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P11215 (ITAM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 165. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-M
Alternative name(s):
CD11 antigen-like family member B
CR-3 alpha chain
Cell surface glycoprotein MAC-1 subunit alpha
Leukocyte adhesion receptor MO1
Neutrophil adherence receptor
CD_antigen=CD11b
Gene names
Name:ITGAM
Synonyms:CD11B, CR3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1152 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Subunit structure

Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3. Ref.10 Ref.11

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Predominantly expressed in monocytes and granulocytes.

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Involvement in disease

Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseSystemic lupus erythematosus
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Magnesium
Metal-binding
   Molecular functionIntegrin
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processactivated T cell proliferation

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Traceable author statement. Source: Reactome

cell adhesion

Traceable author statement Ref.6. Source: ProtInc

cellular extravasation

Inferred from electronic annotation. Source: Ensembl

extracellular matrix organization

Traceable author statement. Source: Reactome

innate immune response

Traceable author statement. Source: Reactome

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

leukocyte cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

leukocyte migration

Traceable author statement. Source: Reactome

microglia development

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

toll-like receptor 4 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integrin complex

Traceable author statement Ref.6. Source: ProtInc

nucleus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionglycoprotein binding

Inferred from physical interaction PubMed 15004192. Source: UniProtKB

heparin binding

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.11. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P11215-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P11215-2)

The sequence of this isoform differs from the canonical sequence as follows:
     499-499: G → GQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Ref.9
Chain17 – 11521136Integrin alpha-M
PRO_0000016289

Regions

Topological domain17 – 11041088Extracellular Potential
Transmembrane1105 – 112824Helical; Potential
Topological domain1129 – 115224Cytoplasmic Potential
Repeat18 – 7558FG-GAP 1
Repeat76 – 13560FG-GAP 2
Domain150 – 328179VWFA
Repeat339 – 39052FG-GAP 3
Repeat391 – 44454FG-GAP 4
Repeat445 – 50359FG-GAP 5
Repeat506 – 56459FG-GAP 6
Repeat569 – 62961FG-GAP 7
Calcium binding465 – 4739 Potential
Calcium binding529 – 5379 Potential
Calcium binding592 – 6009 Potential
Motif1131 – 11355GFFKR motif

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation2401N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation6921N-linked (GlcNAc...) Potential
Glycosylation6961N-linked (GlcNAc...) Potential
Glycosylation7341N-linked (GlcNAc...) Potential
Glycosylation8011N-linked (GlcNAc...) Potential
Glycosylation8801N-linked (GlcNAc...) Potential
Glycosylation9001N-linked (GlcNAc...) Ref.12
Glycosylation9111N-linked (GlcNAc...) Potential
Glycosylation9401N-linked (GlcNAc...) Ref.12
Glycosylation9461N-linked (GlcNAc...) Ref.12
Glycosylation9781N-linked (GlcNAc...) Potential
Glycosylation9931N-linked (GlcNAc...) Potential
Glycosylation10211N-linked (GlcNAc...) Potential
Glycosylation10441N-linked (GlcNAc...) Potential
Glycosylation10501N-linked (GlcNAc...) Potential
Glycosylation10751N-linked (GlcNAc...) Potential
Disulfide bond66 ↔ 73 By similarity
Disulfide bond105 ↔ 123 By similarity
Disulfide bond654 ↔ 711 By similarity
Disulfide bond770 ↔ 776 By similarity
Disulfide bond847 ↔ 864 By similarity
Disulfide bond998 ↔ 1022 By similarity
Disulfide bond1027 ↔ 1032 By similarity

Natural variations

Alternative sequence4991G → GQ in isoform 2.
VSP_047365
Natural variant771R → H Influences susceptibility to SLE. Ref.5 Ref.17
Corresponds to variant rs1143679 [ dbSNP | Ensembl ].
VAR_043870
Natural variant4411M → T. Ref.5
Corresponds to variant rs11861251 [ dbSNP | Ensembl ].
VAR_043871
Natural variant8581A → V. Ref.5
Corresponds to variant rs1143683 [ dbSNP | Ensembl ].
VAR_043872
Natural variant11461P → S. Ref.5
Corresponds to variant rs1143678 [ dbSNP | Ensembl ].
VAR_043873

Experimental info

Sequence conflict9651L → P in AAA59491. Ref.2

Secondary structure

..................................... 1152
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: DF77408ED5EE25F9

FASTA1,152127,179
        10         20         30         40         50         60 
MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA PQEIVAANQR 

        70         80         90        100        110        120 
GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP QLLACGPTVH QTCSENTYVK 

       130        140        150        160        170        180 
GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL 

       190        200        210        220        230        240 
KKSKTLFSLM QYSEEFRIHF TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN 

       250        260        270        280        290        300 
ITNGARKNAF KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL 

       310        320        330        340        350        360 
NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM SQEGFSAAIT 

       370        380        390        400        410        420 
SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN DAYLGYAAAI ILRNRVQSLV 

       430        440        450        460        470        480 
LGAPRYQHIG LVAMFRQNTG MWESNANVKG TQIGAYFGAS LCSVDVDSNG STDLVLIGAP 

       490        500        510        520        530        540 
HYYEQTRGGQ VSVCPLPRGR ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI 

       550        560        570        580        590        600 
GAPGEEDNRG AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD 

       610        620        630        640        650        660 
LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE VRVCLHVQKS 

       670        680        690        700        710        720 
TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR QTQVLGLTQT CETLKLQLPN 

       730        740        750        760        770        780 
CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP VLAEDAQRLF TALFPFEKNC GNDNICQDDL 

       790        800        810        820        830        840 
SITFSFMSLD CLVVGGPREF NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ 

       850        860        870        880        890        900 
RSWRLACESA SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN 

       910        920        930        940        950        960 
VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV MQHQYQVSNL 

       970        980        990       1000       1010       1020 
GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT KERLPSHSDF LAELRKAPVV 

      1030       1040       1050       1060       1070       1080 
NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN LSFDWYIKTS HNHLLIVSTA EILFNDSVFT 

      1090       1100       1110       1120       1130       1140 
LLPGQGAFVR SQTETKVEPF EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM 

      1150 
MSEGGPPGAE PQ 

« Hide

Isoform 2 [UniParc].

Checksum: 4383332408BB4234
Show »

FASTA1,153127,307

References

« Hide 'large scale' references
[1]"The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."
Corbi A.L., Kishimoto T.K., Miller L.J., Springer T.A.
J. Biol. Chem. 263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."
Arnaout M.A., Remold-O'Donnell E., Pierce M.W., Harris P., Tenen D.G.
Proc. Natl. Acad. Sci. U.S.A. 85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."
Arnaout M.A., Gupta S.K., Pierce M.W., Tenen D.G.
J. Cell Biol. 106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."
Fleming J.C., Pahl H.L., Gonzalez D.A., Smith T.F., Tenen D.G.
J. Immunol. 150:480-490(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-77; THR-441; VAL-858 AND SER-1146.
[6]"cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."
Hickstein D.D., Hickey M.J., Ozols J., Baker D.M., Back A.L., Roth G.J.
Proc. Natl. Acad. Sci. U.S.A. 86:257-261(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1152 (ISOFORM 2).
[7]"The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."
Shelley C.S., Arnaout M.A.
Proc. Natl. Acad. Sci. U.S.A. 88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
[8]"Characterization of the myeloid-specific CD11b promoter."
Pahl H.L., Rosmarin A.G., Tenen D.G.
Blood 79:865-870(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
Tissue: Blood.
[9]"N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."
Pierce M.W., Remold-O'Donnell E., Todd R.F. III, Arnaout M.A.
Biochim. Biophys. Acta 874:368-371(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 17-31.
[10]"The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
Santoso S., Sachs U.J.H., Kroll H., Linder M., Ruf A., Preissner K.T., Chavakis T.
J. Exp. Med. 196:679-691(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH JAM3.
[11]"JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
Zen K., Babbin B.A., Liu Y., Whelan J.B., Nusrat A., Parkos C.A.
Mol. Biol. Cell 15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH JAM3.
[12]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-900; ASN-940 AND ASN-946.
Tissue: Liver.
[13]"Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."
Lee J.O., Rieu P., Arnaout M.A., Liddington R.
Cell 80:631-638(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 148-331.
[14]"Two conformations of the integrin A-domain (I-domain): a pathway for activation?"
Lee J.O., Bankston L.A., Arnaout M.A., Liddington R.C.
Structure 3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 148-334.
[15]"Cation binding to the integrin CD11b I domain and activation model assessment."
Baldwin E.T., Sarver R.W., Bryant G.L. Jr., Curry K.A., Fairbanks M.B., Finzel B.C., Garlick R.L., Heinrikson R.L., Horton N.C., Kelley L.L., Mildner A.M., Moon J.B., Mott J.E., Mutchler V.T., Tomich C.S., Watenpaugh K.D., Wiley V.H.
Structure 6:923-935(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 148-337.
[16]"Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."
Oxvig C., Springer T.A.
Proc. Natl. Acad. Sci. U.S.A. 95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 17-616.
[17]"A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus."
Nath S.K., Han S., Kim-Howard X., Kelly J.A., Viswanathan P., Gilkeson G.S., Chen W., Zhu C., McEver R.P., Kimberly R.P., Alarcon-Riquelme M.E., Vyse T.J., Li Q.-Z., Wakeland E.K., Merrill J.T., James J.A., Kaufman K.M., Guthridge J.M., Harley J.B.
Nat. Genet. 40:152-154(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE, VARIANT HIS-77.
[18]"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci."
Harley J.B., Alarcon-Riquelme M.E., Criswell L.A., Jacob C.O., Kimberly R.P., Moser K.L., Tsao B.P., Vyse T.J., Langefeld C.D., Nath S.K., Guthridge J.M., Cobb B.L., Mirel D.B., Marion M.C., Williams A.H., Divers J., Wang W., Frank S.G. expand/collapse author list , Namjou B., Gabriel S.B., Lee A.T., Gregersen P.K., Behrens T.W., Taylor K.E., Fernando M., Zidovetzki R., Gaffney P.M., Edberg J.C., Rioux J.D., Ojwang J.O., James J.A., Merrill J.T., Gilkeson G.S., Seldin M.F., Yin H., Baechler E.C., Li Q.-Z., Wakeland E.K., Bruner G.R., Kaufman K.M., Kelly J.A.
Nat. Genet. 40:204-210(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03925 mRNA. Translation: AAA59544.1.
M18044 mRNA. Translation: AAA59491.1.
S52227 expand/collapse EMBL AC list , S52152, S52153, S52154, S52155, S52157, S52159, S52161, S52164, S52165, S52167, S52169, S52170, S52173, S52174, S52180, S52181, S52184, S52189, S52191, S52192, S52203, S52212, S52213, S52216, S52219, S52220, S52221, S52222, S52226 Genomic DNA. Translation: AAB24821.1.
BC096346 mRNA. Translation: AAH96346.1.
BC096347 mRNA. Translation: AAH96347.1.
BC096348 mRNA. Translation: AAH96348.1.
BC099660 mRNA. Translation: AAH99660.1.
J04145 mRNA. Translation: AAA59903.1.
M76724 Genomic DNA. Translation: AAA58410.1.
M84477 Genomic DNA. Translation: AAA51960.1.
CCDSCCDS45470.1. [P11215-1]
CCDS54004.1. [P11215-2]
PIRRWHU1B. A31108.
RefSeqNP_000623.2. NM_000632.3. [P11215-1]
NP_001139280.1. NM_001145808.1. [P11215-2]
UniGeneHs.172631.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A8Xmodel-A17-1152[»]
1BHOX-ray2.701/2149-337[»]
1BHQX-ray2.701/2149-337[»]
1IDNX-ray2.701/2149-337[»]
1IDOX-ray1.70A143-331[»]
1JLMX-ray2.00A143-334[»]
1M1UX-ray2.30A139-331[»]
1MF7X-ray1.25A144-333[»]
1N9ZX-ray2.50A144-335[»]
1NA5X-ray1.50A144-335[»]
2LKENMR-A1129-1152[»]
2LKJNMR-A1129-1152[»]
3Q3GX-ray2.70E/G/I/L148-337[»]
3QA3X-ray3.00E/G/I/L148-337[»]
4M76X-ray2.80B143-337[»]
ProteinModelPortalP11215.
SMRP11215. Positions 17-1143.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109890. 8 interactions.
MINTMINT-1489258.
STRING9606.ENSP00000287497.

Chemistry

BindingDBP11215.
ChEMBLCHEMBL3826.

PTM databases

PhosphoSiteP11215.

Polymorphism databases

DMDM1708572.

Proteomic databases

PaxDbP11215.
PRIDEP11215.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000287497; ENSP00000287497; ENSG00000169896. [P11215-1]
ENST00000544665; ENSP00000441691; ENSG00000169896. [P11215-2]
GeneID3684.
KEGGhsa:3684.
UCSCuc002ebq.3. human. [P11215-1]

Organism-specific databases

CTD3684.
GeneCardsGC16P031271.
HGNCHGNC:6149. ITGAM.
HPACAB025091.
HPA002274.
MIM120980. gene.
609939. phenotype.
neXtProtNX_P11215.
Orphanet536. Systemic lupus erythematosus.
PharmGKBPA29949.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301393.
HOGENOMHOG000113114.
HOVERGENHBG100530.
InParanoidP11215.
KOK06461.
OMAMMSEAGP.
OrthoDBEOG7353W1.
PhylomeDBP11215.
TreeFamTF105391.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.
REACT_604. Hemostasis.
REACT_6900. Immune System.
SignaLinkP11215.

Gene expression databases

ArrayExpressP11215.
BgeeP11215.
CleanExHS_ITGAM.
GenevestigatorP11215.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP11215.
GeneWikiIntegrin_alpha_M.
GenomeRNAi3684.
NextBio14419.
PROP11215.
SOURCESearch...

Entry information

Entry nameITAM_HUMAN
AccessionPrimary (citable) accession number: P11215
Secondary accession number(s): Q4VAK0, Q4VAK1, Q4VAK2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries