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Protein

Nucleoprotein

Gene

N

Organism
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Replication is dependent on intracellular concentration of newly synthesized N, termed N0, which corresponds to the protein not associated with RNA. In contrast, when associated with RNA, it is termed N. During replication, encapsidation by N0 is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Short name:
NP
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:N
OrganismiVesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
Taxonomic identifieri11278 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeVesiculovirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Culicoides [TaxID: 58271]
Equus asinus (Donkey) (Equus africanus asinus) [TaxID: 9793]
Equus caballus (Horse) [TaxID: 9796]
Homo sapiens (Human) [TaxID: 9606]
Lutzomyia [TaxID: 252607]
Musca domestica (House fly) [TaxID: 7370]
Simuliidae (black flies) [TaxID: 7190]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000007544 Componenti: Genome

Subcellular locationi

  • Virion
  • Host cytoplasm

  • Note: The nucleocapsid is synthesized in the cytoplasm, and is subsequently transported via microtubules to the cell periphery.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422NucleoproteinPRO_0000222821Add
BLAST

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. N in nucleocapsid binds the P protein and thereby positions the polymerase on the template. Interaction of N0 with the P protein prevents the uncontrolled aggregation of N0 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-1087N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KBGX-ray2.20P52-59[»]
1NAMX-ray2.70P52-59[»]
2MHAX-ray2.50E/F52-59[»]
2VAAX-ray2.30P52-59[»]
ProteinModelPortaliP11212.
SMRiP11212. Positions 2-422.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11212.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.3570.10. 1 hit.
1.10.3610.10. 1 hit.
InterProiIPR000448. Rhabdo_ncapsid.
IPR023331. Rhabdovirus_ncapsid_C.
IPR023330. Rhabdovirus_ncapsid_N.
[Graphical view]
PfamiPF00945. Rhabdo_ncap. 1 hit.
[Graphical view]
ProDomiPD002087. Rhabd_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF140809. SSF140809. 1 hit.

Sequencei

Sequence statusi: Complete.

P11212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTVKRIID NTVIVPKLPA NEDPVEYPAD YFRKSKEIPL YINTTKSLSD
60 70 80 90 100
LRGYVYQGLK SGNVSIIHVN SYLYGALKDI RGKLDKDWSS FGINIGKAGD
110 120 130 140 150
TIGIFDLVSL KGLDGVLPDG VSDASRTRAD DKWLPLYLLG LYRVGRTQMP
160 170 180 190 200
EYRKKLMDGL TNQCKMINEQ FEPLVPEGRD IFDVWGNDSN YTKIVAAVDM
210 220 230 240 250
FFHMFKKHEC ASFRYGTIVS RFKDCAALAT FGHLCKITGM STEDVTTWIL
260 270 280 290 300
NREVADEMVQ MMLPGQEIDK ADSYMPYLID FGLSSKSPYS SVKNPAFHFW
310 320 330 340 350
GQLTALLLRS TRARNARQPD DIEYTSLTTA GLLYAYAVGS SADLAQQFCV
360 370 380 390 400
GDSKYTPDDS TGGLTTNAPP QGRDVVEWLG WFEDQNRKPT PDMMQYAKRA
410 420
VMSLQGLREK TIGKYAKSEF DK
Length:422
Mass (Da):47,437
Last modified:July 1, 1989 - v1
Checksum:i926374B195574200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15213 Genomic RNA. Translation: AAA48376.1.
PIRiB26794. VHVNV4.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15213 Genomic RNA. Translation: AAA48376.1.
PIRiB26794. VHVNV4.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KBGX-ray2.20P52-59[»]
1NAMX-ray2.70P52-59[»]
2MHAX-ray2.50E/F52-59[»]
2VAAX-ray2.30P52-59[»]
ProteinModelPortaliP11212.
SMRiP11212. Positions 2-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-1087N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP11212.

Family and domain databases

Gene3Di1.10.3570.10. 1 hit.
1.10.3610.10. 1 hit.
InterProiIPR000448. Rhabdo_ncapsid.
IPR023331. Rhabdovirus_ncapsid_C.
IPR023330. Rhabdovirus_ncapsid_N.
[Graphical view]
PfamiPF00945. Rhabdo_ncap. 1 hit.
[Graphical view]
ProDomiPD002087. Rhabd_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF140809. SSF140809. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCAP_VSIVG
AccessioniPrimary (citable) accession number: P11212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.