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P11187

- LYS_BPPH2

UniProt

P11187 - LYS_BPPH2

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Protein

Lysozyme

Gene

15

Organism
Bacillus phage phi29 (Bacteriophage phi-29)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151Proton donorBy similarity

GO - Molecular functioni

  1. lysozyme activity Source: CACAO

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.
GH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Morphogenesis protein 2
Muramidase
Gene namesi
Name:15
OrganismiBacillus phage phi29 (Bacteriophage phi-29)
Taxonomic identifieri10756 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaePhi29likevirus
Virus hostiBacillus subtilis [TaxID: 1423]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258LysozymePRO_0000218103Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

3D structure databases

ProteinModelPortaliP11187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati163 – 20745LysM 1Add
BLAST
Repeati214 – 25845LysM 2Add
BLAST

Domaini

LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated
Contains 2 LysM repeats.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
3.10.350.10. 2 hits.
InterProiIPR002196. Glyco_hydro_24.
IPR018392. LysM_dom.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF01476. LysM. 2 hits.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF54106. SSF54106. 2 hits.

Sequencei

Sequence statusi: Complete.

P11187-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQISQAGINL IKSFEGLQLK AYKAVPTEKH YTIGYGHYGS DVSPRQVITA
60 70 80 90 100
KQAEDMLRDD VQAFVDGVNK ALKVSVTQNQ FDALVSFAYN VGLGAFRSSS
110 120 130 140 150
LLEYLNEGRT ALAAAEFPKW NKSGGKVYQG LINRRAQEQA LFNSGTPKNV
160 170 180 190 200
SRGTSSTKTT PKYKVKSGDN LTKIAKKHNT TVATLLKLNP SIKDPNMIRV
210 220 230 240 250
GQTINVTGSG GKTHKVKSGD TLSKIAVDNK TTVSRLMSLN PEITNPNHIK

VGQTIRLS
Length:258
Mass (Da):28,054
Last modified:July 1, 1989 - v1
Checksum:i26AE0C1D927B42D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04962 Genomic DNA. Translation: CAA28632.1.
M14782 Genomic DNA. Translation: AAA32288.1.
M14431 Genomic DNA. Translation: AAA88347.1.
PIRiB24721. WMBPP9.
RefSeqiYP_002004544.1. NC_011048.1.

Genome annotation databases

GeneIDi6446520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04962 Genomic DNA. Translation: CAA28632.1 .
M14782 Genomic DNA. Translation: AAA32288.1 .
M14431 Genomic DNA. Translation: AAA88347.1 .
PIRi B24721. WMBPP9.
RefSeqi YP_002004544.1. NC_011048.1.

3D structure databases

ProteinModelPortali P11187.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM50. Carbohydrate-Binding Module Family 50.
GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6446520.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
3.10.350.10. 2 hits.
InterProi IPR002196. Glyco_hydro_24.
IPR018392. LysM_dom.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF01476. LysM. 2 hits.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SMARTi SM00257. LysM. 2 hits.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
SSF54106. SSF54106. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of Bacillus phage phi 29 genes 14 and 15: homology of gene 15 with other phage lysozymes."
    Garvey K.J., Saedi M.S., Ito J.
    Nucleic Acids Res. 14:10001-10008(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the late region of Bacillus phage phi 29 completes the 19,285-bp sequence of phi 29 genome. Comparison with the homologous sequence of phage PZA."
    Vlcek C., Paces V.
    Gene 46:215-225(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete sequence of Bacillus phage phi 29 gene 16: a protein required for the genome encapsidation reaction."
    Garvey K.J., Saedi M.S., Ito J.
    Gene 40:311-316(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-258.

Entry informationi

Entry nameiLYS_BPPH2
AccessioniPrimary (citable) accession number: P11187
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 1, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3