P11210 (VIE1_MUHVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immediate-early protein 1
Short name=IE1

Alternative name(s):
Immediate-early phosphoprotein PP89

Gene names

Name:

IE1

Organism

Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) [Reference proteome]

Taxonomic identifier

10367 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Muromegalovirus › Murid herpesvirus 1

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	595 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	The IE1 protein has some additive effect on the trans-activating properties of the IE3 protein.
Subcellular location	Host nucleus Potential.

Ontologies

Keywords
Cellular component	Host nucleus
Coding sequence diversity	Alternative splicing
Developmental stage	Early protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]

Isoform IE1 (identifier: P11210-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform IE3 (identifier: P11210-2)

The sequence of this isoform is not available.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 595	595	Immediate-early protein 1		PRO_0000115357

Sequences

	Sequence		Length	Mass (Da)
	Isoform IE1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: F97FFC7AA1A9FE63	FASTA	595	66,709
	10 20 30 40 50 60 MEPAAPSCNM IMIADQASVN AHGRHLDENR VYPSDKVPAH VANKILESGT ETVRCDLTLE 70 80 90 100 110 120 DMLGDYEYDD PTEEEKILMD RIADHVGNDN SDMAIKHAAV RSVLLSCKIA HLMIKQNYQS 130 140 150 160 170 180 AINSATNILC QLANDIFERI ERQRKMIYGC FRSEFDNVQL GRLMYDMYPH FMPTNLGPSE 190 200 210 220 230 240 KRVWMSYVGE AIVAATNIDH ALDERAAWAK TDCSLPGEFK PELCVLVGAI RRLHDPPCYT 250 260 270 280 290 300 KPFLDAKSQL AVWQQMKAIE SESVSTHVVV VEALKLRENL AKAVQETIAY ERHQYHRVCQ 310 320 330 340 350 360 MMCNNMKDHL ETTCMLARGR TLATLADLRS TRYNLALFLL SEMHIFDSFT MPRIRGAMKQ 370 380 390 400 410 420 ARCMSYVERT ISLAKFRELA DRVHNRSAPS PQGVIEEQQQ AGEEEQQQQQ EIEYDPEMPP 430 440 450 460 470 480 LEREEEQEDE QVEEEPPADE EEGGAVGGVT QEEPAGEATE EAEEDESQPG PSDNQVVPES 490 500 510 520 530 540 SETPTPAEDE ETQSADEGES QELEGSQQLI LSRPAAPLTD SETDSDSEDD DEVTRIPVGF 550 560 570 580 590 SLMTSPVLQP TTRSATAAAS SGTAPRPALK RQYAMVHTRS KSSENQQQPK KKSKK
	Isoform IE3 (Sequence not available).		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and structural organization of murine cytomegalovirus immediate-early gene 1." Keil G.M., Ebeling-Keil A., Koszinowski U.H. J. Virol. 61:1901-1908(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate ATCC VR-1399.
[2]	"Analysis of the complete DNA sequence of murine cytomegalovirus." Rawlinson W.D., Farrell H.E., Barrell B.G. J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11788 Genomic DNA. Translation: AAA45981.1. U68299 Genomic DNA. No translation available.
PIR	EDBEMC. A27823.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

VIE1_MUHVS

Accession

Primary (citable) accession number: P11210

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program