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P11187

- LYS_BPPH2

UniProt

P11187 - LYS_BPPH2

Protein

Lysozyme

Gene

15

Organism
Bacillus phage phi29 (Bacteriophage phi-29)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei15 – 151Proton donorBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: CACAO

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiCBM50. Carbohydrate-Binding Module Family 50.
    GH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Lysis protein
    Morphogenesis protein 2
    Muramidase
    Gene namesi
    Name:15
    OrganismiBacillus phage phi29 (Bacteriophage phi-29)
    Taxonomic identifieri10756 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaePhi29likevirus
    Virus hostiBacillus subtilis [TaxID: 1423]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258LysozymePRO_0000218103Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Structurei

    3D structure databases

    ProteinModelPortaliP11187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati163 – 20745LysM 1Add
    BLAST
    Repeati214 – 25845LysM 2Add
    BLAST

    Domaini

    LysM repeats are thought to be involved in peptidoglycan binding.

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated
    Contains 2 LysM repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    3.10.350.10. 2 hits.
    InterProiIPR002196. Glyco_hydro_24.
    IPR018392. LysM_dom.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF01476. LysM. 2 hits.
    PF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SMARTiSM00257. LysM. 2 hits.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    SSF54106. SSF54106. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P11187-1 [UniParc]FASTAAdd to Basket

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    MQISQAGINL IKSFEGLQLK AYKAVPTEKH YTIGYGHYGS DVSPRQVITA    50
    KQAEDMLRDD VQAFVDGVNK ALKVSVTQNQ FDALVSFAYN VGLGAFRSSS 100
    LLEYLNEGRT ALAAAEFPKW NKSGGKVYQG LINRRAQEQA LFNSGTPKNV 150
    SRGTSSTKTT PKYKVKSGDN LTKIAKKHNT TVATLLKLNP SIKDPNMIRV 200
    GQTINVTGSG GKTHKVKSGD TLSKIAVDNK TTVSRLMSLN PEITNPNHIK 250
    VGQTIRLS 258
    Length:258
    Mass (Da):28,054
    Last modified:July 1, 1989 - v1
    Checksum:i26AE0C1D927B42D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04962 Genomic DNA. Translation: CAA28632.1.
    M14782 Genomic DNA. Translation: AAA32288.1.
    M14431 Genomic DNA. Translation: AAA88347.1.
    PIRiB24721. WMBPP9.
    RefSeqiYP_002004544.1. NC_011048.1.

    Genome annotation databases

    GeneIDi6446520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04962 Genomic DNA. Translation: CAA28632.1 .
    M14782 Genomic DNA. Translation: AAA32288.1 .
    M14431 Genomic DNA. Translation: AAA88347.1 .
    PIRi B24721. WMBPP9.
    RefSeqi YP_002004544.1. NC_011048.1.

    3D structure databases

    ProteinModelPortali P11187.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM50. Carbohydrate-Binding Module Family 50.
    GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6446520.

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    3.10.350.10. 2 hits.
    InterProi IPR002196. Glyco_hydro_24.
    IPR018392. LysM_dom.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF01476. LysM. 2 hits.
    PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SMARTi SM00257. LysM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    SSF54106. SSF54106. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of Bacillus phage phi 29 genes 14 and 15: homology of gene 15 with other phage lysozymes."
      Garvey K.J., Saedi M.S., Ito J.
      Nucleic Acids Res. 14:10001-10008(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of the late region of Bacillus phage phi 29 completes the 19,285-bp sequence of phi 29 genome. Comparison with the homologous sequence of phage PZA."
      Vlcek C., Paces V.
      Gene 46:215-225(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The complete sequence of Bacillus phage phi 29 gene 16: a protein required for the genome encapsidation reaction."
      Garvey K.J., Saedi M.S., Ito J.
      Gene 40:311-316(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-258.

    Entry informationi

    Entry nameiLYS_BPPH2
    AccessioniPrimary (citable) accession number: P11187
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3