Solute carrier family 2, facilitated glucose transporter member 3

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Reviewed, UniProtKB/Swiss-Prot P11169 (GTR3_HUMAN)

Last modified June 16, 2009. Version 101. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
    Glucose transporter type 3, brain
      Short name=GLUT-3

Gene names

Name:	SLC2A3
Synonyms:	GLUT3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Facilitative glucose transporter. Probably a neuronal glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in brain. Expressed in many tissues. Ref.1
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

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Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Non-traceable author statement. Source: ProtInc glucose transport Traceable author statement. Source: ProtInc transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: HPA
Molecular function	glucose transmembrane transporter activity Traceable author statement. Source: ProtInc sugar:hydrogen symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 496

496

Solute carrier family 2, facilitated glucose transporter member 3

PRO_0000050353

Regions

Topological domain

1 – 5

Cytoplasmic Potential

Transmembrane

6 – 26

1 Potential

Topological domain

27 – 64

Extracellular Potential

Transmembrane

65 – 85

2 Potential

Topological domain

86 – 93

Cytoplasmic Potential

Transmembrane

94 – 114

3 Potential

Topological domain

115 – 124

Extracellular Potential

Transmembrane

125 – 145

4 Potential

Topological domain

146 – 153

Cytoplasmic Potential

Transmembrane

154 – 174

5 Potential

Topological domain

175 – 183

Extracellular Potential

Transmembrane

184 – 204

6 Potential

Topological domain

205 – 269

Cytoplasmic Potential

Transmembrane

270 – 290

7 Potential

Topological domain

291 – 304

Extracellular Potential

Transmembrane

305 – 325

8 Potential

Topological domain

326 – 334

Cytoplasmic Potential

Transmembrane

335 – 355

9 Potential

Topological domain

356 – 368

Extracellular Potential

Transmembrane

369 – 389

10 Potential

Topological domain

390 – 399

Cytoplasmic Potential

Transmembrane

400 – 420

11 Potential

Topological domain

421 – 427

Extracellular Potential

Transmembrane

428 – 448

12 Potential

Topological domain

449 – 496

Cytoplasmic Potential

Region

277 – 279

Defines substrate specificity By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

V → L: dbSNP rs17728193.

VAR_052502

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Sequences

Sequence

Length

Mass (Da)

Tools

P11169-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: F601CD6892F16516
Show »

FASTA

496

53,924

        10         20         30         40         50         60 
MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG NAPPSEVLLT 

        70         80         90        100        110        120 
SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL AVTGGCFMGL CKVAKSVEML 

       130        140        150        160        170        180 
ILGRLVIGLF CGLCTGFVPM YIGEISPTAL RGAFGTLNQL GIVVGILVAQ IFGLEFILGS 

       190        200        210        220        230        240 
EELWPLLLGF TILPAILQSA ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ 

       250        260        270        280        290        300 
EMKDESARMS QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG 

       310        320        330        340        350        360 
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT VSLLLKDNYN 

       370        380        390        400        410        420 
GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGLLF 

       430        440        450        460        470        480 
PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV PETRGRTFED ITRAFEGQAH GADRSGKDGV 

       490 
MEMNSIEPAK ETTTNV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues." Kayano T., Fukumoto H., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Bell G.I. J. Biol. Chem. 263:15245-15248(1988) [PubMed: 3170580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal skeletal muscle.
[2]	"Resistance and expression of glucose transporters in human skeletal muscle." Stuart C.A., Wen K.G., Acosta M., Wood T.G. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum.
[5]	"Molecular characterization and cloning of glucose transporters in human articular chondrocytes." Neama G., Richardson S., Bell S., Carter S., Mobasheri A. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-453. Tissue: Articular cartilage.
[6]	"QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site." Seatter M.J., de la Rue S.A., Porter L.M., Gould G.W. Biochemistry 37:1322-1326(1998) [PubMed: 9477959] [Abstract] Cited for: SUBSTRATE SPECIFICITY SITE.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M20681 mRNA. Translation: AAB61083.1. AF274892 , AF274889, AF274890, AF274891 Genomic DNA. Translation: AAF82116.1. CR457413 mRNA. Translation: CAG33694.1. BC039196 mRNA. Translation: AAH39196.1. AY034634 mRNA. Translation: AAK56796.1.
IPI	IPI00003909.
PIR	A31986. T14798.
RefSeq	NP_008862.1.
UniGene	Hs.419240 Hs.655169
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P11169. 1 interaction.
PTM databases
PhosphoSite	P11169.
Proteomic databases
PRIDE	P11169.
Genome annotation databases
Ensembl	ENSG00000059804. Homo sapiens. [Contig view]
GeneID	6515.
KEGG	hsa:6515.
Organism-specific databases
GeneCards	GC12M007963.
H-InvDB	HIX0026355. HIX0056880.
HGNC	HGNC:11007. SLC2A3.
HPA	CAB002763. HPA006539.
MIM	138170. gene.
PharmGKB	PA35877.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P11169.
HOVERGEN	P11169.
OMA	P11169. CKVAKSV.
Enzyme and pathway databases
Reactome	REACT_11193. Metabolism of vitamins and cofactors. REACT_474. Metabolism of carbohydrates.
Gene expression databases
ArrayExpress	P11169.
Bgee	P11169.
CleanEx	HS_SLC2A3.
GermOnline	ENSG00000059804. Homo sapiens.
Family and domain databases
InterPro	IPR002945. Glc_transpt_3. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
PANTHER	PTHR11600:SF113. Glu_transpt3. 1 hit.
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR01192. GLUCTRSPORT3. PR00171. SUGRTRNSPORT.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25335.
SOURCE	Search...

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Entry information

Entry name

GTR3_HUMAN

Accession

Primary (citable) accession number: P11169
Secondary accession number(s): Q6I9U2, Q9UG15

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	June 16, 2009
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents