteinModelPortaliP11229.
SMRiP11229. Positions 23-242, 362-430.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250863.
HOGENOMiHOG000231484.
HOVERGENiHBG105720.
InParanoidiP11229.
KOiK04129.
OMAiRCCRTPR.
OrthoDBiEOG7V49Z7.
PhylomeDBiP11229.
TreeFamiTF320495.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002228. Musac_Ach_M1_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00538. MUSCRINICM1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11229-1 [UniParc]FASTAAdd to Basket

« Hide

MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF    50
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL 100
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW 150
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP 200
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG 250
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 300
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA 350
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW 400
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG 450
SVHRTPSRQC 460
Length:460
Mass (Da):51,421
Last modified:November 1, 1990 - v2
Checksum:i567C20F63541C8D0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731V → M in CAA33334. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00508 Genomic DNA. Translation: CAA68560.1.
X52068 Genomic DNA. Translation: CAA36291.1.
X15263 Genomic DNA. Translation: CAA33334.1.
AF498915 mRNA. Translation: AAM18938.1.
BC007740 mRNA. Translation: AAH07740.1.
BC022984 mRNA. Translation: AAH22984.1.
CCDSiCCDS8040.1.
PIRiS09508.
RefSeqiNP_000729.2. NM_000738.2.
UniGeneiHs.632119.

Genome annotation databases

EnsembliENST00000306960; ENSP00000306490; ENSG00000168539.
GeneIDi1128.
KEGGihsa:1128.
UCSCiuc001nwi.3. human.

Polymorphism databases

DMDMi113118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00508 Genomic DNA. Translation: CAA68560.1 .
X52068 Genomic DNA. Translation: CAA36291.1 .
X15263 Genomic DNA. Translation: CAA33334.1 .
AF498915 mRNA. Translation: AAM18938.1 .
BC007740 mRNA. Translation: AAH07740.1 .
BC022984 mRNA. Translation: AAH22984.1 .
CCDSi CCDS8040.1.
PIRi S09508.
RefSeqi NP_000729.2. NM_000738.2.
UniGenei Hs.632119.

3D structure databases

ProteinModelPortali P11229.
SMRi P11229. Positions 23-242, 362-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107550. 4 interactions.
IntActi P11229. 5 interactions.
MINTi MINT-7970464.
STRINGi 9606.ENSP00000306490.

Chemistry

BindingDBi P11229.
ChEMBLi CHEMBL2094109.
DrugBanki DB00517. Anisotropine Methylbromide.
DB00572. Atropine.
DB00767. Benzquinamide.
DB00245. Benztropine.
DB01019. Bethanechol.
DB00810. Biperiden.
DB00354. Buclizine.
DB00411. Carbachol.
DB00748. Carbinoxamine.
DB00185. Cevimeline.
DB00771. Clidinium.
DB00785. Cryptenamine.
DB01176. Cyclizine.
DB00979. Cyclopentolate.
DB00942. Cycrimine.
DB01151. Desipramine.
DB00804. Dicyclomine.
DB01231. Diphenidol.
DB00366. Doxylamine.
DB00392. Ethopropazine.
DB01148. Flavoxate.
DB00986. Glycopyrrolate.
DB00725. Homatropine Methylbromide.
DB00424. Hyoscyamine.
DB00332. Ipratropium.
DB00940. Methantheline.
DB01403. Methotrimeprazine.
DB00462. Methylscopolamine.
DB00340. Metixene.
DB01233. Metoclopramide.
DB00334. Olanzapine.
DB01062. Oxybutynin.
DB00383. Oxyphencyclimine.
DB00219. Oxyphenonium.
DB01085. Pilocarpine.
DB00670. Pirenzepine.
DB00387. Procyclidine.
DB00420. Promazine.
DB01069. Promethazine.
DB00782. Propantheline.
DB00777. Propiomazine.
DB01103. Quinacrine.
DB00747. Scopolamine.
DB01591. Solifenacin.
DB00202. Succinylcholine.
DB00372. Thiethylperazine.
DB01036. Tolterodine.
DB00505. Tridihexethyl.
DB00508. Triflupromazine.
DB00376. Trihexyphenidyl.
DB00209. Trospium.
GuidetoPHARMACOLOGYi 13.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P11229.

Polymorphism databases

DMDMi 113118.

Proteomic databases

PaxDbi P11229.
PRIDEi P11229.

Protocols and materials databases

DNASUi 1128.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306960 ; ENSP00000306490 ; ENSG00000168539 .
GeneIDi 1128.
KEGGi hsa:1128.
UCSCi uc001nwi.3. human.

Organism-specific databases

CTDi 1128.
GeneCardsi GC11M062695.
HGNCi HGNC:1950. CHRM1.
HPAi CAB022366.
HPA014101.
MIMi 118510. gene.
neXtProti NX_P11229.
PharmGKBi PA26484.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250863.
HOGENOMi HOG000231484.
HOVERGENi HBG105720.
InParanoidi P11229.
KOi K04129.
OMAi RCCRTPR.
OrthoDBi EOG7V49Z7.
PhylomeDBi P11229.
TreeFami TF320495.

Enzyme and pathway databases

Reactomei REACT_16943. Muscarinic acetylcholine receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Muscarinic_acetylcholine_receptor_M1.
GenomeRNAii 1128.
NextBioi 4676.
PROi P11229.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11229.
Bgeei P11229.
CleanExi HS_CHRM1.
Genevestigatori P11229.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002228. Musac_Ach_M1_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00538. MUSCRINICM1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor."
    Allard W.J., Sigal I.S., Dixon R.A.F.
    Nucleic Acids Res. 15:10604-10604(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification."
    Chapman C.G., Browne M.J.
    Nucleic Acids Res. 18:2191-2191(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors."
    Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J., Capon D.J.
    EMBO J. 6:3923-3929(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor."
    Arden J.R., Nagata O., Shockley M.S., Philip M., Lameh J., Sadee W.
    Biochem. Biophys. Res. Commun. 188:1111-1115(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  7. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
    Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
    J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPRASP2.

Entry informationi

Entry nameiACM1_HUMAN
AccessioniPrimary (citable) accession number: P11229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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