Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P11187 (LYS_BPPH2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
Endolysin
Lysis protein
Morphogenesis protein 2
Muramidase
Gene names
Name:15
OrganismBacillus phage phi29 (Bacteriophage phi-29)
Taxonomic identifier10756 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaePhi29likevirus
Virus hostBacillus subtilis [TaxID: 1423]

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Domain

LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Contains 2 LysM repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Lysozyme
PRO_0000218103

Regions

Repeat163 – 20745LysM 1
Repeat214 – 25845LysM 2

Sites

Active site151Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P11187 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 26AE0C1D927B42D8

FASTA25828,054
        10         20         30         40         50         60 
MQISQAGINL IKSFEGLQLK AYKAVPTEKH YTIGYGHYGS DVSPRQVITA KQAEDMLRDD 

        70         80         90        100        110        120 
VQAFVDGVNK ALKVSVTQNQ FDALVSFAYN VGLGAFRSSS LLEYLNEGRT ALAAAEFPKW 

       130        140        150        160        170        180 
NKSGGKVYQG LINRRAQEQA LFNSGTPKNV SRGTSSTKTT PKYKVKSGDN LTKIAKKHNT 

       190        200        210        220        230        240 
TVATLLKLNP SIKDPNMIRV GQTINVTGSG GKTHKVKSGD TLSKIAVDNK TTVSRLMSLN 

       250 
PEITNPNHIK VGQTIRLS 

« Hide

References

[1]"Nucleotide sequence of Bacillus phage phi 29 genes 14 and 15: homology of gene 15 with other phage lysozymes."
Garvey K.J., Saedi M.S., Ito J.
Nucleic Acids Res. 14:10001-10008(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of the late region of Bacillus phage phi 29 completes the 19,285-bp sequence of phi 29 genome. Comparison with the homologous sequence of phage PZA."
Vlcek C., Paces V.
Gene 46:215-225(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The complete sequence of Bacillus phage phi 29 gene 16: a protein required for the genome encapsidation reaction."
Garvey K.J., Saedi M.S., Ito J.
Gene 40:311-316(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-258.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04962 Genomic DNA. Translation: CAA28632.1.
M14782 Genomic DNA. Translation: AAA32288.1.
M14431 Genomic DNA. Translation: AAA88347.1.
PIRWMBPP9. B24721.
RefSeqYP_002004544.1. NC_011048.1.

3D structure databases

ProteinModelPortalP11187.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyCBM50. Carbohydrate-Binding Module Family 50.
GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6446520.

Phylogenomic databases

ProtClustDBCLSP2343229.

Family and domain databases

Gene3D1.10.530.40. 1 hit.
3.10.350.10. 2 hits.
InterProIPR002196. Glyco_hydro_24.
IPR018392. LysM_dom.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamPF01476. LysM. 2 hits.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SMARTSM00257. LysM. 2 hits.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
SSF54106. SSF54106. 2 hits.
ProtoNetSearch...

Entry information

Entry nameLYS_BPPH2
AccessionPrimary (citable) accession number: P11187
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries