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P11169 (GTR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 149. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name=GLUT-3
Gene names
Name:SLC2A3
Synonyms:GLUT3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Facilitative glucose transporter. Probably a neuronal glucose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in brain. Expressed in many tissues. Ref.1

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Solute carrier family 2, facilitated glucose transporter member 3
PRO_0000050353

Regions

Topological domain1 – 55Cytoplasmic Potential
Transmembrane6 – 2621Helical; Name=1; Potential
Topological domain27 – 6438Extracellular Potential
Transmembrane65 – 8521Helical; Name=2; Potential
Topological domain86 – 938Cytoplasmic Potential
Transmembrane94 – 11421Helical; Name=3; Potential
Topological domain115 – 12410Extracellular Potential
Transmembrane125 – 14521Helical; Name=4; Potential
Topological domain146 – 1538Cytoplasmic Potential
Transmembrane154 – 17421Helical; Name=5; Potential
Topological domain175 – 1839Extracellular Potential
Transmembrane184 – 20421Helical; Name=6; Potential
Topological domain205 – 26965Cytoplasmic Potential
Transmembrane270 – 29021Helical; Name=7; Potential
Topological domain291 – 30414Extracellular Potential
Transmembrane305 – 32521Helical; Name=8; Potential
Topological domain326 – 3349Cytoplasmic Potential
Transmembrane335 – 35521Helical; Name=9; Potential
Topological domain356 – 36813Extracellular Potential
Transmembrane369 – 38921Helical; Name=10; Potential
Topological domain390 – 39910Cytoplasmic Potential
Transmembrane400 – 42021Helical; Name=11; Potential
Topological domain421 – 4277Extracellular Potential
Transmembrane428 – 44821Helical; Name=12; Potential
Topological domain449 – 49648Cytoplasmic Potential
Region277 – 2793Defines substrate specificity By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential

Natural variations

Natural variant851V → L.
Corresponds to variant rs17728193 [ dbSNP | Ensembl ].
VAR_052502

Sequences

Sequence LengthMass (Da)Tools
P11169 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: F601CD6892F16516

FASTA49653,924
        10         20         30         40         50         60 
MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG NAPPSEVLLT 

        70         80         90        100        110        120 
SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL AVTGGCFMGL CKVAKSVEML 

       130        140        150        160        170        180 
ILGRLVIGLF CGLCTGFVPM YIGEISPTAL RGAFGTLNQL GIVVGILVAQ IFGLEFILGS 

       190        200        210        220        230        240 
EELWPLLLGF TILPAILQSA ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ 

       250        260        270        280        290        300 
EMKDESARMS QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG 

       310        320        330        340        350        360 
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT VSLLLKDNYN 

       370        380        390        400        410        420 
GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGLLF 

       430        440        450        460        470        480 
PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV PETRGRTFED ITRAFEGQAH GADRSGKDGV 

       490 
MEMNSIEPAK ETTTNV 

« Hide

References

« Hide 'large scale' references
[1]"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues."
Kayano T., Fukumoto H., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Bell G.I.
J. Biol. Chem. 263:15245-15248(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal skeletal muscle.
[2]"Resistance and expression of glucose transporters in human skeletal muscle."
Stuart C.A., Wen K.G., Acosta M., Wood T.G.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Duodenum.
[7]"Molecular characterization and cloning of glucose transporters in human articular chondrocytes."
Neama G., Richardson S., Bell S., Carter S., Mobasheri A.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-453.
Tissue: Articular cartilage.
[8]"QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site."
Seatter M.J., de la Rue S.A., Porter L.M., Gould G.W.
Biochemistry 37:1322-1326(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBSTRATE SPECIFICITY SITE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M20681 mRNA. Translation: AAB61083.1.
AF274892 expand/collapse EMBL AC list , AF274889, AF274890, AF274891 Genomic DNA. Translation: AAF82116.1.
CR457413 mRNA. Translation: CAG33694.1.
AK312386 mRNA. Translation: BAG35303.1.
CH471116 Genomic DNA. Translation: EAW88644.1.
CH471116 Genomic DNA. Translation: EAW88645.1.
BC039196 mRNA. Translation: AAH39196.1.
AY034634 mRNA. Translation: AAK56796.1.
PIRA31986.
T14798.
RefSeqNP_008862.1. NM_006931.2.
UniGeneHs.419240.

3D structure databases

ProteinModelPortalP11169.
SMRP11169. Positions 9-466.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112406. 3 interactions.
IntActP11169. 4 interactions.
MINTMINT-4999361.
STRING9606.ENSP00000075120.

Chemistry

ChEMBLCHEMBL5215.
GuidetoPHARMACOLOGY877.

Protein family/group databases

TCDB2.A.1.1.91. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteP11169.

Polymorphism databases

DMDM121760.

Proteomic databases

PaxDbP11169.
PRIDEP11169.

Protocols and materials databases

DNASU6515.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000075120; ENSP00000075120; ENSG00000059804.
GeneID6515.
KEGGhsa:6515.
UCSCuc001qtr.3. human.

Organism-specific databases

CTD6515.
GeneCardsGC12M008071.
HGNCHGNC:11007. SLC2A3.
HPACAB002763.
HPA006539.
MIM138170. gene.
neXtProtNX_P11169.
PharmGKBPA35877.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000202871.
HOVERGENHBG014816.
InParanoidP11169.
KOK08142.
OMAFRAPSYR.
OrthoDBEOG7QVM2R.
PhylomeDBP11169.
TreeFamTF313762.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP11169.
BgeeP11169.
CleanExHS_SLC2A3.
GenevestigatorP11169.

Family and domain databases

InterProIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi6515.
NextBio25335.
PROP11169.
SOURCESearch...

Entry information

Entry nameGTR3_HUMAN
AccessionPrimary (citable) accession number: P11169
Secondary accession number(s): B2R606 expand/collapse secondary AC list , D3DUU6, Q6I9U2, Q9UG15
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM