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P11169

- GTR3_HUMAN

UniProt

P11169 - GTR3_HUMAN

Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

SLC2A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Facilitative glucose transporter. Probably a neuronal glucose transporter.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei315 – 3151MonosaccharideBy similarity
    Binding sitei386 – 3861MonosaccharideBy similarity

    GO - Molecular functioni

    1. glucose transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. glucose transport Source: Reactome
    3. hexose transport Source: Reactome
    4. L-ascorbic acid metabolic process Source: Reactome
    5. small molecule metabolic process Source: Reactome
    6. transmembrane transport Source: Reactome
    7. vitamin metabolic process Source: Reactome
    8. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11202. Vitamin C (ascorbate) metabolism.
    REACT_19343. Facilitative Na+-independent glucose transporters.
    REACT_212. Glucose transport.

    Protein family/group databases

    TCDBi2.A.1.1.91. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 3
    Alternative name(s):
    Glucose transporter type 3, brain
    Short name:
    GLUT-3
    Gene namesi
    Name:SLC2A3
    Synonyms:GLUT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11007. SLC2A3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35877.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Solute carrier family 2, facilitated glucose transporter member 3PRO_0000050353Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP11169.
    PaxDbiP11169.
    PRIDEiP11169.

    PTM databases

    PhosphoSiteiP11169.

    Expressioni

    Tissue specificityi

    Highly expressed in brain. Expressed in many tissues.1 Publication

    Gene expression databases

    ArrayExpressiP11169.
    BgeeiP11169.
    CleanExiHS_SLC2A3.
    GenevestigatoriP11169.

    Organism-specific databases

    HPAiCAB002763.
    HPA006539.

    Interactioni

    Protein-protein interaction databases

    BioGridi112406. 3 interactions.
    IntActiP11169. 4 interactions.
    MINTiMINT-4999361.
    STRINGi9606.ENSP00000075120.

    Structurei

    3D structure databases

    ProteinModelPortaliP11169.
    SMRiP11169. Positions 9-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55CytoplasmicSequence Analysis
    Topological domaini27 – 6438ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini86 – 938CytoplasmicSequence Analysis
    Topological domaini115 – 12410ExtracellularSequence Analysis
    Topological domaini146 – 1538CytoplasmicSequence Analysis
    Topological domaini175 – 1839ExtracellularSequence Analysis
    Topological domaini205 – 26965CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini291 – 30414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 3349CytoplasmicSequence Analysis
    Topological domaini356 – 36813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini390 – 39910CytoplasmicSequence Analysis
    Topological domaini421 – 4277ExtracellularSequence Analysis
    Topological domaini449 – 49648CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei400 – 42021Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni280 – 2867Monosaccharide bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000202871.
    HOVERGENiHBG014816.
    InParanoidiP11169.
    KOiK08142.
    OMAiPIMEMNS.
    OrthoDBiEOG7QVM2R.
    PhylomeDBiP11169.
    TreeFamiTF313762.

    Family and domain databases

    InterProiIPR002945. Glc_transpt_3.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR01192. GLUCTRSPORT3.
    PR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11169-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG    50
    NAPPSEVLLT SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL 100
    AVTGGCFMGL CKVAKSVEML ILGRLVIGLF CGLCTGFVPM YIGEISPTAL 150
    RGAFGTLNQL GIVVGILVAQ IFGLEFILGS EELWPLLLGF TILPAILQSA 200
    ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ EMKDESARMS 250
    QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG 300
    VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT 350
    VSLLLKDNYN GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA 400
    AMAVAGCSNW TSNFLVGLLF PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV 450
    PETRGRTFED ITRAFEGQAH GADRSGKDGV MEMNSIEPAK ETTTNV 496
    Length:496
    Mass (Da):53,924
    Last modified:July 1, 1989 - v1
    Checksum:iF601CD6892F16516
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851V → L.
    Corresponds to variant rs17728193 [ dbSNP | Ensembl ].
    VAR_052502

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20681 mRNA. Translation: AAB61083.1.
    AF274892
    , AF274889, AF274890, AF274891 Genomic DNA. Translation: AAF82116.1.
    CR457413 mRNA. Translation: CAG33694.1.
    AK312386 mRNA. Translation: BAG35303.1.
    CH471116 Genomic DNA. Translation: EAW88644.1.
    CH471116 Genomic DNA. Translation: EAW88645.1.
    BC039196 mRNA. Translation: AAH39196.1.
    AY034634 mRNA. Translation: AAK56796.1.
    CCDSiCCDS8586.1.
    PIRiA31986.
    T14798.
    RefSeqiNP_008862.1. NM_006931.2.
    UniGeneiHs.419240.

    Genome annotation databases

    EnsembliENST00000075120; ENSP00000075120; ENSG00000059804.
    GeneIDi6515.
    KEGGihsa:6515.
    UCSCiuc001qtr.3. human.

    Polymorphism databases

    DMDMi121760.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20681 mRNA. Translation: AAB61083.1 .
    AF274892
    , AF274889 , AF274890 , AF274891 Genomic DNA. Translation: AAF82116.1 .
    CR457413 mRNA. Translation: CAG33694.1 .
    AK312386 mRNA. Translation: BAG35303.1 .
    CH471116 Genomic DNA. Translation: EAW88644.1 .
    CH471116 Genomic DNA. Translation: EAW88645.1 .
    BC039196 mRNA. Translation: AAH39196.1 .
    AY034634 mRNA. Translation: AAK56796.1 .
    CCDSi CCDS8586.1.
    PIRi A31986.
    T14798.
    RefSeqi NP_008862.1. NM_006931.2.
    UniGenei Hs.419240.

    3D structure databases

    ProteinModelPortali P11169.
    SMRi P11169. Positions 9-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112406. 3 interactions.
    IntActi P11169. 4 interactions.
    MINTi MINT-4999361.
    STRINGi 9606.ENSP00000075120.

    Chemistry

    ChEMBLi CHEMBL5215.
    GuidetoPHARMACOLOGYi 877.

    Protein family/group databases

    TCDBi 2.A.1.1.91. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei P11169.

    Polymorphism databases

    DMDMi 121760.

    Proteomic databases

    MaxQBi P11169.
    PaxDbi P11169.
    PRIDEi P11169.

    Protocols and materials databases

    DNASUi 6515.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000075120 ; ENSP00000075120 ; ENSG00000059804 .
    GeneIDi 6515.
    KEGGi hsa:6515.
    UCSCi uc001qtr.3. human.

    Organism-specific databases

    CTDi 6515.
    GeneCardsi GC12M008071.
    HGNCi HGNC:11007. SLC2A3.
    HPAi CAB002763.
    HPA006539.
    MIMi 138170. gene.
    neXtProti NX_P11169.
    PharmGKBi PA35877.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000202871.
    HOVERGENi HBG014816.
    InParanoidi P11169.
    KOi K08142.
    OMAi PIMEMNS.
    OrthoDBi EOG7QVM2R.
    PhylomeDBi P11169.
    TreeFami TF313762.

    Enzyme and pathway databases

    Reactomei REACT_11202. Vitamin C (ascorbate) metabolism.
    REACT_19343. Facilitative Na+-independent glucose transporters.
    REACT_212. Glucose transport.

    Miscellaneous databases

    GenomeRNAii 6515.
    NextBioi 25335.
    PROi P11169.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11169.
    Bgeei P11169.
    CleanExi HS_SLC2A3.
    Genevestigatori P11169.

    Family and domain databases

    InterProi IPR002945. Glc_transpt_3.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR01192. GLUCTRSPORT3.
    PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues."
      Kayano T., Fukumoto H., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Bell G.I.
      J. Biol. Chem. 263:15245-15248(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal skeletal muscle.
    2. "Resistance and expression of glucose transporters in human skeletal muscle."
      Stuart C.A., Wen K.G., Acosta M., Wood T.G.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Duodenum.
    7. "Molecular characterization and cloning of glucose transporters in human articular chondrocytes."
      Neama G., Richardson S., Bell S., Carter S., Mobasheri A.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-453.
      Tissue: Articular cartilage.
    8. "QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site."
      Seatter M.J., de la Rue S.A., Porter L.M., Gould G.W.
      Biochemistry 37:1322-1326(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBSTRATE SPECIFICITY SITE.

    Entry informationi

    Entry nameiGTR3_HUMAN
    AccessioniPrimary (citable) accession number: P11169
    Secondary accession number(s): B2R606
    , D3DUU6, Q6I9U2, Q9UG15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 153 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3