##gff-version 3 P11182 UniProtKB Transit peptide 1 61 . . . Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 P11182 UniProtKB Chain 62 482 . . . ID=PRO_0000020489;Note=Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex%2C mitochondrial P11182 UniProtKB Domain 64 139 . . . Note=Lipoyl-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01066 P11182 UniProtKB Domain 172 209 . . . Note=Peripheral subunit-binding (PSBD);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01170 P11182 UniProtKB Region 145 160 . . . Note=Critical for association with PPM1K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22291014;Dbxref=PMID:22291014 P11182 UniProtKB Region 147 168 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P11182 UniProtKB Active site 452 452 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P11182 UniProtKB Active site 456 456 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P11182 UniProtKB Binding site 291 291 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 306 306 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 349 349 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 378 378 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 399 399 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 400 400 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 403 403 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 424 424 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Binding site 426 426 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11181 P11182 UniProtKB Modified residue 105 105 . . . Note=N6-lipoyllysine;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P11181,ECO:0000255|PROSITE-ProRule:PRU01066 P11182 UniProtKB Modified residue 133 133 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 196 196 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 196 196 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 202 202 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 220 220 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P11182 UniProtKB Modified residue 243 243 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 250 250 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 261 261 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 289 289 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 289 289 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 295 295 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P11182 UniProtKB Modified residue 304 304 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 435 435 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 440 440 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Modified residue 440 440 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P53395 P11182 UniProtKB Natural variant 98 98 . . . ID=VAR_015099;Note=In MSUD2. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9621512;Dbxref=dbSNP:rs121965001,PMID:9621512 P11182 UniProtKB Natural variant 276 276 . . . ID=VAR_004978;Note=In MSUD2. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1847055;Dbxref=dbSNP:rs121964999,PMID:1847055 P11182 UniProtKB Natural variant 384 384 . . . ID=VAR_015100;Note=G->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16710414,ECO:0000269|PubMed:9621512;Dbxref=dbSNP:rs12021720,PMID:16710414,PMID:9621512 P11182 UniProtKB Mutagenesis 105 105 . . . Note=Abolishes lipoylation but retains normal interaction with PPM1K. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22291014;Dbxref=PMID:22291014 P11182 UniProtKB Mutagenesis 147 147 . . . Note=Has no effect on the interaction with PPM1K. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22291014;Dbxref=PMID:22291014 P11182 UniProtKB Mutagenesis 148 148 . . . Note=Completely abolishes the interaction with PPM1K. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22291014;Dbxref=PMID:22291014 P11182 UniProtKB Mutagenesis 149 149 . . . Note=Completely abolishes the interaction with PPM1K. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22291014;Dbxref=PMID:22291014 P11182 UniProtKB Mutagenesis 152 152 . . . Note=Has no effect on the interaction with PPM1K. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22291014;Dbxref=PMID:22291014 P11182 UniProtKB Mutagenesis 159 159 . . . Note=Has no effect on the interaction with PPM1K. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22291014;Dbxref=PMID:22291014 P11182 UniProtKB Sequence conflict 321 321 . . . Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11182 UniProtKB Sequence conflict 354 354 . . . Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P11182 UniProtKB Beta strand 65 68 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8M P11182 UniProtKB Beta strand 79 84 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8M P11182 UniProtKB Beta strand 94 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8M P11182 UniProtKB Beta strand 99 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8M P11182 UniProtKB Beta strand 107 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8M P11182 UniProtKB Beta strand 116 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8M P11182 UniProtKB Beta strand 125 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8O P11182 UniProtKB Beta strand 133 139 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1K8M P11182 UniProtKB Helix 175 183 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3RNM P11182 UniProtKB Helix 188 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3RNM P11182 UniProtKB Helix 196 198 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3RNM P11182 UniProtKB Helix 202 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3RNM