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Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

SLC2A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. Probably a neuronal glucose transporter.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei315 – 3151MonosaccharideBy similarity
Binding sitei386 – 3861MonosaccharideBy similarity

GO - Molecular functioni

  1. glucose transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. glucose transport Source: Reactome
  3. hexose transport Source: Reactome
  4. L-ascorbic acid metabolic process Source: Reactome
  5. pathogenesis Source: Reactome
  6. small molecule metabolic process Source: Reactome
  7. transmembrane transport Source: Reactome
  8. vitamin metabolic process Source: Reactome
  9. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11202. Vitamin C (ascorbate) metabolism.
REACT_19343. Facilitative Na+-independent glucose transporters.
REACT_212. Glucose transport.

Protein family/group databases

TCDBi2.A.1.1.91. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name:
GLUT-3
Gene namesi
Name:SLC2A3
Synonyms:GLUT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11007. SLC2A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence Analysis
Transmembranei6 – 2621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini27 – 6438ExtracellularSequence AnalysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini86 – 938CytoplasmicSequence Analysis
Transmembranei94 – 11421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini115 – 12410ExtracellularSequence Analysis
Transmembranei125 – 14521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini146 – 1538CytoplasmicSequence Analysis
Transmembranei154 – 17421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini175 – 1839ExtracellularSequence Analysis
Transmembranei184 – 20421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini205 – 26965CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 30414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei305 – 32521Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini326 – 3349CytoplasmicSequence Analysis
Transmembranei335 – 35521Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini356 – 36813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei369 – 38921Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini390 – 39910CytoplasmicSequence Analysis
Transmembranei400 – 42021Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini421 – 4277ExtracellularSequence Analysis
Transmembranei428 – 44821Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini449 – 49648CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti399. Huntington disease.
PharmGKBiPA35877.

Polymorphism and mutation databases

BioMutaiSLC2A3.
DMDMi121760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Solute carrier family 2, facilitated glucose transporter member 3PRO_0000050353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP11169.
PaxDbiP11169.
PRIDEiP11169.

PTM databases

PhosphoSiteiP11169.

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed in many tissues.1 Publication

Gene expression databases

BgeeiP11169.
CleanExiHS_SLC2A3.
ExpressionAtlasiP11169. baseline and differential.
GenevestigatoriP11169.

Organism-specific databases

HPAiCAB002763.
HPA006539.

Interactioni

Protein-protein interaction databases

BioGridi112406. 3 interactions.
IntActiP11169. 4 interactions.
MINTiMINT-4999361.
STRINGi9606.ENSP00000075120.

Structurei

3D structure databases

ProteinModelPortaliP11169.
SMRiP11169. Positions 7-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 2867Monosaccharide bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP11169.
KOiK08142.
OMAiXLFLVER.
OrthoDBiEOG7QVM2R.
PhylomeDBiP11169.
TreeFamiTF313762.

Family and domain databases

InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG
60 70 80 90 100
NAPPSEVLLT SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL
110 120 130 140 150
AVTGGCFMGL CKVAKSVEML ILGRLVIGLF CGLCTGFVPM YIGEISPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ IFGLEFILGS EELWPLLLGF TILPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ EMKDESARMS
260 270 280 290 300
QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT
360 370 380 390 400
VSLLLKDNYN GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AMAVAGCSNW TSNFLVGLLF PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV
460 470 480 490
PETRGRTFED ITRAFEGQAH GADRSGKDGV MEMNSIEPAK ETTTNV
Length:496
Mass (Da):53,924
Last modified:July 1, 1989 - v1
Checksum:iF601CD6892F16516
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851V → L.
Corresponds to variant rs17728193 [ dbSNP | Ensembl ].
VAR_052502

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20681 mRNA. Translation: AAB61083.1.
AF274892
, AF274889, AF274890, AF274891 Genomic DNA. Translation: AAF82116.1.
CR457413 mRNA. Translation: CAG33694.1.
AK312386 mRNA. Translation: BAG35303.1.
CH471116 Genomic DNA. Translation: EAW88644.1.
CH471116 Genomic DNA. Translation: EAW88645.1.
BC039196 mRNA. Translation: AAH39196.1.
AY034634 mRNA. Translation: AAK56796.1.
CCDSiCCDS8586.1.
PIRiA31986.
T14798.
RefSeqiNP_008862.1. NM_006931.2.
UniGeneiHs.419240.

Genome annotation databases

EnsembliENST00000075120; ENSP00000075120; ENSG00000059804.
GeneIDi6515.
KEGGihsa:6515.
UCSCiuc001qtr.3. human.

Polymorphism and mutation databases

BioMutaiSLC2A3.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20681 mRNA. Translation: AAB61083.1.
AF274892
, AF274889, AF274890, AF274891 Genomic DNA. Translation: AAF82116.1.
CR457413 mRNA. Translation: CAG33694.1.
AK312386 mRNA. Translation: BAG35303.1.
CH471116 Genomic DNA. Translation: EAW88644.1.
CH471116 Genomic DNA. Translation: EAW88645.1.
BC039196 mRNA. Translation: AAH39196.1.
AY034634 mRNA. Translation: AAK56796.1.
CCDSiCCDS8586.1.
PIRiA31986.
T14798.
RefSeqiNP_008862.1. NM_006931.2.
UniGeneiHs.419240.

3D structure databases

ProteinModelPortaliP11169.
SMRiP11169. Positions 7-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112406. 3 interactions.
IntActiP11169. 4 interactions.
MINTiMINT-4999361.
STRINGi9606.ENSP00000075120.

Chemistry

ChEMBLiCHEMBL5215.
GuidetoPHARMACOLOGYi877.

Protein family/group databases

TCDBi2.A.1.1.91. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiP11169.

Polymorphism and mutation databases

BioMutaiSLC2A3.
DMDMi121760.

Proteomic databases

MaxQBiP11169.
PaxDbiP11169.
PRIDEiP11169.

Protocols and materials databases

DNASUi6515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000075120; ENSP00000075120; ENSG00000059804.
GeneIDi6515.
KEGGihsa:6515.
UCSCiuc001qtr.3. human.

Organism-specific databases

CTDi6515.
GeneCardsiGC12M008071.
HGNCiHGNC:11007. SLC2A3.
HPAiCAB002763.
HPA006539.
MIMi138170. gene.
neXtProtiNX_P11169.
Orphaneti399. Huntington disease.
PharmGKBiPA35877.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP11169.
KOiK08142.
OMAiXLFLVER.
OrthoDBiEOG7QVM2R.
PhylomeDBiP11169.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiREACT_11202. Vitamin C (ascorbate) metabolism.
REACT_19343. Facilitative Na+-independent glucose transporters.
REACT_212. Glucose transport.

Miscellaneous databases

ChiTaRSiSLC2A3. human.
GenomeRNAii6515.
NextBioi25335.
PROiP11169.
SOURCEiSearch...

Gene expression databases

BgeeiP11169.
CleanExiHS_SLC2A3.
ExpressionAtlasiP11169. baseline and differential.
GenevestigatoriP11169.

Family and domain databases

InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues."
    Kayano T., Fukumoto H., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Bell G.I.
    J. Biol. Chem. 263:15245-15248(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal skeletal muscle.
  2. "Resistance and expression of glucose transporters in human skeletal muscle."
    Stuart C.A., Wen K.G., Acosta M., Wood T.G.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Duodenum.
  7. "Molecular characterization and cloning of glucose transporters in human articular chondrocytes."
    Neama G., Richardson S., Bell S., Carter S., Mobasheri A.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-453.
    Tissue: Articular cartilage.
  8. "QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site."
    Seatter M.J., de la Rue S.A., Porter L.M., Gould G.W.
    Biochemistry 37:1322-1326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBSTRATE SPECIFICITY SITE.

Entry informationi

Entry nameiGTR3_HUMAN
AccessioniPrimary (citable) accession number: P11169
Secondary accession number(s): B2R606
, D3DUU6, Q6I9U2, Q9UG15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 29, 2015
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.