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Protein

Uridine 5'-monophosphate synthase

Gene

UMPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (UMPS)
  2. Orotidine 5'-phosphate decarboxylase (UMPS), Uridine 5'-monophosphate synthase (UMPS), Orotidine 5'-phosphate decarboxylase (UMPS)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei312 – 3121For OMPdecase activity1 Publication
Active sitei314 – 3141For OMPdecase activity1 Publication
Active sitei317 – 3171For OMPdecase activity1 Publication

GO - Molecular functioni

  • orotate phosphoribosyltransferase activity Source: UniProtKB
  • orotidine-5'-phosphate decarboxylase activity Source: UniProtKB

GO - Biological processi

Keywords - Molecular functioni

Decarboxylase, Glycosyltransferase, Lyase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BRENDAi4.1.1.23. 2681.
ReactomeiR-HSA-500753. Pyrimidine biosynthesis.
UniPathwayiUPA00070; UER00119.
UPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRT
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Short name:
ODC
Alternative name(s):
OMPdecase
Gene namesi
Name:UMPS
ORF Names:OK/SW-cl.21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12563. UMPS.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • nucleus Source: UniProtKB

Pathology & Biotechi

Involvement in diseasei

Orotic aciduria 1 (ORAC1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.
See also OMIM:258900
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961R → G in ORAC1. 1 Publication
Corresponds to variant rs121917890 [ dbSNP | Ensembl ].
VAR_006807
Natural varianti109 – 1091V → G in ORAC1. 1 Publication
Corresponds to variant rs121917892 [ dbSNP | Ensembl ].
VAR_006808
Natural varianti429 – 4291G → R in ORAC1. 1 Publication
Corresponds to variant rs121917891 [ dbSNP | Ensembl ].
VAR_006810

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi312 – 3121D → N: Loss of OMPdecase activity. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiUMPS.
MIMi258900. phenotype.
Orphaneti30. Hereditary orotic aciduria.
PharmGKBiPA363.

Chemistry

ChEMBLiCHEMBL5216.
DrugBankiDB00544. Fluorouracil.

Polymorphism and mutation databases

BioMutaiUMPS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 480479Uridine 5'-monophosphate synthasePRO_0000139649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei37 – 371PhosphotyrosineCombined sources
Modified residuei214 – 2141PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP11172.
MaxQBiP11172.
PaxDbiP11172.
PeptideAtlasiP11172.
PRIDEiP11172.

PTM databases

iPTMnetiP11172.
PhosphoSiteiP11172.

Expressioni

Gene expression databases

BgeeiENSG00000114491.
CleanExiHS_UMPS.
ExpressionAtlasiP11172. baseline and differential.
GenevisibleiP11172. HS.

Organism-specific databases

HPAiHPA036178.
HPA036179.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi113218. 47 interactions.
DIPiDIP-29595N.
IntActiP11172. 22 interactions.
MINTiMINT-1397000.
STRINGi9606.ENSP00000232607.

Chemistry

BindingDBiP11172.

Structurei

Secondary structure

1
480
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 169Combined sources
Turni17 – 193Combined sources
Beta strandi21 – 277Combined sources
Beta strandi33 – 386Combined sources
Helixi40 – 456Combined sources
Helixi47 – 6317Combined sources
Beta strandi69 – 735Combined sources
Turni75 – 784Combined sources
Helixi79 – 8911Combined sources
Beta strandi93 – 964Combined sources
Turni99 – 1024Combined sources
Beta strandi103 – 1053Combined sources
Beta strandi108 – 1114Combined sources
Beta strandi118 – 12912Combined sources
Helixi130 – 14112Combined sources
Beta strandi148 – 1547Combined sources
Helixi159 – 1646Combined sources
Turni165 – 1673Combined sources
Beta strandi169 – 1757Combined sources
Helixi176 – 18510Combined sources
Helixi191 – 20212Combined sources
Helixi227 – 2304Combined sources
Helixi238 – 25013Combined sources
Beta strandi254 – 2574Combined sources
Helixi263 – 27311Combined sources
Helixi274 – 2763Combined sources
Beta strandi278 – 2825Combined sources
Helixi284 – 2863Combined sources
Helixi292 – 30514Combined sources
Beta strandi308 – 3158Combined sources
Helixi319 – 3279Combined sources
Turni329 – 3313Combined sources
Helixi333 – 3353Combined sources
Beta strandi338 – 3447Combined sources
Helixi349 – 35810Combined sources
Turni359 – 3624Combined sources
Beta strandi364 – 3685Combined sources
Helixi381 – 39212Combined sources
Turni393 – 3964Combined sources
Beta strandi397 – 4015Combined sources
Beta strandi412 – 4165Combined sources
Beta strandi421 – 4255Combined sources
Beta strandi427 – 4293Combined sources
Beta strandi431 – 4333Combined sources
Helixi435 – 4395Combined sources
Turni440 – 4423Combined sources
Beta strandi445 – 4506Combined sources
Helixi451 – 4544Combined sources
Beta strandi456 – 4583Combined sources
Helixi459 – 47820Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EAWX-ray2.88A/B190-480[»]
2JGYX-ray1.95A/B224-479[»]
2P1FX-ray1.76A190-480[»]
2QCCX-ray1.85A/B224-480[»]
2QCDX-ray2.03A/B224-480[»]
2QCEX-ray1.43A224-480[»]
2QCFX-ray1.22A224-480[»]
2QCGX-ray1.75A/B224-480[»]
2QCHX-ray1.95A/B224-480[»]
2QCLX-ray1.85A/B224-480[»]
2QCMX-ray1.67A224-480[»]
2QCNX-ray1.85A/B224-480[»]
2V30X-ray2.00A/B224-479[»]
2WNSX-ray1.90A/B7-203[»]
3BGGX-ray1.93A190-480[»]
3BGJX-ray2.00A/B190-480[»]
3BK0X-ray1.60A/B223-480[»]
3BVJX-ray1.80A/B190-480[»]
3DBPX-ray1.50A/B223-480[»]
3EWUX-ray1.60A/B224-480[»]
3EWWX-ray1.10A/B224-480[»]
3EWXX-ray1.40A224-480[»]
3EWYX-ray1.10A224-480[»]
3EWZX-ray1.40A/B/C/D224-480[»]
3EX1X-ray1.40A/B224-480[»]
3EX2X-ray1.55A/B224-480[»]
3EX3X-ray1.45A/B224-480[»]
3EX4X-ray1.24A224-480[»]
3EX6X-ray1.30A/B224-480[»]
3G3DX-ray1.70A/B190-480[»]
3G3MX-ray1.40A223-480[»]
3L0KX-ray1.34A/B224-480[»]
3L0NX-ray1.74A/B224-480[»]
3MI2X-ray1.20A/B223-480[»]
3MO7X-ray1.35A223-480[»]
3MW7X-ray2.32A/B190-480[»]
4HIBX-ray1.80A/B190-480[»]
4HKPX-ray1.75A/B190-480[»]
ProteinModelPortaliP11172.
SMRiP11172. Positions 7-203, 224-479.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11172.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 214213OPRTaseAdd
BLAST
Regioni215 – 2206Domain linker
Regioni221 – 480260OMPdecaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
COG0461. LUCA.
GeneTreeiENSGT00390000001856.
HOGENOMiHOG000213905.
HOVERGENiHBG000870.
KOiK13421.
OMAiSMKPEFL.
OrthoDBiEOG091G06JT.
PhylomeDBiP11172.
TreeFamiTF314694.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPiMF_01208. PyrE. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11172-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL
60 70 80 90 100
SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET
110 120 130 140 150
KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI
160 170 180 190 200
VLLDREQGGK DKLQAHGIRL HSVCTLSKML EILEQQKKVD AETVGRVKRF
210 220 230 240 250
IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK
260 270 280 290 300
ETNLCLSADV SLARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT
310 320 330 340 350
LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV
360 370 380 390 400
VKGLQEVGLP LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF
410 420 430 440 450
ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG
460 470 480
RGIISAADRL EAAEMYRKAA WEAYLSRLGV
Length:480
Mass (Da):52,222
Last modified:July 1, 1989 - v1
Checksum:iD985CD566B72F5CA
GO
Isoform 2 (identifier: P11172-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,051
Checksum:i4B88EE5A8DC6FA65
GO
Isoform 3 (identifier: P11172-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:388
Mass (Da):42,495
Checksum:i1AA9931DE4283ABB
GO
Isoform 4 (identifier: P11172-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     328-424: Missing.

Show »
Length:205
Mass (Da):22,922
Checksum:i464CD94C5FDD0E5A
GO

Sequence cautioni

The sequence CAB45710 differs from that shown. Reason: Erroneous termination at position 430. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131T → G in AAA61256 (Ref. 11) Curated
Sequence conflicti377 – 3771L → Q in AAA61256 (Ref. 11) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301S → G.1 Publication
Corresponds to variant rs17843776 [ dbSNP | Ensembl ].
VAR_020614
Natural varianti96 – 961R → G in ORAC1. 1 Publication
Corresponds to variant rs121917890 [ dbSNP | Ensembl ].
VAR_006807
Natural varianti109 – 1091V → G in ORAC1. 1 Publication
Corresponds to variant rs121917892 [ dbSNP | Ensembl ].
VAR_006808
Natural varianti213 – 2131G → A.2 Publications
Corresponds to variant rs1801019 [ dbSNP | Ensembl ].
VAR_006809
Natural varianti429 – 4291G → R in ORAC1. 1 Publication
Corresponds to variant rs121917891 [ dbSNP | Ensembl ].
VAR_006810
Natural varianti446 – 4461I → V.1 Publication
Corresponds to variant rs3772809 [ dbSNP | Ensembl ].
VAR_020615

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 178178Missing in isoform 2 and isoform 4. 2 PublicationsVSP_009273Add
BLAST
Alternative sequencei1 – 9292Missing in isoform 3. 1 PublicationVSP_047611Add
BLAST
Alternative sequencei328 – 42497Missing in isoform 4. 1 PublicationVSP_047612Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03626 mRNA. Translation: AAA61255.1.
D86227 mRNA. Translation: BAA19920.1.
D86228 mRNA. Translation: BAA19921.1.
D86230 mRNA. Translation: BAA19923.1.
AB041359 Genomic DNA. Translation: BAB20663.1.
EU921891 mRNA. Translation: ACH48229.1.
EU921895 mRNA. Translation: ACH48233.1.
AB062285 mRNA. Translation: BAB93468.1.
CR456787 mRNA. Translation: CAG33068.1.
AL080099 mRNA. Translation: CAB45710.3. Sequence problems.
AY691629 Genomic DNA. Translation: AAT85801.1.
AC022336 Genomic DNA. No translation available.
BC000364 mRNA. Translation: AAH00364.1.
BC007511 mRNA. Translation: AAH07511.1.
M36661 mRNA. Translation: AAA61256.1.
CCDSiCCDS3029.1. [P11172-1]
PIRiA30148.
RefSeqiNP_000364.1. NM_000373.3. [P11172-1]
UniGeneiHs.2057.

Genome annotation databases

EnsembliENST00000232607; ENSP00000232607; ENSG00000114491. [P11172-1]
GeneIDi7372.
KEGGihsa:7372.
UCSCiuc003ehl.5. human. [P11172-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03626 mRNA. Translation: AAA61255.1.
D86227 mRNA. Translation: BAA19920.1.
D86228 mRNA. Translation: BAA19921.1.
D86230 mRNA. Translation: BAA19923.1.
AB041359 Genomic DNA. Translation: BAB20663.1.
EU921891 mRNA. Translation: ACH48229.1.
EU921895 mRNA. Translation: ACH48233.1.
AB062285 mRNA. Translation: BAB93468.1.
CR456787 mRNA. Translation: CAG33068.1.
AL080099 mRNA. Translation: CAB45710.3. Sequence problems.
AY691629 Genomic DNA. Translation: AAT85801.1.
AC022336 Genomic DNA. No translation available.
BC000364 mRNA. Translation: AAH00364.1.
BC007511 mRNA. Translation: AAH07511.1.
M36661 mRNA. Translation: AAA61256.1.
CCDSiCCDS3029.1. [P11172-1]
PIRiA30148.
RefSeqiNP_000364.1. NM_000373.3. [P11172-1]
UniGeneiHs.2057.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EAWX-ray2.88A/B190-480[»]
2JGYX-ray1.95A/B224-479[»]
2P1FX-ray1.76A190-480[»]
2QCCX-ray1.85A/B224-480[»]
2QCDX-ray2.03A/B224-480[»]
2QCEX-ray1.43A224-480[»]
2QCFX-ray1.22A224-480[»]
2QCGX-ray1.75A/B224-480[»]
2QCHX-ray1.95A/B224-480[»]
2QCLX-ray1.85A/B224-480[»]
2QCMX-ray1.67A224-480[»]
2QCNX-ray1.85A/B224-480[»]
2V30X-ray2.00A/B224-479[»]
2WNSX-ray1.90A/B7-203[»]
3BGGX-ray1.93A190-480[»]
3BGJX-ray2.00A/B190-480[»]
3BK0X-ray1.60A/B223-480[»]
3BVJX-ray1.80A/B190-480[»]
3DBPX-ray1.50A/B223-480[»]
3EWUX-ray1.60A/B224-480[»]
3EWWX-ray1.10A/B224-480[»]
3EWXX-ray1.40A224-480[»]
3EWYX-ray1.10A224-480[»]
3EWZX-ray1.40A/B/C/D224-480[»]
3EX1X-ray1.40A/B224-480[»]
3EX2X-ray1.55A/B224-480[»]
3EX3X-ray1.45A/B224-480[»]
3EX4X-ray1.24A224-480[»]
3EX6X-ray1.30A/B224-480[»]
3G3DX-ray1.70A/B190-480[»]
3G3MX-ray1.40A223-480[»]
3L0KX-ray1.34A/B224-480[»]
3L0NX-ray1.74A/B224-480[»]
3MI2X-ray1.20A/B223-480[»]
3MO7X-ray1.35A223-480[»]
3MW7X-ray2.32A/B190-480[»]
4HIBX-ray1.80A/B190-480[»]
4HKPX-ray1.75A/B190-480[»]
ProteinModelPortaliP11172.
SMRiP11172. Positions 7-203, 224-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113218. 47 interactions.
DIPiDIP-29595N.
IntActiP11172. 22 interactions.
MINTiMINT-1397000.
STRINGi9606.ENSP00000232607.

Chemistry

BindingDBiP11172.
ChEMBLiCHEMBL5216.
DrugBankiDB00544. Fluorouracil.

PTM databases

iPTMnetiP11172.
PhosphoSiteiP11172.

Polymorphism and mutation databases

BioMutaiUMPS.

Proteomic databases

EPDiP11172.
MaxQBiP11172.
PaxDbiP11172.
PeptideAtlasiP11172.
PRIDEiP11172.

Protocols and materials databases

DNASUi7372.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232607; ENSP00000232607; ENSG00000114491. [P11172-1]
GeneIDi7372.
KEGGihsa:7372.
UCSCiuc003ehl.5. human. [P11172-1]

Organism-specific databases

CTDi7372.
GeneCardsiUMPS.
HGNCiHGNC:12563. UMPS.
HPAiHPA036178.
HPA036179.
MalaCardsiUMPS.
MIMi258900. phenotype.
613891. gene.
neXtProtiNX_P11172.
Orphaneti30. Hereditary orotic aciduria.
PharmGKBiPA363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
COG0461. LUCA.
GeneTreeiENSGT00390000001856.
HOGENOMiHOG000213905.
HOVERGENiHBG000870.
KOiK13421.
OMAiSMKPEFL.
OrthoDBiEOG091G06JT.
PhylomeDBiP11172.
TreeFamiTF314694.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00119.
UPA00070; UER00120.
BRENDAi4.1.1.23. 2681.
ReactomeiR-HSA-500753. Pyrimidine biosynthesis.

Miscellaneous databases

ChiTaRSiUMPS. human.
EvolutionaryTraceiP11172.
GeneWikiiUridine_monophosphate_synthetase.
GenomeRNAii7372.
PROiP11172.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114491.
CleanExiHS_UMPS.
ExpressionAtlasiP11172. baseline and differential.
GenevisibleiP11172. HS.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPiMF_01208. PyrE. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUMPS_HUMAN
AccessioniPrimary (citable) accession number: P11172
Secondary accession number(s): B5LY68
, B5LY72, O00758, O00759, O00760, Q16862, Q9H3Q2, Q9UG49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 191 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.