Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

SLC2A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315Monosaccharide1 Publication1
Binding sitei378Monosaccharide1 Publication1
Binding sitei386Monosaccharide1 Publication1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • glucose transmembrane transport Source: UniProtKB
  • glucose transport Source: Reactome
  • L-ascorbic acid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000059804-MONOMER.
ReactomeiR-HSA-196836. Vitamin C (ascorbate) metabolism.
R-HSA-428790. Facilitative Na+-independent glucose transporters.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-70153. Glucose transport.

Protein family/group databases

TCDBi2.A.1.1.91. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name:
GLUT-3
Gene namesi
Name:SLC2A3
Synonyms:GLUT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11007. SLC2A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicCurated10
Transmembranei11 – 32Helical; Name=1Sequence analysis1 PublicationAdd BLAST22
Topological domaini33 – 64ExtracellularCuratedAdd BLAST32
Transmembranei65 – 85Helical; Name=2Sequence analysis1 PublicationAdd BLAST21
Topological domaini86 – 90CytoplasmicCurated5
Transmembranei91 – 111Helical; Name=3Sequence analysis1 PublicationAdd BLAST21
Topological domaini112 – 118ExtracellularCurated7
Transmembranei119 – 142Helical; Name=4Sequence analysis1 PublicationAdd BLAST24
Topological domaini143 – 153CytoplasmicCuratedAdd BLAST11
Transmembranei154 – 174Helical; Name=5Sequence analysis1 PublicationAdd BLAST21
Topological domaini175 – 183ExtracellularCurated9
Transmembranei184 – 204Helical; Name=6Sequence analysis1 PublicationAdd BLAST21
Topological domaini205 – 269CytoplasmicCuratedAdd BLAST65
Transmembranei270 – 290Helical; Name=7Sequence analysis1 PublicationAdd BLAST21
Topological domaini291 – 304ExtracellularCuratedAdd BLAST14
Transmembranei305 – 325Helical; Name=8Sequence analysis1 PublicationAdd BLAST21
Topological domaini326 – 331CytoplasmicCurated6
Transmembranei332 – 352Helical; Name=9Sequence analysis1 PublicationAdd BLAST21
Topological domaini353 – 363ExtracellularCuratedAdd BLAST11
Transmembranei364 – 389Helical; Name=10Sequence analysis1 PublicationAdd BLAST26
Topological domaini390 – 399CytoplasmicCurated10
Transmembranei400 – 420Helical; Name=11Sequence analysis1 PublicationAdd BLAST21
Topological domaini421 – 429ExtracellularCurated9
Transmembranei430 – 450Helical; Name=12Sequence analysis1 PublicationAdd BLAST21
Topological domaini451 – 496CytoplasmicCuratedAdd BLAST46

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi277 – 279QLS → HVA: Confers moderate fructose trasnport activity. 1 Publication3

Organism-specific databases

DisGeNETi6515.
MalaCardsiSLC2A3.
OpenTargetsiENSG00000059804.
Orphaneti399. Huntington disease.
PharmGKBiPA35877.

Chemistry databases

ChEMBLiCHEMBL5215.

Polymorphism and mutation databases

BioMutaiSLC2A3.
DMDMi121760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503531 – 496Solute carrier family 2, facilitated glucose transporter member 3Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Modified residuei232PhosphothreonineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei492PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP11169.
MaxQBiP11169.
PaxDbiP11169.
PeptideAtlasiP11169.
PRIDEiP11169.

PTM databases

iPTMnetiP11169.
PhosphoSitePlusiP11169.

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed in many tissues.1 Publication

Gene expression databases

BgeeiENSG00000059804.
CleanExiHS_SLC2A3.
ExpressionAtlasiP11169. baseline and differential.
GenevisibleiP11169. HS.

Organism-specific databases

HPAiCAB002763.
HPA006539.

Interactioni

Protein-protein interaction databases

BioGridi112406. 4 interactors.
IntActiP11169. 6 interactors.
MINTiMINT-4999361.
STRINGi9606.ENSP00000075120.

Structurei

Secondary structure

1496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 29Combined sources22
Beta strandi30 – 32Combined sources3
Helixi35 – 48Combined sources14
Beta strandi50 – 52Combined sources3
Helixi56 – 79Combined sources24
Helixi81 – 88Combined sources8
Helixi90 – 96Combined sources7
Helixi98 – 110Combined sources13
Turni111 – 115Combined sources5
Helixi117 – 145Combined sources29
Helixi148 – 150Combined sources3
Helixi151 – 173Combined sources23
Turni175 – 178Combined sources4
Turni181 – 183Combined sources3
Helixi184 – 189Combined sources6
Helixi192 – 201Combined sources10
Helixi202 – 204Combined sources3
Helixi209 – 214Combined sources6
Helixi219 – 230Combined sources12
Helixi236 – 251Combined sources16
Helixi259 – 262Combined sources4
Helixi264 – 281Combined sources18
Turni282 – 284Combined sources3
Helixi285 – 299Combined sources15
Helixi304 – 355Combined sources52
Turni356 – 358Combined sources3
Helixi362 – 379Combined sources18
Turni380 – 382Combined sources3
Helixi383 – 391Combined sources9
Turni395 – 397Combined sources3
Helixi398 – 427Combined sources30
Helixi428 – 430Combined sources3
Helixi431 – 449Combined sources19
Helixi458 – 469Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZW9X-ray1.50A1-496[»]
4ZWBX-ray2.40A1-496[»]
4ZWCX-ray2.60A/B1-496[»]
5C65X-ray2.65A/B1-474[»]
ProteinModelPortaliP11169.
SMRiP11169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 279Important for selectivity against fructose1 Publication3
Regioni280 – 286Monosaccharide binding1 Publication7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP11169.
KOiK08142.
OMAiXLFLVER.
OrthoDBiEOG091G0A9K.
PhylomeDBiP11169.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG
60 70 80 90 100
NAPPSEVLLT SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL
110 120 130 140 150
AVTGGCFMGL CKVAKSVEML ILGRLVIGLF CGLCTGFVPM YIGEISPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ IFGLEFILGS EELWPLLLGF TILPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ EMKDESARMS
260 270 280 290 300
QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT
360 370 380 390 400
VSLLLKDNYN GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AMAVAGCSNW TSNFLVGLLF PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV
460 470 480 490
PETRGRTFED ITRAFEGQAH GADRSGKDGV MEMNSIEPAK ETTTNV
Length:496
Mass (Da):53,924
Last modified:July 1, 1989 - v1
Checksum:iF601CD6892F16516
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05250285V → L.Corresponds to variant rs17728193dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20681 mRNA. Translation: AAB61083.1.
AF274892
, AF274889, AF274890, AF274891 Genomic DNA. Translation: AAF82116.1.
CR457413 mRNA. Translation: CAG33694.1.
AK312386 mRNA. Translation: BAG35303.1.
CH471116 Genomic DNA. Translation: EAW88644.1.
CH471116 Genomic DNA. Translation: EAW88645.1.
BC039196 mRNA. Translation: AAH39196.1.
AY034634 mRNA. Translation: AAK56796.1.
CCDSiCCDS8586.1.
PIRiA31986.
T14798.
RefSeqiNP_008862.1. NM_006931.2.
UniGeneiHs.419240.

Genome annotation databases

EnsembliENST00000075120; ENSP00000075120; ENSG00000059804.
GeneIDi6515.
KEGGihsa:6515.
UCSCiuc001qtr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20681 mRNA. Translation: AAB61083.1.
AF274892
, AF274889, AF274890, AF274891 Genomic DNA. Translation: AAF82116.1.
CR457413 mRNA. Translation: CAG33694.1.
AK312386 mRNA. Translation: BAG35303.1.
CH471116 Genomic DNA. Translation: EAW88644.1.
CH471116 Genomic DNA. Translation: EAW88645.1.
BC039196 mRNA. Translation: AAH39196.1.
AY034634 mRNA. Translation: AAK56796.1.
CCDSiCCDS8586.1.
PIRiA31986.
T14798.
RefSeqiNP_008862.1. NM_006931.2.
UniGeneiHs.419240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZW9X-ray1.50A1-496[»]
4ZWBX-ray2.40A1-496[»]
4ZWCX-ray2.60A/B1-496[»]
5C65X-ray2.65A/B1-474[»]
ProteinModelPortaliP11169.
SMRiP11169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112406. 4 interactors.
IntActiP11169. 6 interactors.
MINTiMINT-4999361.
STRINGi9606.ENSP00000075120.

Chemistry databases

ChEMBLiCHEMBL5215.

Protein family/group databases

TCDBi2.A.1.1.91. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP11169.
PhosphoSitePlusiP11169.

Polymorphism and mutation databases

BioMutaiSLC2A3.
DMDMi121760.

Proteomic databases

EPDiP11169.
MaxQBiP11169.
PaxDbiP11169.
PeptideAtlasiP11169.
PRIDEiP11169.

Protocols and materials databases

DNASUi6515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000075120; ENSP00000075120; ENSG00000059804.
GeneIDi6515.
KEGGihsa:6515.
UCSCiuc001qtr.4. human.

Organism-specific databases

CTDi6515.
DisGeNETi6515.
GeneCardsiSLC2A3.
HGNCiHGNC:11007. SLC2A3.
HPAiCAB002763.
HPA006539.
MalaCardsiSLC2A3.
MIMi138170. gene.
neXtProtiNX_P11169.
OpenTargetsiENSG00000059804.
Orphaneti399. Huntington disease.
PharmGKBiPA35877.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP11169.
KOiK08142.
OMAiXLFLVER.
OrthoDBiEOG091G0A9K.
PhylomeDBiP11169.
TreeFamiTF313762.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000059804-MONOMER.
ReactomeiR-HSA-196836. Vitamin C (ascorbate) metabolism.
R-HSA-428790. Facilitative Na+-independent glucose transporters.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-70153. Glucose transport.

Miscellaneous databases

ChiTaRSiSLC2A3. human.
GenomeRNAii6515.
PROiP11169.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000059804.
CleanExiHS_SLC2A3.
ExpressionAtlasiP11169. baseline and differential.
GenevisibleiP11169. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR3_HUMAN
AccessioniPrimary (citable) accession number: P11169
Secondary accession number(s): B2R606
, D3DUU6, Q6I9U2, Q9UG15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 173 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.