Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P11215

- ITAM_HUMAN

UniProt

P11215 - ITAM_HUMAN

Protein

Integrin alpha-M

Gene

ITGAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 167 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi465 – 4739Sequence Analysis
    Calcium bindingi529 – 5379Sequence Analysis
    Calcium bindingi592 – 6009Sequence Analysis

    GO - Molecular functioni

    1. glycoprotein binding Source: UniProtKB
    2. heparin binding Source: Ensembl
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. activated T cell proliferation Source: Ensembl
    2. blood coagulation Source: Reactome
    3. cell adhesion Source: ProtInc
    4. cellular extravasation Source: Ensembl
    5. extracellular matrix organization Source: Reactome
    6. innate immune response Source: Reactome
    7. integrin-mediated signaling pathway Source: UniProtKB-KW
    8. leukocyte cell-cell adhesion Source: Ensembl
    9. leukocyte migration Source: Reactome
    10. microglia development Source: Ensembl
    11. neutrophil chemotaxis Source: Ensembl
    12. toll-like receptor 4 signaling pathway Source: Reactome
    13. toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
    REACT_13552. Integrin cell surface interactions.
    REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
    SignaLinkiP11215.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-M
    Alternative name(s):
    CD11 antigen-like family member B
    CR-3 alpha chain
    Cell surface glycoprotein MAC-1 subunit alpha
    Leukocyte adhesion receptor MO1
    Neutrophil adherence receptor
    CD_antigen: CD11b
    Gene namesi
    Name:ITGAM
    Synonyms:CD11B, CR3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:6149. ITGAM.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. external side of plasma membrane Source: Ensembl
    3. extracellular vesicular exosome Source: UniProt
    4. integrin complex Source: ProtInc
    5. nucleus Source: Ensembl
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
    Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Systemic lupus erythematosus

    Organism-specific databases

    MIMi609939. phenotype.
    Orphaneti536. Systemic lupus erythematosus.
    PharmGKBiPA29949.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 16161 PublicationAdd
    BLAST
    Chaini17 – 11521136Integrin alpha-MPRO_0000016289Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi66 ↔ 73By similarity
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 123By similarity
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi654 ↔ 711By similarity
    Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi734 – 7341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi770 ↔ 776By similarity
    Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi847 ↔ 864By similarity
    Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi900 – 9001N-linked (GlcNAc...)1 Publication
    Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi940 – 9401N-linked (GlcNAc...)1 Publication
    Glycosylationi946 – 9461N-linked (GlcNAc...)1 Publication
    Glycosylationi978 – 9781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi993 – 9931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi998 ↔ 1022By similarity
    Glycosylationi1021 – 10211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1027 ↔ 1032By similarity
    Glycosylationi1044 – 10441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1050 – 10501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1075 – 10751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP11215.
    PRIDEiP11215.

    PTM databases

    PhosphoSiteiP11215.

    Expressioni

    Tissue specificityi

    Predominantly expressed in monocytes and granulocytes.

    Gene expression databases

    ArrayExpressiP11215.
    BgeeiP11215.
    CleanExiHS_ITGAM.
    GenevestigatoriP11215.

    Organism-specific databases

    HPAiCAB025091.
    HPA002274.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.2 Publications

    Protein-protein interaction databases

    BioGridi109890. 8 interactions.
    MINTiMINT-1489258.
    STRINGi9606.ENSP00000287497.

    Structurei

    Secondary structure

    1
    1152
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi149 – 1568
    Helixi163 – 18018
    Beta strandi185 – 20016
    Helixi202 – 2076
    Helixi211 – 2155
    Helixi227 – 23610
    Turni237 – 2393
    Helixi241 – 2433
    Beta strandi249 – 25911
    Helixi268 – 2703
    Helixi272 – 2776
    Beta strandi280 – 2889
    Helixi289 – 2913
    Helixi294 – 30310
    Helixi308 – 3114
    Beta strandi312 – 3176
    Helixi318 – 3247
    Helixi325 – 3339
    Helixi1130 – 11323
    Helixi1133 – 114311
    Beta strandi1147 – 11493

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A8Xmodel-A17-1152[»]
    1BHOX-ray2.701/2149-337[»]
    1BHQX-ray2.701/2149-337[»]
    1IDNX-ray2.701/2149-337[»]
    1IDOX-ray1.70A143-331[»]
    1JLMX-ray2.00A143-334[»]
    1M1UX-ray2.30A139-331[»]
    1MF7X-ray1.25A144-333[»]
    1N9ZX-ray2.50A144-335[»]
    1NA5X-ray1.50A144-335[»]
    2LKENMR-A1129-1152[»]
    2LKJNMR-A1129-1152[»]
    3Q3GX-ray2.70E/G/I/L148-337[»]
    3QA3X-ray3.00E/G/I/L148-337[»]
    4M76X-ray2.80B143-337[»]
    ProteinModelPortaliP11215.
    SMRiP11215. Positions 17-1143.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11215.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 11041088ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1129 – 115224CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1105 – 112824HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati18 – 7558FG-GAP 1Add
    BLAST
    Repeati76 – 13560FG-GAP 2Add
    BLAST
    Domaini150 – 328179VWFAPROSITE-ProRule annotationAdd
    BLAST
    Repeati339 – 39052FG-GAP 3Add
    BLAST
    Repeati391 – 44454FG-GAP 4Add
    BLAST
    Repeati445 – 50359FG-GAP 5Add
    BLAST
    Repeati506 – 56459FG-GAP 6Add
    BLAST
    Repeati569 – 62961FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1131 – 11355GFFKR motif

    Domaini

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301393.
    HOGENOMiHOG000113114.
    HOVERGENiHBG100530.
    InParanoidiP11215.
    KOiK06461.
    OMAiMMSEAGP.
    OrthoDBiEOG7353W1.
    PhylomeDBiP11215.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P11215-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA     50
    PQEIVAANQR GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP 100
    QLLACGPTVH QTCSENTYVK GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD 150
    IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL KKSKTLFSLM QYSEEFRIHF 200
    TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN ITNGARKNAF 250
    KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL 300
    NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM 350
    SQEGFSAAIT SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN 400
    DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG 450
    TQIGAYFGAS LCSVDVDSNG STDLVLIGAP HYYEQTRGGQ VSVCPLPRGR 500
    ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI GAPGEEDNRG 550
    AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD 600
    LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE 650
    VRVCLHVQKS TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR 700
    QTQVLGLTQT CETLKLQLPN CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP 750
    VLAEDAQRLF TALFPFEKNC GNDNICQDDL SITFSFMSLD CLVVGGPREF 800
    NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ RSWRLACESA 850
    SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN 900
    VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV 950
    MQHQYQVSNL GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT 1000
    KERLPSHSDF LAELRKAPVV NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN 1050
    LSFDWYIKTS HNHLLIVSTA EILFNDSVFT LLPGQGAFVR SQTETKVEPF 1100
    EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM MSEGGPPGAE 1150
    PQ 1152
    Length:1,152
    Mass (Da):127,179
    Last modified:October 1, 1996 - v2
    Checksum:iDF77408ED5EE25F9
    GO
    Isoform 2 (identifier: P11215-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         499-499: G → GQ

    Show »
    Length:1,153
    Mass (Da):127,307
    Checksum:i4383332408BB4234
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti965 – 9651L → P in AAA59491. (PubMed:2833753)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771R → H Influences susceptibility to SLE. 2 Publications
    Corresponds to variant rs1143679 [ dbSNP | Ensembl ].
    VAR_043870
    Natural varianti441 – 4411M → T.1 Publication
    Corresponds to variant rs11861251 [ dbSNP | Ensembl ].
    VAR_043871
    Natural varianti858 – 8581A → V.1 Publication
    Corresponds to variant rs1143683 [ dbSNP | Ensembl ].
    VAR_043872
    Natural varianti1146 – 11461P → S.1 Publication
    Corresponds to variant rs1143678 [ dbSNP | Ensembl ].
    VAR_043873

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei499 – 4991G → GQ in isoform 2. 2 PublicationsVSP_047365

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03925 mRNA. Translation: AAA59544.1.
    M18044 mRNA. Translation: AAA59491.1.
    S52227
    , S52152, S52153, S52154, S52155, S52157, S52159, S52161, S52164, S52165, S52167, S52169, S52170, S52173, S52174, S52180, S52181, S52184, S52189, S52191, S52192, S52203, S52212, S52213, S52216, S52219, S52220, S52221, S52222, S52226 Genomic DNA. Translation: AAB24821.1.
    BC096346 mRNA. Translation: AAH96346.1.
    BC096347 mRNA. Translation: AAH96347.1.
    BC096348 mRNA. Translation: AAH96348.1.
    BC099660 mRNA. Translation: AAH99660.1.
    J04145 mRNA. Translation: AAA59903.1.
    M76724 Genomic DNA. Translation: AAA58410.1.
    M84477 Genomic DNA. Translation: AAA51960.1.
    CCDSiCCDS45470.1. [P11215-1]
    CCDS54004.1. [P11215-2]
    PIRiA31108. RWHU1B.
    RefSeqiNP_000623.2. NM_000632.3. [P11215-1]
    NP_001139280.1. NM_001145808.1. [P11215-2]
    UniGeneiHs.172631.

    Genome annotation databases

    EnsembliENST00000287497; ENSP00000287497; ENSG00000169896. [P11215-1]
    ENST00000544665; ENSP00000441691; ENSG00000169896. [P11215-2]
    GeneIDi3684.
    KEGGihsa:3684.
    UCSCiuc002ebq.3. human. [P11215-1]

    Polymorphism databases

    DMDMi1708572.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03925 mRNA. Translation: AAA59544.1 .
    M18044 mRNA. Translation: AAA59491.1 .
    S52227
    , S52152 , S52153 , S52154 , S52155 , S52157 , S52159 , S52161 , S52164 , S52165 , S52167 , S52169 , S52170 , S52173 , S52174 , S52180 , S52181 , S52184 , S52189 , S52191 , S52192 , S52203 , S52212 , S52213 , S52216 , S52219 , S52220 , S52221 , S52222 , S52226 Genomic DNA. Translation: AAB24821.1 .
    BC096346 mRNA. Translation: AAH96346.1 .
    BC096347 mRNA. Translation: AAH96347.1 .
    BC096348 mRNA. Translation: AAH96348.1 .
    BC099660 mRNA. Translation: AAH99660.1 .
    J04145 mRNA. Translation: AAA59903.1 .
    M76724 Genomic DNA. Translation: AAA58410.1 .
    M84477 Genomic DNA. Translation: AAA51960.1 .
    CCDSi CCDS45470.1. [P11215-1 ]
    CCDS54004.1. [P11215-2 ]
    PIRi A31108. RWHU1B.
    RefSeqi NP_000623.2. NM_000632.3. [P11215-1 ]
    NP_001139280.1. NM_001145808.1. [P11215-2 ]
    UniGenei Hs.172631.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A8X model - A 17-1152 [» ]
    1BHO X-ray 2.70 1/2 149-337 [» ]
    1BHQ X-ray 2.70 1/2 149-337 [» ]
    1IDN X-ray 2.70 1/2 149-337 [» ]
    1IDO X-ray 1.70 A 143-331 [» ]
    1JLM X-ray 2.00 A 143-334 [» ]
    1M1U X-ray 2.30 A 139-331 [» ]
    1MF7 X-ray 1.25 A 144-333 [» ]
    1N9Z X-ray 2.50 A 144-335 [» ]
    1NA5 X-ray 1.50 A 144-335 [» ]
    2LKE NMR - A 1129-1152 [» ]
    2LKJ NMR - A 1129-1152 [» ]
    3Q3G X-ray 2.70 E/G/I/L 148-337 [» ]
    3QA3 X-ray 3.00 E/G/I/L 148-337 [» ]
    4M76 X-ray 2.80 B 143-337 [» ]
    ProteinModelPortali P11215.
    SMRi P11215. Positions 17-1143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109890. 8 interactions.
    MINTi MINT-1489258.
    STRINGi 9606.ENSP00000287497.

    Chemistry

    BindingDBi P11215.
    ChEMBLi CHEMBL3826.

    PTM databases

    PhosphoSitei P11215.

    Polymorphism databases

    DMDMi 1708572.

    Proteomic databases

    PaxDbi P11215.
    PRIDEi P11215.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287497 ; ENSP00000287497 ; ENSG00000169896 . [P11215-1 ]
    ENST00000544665 ; ENSP00000441691 ; ENSG00000169896 . [P11215-2 ]
    GeneIDi 3684.
    KEGGi hsa:3684.
    UCSCi uc002ebq.3. human. [P11215-1 ]

    Organism-specific databases

    CTDi 3684.
    GeneCardsi GC16P031271.
    HGNCi HGNC:6149. ITGAM.
    HPAi CAB025091.
    HPA002274.
    MIMi 120980. gene.
    609939. phenotype.
    neXtProti NX_P11215.
    Orphaneti 536. Systemic lupus erythematosus.
    PharmGKBi PA29949.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301393.
    HOGENOMi HOG000113114.
    HOVERGENi HBG100530.
    InParanoidi P11215.
    KOi K06461.
    OMAi MMSEAGP.
    OrthoDBi EOG7353W1.
    PhylomeDBi P11215.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_12051. Cell surface interactions at the vascular wall.
    REACT_13552. Integrin cell surface interactions.
    REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
    SignaLinki P11215.

    Miscellaneous databases

    EvolutionaryTracei P11215.
    GeneWikii Integrin_alpha_M.
    GenomeRNAii 3684.
    NextBioi 14419.
    PROi P11215.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11215.
    Bgeei P11215.
    CleanExi HS_ITGAM.
    Genevestigatori P11215.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."
      Corbi A.L., Kishimoto T.K., Miller L.J., Springer T.A.
      J. Biol. Chem. 263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."
      Arnaout M.A., Remold-O'Donnell E., Pierce M.W., Harris P., Tenen D.G.
      Proc. Natl. Acad. Sci. U.S.A. 85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."
      Arnaout M.A., Gupta S.K., Pierce M.W., Tenen D.G.
      J. Cell Biol. 106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."
      Fleming J.C., Pahl H.L., Gonzalez D.A., Smith T.F., Tenen D.G.
      J. Immunol. 150:480-490(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-77; THR-441; VAL-858 AND SER-1146.
    6. "cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."
      Hickstein D.D., Hickey M.J., Ozols J., Baker D.M., Back A.L., Roth G.J.
      Proc. Natl. Acad. Sci. U.S.A. 86:257-261(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1152 (ISOFORM 2).
    7. "The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."
      Shelley C.S., Arnaout M.A.
      Proc. Natl. Acad. Sci. U.S.A. 88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
    8. "Characterization of the myeloid-specific CD11b promoter."
      Pahl H.L., Rosmarin A.G., Tenen D.G.
      Blood 79:865-870(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
      Tissue: Blood.
    9. "N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."
      Pierce M.W., Remold-O'Donnell E., Todd R.F. III, Arnaout M.A.
      Biochim. Biophys. Acta 874:368-371(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 17-31.
    10. "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
      Santoso S., Sachs U.J.H., Kroll H., Linder M., Ruf A., Preissner K.T., Chavakis T.
      J. Exp. Med. 196:679-691(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH JAM3.
    11. "JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
      Zen K., Babbin B.A., Liu Y., Whelan J.B., Nusrat A., Parkos C.A.
      Mol. Biol. Cell 15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH JAM3.
    12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-900; ASN-940 AND ASN-946.
      Tissue: Liver.
    13. "Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."
      Lee J.O., Rieu P., Arnaout M.A., Liddington R.
      Cell 80:631-638(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 148-331.
    14. "Two conformations of the integrin A-domain (I-domain): a pathway for activation?"
      Lee J.O., Bankston L.A., Arnaout M.A., Liddington R.C.
      Structure 3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 148-334.
    15. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 148-337.
    16. "Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."
      Oxvig C., Springer T.A.
      Proc. Natl. Acad. Sci. U.S.A. 95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 17-616.
    17. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE, VARIANT HIS-77.
    18. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE.

    Entry informationi

    Entry nameiITAM_HUMAN
    AccessioniPrimary (citable) accession number: P11215
    Secondary accession number(s): Q4VAK0, Q4VAK1, Q4VAK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 167 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3