Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-structural protein V

Gene

P/V

Organism
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Efficiently blocks type I IFN signaling following infection by behaving as a substrate receptor for CUL4-DDB1 E3 ligase complex and targeting host STAT1 for proteasomal degradation.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi171Zinc 11
Metal bindingi190Zinc 11
Metal bindingi194Zinc 21
Metal bindingi206Zinc 21
Metal bindingi208Zinc 21
Metal bindingi211Zinc 21
Metal bindingi215Zinc 11
Metal bindingi218Zinc 11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MDA5 by virus, Inhibition of host RLR pathway by virus, Inhibition of host STAT1 by virus, Interferon antiviral system evasion, Ubl conjugation pathway, Viral immunoevasion

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein V
Gene namesi
Name:P/V
OrganismiParainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5)
Taxonomic identifieri11208 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeRubulavirus
Virus hostiCanis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]
Homo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007232 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001428301 – 222Non-structural protein VAdd BLAST222

Interactioni

Subunit structurei

Interacts with host DDB1, STAT2 and IFIH1/MDA5.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DDB1Q165313EBI-6148694,EBI-350322From a different organism.
DHX58Q96C102EBI-6148694,EBI-744193From a different organism.
IFIH1Q9BYX42EBI-6148694,EBI-6115771From a different organism.
STAT2P526302EBI-6148694,EBI-1546963From a different organism.

Protein-protein interaction databases

DIPiDIP-48759N.
IntActiP11207. 6 interactors.
MINTiMINT-6623137.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 32Combined sources10
Beta strandi95 – 97Combined sources3
Turni101 – 104Combined sources4
Beta strandi109 – 116Combined sources8
Beta strandi119 – 121Combined sources3
Helixi127 – 138Combined sources12
Beta strandi143 – 146Combined sources4
Beta strandi164 – 167Combined sources4
Beta strandi170 – 180Combined sources11
Beta strandi183 – 192Combined sources10
Beta strandi202 – 204Combined sources3
Beta strandi207 – 209Combined sources3
Helixi216 – 218Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B5LX-ray2.85C/D1-222[»]
2HYEX-ray3.10B1-222[»]
2K48NMR-A95-108[»]
4I1SX-ray2.29B168-219[»]
ProteinModelPortaliP11207.
SMRiP11207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11207.

Family & Domainsi

Sequence similaritiesi

Belongs to the paramyxoviruses V protein family.Curated

Family and domain databases

InterProiIPR024279. Paramyx_V_Zn-bd.
IPR025909. Soyouz_module.
[Graphical view]
PfamiPF14313. Soyouz_module. 1 hit.
PF13008. zf-Paramyx-P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTDLSFSP DEINKLIETG LNTVEYFTSQ QVTGTSSLGK NTIPPGVTGL
60 70 80 90 100
LTNAAEAKIQ ESTNHQKGSV GGGAKPKKPR PKIAIVPADD KTVPGKPIPN
110 120 130 140 150
PLLGLDSTPS TQTVLDLSGK TLPSGSYKGV KLAKFGKENL MTRFIEEPRE
160 170 180 190 200
NPIATSSPID FKRGRDTGGF HRREYSIGWV GDEVKVTEWC NPSCSPITAA
210 220
ARRFECTCHQ CPVTCSECER DT
Length:222
Mass (Da):23,935
Last modified:July 1, 1989 - v1
Checksum:i13D2F1627D15AFA3
GO

RNA editingi

Edited at position 164.1 Publication
Partially edited. RNA editing at this position consists of an insertion of two guanine nucleotides. The sequence displayed here is the V protein, derived from the unedited RNA. The edited RNA gives rise to the P protein (AC P11208).

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03142 mRNA. Translation: AAA47882.1.
AF052755 Genomic RNA. Translation: AAC95512.1.
PIRiA31594. MNNZSP.
RefSeqiYP_138513.1. NC_006430.1.

Genome annotation databases

GeneIDi3160800.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03142 mRNA. Translation: AAA47882.1.
AF052755 Genomic RNA. Translation: AAC95512.1.
PIRiA31594. MNNZSP.
RefSeqiYP_138513.1. NC_006430.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B5LX-ray2.85C/D1-222[»]
2HYEX-ray3.10B1-222[»]
2K48NMR-A95-108[»]
4I1SX-ray2.29B168-219[»]
ProteinModelPortaliP11207.
SMRiP11207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48759N.
IntActiP11207. 6 interactors.
MINTiMINT-6623137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3160800.

Miscellaneous databases

EvolutionaryTraceiP11207.

Family and domain databases

InterProiIPR024279. Paramyx_V_Zn-bd.
IPR025909. Soyouz_module.
[Graphical view]
PfamiPF14313. Soyouz_module. 1 hit.
PF13008. zf-Paramyx-P. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV_PIV5
AccessioniPrimary (citable) accession number: P11207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.