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Reviewed, UniProtKB/Swiss-Prot P11180 (ODP2_BOVIN)

Last modified February 9, 2010. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    EC=2.3.1.12
Alternative name(s):
    Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
    Pyruvate dehydrogenase complex component E2
Gene names
Name: DLAT
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length10 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activity

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

Cofactor

Binds 2 lipoyl cofactors covalently By similarity.

Subunit structure

Forms a 24-polypeptide structural core with octahedral symmetry.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family.

Contains 2 lipoyl-binding domains.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentMitochondrion
   DomainLipoyl
Repeat
   Molecular functionAcyltransferase
Transferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrolipoyllysine-residue acetyltransferase activity

Inferred from electronic annotation. Source: EC

lipoic acid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›10›10Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
PRO_0000162297

Amino acid modifications

Modified residue51N6-lipoyllysine

Experimental info

Non-terminal residue11
Non-terminal residue101

Sequences

Sequence LengthMass (Da)Tools
P11180-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 889BECD1ADD33AB1

FASTA101,066
        10 
VETDKATVGF 

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References

[1]"Primary structure around the lipoate-attachment site on the E2 component of bovine heart pyruvate dehydrogenase complex."
Bradford A.P., Howell S., Aitken A., James L.A., Yeaman S.J.
Biochem. J. 245:919-922(1987) [PubMed: 3117054] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

IPIIPI00704214.

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENP11180.

Enzyme and pathway databases

BRENDA2.3.1.12. 251.

Family and domain databases

PROSITEPS00189. LIPOYL. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameODP2_BOVIN
AccessionPrimary (citable) accession number: P11180
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents