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P11215

- ITAM_HUMAN

UniProt

P11215 - ITAM_HUMAN

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Protein

Integrin alpha-M

Gene

ITGAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi465 – 4739Sequence Analysis
Calcium bindingi529 – 5379Sequence Analysis
Calcium bindingi592 – 6009Sequence Analysis

GO - Molecular functioni

  1. glycoprotein binding Source: UniProtKB
  2. heparin binding Source: Ensembl
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activated T cell proliferation Source: Ensembl
  2. blood coagulation Source: Reactome
  3. cell adhesion Source: ProtInc
  4. cellular extravasation Source: Ensembl
  5. ectodermal cell differentiation Source: UniProtKB
  6. extracellular matrix organization Source: Reactome
  7. innate immune response Source: Reactome
  8. integrin-mediated signaling pathway Source: UniProtKB-KW
  9. leukocyte cell-cell adhesion Source: Ensembl
  10. leukocyte migration Source: Reactome
  11. leukocyte migration involved in inflammatory response Source: Ensembl
  12. microglia development Source: Ensembl
  13. neutrophil chemotaxis Source: Ensembl
  14. toll-like receptor 4 signaling pathway Source: Reactome
  15. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_13552. Integrin cell surface interactions.
REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
SignaLinkiP11215.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-M
Alternative name(s):
CD11 antigen-like family member B
CR-3 alpha chain
Cell surface glycoprotein MAC-1 subunit alpha
Leukocyte adhesion receptor MO1
Neutrophil adherence receptor
CD_antigen: CD11b
Gene namesi
Name:ITGAM
Synonyms:CD11B, CR3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:6149. ITGAM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 11041088ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1105 – 112824HelicalSequence AnalysisAdd
BLAST
Topological domaini1129 – 115224CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. external side of plasma membrane Source: Ensembl
  3. extracellular vesicular exosome Source: UniProtKB
  4. integrin complex Source: ProtInc
  5. nucleus Source: Ensembl
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

MIMi609939. phenotype.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA29949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Chaini17 – 11521136Integrin alpha-MPRO_0000016289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 73By similarity
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 123By similarity
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi654 ↔ 711By similarity
Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi734 – 7341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi770 ↔ 776By similarity
Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi847 ↔ 864By similarity
Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi900 – 9001N-linked (GlcNAc...)1 Publication
Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi940 – 9401N-linked (GlcNAc...)1 Publication
Glycosylationi946 – 9461N-linked (GlcNAc...)1 Publication
Glycosylationi978 – 9781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi993 – 9931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi998 ↔ 1022By similarity
Glycosylationi1021 – 10211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1027 ↔ 1032By similarity
Glycosylationi1044 – 10441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1050 – 10501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1075 – 10751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11215.
PRIDEiP11215.

PTM databases

PhosphoSiteiP11215.

Expressioni

Tissue specificityi

Predominantly expressed in monocytes and granulocytes.

Gene expression databases

BgeeiP11215.
CleanExiHS_ITGAM.
ExpressionAtlasiP11215. baseline and differential.
GenevestigatoriP11215.

Organism-specific databases

HPAiCAB025091.
HPA002274.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.2 Publications

Protein-protein interaction databases

BioGridi109890. 8 interactions.
MINTiMINT-1489258.
STRINGi9606.ENSP00000287497.

Structurei

Secondary structure

1
1152
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi149 – 1568Combined sources
Helixi163 – 18018Combined sources
Beta strandi185 – 20016Combined sources
Helixi202 – 2076Combined sources
Helixi211 – 2155Combined sources
Helixi227 – 23610Combined sources
Turni237 – 2393Combined sources
Helixi241 – 2433Combined sources
Beta strandi249 – 25911Combined sources
Helixi268 – 2703Combined sources
Helixi272 – 2776Combined sources
Beta strandi280 – 2889Combined sources
Helixi289 – 2913Combined sources
Helixi294 – 30310Combined sources
Helixi308 – 3114Combined sources
Beta strandi312 – 3176Combined sources
Helixi318 – 3247Combined sources
Helixi325 – 3339Combined sources
Helixi1130 – 11323Combined sources
Helixi1133 – 114311Combined sources
Beta strandi1147 – 11493Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A8Xmodel-A17-1152[»]
1BHOX-ray2.701/2149-337[»]
1BHQX-ray2.701/2149-337[»]
1IDNX-ray2.701/2149-337[»]
1IDOX-ray1.70A143-331[»]
1JLMX-ray2.00A143-334[»]
1M1UX-ray2.30A139-331[»]
1MF7X-ray1.25A144-333[»]
1N9ZX-ray2.50A144-335[»]
1NA5X-ray1.50A144-335[»]
2LKENMR-A1129-1152[»]
2LKJNMR-A1129-1152[»]
3Q3GX-ray2.70E/G/I/L148-337[»]
3QA3X-ray3.00E/G/I/L148-337[»]
4M76X-ray2.80B143-337[»]
ProteinModelPortaliP11215.
SMRiP11215. Positions 17-335, 345-1101.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11215.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 7558FG-GAP 1Add
BLAST
Repeati76 – 13560FG-GAP 2Add
BLAST
Domaini150 – 328179VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati339 – 39052FG-GAP 3Add
BLAST
Repeati391 – 44454FG-GAP 4Add
BLAST
Repeati445 – 50359FG-GAP 5Add
BLAST
Repeati506 – 56459FG-GAP 6Add
BLAST
Repeati569 – 62961FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1131 – 11355GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301393.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiP11215.
KOiK06461.
OMAiMMSEAGP.
OrthoDBiEOG7353W1.
PhylomeDBiP11215.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P11215-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA
60 70 80 90 100
PQEIVAANQR GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP
110 120 130 140 150
QLLACGPTVH QTCSENTYVK GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD
160 170 180 190 200
IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL KKSKTLFSLM QYSEEFRIHF
210 220 230 240 250
TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN ITNGARKNAF
260 270 280 290 300
KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL
310 320 330 340 350
NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM
360 370 380 390 400
SQEGFSAAIT SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN
410 420 430 440 450
DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG
460 470 480 490 500
TQIGAYFGAS LCSVDVDSNG STDLVLIGAP HYYEQTRGGQ VSVCPLPRGR
510 520 530 540 550
ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI GAPGEEDNRG
560 570 580 590 600
AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD
610 620 630 640 650
LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE
660 670 680 690 700
VRVCLHVQKS TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR
710 720 730 740 750
QTQVLGLTQT CETLKLQLPN CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP
760 770 780 790 800
VLAEDAQRLF TALFPFEKNC GNDNICQDDL SITFSFMSLD CLVVGGPREF
810 820 830 840 850
NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ RSWRLACESA
860 870 880 890 900
SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN
910 920 930 940 950
VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV
960 970 980 990 1000
MQHQYQVSNL GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT
1010 1020 1030 1040 1050
KERLPSHSDF LAELRKAPVV NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN
1060 1070 1080 1090 1100
LSFDWYIKTS HNHLLIVSTA EILFNDSVFT LLPGQGAFVR SQTETKVEPF
1110 1120 1130 1140 1150
EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM MSEGGPPGAE

PQ
Length:1,152
Mass (Da):127,179
Last modified:October 1, 1996 - v2
Checksum:iDF77408ED5EE25F9
GO
Isoform 2 (identifier: P11215-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-499: G → GQ

Show »
Length:1,153
Mass (Da):127,307
Checksum:i4383332408BB4234
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti965 – 9651L → P in AAA59491. (PubMed:2833753)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771R → H Influences susceptibility to SLE. 2 Publications
Corresponds to variant rs1143679 [ dbSNP | Ensembl ].
VAR_043870
Natural varianti441 – 4411M → T.1 Publication
Corresponds to variant rs11861251 [ dbSNP | Ensembl ].
VAR_043871
Natural varianti858 – 8581A → V.1 Publication
Corresponds to variant rs1143683 [ dbSNP | Ensembl ].
VAR_043872
Natural varianti1146 – 11461P → S.1 Publication
Corresponds to variant rs1143678 [ dbSNP | Ensembl ].
VAR_043873

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei499 – 4991G → GQ in isoform 2. 2 PublicationsVSP_047365

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03925 mRNA. Translation: AAA59544.1.
M18044 mRNA. Translation: AAA59491.1.
S52227
, S52152, S52153, S52154, S52155, S52157, S52159, S52161, S52164, S52165, S52167, S52169, S52170, S52173, S52174, S52180, S52181, S52184, S52189, S52191, S52192, S52203, S52212, S52213, S52216, S52219, S52220, S52221, S52222, S52226 Genomic DNA. Translation: AAB24821.1.
BC096346 mRNA. Translation: AAH96346.1.
BC096347 mRNA. Translation: AAH96347.1.
BC096348 mRNA. Translation: AAH96348.1.
BC099660 mRNA. Translation: AAH99660.1.
J04145 mRNA. Translation: AAA59903.1.
M76724 Genomic DNA. Translation: AAA58410.1.
M84477 Genomic DNA. Translation: AAA51960.1.
CCDSiCCDS45470.1. [P11215-1]
CCDS54004.1. [P11215-2]
PIRiA31108. RWHU1B.
RefSeqiNP_000623.2. NM_000632.3. [P11215-1]
NP_001139280.1. NM_001145808.1. [P11215-2]
UniGeneiHs.172631.

Genome annotation databases

EnsembliENST00000287497; ENSP00000287497; ENSG00000169896. [P11215-1]
ENST00000544665; ENSP00000441691; ENSG00000169896. [P11215-2]
GeneIDi3684.
KEGGihsa:3684.
UCSCiuc002ebq.3. human. [P11215-1]

Polymorphism databases

DMDMi1708572.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03925 mRNA. Translation: AAA59544.1 .
M18044 mRNA. Translation: AAA59491.1 .
S52227
, S52152 , S52153 , S52154 , S52155 , S52157 , S52159 , S52161 , S52164 , S52165 , S52167 , S52169 , S52170 , S52173 , S52174 , S52180 , S52181 , S52184 , S52189 , S52191 , S52192 , S52203 , S52212 , S52213 , S52216 , S52219 , S52220 , S52221 , S52222 , S52226 Genomic DNA. Translation: AAB24821.1 .
BC096346 mRNA. Translation: AAH96346.1 .
BC096347 mRNA. Translation: AAH96347.1 .
BC096348 mRNA. Translation: AAH96348.1 .
BC099660 mRNA. Translation: AAH99660.1 .
J04145 mRNA. Translation: AAA59903.1 .
M76724 Genomic DNA. Translation: AAA58410.1 .
M84477 Genomic DNA. Translation: AAA51960.1 .
CCDSi CCDS45470.1. [P11215-1 ]
CCDS54004.1. [P11215-2 ]
PIRi A31108. RWHU1B.
RefSeqi NP_000623.2. NM_000632.3. [P11215-1 ]
NP_001139280.1. NM_001145808.1. [P11215-2 ]
UniGenei Hs.172631.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A8X model - A 17-1152 [» ]
1BHO X-ray 2.70 1/2 149-337 [» ]
1BHQ X-ray 2.70 1/2 149-337 [» ]
1IDN X-ray 2.70 1/2 149-337 [» ]
1IDO X-ray 1.70 A 143-331 [» ]
1JLM X-ray 2.00 A 143-334 [» ]
1M1U X-ray 2.30 A 139-331 [» ]
1MF7 X-ray 1.25 A 144-333 [» ]
1N9Z X-ray 2.50 A 144-335 [» ]
1NA5 X-ray 1.50 A 144-335 [» ]
2LKE NMR - A 1129-1152 [» ]
2LKJ NMR - A 1129-1152 [» ]
3Q3G X-ray 2.70 E/G/I/L 148-337 [» ]
3QA3 X-ray 3.00 E/G/I/L 148-337 [» ]
4M76 X-ray 2.80 B 143-337 [» ]
ProteinModelPortali P11215.
SMRi P11215. Positions 17-335, 345-1101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109890. 8 interactions.
MINTi MINT-1489258.
STRINGi 9606.ENSP00000287497.

Chemistry

BindingDBi P11215.
ChEMBLi CHEMBL2111362.

PTM databases

PhosphoSitei P11215.

Polymorphism databases

DMDMi 1708572.

Proteomic databases

PaxDbi P11215.
PRIDEi P11215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287497 ; ENSP00000287497 ; ENSG00000169896 . [P11215-1 ]
ENST00000544665 ; ENSP00000441691 ; ENSG00000169896 . [P11215-2 ]
GeneIDi 3684.
KEGGi hsa:3684.
UCSCi uc002ebq.3. human. [P11215-1 ]

Organism-specific databases

CTDi 3684.
GeneCardsi GC16P031271.
HGNCi HGNC:6149. ITGAM.
HPAi CAB025091.
HPA002274.
MIMi 120980. gene.
609939. phenotype.
neXtProti NX_P11215.
Orphaneti 536. Systemic lupus erythematosus.
PharmGKBi PA29949.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301393.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000113114.
HOVERGENi HBG100530.
InParanoidi P11215.
KOi K06461.
OMAi MMSEAGP.
OrthoDBi EOG7353W1.
PhylomeDBi P11215.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.
REACT_13552. Integrin cell surface interactions.
REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
SignaLinki P11215.

Miscellaneous databases

ChiTaRSi ITGAM. human.
EvolutionaryTracei P11215.
GeneWikii Integrin_alpha_M.
GenomeRNAii 3684.
NextBioi 14419.
PROi P11215.
SOURCEi Search...

Gene expression databases

Bgeei P11215.
CleanExi HS_ITGAM.
ExpressionAtlasi P11215. baseline and differential.
Genevestigatori P11215.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."
    Corbi A.L., Kishimoto T.K., Miller L.J., Springer T.A.
    J. Biol. Chem. 263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."
    Arnaout M.A., Remold-O'Donnell E., Pierce M.W., Harris P., Tenen D.G.
    Proc. Natl. Acad. Sci. U.S.A. 85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."
    Arnaout M.A., Gupta S.K., Pierce M.W., Tenen D.G.
    J. Cell Biol. 106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."
    Fleming J.C., Pahl H.L., Gonzalez D.A., Smith T.F., Tenen D.G.
    J. Immunol. 150:480-490(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-77; THR-441; VAL-858 AND SER-1146.
  6. "cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."
    Hickstein D.D., Hickey M.J., Ozols J., Baker D.M., Back A.L., Roth G.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:257-261(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1152 (ISOFORM 2).
  7. "The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."
    Shelley C.S., Arnaout M.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
  8. "Characterization of the myeloid-specific CD11b promoter."
    Pahl H.L., Rosmarin A.G., Tenen D.G.
    Blood 79:865-870(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
    Tissue: Blood.
  9. "N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."
    Pierce M.W., Remold-O'Donnell E., Todd R.F. III, Arnaout M.A.
    Biochim. Biophys. Acta 874:368-371(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-31.
  10. "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
    Santoso S., Sachs U.J.H., Kroll H., Linder M., Ruf A., Preissner K.T., Chavakis T.
    J. Exp. Med. 196:679-691(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JAM3.
  11. "JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
    Zen K., Babbin B.A., Liu Y., Whelan J.B., Nusrat A., Parkos C.A.
    Mol. Biol. Cell 15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JAM3.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-900; ASN-940 AND ASN-946.
    Tissue: Liver.
  13. "Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."
    Lee J.O., Rieu P., Arnaout M.A., Liddington R.
    Cell 80:631-638(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 148-331.
  14. "Two conformations of the integrin A-domain (I-domain): a pathway for activation?"
    Lee J.O., Bankston L.A., Arnaout M.A., Liddington R.C.
    Structure 3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 148-334.
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 148-337.
  16. "Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."
    Oxvig C., Springer T.A.
    Proc. Natl. Acad. Sci. U.S.A. 95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 17-616.
  17. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE, VARIANT HIS-77.
  18. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE.

Entry informationi

Entry nameiITAM_HUMAN
AccessioniPrimary (citable) accession number: P11215
Secondary accession number(s): Q4VAK0, Q4VAK1, Q4VAK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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