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Protein

Mannose-binding protein C

Gene

MBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: GO_Central
  • mannose binding Source: UniProtKB
  • receptor binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

  • acute-phase response Source: BHF-UCL
  • complement activation Source: Reactome
  • complement activation, classical pathway Source: UniProtKB-KW
  • complement activation, lectin pathway Source: UniProtKB
  • defense response to bacterium Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: MGI
  • innate immune response Source: BHF-UCL
  • killing by host of symbiont cells Source: Ensembl
  • negative regulation of growth of symbiont in host Source: MGI
  • negative regulation of viral process Source: BHF-UCL
  • opsonization Source: BHF-UCL
  • positive regulation of phagocytosis Source: Ensembl
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Complement activation lectin pathway, Complement pathway, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin, Mannose-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165471-MONOMER.
ReactomeiR-HSA-166662. Lectin pathway of complement activation.
R-HSA-166663. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-binding protein C
Short name:
MBP-C
Alternative name(s):
Collectin-1
MBP1
Mannan-binding protein
Mannose-binding lectin
Gene namesi
Name:MBL2
Synonyms:COLEC1, MBL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:6922. MBL2.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • collagen trimer Source: UniProtKB-KW
  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4153.
MalaCardsiMBL2.
MIMi610424. phenotype.
614372. phenotype.
OpenTargetsiENSG00000165471.
PharmGKBiPA30665.

Chemistry databases

ChEMBLiCHEMBL1795113.

Polymorphism and mutation databases

BioMutaiMBL2.
DMDMi126676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001740121 – 248Mannose-binding protein CAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Hydroxyproline1 Publication1
Modified residuei73Hydroxyproline1 Publication1
Modified residuei79Hydroxyproline1 Publication1
Modified residuei82Hydroxyproline1 Publication1
Modified residuei88Hydroxyproline1 Publication1
Disulfide bondi155 ↔ 244
Disulfide bondi222 ↔ 236

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PaxDbiP11226.
PeptideAtlasiP11226.
PRIDEiP11226.
TopDownProteomicsiP11226.

PTM databases

iPTMnetiP11226.
PhosphoSitePlusiP11226.

Miscellaneous databases

PMAP-CutDBP11226.

Expressioni

Tissue specificityi

Plasma protein produced mainly in the liver.1 Publication

Gene expression databases

BgeeiENSG00000165471.
CleanExiHS_MBL2.
GenevisibleiP11226. HS.

Organism-specific databases

HPAiCAB016782.
HPA002027.

Interactioni

Subunit structurei

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LRP1Q079545EBI-5325353,EBI-1046087

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110323. 5 interactors.
DIPiDIP-61381N.
IntActiP11226. 4 interactors.
MINTiMINT-6630459.
STRINGi9606.ENSP00000363079.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi110 – 129Combined sources20
Beta strandi131 – 134Combined sources4
Beta strandi137 – 147Combined sources11
Helixi148 – 157Combined sources10
Helixi168 – 177Combined sources10
Beta strandi182 – 187Combined sources6
Beta strandi189 – 191Combined sources3
Helixi216 – 218Combined sources3
Beta strandi222 – 225Combined sources4
Beta strandi231 – 234Combined sources4
Beta strandi238 – 247Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUPX-ray2.50A108-248[»]
ProteinModelPortaliP11226.
SMRiP11226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 99Collagen-likeAdd BLAST58
Domaini134 – 245C-type lectinPROSITE-ProRule annotationAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili112 – 1301 PublicationAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 41Cys-richAdd BLAST21

Domaini

The coiled-coil domain mediates trimerization.

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IS38. Eukaryota.
ENOG410YQHR. LUCA.
GeneTreeiENSGT00700000104102.
HOVERGENiHBG108270.
InParanoidiP11226.
KOiK03991.
OMAiETVTCED.
OrthoDBiEOG091G0R93.
PhylomeDBiP11226.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR008160. Collagen.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFPSLPLL LLSMVAASYS ETVTCEDAQK TCPAVIACSS PGINGFPGKD
60 70 80 90 100
GRDGTKGEKG EPGQGLRGLQ GPPGKLGPPG NPGPSGSPGP KGQKGDPGKS
110 120 130 140 150
PDGDSSLAAS ERKALQTEMA RIKKWLTFSL GKQVGNKFFL TNGEIMTFEK
160 170 180 190 200
VKALCVKFQA SVATPRNAAE NGAIQNLIKE EAFLGITDEK TEGQFVDLTG
210 220 230 240
NRLTYTNWNE GEPNNAGSDE DCVLLLKNGQ WNDVPCSTSH LAVCEFPI
Length:248
Mass (Da):26,144
Last modified:April 1, 1990 - v2
Checksum:iC1F2AAED46D0F774
GO

Polymorphismi

Genetic variations in MBL2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].
Genetic variations in MBL2 are responsible for mannose-binding protein deficiency [MIMi:614372]. This condition is defined as MBL2 protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL2-deficient adults appear healthy, but low levels of MBL2 are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections (PubMed:1675710). Functional MBL2 deficiency may be associated with protection against tuberculosis caused by Mycobacterium africanum but not by Mycobacterium tuberculosis, as observed in studies on Ghanaian patients with pulmonary tuberculosis (PubMed:21695215).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01329424T → A in Chinese. 1 Publication1
Natural variantiVAR_00854352R → C in 0.05% of European and African populations. 3 PublicationsCorresponds to variant rs5030737dbSNPEnsembl.1
Natural variantiVAR_00418254G → D Polymorphism; associated with low serum mannose-binding protein (MBP) concentrations and recurrent infections. 8 PublicationsCorresponds to variant rs1800450dbSNPEnsembl.1
Natural variantiVAR_00418357G → E Polymorphism; associated with low serum mannose-binding protein (MBP) concentrations; associated with protection against tuberculosis caused by Mycobacterium africanum. 5 PublicationsCorresponds to variant rs1800451dbSNPEnsembl.1
Natural variantiVAR_050119214N → Y.Corresponds to variant rs12260094dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15422 mRNA. Translation: CAA33462.1.
X15954
, X15955, X15956, X15957 Genomic DNA. Translation: CAA34079.1.
AF080510, AF080508, AF080509 Genomic DNA. Translation: AAC31937.1.
Y16576 Genomic DNA. Translation: CAB56044.1.
Y16577 Genomic DNA. Translation: CAB56120.1.
Y16578 Genomic DNA. Translation: CAB56045.1.
Y16579 Genomic DNA. Translation: CAB56121.1.
Y16580 Genomic DNA. Translation: CAB56122.1.
Y16581 Genomic DNA. Translation: CAB56123.1.
Y16582 Genomic DNA. Translation: CAB56124.1.
AF360991 mRNA. Translation: AAK52907.1.
AY826184 mRNA. Translation: AAV80468.1.
DQ217939 Genomic DNA. Translation: ABB01009.1.
EU596574 Genomic DNA. Translation: ACC62880.1.
CH471083 Genomic DNA. Translation: EAW54148.1.
CH471083 Genomic DNA. Translation: EAW54149.1.
BC096179 mRNA. Translation: AAH96179.1.
BC096180 mRNA. Translation: AAH96180.3.
BC069338 mRNA. Translation: AAH69338.1.
BC096181 mRNA. Translation: AAH96181.3.
BC096182 mRNA. Translation: AAH96182.3.
AF482699 Genomic DNA. Translation: AAN39274.1.
AF482700 Genomic DNA. Translation: AAN39275.1.
CCDSiCCDS7247.1.
PIRiJL0115. LNHUMC.
RefSeqiNP_000233.1. NM_000242.2.
XP_006717924.1. XM_006717861.3.
XP_011538118.1. XM_011539816.2.
UniGeneiHs.499674.

Genome annotation databases

EnsembliENST00000373968; ENSP00000363079; ENSG00000165471.
GeneIDi4153.
KEGGihsa:4153.
UCSCiuc001jjt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Mannose-binding protein

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15422 mRNA. Translation: CAA33462.1.
X15954
, X15955, X15956, X15957 Genomic DNA. Translation: CAA34079.1.
AF080510, AF080508, AF080509 Genomic DNA. Translation: AAC31937.1.
Y16576 Genomic DNA. Translation: CAB56044.1.
Y16577 Genomic DNA. Translation: CAB56120.1.
Y16578 Genomic DNA. Translation: CAB56045.1.
Y16579 Genomic DNA. Translation: CAB56121.1.
Y16580 Genomic DNA. Translation: CAB56122.1.
Y16581 Genomic DNA. Translation: CAB56123.1.
Y16582 Genomic DNA. Translation: CAB56124.1.
AF360991 mRNA. Translation: AAK52907.1.
AY826184 mRNA. Translation: AAV80468.1.
DQ217939 Genomic DNA. Translation: ABB01009.1.
EU596574 Genomic DNA. Translation: ACC62880.1.
CH471083 Genomic DNA. Translation: EAW54148.1.
CH471083 Genomic DNA. Translation: EAW54149.1.
BC096179 mRNA. Translation: AAH96179.1.
BC096180 mRNA. Translation: AAH96180.3.
BC069338 mRNA. Translation: AAH69338.1.
BC096181 mRNA. Translation: AAH96181.3.
BC096182 mRNA. Translation: AAH96182.3.
AF482699 Genomic DNA. Translation: AAN39274.1.
AF482700 Genomic DNA. Translation: AAN39275.1.
CCDSiCCDS7247.1.
PIRiJL0115. LNHUMC.
RefSeqiNP_000233.1. NM_000242.2.
XP_006717924.1. XM_006717861.3.
XP_011538118.1. XM_011539816.2.
UniGeneiHs.499674.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUPX-ray2.50A108-248[»]
ProteinModelPortaliP11226.
SMRiP11226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110323. 5 interactors.
DIPiDIP-61381N.
IntActiP11226. 4 interactors.
MINTiMINT-6630459.
STRINGi9606.ENSP00000363079.

Chemistry databases

ChEMBLiCHEMBL1795113.

PTM databases

iPTMnetiP11226.
PhosphoSitePlusiP11226.

Polymorphism and mutation databases

BioMutaiMBL2.
DMDMi126676.

Proteomic databases

PaxDbiP11226.
PeptideAtlasiP11226.
PRIDEiP11226.
TopDownProteomicsiP11226.

Protocols and materials databases

DNASUi4153.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373968; ENSP00000363079; ENSG00000165471.
GeneIDi4153.
KEGGihsa:4153.
UCSCiuc001jjt.3. human.

Organism-specific databases

CTDi4153.
DisGeNETi4153.
GeneCardsiMBL2.
HGNCiHGNC:6922. MBL2.
HPAiCAB016782.
HPA002027.
MalaCardsiMBL2.
MIMi154545. gene.
610424. phenotype.
614372. phenotype.
neXtProtiNX_P11226.
OpenTargetsiENSG00000165471.
PharmGKBiPA30665.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS38. Eukaryota.
ENOG410YQHR. LUCA.
GeneTreeiENSGT00700000104102.
HOVERGENiHBG108270.
InParanoidiP11226.
KOiK03991.
OMAiETVTCED.
OrthoDBiEOG091G0R93.
PhylomeDBiP11226.
TreeFamiTF330481.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165471-MONOMER.
ReactomeiR-HSA-166662. Lectin pathway of complement activation.
R-HSA-166663. Initial triggering of complement.

Miscellaneous databases

EvolutionaryTraceiP11226.
GeneWikiiMannan-binding_lectin.
GenomeRNAii4153.
PMAP-CutDBP11226.
PROiP11226.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165471.
CleanExiHS_MBL2.
GenevisibleiP11226. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR008160. Collagen.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMBL2_HUMAN
AccessioniPrimary (citable) accession number: P11226
Secondary accession number(s): Q4VB12
, Q4VB13, Q4VB14, Q5SQS3, Q86SI4, Q96KE4, Q96TF7, Q96TF8, Q96TF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 199 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.