P11168 (GTR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2

Alternative name(s):
Glucose transporter type 2, liver
Short name=GLUT-2

Gene names

Name:	SLC2A2
Synonyms:	GLUT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Liver, insulin-producing beta cell, small intestine and kidney.
Post-translational modification	N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells By similarity.
Involvement in disease	Fanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome endocrine pancreas development Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome regulation of insulin secretion Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	brush border Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.6. Source: ProtInc
Molecular_function	D-glucose transmembrane transporter activity Inferred from electronic annotation. Source: Compara dehydroascorbic acid transporter activity Inferred from electronic annotation. Source: Compara glucose transmembrane transporter activity Inferred from experiment. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Solute carrier family 2, facilitated glucose transporter member 2		PRO_0000050346
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Name=1; Potential
	Topological domain	32 – 98	67	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Name=2; Potential
	Topological domain	120 – 127	8	Cytoplasmic Potential
	Transmembrane	128 – 148	21	Helical; Name=3; Potential
	Topological domain	149 – 158	10	Extracellular Potential
	Transmembrane	159 – 179	21	Helical; Name=4; Potential
	Topological domain	180 – 187	8	Cytoplasmic Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 217	9	Extracellular Potential
	Transmembrane	218 – 238	21	Helical; Name=6; Potential
	Topological domain	239 – 303	65	Cytoplasmic Potential
	Transmembrane	304 – 324	21	Helical; Name=7; Potential
	Topological domain	325 – 338	14	Extracellular Potential
	Transmembrane	339 – 359	21	Helical; Name=8; Potential
	Topological domain	360 – 368	9	Cytoplasmic Potential
	Transmembrane	369 – 389	21	Helical; Name=9; Potential
	Topological domain	390 – 400	11	Extracellular Potential
	Transmembrane	401 – 421	21	Helical; Name=10; Potential
	Topological domain	422 – 433	12	Cytoplasmic Potential
	Transmembrane	434 – 454	21	Helical; Name=11; Potential
	Topological domain	455 – 461	7	Extracellular Potential
	Transmembrane	462 – 482	21	Helical; Name=12; Potential
	Topological domain	483 – 524	42	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	68	1	P → L. Ref.1 Ref.4 Corresponds to variant rs7637863 [ dbSNP | Ensembl ].		VAR_007169
	Natural variant	101	1	V → I. Corresponds to variant rs1800572 [ dbSNP | Ensembl ].		VAR_014718
	Natural variant	110	1	T → I. Ref.4 Ref.5 Ref.6 Corresponds to variant rs5400 [ dbSNP | Ensembl ].		VAR_014719
	Natural variant	197	1	V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. Ref.5 Ref.6		VAR_018650
	Natural variant	389	1	L → P in FBS. Ref.8		VAR_018651
	Natural variant	404	1	I → T. Corresponds to variant rs2229608 [ dbSNP | Ensembl ].		VAR_052501
	Natural variant	417	1	P → L in FBS. Ref.7		VAR_018652
	Natural variant	423	1	V → E in FBS. Ref.8 Corresponds to variant rs28928874 [ dbSNP | Ensembl ].		VAR_018653
	Natural variant	478	1	L → V. Corresponds to variant rs5397 [ dbSNP | Ensembl ].		VAR_014720
Experimental info
	Sequence conflict	183	1	A → S in BAF83535. Ref.2
	Sequence conflict	374	1	S → N in BAF83535. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P11168 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: DA600577207EC083	FASTA	524	57,490
	10 20 30 40 50 60 MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL DDRKAINNYV 70 80 90 100 110 120 INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS VSSFAVGGMT ASFFGGWLGD 130 140 150 160 170 180 TLGRIKAMLV ANILSLVGAL LMGFSKLGPS HILIIAGRSI SGLYCGLISG LVPMYIGEIA 190 200 210 220 230 240 PTALRGALGT FHQLAIVTGI LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP 250 260 270 280 290 300 ESPRYLYIKL DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 310 320 330 340 350 360 RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM VFTAVSVFLV 370 380 390 400 410 420 EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS MIAIFLFVSF FEIGPGPIPW 430 440 450 460 470 480 FMVAEFFSQG PRPAALAIAA FSNWTCNFIV ALCFQYIADF CGPYVFFLFA GVLLAFTLFT 490 500 510 520 FFKVPETKGK SFEEIAAEFQ KKSGSAHRPK AAVEMKFLGA TETV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein." Fukumoto H., Seino S., Imura H., Sieno Y., Eddy R.L., Fukushima Y., Byers M.G., Shows T.B., Bell G.I. Proc. Natl. Acad. Sci. U.S.A. 85:5434-5438(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-68. Tissue: Kidney and Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus." Matsubara A., Tanizawa Y., Matsutani A., Kaneko T., Kaku K. J. Clin. Endocrinol. Metab. 80:3131-3135(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-100, VARIANTS LEU-68 AND ILE-110. Tissue: Peripheral blood.
[5]	"Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients." Tanizawa Y., Riggs A.C., Chiu K.C., Janssen R.C., Bell D.S.H., Go R.P.C., Roseman J.M., Acton R.T., Permutt M.A. Diabetologia 37:420-427(1994) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT NIDDM ILE-197, VARIANT ILE-110.
[6]	"A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity." Mueckler M., Kruse M., Strube M., Riggs A.C., Chiu K.C., Permutt M.A. J. Biol. Chem. 269:17765-17767(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANT NIDDM ILE-197, CHARACTERIZATION OF VARIANT ILE-110.
[7]	"A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity." Burwinkel B., Sanjad S.A., Al-Sabban E., Al-Abbad A., Kilimann M.W. Hum. Genet. 105:240-243(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT FBS LEU-417.
[8]	"Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome." Sakamoto O., Ogawa E., Ohura T., Igarashi Y., Matsubara Y., Narisawa K., Iinuma K. Pediatr. Res. 48:586-589(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS FBS PRO-389 AND GLU-423.
+	Additional computationally mapped references.

Web resources

GeneReviews

Wikipedia

GLUT2 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03810 mRNA. Translation: AAA59514.1. AK290846 mRNA. Translation: BAF83535.1. AK313622 mRNA. Translation: BAG36383.1. CH471052 Genomic DNA. Translation: EAW78499.1.
IPI	IPI00003905.
PIR	A31318.
RefSeq	NP_000331.1. NM_000340.1.
UniGene	Hs.167584.
3D structure databases
ProteinModelPortal	P11168.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000323568.
Protein family/group databases
TCDB	2.A.1.1.29. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	P11168.
Polymorphism databases
DMDM	121756.
Proteomic databases
PaxDb	P11168.
PRIDE	P11168.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314251; ENSP00000323568; ENSG00000163581.
GeneID	6514.
KEGG	hsa:6514.
UCSC	uc003fhe.1. human.
Organism-specific databases
CTD	6514.
GeneCards	GC03M170714.
HGNC	HGNC:11006. SLC2A2.
HPA	CAB010444.
MIM	138160. gene. 227810. phenotype.
neXtProt	NX_P11168.
Orphanet	2088. Bickel-Fanconi glycogenosis.
PharmGKB	PA35876.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000202871.
HOVERGEN	HBG014816.
InParanoid	P11168.
KO	K07593.
OMA	DLWHILL.
OrthoDB	EOG4K6G40.
PhylomeDB	P11168.
Enzyme and pathway databases
Pathway_Interaction_DB	hnf3bpathway. FOXA2 and FOXA3 transcription factor networks.
Reactome	REACT_111045. Developmental Biology. REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P11168.
Bgee	P11168.
CleanEx	HS_SLC2A2.
Genevestigator	P11168.
GermOnline	ENSG00000163581. Homo sapiens.
Family and domain databases
InterPro	IPR002440. Glc_transpt_2. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR01191. GLUCTRSPORT2. PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P11168.
ChEMBL	CHEMBL5873.
GenomeRNAi	6514.
NextBio	25331.
SOURCE	Search...

Entry information

Entry name

GTR2_HUMAN

Accession

Primary (citable) accession number: P11168
Secondary accession number(s): A8K481, B2R936, Q9UCW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 132 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.