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P11215

- ITAM_HUMAN

UniProt

P11215 - ITAM_HUMAN

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Protein
Integrin alpha-M
Gene
ITGAM, CD11B, CR3A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi465 – 4739 Reviewed prediction
Calcium bindingi529 – 5379 Reviewed prediction
Calcium bindingi592 – 6009 Reviewed prediction

GO - Molecular functioni

  1. glycoprotein binding Source: UniProtKB
  2. heparin binding Source: Ensembl
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. activated T cell proliferation Source: Ensembl
  2. blood coagulation Source: Reactome
  3. cell adhesion Source: ProtInc
  4. cellular extravasation Source: Ensembl
  5. extracellular matrix organization Source: Reactome
  6. innate immune response Source: Reactome
  7. integrin-mediated signaling pathway Source: UniProtKB-KW
  8. leukocyte cell-cell adhesion Source: Ensembl
  9. leukocyte migration Source: Reactome
  10. microglia development Source: Ensembl
  11. neutrophil chemotaxis Source: Ensembl
  12. toll-like receptor 4 signaling pathway Source: Reactome
  13. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_13552. Integrin cell surface interactions.
REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
SignaLinkiP11215.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-M
Alternative name(s):
CD11 antigen-like family member B
CR-3 alpha chain
Cell surface glycoprotein MAC-1 subunit alpha
Leukocyte adhesion receptor MO1
Neutrophil adherence receptor
CD_antigen: CD11b
Gene namesi
Name:ITGAM
Synonyms:CD11B, CR3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:6149. ITGAM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 11041088Extracellular Reviewed prediction
Add
BLAST
Transmembranei1105 – 112824Helical; Reviewed prediction
Add
BLAST
Topological domaini1129 – 115224Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integrin complex Source: ProtInc
  4. nucleus Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

MIMi609939. phenotype.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA29949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 Publication
Add
BLAST
Chaini17 – 11521136Integrin alpha-M
PRO_0000016289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 73 By similarity
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi105 ↔ 123 By similarity
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi654 ↔ 711 By similarity
Glycosylationi692 – 6921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi696 – 6961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi734 – 7341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi770 ↔ 776 By similarity
Glycosylationi801 – 8011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi847 ↔ 864 By similarity
Glycosylationi880 – 8801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi900 – 9001N-linked (GlcNAc...)1 Publication
Glycosylationi911 – 9111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi940 – 9401N-linked (GlcNAc...)1 Publication
Glycosylationi946 – 9461N-linked (GlcNAc...)1 Publication
Glycosylationi978 – 9781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi993 – 9931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi998 ↔ 1022 By similarity
Glycosylationi1021 – 10211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1027 ↔ 1032 By similarity
Glycosylationi1044 – 10441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1050 – 10501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1075 – 10751N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11215.
PRIDEiP11215.

PTM databases

PhosphoSiteiP11215.

Expressioni

Tissue specificityi

Predominantly expressed in monocytes and granulocytes.

Gene expression databases

ArrayExpressiP11215.
BgeeiP11215.
CleanExiHS_ITGAM.
GenevestigatoriP11215.

Organism-specific databases

HPAiCAB025091.
HPA002274.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.2 Publications

Protein-protein interaction databases

BioGridi109890. 8 interactions.
MINTiMINT-1489258.
STRINGi9606.ENSP00000287497.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi149 – 1568
Helixi163 – 18018
Beta strandi185 – 20016
Helixi202 – 2076
Helixi211 – 2155
Helixi227 – 23610
Turni237 – 2393
Helixi241 – 2433
Beta strandi249 – 25911
Helixi268 – 2703
Helixi272 – 2776
Beta strandi280 – 2889
Helixi289 – 2913
Helixi294 – 30310
Helixi308 – 3114
Beta strandi312 – 3176
Helixi318 – 3247
Helixi325 – 3339
Helixi1130 – 11323
Helixi1133 – 114311
Beta strandi1147 – 11493

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A8Xmodel-A17-1152[»]
1BHOX-ray2.701/2149-337[»]
1BHQX-ray2.701/2149-337[»]
1IDNX-ray2.701/2149-337[»]
1IDOX-ray1.70A143-331[»]
1JLMX-ray2.00A143-334[»]
1M1UX-ray2.30A139-331[»]
1MF7X-ray1.25A144-333[»]
1N9ZX-ray2.50A144-335[»]
1NA5X-ray1.50A144-335[»]
2LKENMR-A1129-1152[»]
2LKJNMR-A1129-1152[»]
3Q3GX-ray2.70E/G/I/L148-337[»]
3QA3X-ray3.00E/G/I/L148-337[»]
4M76X-ray2.80B143-337[»]
ProteinModelPortaliP11215.
SMRiP11215. Positions 17-1143.

Miscellaneous databases

EvolutionaryTraceiP11215.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 7558FG-GAP 1
Add
BLAST
Repeati76 – 13560FG-GAP 2
Add
BLAST
Domaini150 – 328179VWFA
Add
BLAST
Repeati339 – 39052FG-GAP 3
Add
BLAST
Repeati391 – 44454FG-GAP 4
Add
BLAST
Repeati445 – 50359FG-GAP 5
Add
BLAST
Repeati506 – 56459FG-GAP 6
Add
BLAST
Repeati569 – 62961FG-GAP 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1131 – 11355GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301393.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiP11215.
KOiK06461.
OMAiMMSEAGP.
OrthoDBiEOG7353W1.
PhylomeDBiP11215.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P11215-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA     50
PQEIVAANQR GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP 100
QLLACGPTVH QTCSENTYVK GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD 150
IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL KKSKTLFSLM QYSEEFRIHF 200
TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN ITNGARKNAF 250
KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL 300
NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM 350
SQEGFSAAIT SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN 400
DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG 450
TQIGAYFGAS LCSVDVDSNG STDLVLIGAP HYYEQTRGGQ VSVCPLPRGR 500
ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI GAPGEEDNRG 550
AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD 600
LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE 650
VRVCLHVQKS TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR 700
QTQVLGLTQT CETLKLQLPN CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP 750
VLAEDAQRLF TALFPFEKNC GNDNICQDDL SITFSFMSLD CLVVGGPREF 800
NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ RSWRLACESA 850
SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN 900
VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV 950
MQHQYQVSNL GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT 1000
KERLPSHSDF LAELRKAPVV NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN 1050
LSFDWYIKTS HNHLLIVSTA EILFNDSVFT LLPGQGAFVR SQTETKVEPF 1100
EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM MSEGGPPGAE 1150
PQ 1152
Length:1,152
Mass (Da):127,179
Last modified:October 1, 1996 - v2
Checksum:iDF77408ED5EE25F9
GO
Isoform 2 (identifier: P11215-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-499: G → GQ

Show »
Length:1,153
Mass (Da):127,307
Checksum:i4383332408BB4234
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771R → H Influences susceptibility to SLE. 2 Publications
Corresponds to variant rs1143679 [ dbSNP | Ensembl ].
VAR_043870
Natural varianti441 – 4411M → T.1 Publication
Corresponds to variant rs11861251 [ dbSNP | Ensembl ].
VAR_043871
Natural varianti858 – 8581A → V.1 Publication
Corresponds to variant rs1143683 [ dbSNP | Ensembl ].
VAR_043872
Natural varianti1146 – 11461P → S.1 Publication
Corresponds to variant rs1143678 [ dbSNP | Ensembl ].
VAR_043873

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei499 – 4991G → GQ in isoform 2.
VSP_047365

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti965 – 9651L → P in AAA59491. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03925 mRNA. Translation: AAA59544.1.
M18044 mRNA. Translation: AAA59491.1.
S52227
, S52152, S52153, S52154, S52155, S52157, S52159, S52161, S52164, S52165, S52167, S52169, S52170, S52173, S52174, S52180, S52181, S52184, S52189, S52191, S52192, S52203, S52212, S52213, S52216, S52219, S52220, S52221, S52222, S52226 Genomic DNA. Translation: AAB24821.1.
BC096346 mRNA. Translation: AAH96346.1.
BC096347 mRNA. Translation: AAH96347.1.
BC096348 mRNA. Translation: AAH96348.1.
BC099660 mRNA. Translation: AAH99660.1.
J04145 mRNA. Translation: AAA59903.1.
M76724 Genomic DNA. Translation: AAA58410.1.
M84477 Genomic DNA. Translation: AAA51960.1.
CCDSiCCDS45470.1. [P11215-1]
CCDS54004.1. [P11215-2]
PIRiA31108. RWHU1B.
RefSeqiNP_000623.2. NM_000632.3. [P11215-1]
NP_001139280.1. NM_001145808.1. [P11215-2]
UniGeneiHs.172631.

Genome annotation databases

EnsembliENST00000287497; ENSP00000287497; ENSG00000169896. [P11215-1]
ENST00000544665; ENSP00000441691; ENSG00000169896. [P11215-2]
GeneIDi3684.
KEGGihsa:3684.
UCSCiuc002ebq.3. human. [P11215-1]

Polymorphism databases

DMDMi1708572.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03925 mRNA. Translation: AAA59544.1 .
M18044 mRNA. Translation: AAA59491.1 .
S52227
, S52152 , S52153 , S52154 , S52155 , S52157 , S52159 , S52161 , S52164 , S52165 , S52167 , S52169 , S52170 , S52173 , S52174 , S52180 , S52181 , S52184 , S52189 , S52191 , S52192 , S52203 , S52212 , S52213 , S52216 , S52219 , S52220 , S52221 , S52222 , S52226 Genomic DNA. Translation: AAB24821.1 .
BC096346 mRNA. Translation: AAH96346.1 .
BC096347 mRNA. Translation: AAH96347.1 .
BC096348 mRNA. Translation: AAH96348.1 .
BC099660 mRNA. Translation: AAH99660.1 .
J04145 mRNA. Translation: AAA59903.1 .
M76724 Genomic DNA. Translation: AAA58410.1 .
M84477 Genomic DNA. Translation: AAA51960.1 .
CCDSi CCDS45470.1. [P11215-1 ]
CCDS54004.1. [P11215-2 ]
PIRi A31108. RWHU1B.
RefSeqi NP_000623.2. NM_000632.3. [P11215-1 ]
NP_001139280.1. NM_001145808.1. [P11215-2 ]
UniGenei Hs.172631.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A8X model - A 17-1152 [» ]
1BHO X-ray 2.70 1/2 149-337 [» ]
1BHQ X-ray 2.70 1/2 149-337 [» ]
1IDN X-ray 2.70 1/2 149-337 [» ]
1IDO X-ray 1.70 A 143-331 [» ]
1JLM X-ray 2.00 A 143-334 [» ]
1M1U X-ray 2.30 A 139-331 [» ]
1MF7 X-ray 1.25 A 144-333 [» ]
1N9Z X-ray 2.50 A 144-335 [» ]
1NA5 X-ray 1.50 A 144-335 [» ]
2LKE NMR - A 1129-1152 [» ]
2LKJ NMR - A 1129-1152 [» ]
3Q3G X-ray 2.70 E/G/I/L 148-337 [» ]
3QA3 X-ray 3.00 E/G/I/L 148-337 [» ]
4M76 X-ray 2.80 B 143-337 [» ]
ProteinModelPortali P11215.
SMRi P11215. Positions 17-1143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109890. 8 interactions.
MINTi MINT-1489258.
STRINGi 9606.ENSP00000287497.

Chemistry

BindingDBi P11215.
ChEMBLi CHEMBL3826.

PTM databases

PhosphoSitei P11215.

Polymorphism databases

DMDMi 1708572.

Proteomic databases

PaxDbi P11215.
PRIDEi P11215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287497 ; ENSP00000287497 ; ENSG00000169896 . [P11215-1 ]
ENST00000544665 ; ENSP00000441691 ; ENSG00000169896 . [P11215-2 ]
GeneIDi 3684.
KEGGi hsa:3684.
UCSCi uc002ebq.3. human. [P11215-1 ]

Organism-specific databases

CTDi 3684.
GeneCardsi GC16P031271.
HGNCi HGNC:6149. ITGAM.
HPAi CAB025091.
HPA002274.
MIMi 120980. gene.
609939. phenotype.
neXtProti NX_P11215.
Orphaneti 536. Systemic lupus erythematosus.
PharmGKBi PA29949.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301393.
HOGENOMi HOG000113114.
HOVERGENi HBG100530.
InParanoidi P11215.
KOi K06461.
OMAi MMSEAGP.
OrthoDBi EOG7353W1.
PhylomeDBi P11215.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.
REACT_13552. Integrin cell surface interactions.
REACT_6894. Toll Like Receptor 4 (TLR4) Cascade.
SignaLinki P11215.

Miscellaneous databases

EvolutionaryTracei P11215.
GeneWikii Integrin_alpha_M.
GenomeRNAii 3684.
NextBioi 14419.
PROi P11215.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11215.
Bgeei P11215.
CleanExi HS_ITGAM.
Genevestigatori P11215.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B."
    Corbi A.L., Kishimoto T.K., Miller L.J., Springer T.A.
    J. Biol. Chem. 263:12403-12411(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins."
    Arnaout M.A., Remold-O'Donnell E., Pierce M.W., Harris P., Tenen D.G.
    Proc. Natl. Acad. Sci. U.S.A. 85:2776-2780(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)."
    Arnaout M.A., Gupta S.K., Pierce M.W., Tenen D.G.
    J. Cell Biol. 106:2153-2158(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution."
    Fleming J.C., Pahl H.L., Gonzalez D.A., Smith T.F., Tenen D.G.
    J. Immunol. 150:480-490(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-77; THR-441; VAL-858 AND SER-1146.
  6. "cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits."
    Hickstein D.D., Hickey M.J., Ozols J., Baker D.M., Back A.L., Roth G.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:257-261(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-1152 (ISOFORM 2).
  7. "The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression."
    Shelley C.S., Arnaout M.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:10525-10529(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
  8. "Characterization of the myeloid-specific CD11b promoter."
    Pahl H.L., Rosmarin A.G., Tenen D.G.
    Blood 79:865-870(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
    Tissue: Blood.
  9. "N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa."
    Pierce M.W., Remold-O'Donnell E., Todd R.F. III, Arnaout M.A.
    Biochim. Biophys. Acta 874:368-371(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-31.
  10. "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
    Santoso S., Sachs U.J.H., Kroll H., Linder M., Ruf A., Preissner K.T., Chavakis T.
    J. Exp. Med. 196:679-691(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JAM3.
  11. "JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
    Zen K., Babbin B.A., Liu Y., Whelan J.B., Nusrat A., Parkos C.A.
    Mol. Biol. Cell 15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JAM3.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-900; ASN-940 AND ASN-946.
    Tissue: Liver.
  13. "Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)."
    Lee J.O., Rieu P., Arnaout M.A., Liddington R.
    Cell 80:631-638(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 148-331.
  14. "Two conformations of the integrin A-domain (I-domain): a pathway for activation?"
    Lee J.O., Bankston L.A., Arnaout M.A., Liddington R.C.
    Structure 3:1333-1340(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 148-334.
  15. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 148-337.
  16. "Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface."
    Oxvig C., Springer T.A.
    Proc. Natl. Acad. Sci. U.S.A. 95:4870-4875(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 17-616.
  17. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE, VARIANT HIS-77.
  18. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLE.

Entry informationi

Entry nameiITAM_HUMAN
AccessioniPrimary (citable) accession number: P11215
Secondary accession number(s): Q4VAK0, Q4VAK1, Q4VAK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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