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Protein

Chitinase 63

Gene

chtA

Organism
Streptomyces plicatus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei383Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Keywords - Ligandi

Chitin-binding

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase 63 (EC:3.2.1.14)
Gene namesi
Name:chtA
OrganismiStreptomyces plicatus
Taxonomic identifieri1922 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000001191231 – 610Chitinase 63Add BLAST580

Proteomic databases

PRIDEiP11220.

Expressioni

Inductioni

By chitin.

Structurei

3D structure databases

ProteinModelPortaliP11220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 134CBM2PROSITE-ProRule annotationAdd BLAST104
Domaini144 – 229Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 610CatalyticAdd BLAST375

Sequence similaritiesi

Contains 1 CBM2 (carbohydrate binding type-2) domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
2.60.40.290. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008965. Carb-bd_dom.
IPR001919. CBD2.
IPR012291. CBD_carb-bd_dom.
IPR018366. CBM2_CS.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR003961. FN3_dom.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00041. fn3. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
SM00060. FN3. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS01095. CHITINASE_18. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFRHKAAAL AATLALPLAG LVGLASPAQA ATSATATFQK TSDWGTGFGG
60 70 80 90 100
KWTVKNTGTT SLSSWTVEWD FPSGTKVTSA WDATVTNSAD HWTAKNVGWN
110 120 130 140 150
GTLAPGASVS FGFNGSGPGS PSGCKINGGS CDGSSVPGDE APSAPGTPTA
160 170 180 190 200
SNITDTSVKL SWSAATDDKG VKNYDVLRDG ATVATVTGTT YTDNGLTKGT
210 220 230 240 250
DYSYSVKARD TGDQTGPASG SVKVTTTGGD GGEPNPNPGA EVKMGYFTNW
260 270 280 290 300
GVYGRNYHVK NLVTSGSAEK ITHINLRFGN VQGGKCTIGD AYADYDKAYT
310 320 330 340 350
ADQSVDGVAD TWDQPLRANF NQLRNLKAEY PHIKILYSFG GWTWSGGFPD
360 370 380 390 400
AVKNPAAFAK SCHDLVEDPR WADVFDGIDL DWEYPNACGL SCDETSAPNA
410 420 430 440 450
FSSMMKAMRA EFGQDYLITA AVTADGSDGG KIDAADYGEA SKYIDWYNVM
460 470 480 490 500
TYDFFGAWAK NGPTAPHSPL NAYDGIPQQG FTTADAMAKF KSKGVPADKL
510 520 530 540 550
LIGIGFYGRG WTGVTQSAPG GTATGPAAGT YEAGIEDYKV LKNSCPATGT
560 570 580 590 600
VAGTAYAHCG TNWWSYDTPA TIKSKMDWAE QQGLGGAFFW EFSGDTTNGE
610
LVSAIDSGLK
Length:610
Mass (Da):63,974
Last modified:December 1, 1992 - v2
Checksum:i6A202EF361CCD500
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → I in AAA26717 (PubMed:3275646).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82804 Genomic DNA. Translation: AAA26720.1.
M18397 Genomic DNA. Translation: AAA26717.1.
PIRiJH0573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82804 Genomic DNA. Translation: AAA26720.1.
M18397 Genomic DNA. Translation: AAA26717.1.
PIRiJH0573.

3D structure databases

ProteinModelPortaliP11220.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH18. Glycoside Hydrolase Family 18.

Proteomic databases

PRIDEiP11220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
2.60.40.290. 1 hit.
3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008965. Carb-bd_dom.
IPR001919. CBD2.
IPR012291. CBD_carb-bd_dom.
IPR018366. CBM2_CS.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR003961. FN3_dom.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00041. fn3. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
SM00060. FN3. 1 hit.
SM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS00561. CBM2_A. 1 hit.
PS01095. CHITINASE_18. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHIT_STRPL
AccessioniPrimary (citable) accession number: P11220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.