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P11168

- GTR2_HUMAN

UniProt

P11168 - GTR2_HUMAN

Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei349 – 3491MonosaccharideBy similarity
    Binding sitei420 – 4201MonosaccharideBy similarity

    GO - Molecular functioni

    1. dehydroascorbic acid transporter activity Source: Ensembl
    2. D-glucose transmembrane transporter activity Source: Ensembl
    3. glucose transmembrane transporter activity Source: Reactome
    4. hexose transmembrane transporter activity Source: Reactome

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. endocrine pancreas development Source: Reactome
    3. energy reserve metabolic process Source: Reactome
    4. glucose transport Source: Reactome
    5. hexose transmembrane transport Source: GOC
    6. hexose transport Source: Reactome
    7. regulation of insulin secretion Source: Reactome
    8. small molecule metabolic process Source: Reactome
    9. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13819. Regulation of gene expression in beta cells.
    REACT_18325. Regulation of insulin secretion.
    REACT_19343. Facilitative Na+-independent glucose transporters.
    REACT_212. Glucose transport.
    REACT_9441. Hexose transport.

    Protein family/group databases

    TCDBi2.A.1.1.29. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 2
    Alternative name(s):
    Glucose transporter type 2, liver
    Short name:
    GLUT-2
    Gene namesi
    Name:SLC2A2
    Synonyms:GLUT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11006. SLC2A2.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. membrane Source: ProtInc
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Fanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti389 – 3891L → P in FBS. 1 Publication
    VAR_018651
    Natural varianti417 – 4171P → L in FBS. 1 Publication
    VAR_018652
    Natural varianti423 – 4231V → E in FBS. 1 Publication
    Corresponds to variant rs28928874 [ dbSNP | Ensembl ].
    VAR_018653

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi227810. phenotype.
    Orphaneti2088. Glycogen storage disease due to GLUT2 deficiency.
    PharmGKBiPA35876.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Solute carrier family 2, facilitated glucose transporter member 2PRO_0000050346Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP11168.
    PaxDbiP11168.
    PRIDEiP11168.

    PTM databases

    PhosphoSiteiP11168.

    Expressioni

    Tissue specificityi

    Liver, insulin-producing beta cell, small intestine and kidney.

    Gene expression databases

    ArrayExpressiP11168.
    BgeeiP11168.
    CleanExiHS_SLC2A2.
    GenevestigatoriP11168.

    Organism-specific databases

    HPAiCAB010444.
    HPA028997.

    Interactioni

    Protein-protein interaction databases

    BioGridi112405. 2 interactions.
    STRINGi9606.ENSP00000323568.

    Structurei

    3D structure databases

    ProteinModelPortaliP11168.
    SMRiP11168. Positions 101-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 9867ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 1278CytoplasmicSequence Analysis
    Topological domaini149 – 15810ExtracellularSequence Analysis
    Topological domaini180 – 1878CytoplasmicSequence Analysis
    Topological domaini209 – 2179ExtracellularSequence Analysis
    Topological domaini239 – 30365CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini325 – 33814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 3689CytoplasmicSequence Analysis
    Topological domaini390 – 40011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini422 – 43312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini455 – 4617ExtracellularSequence Analysis
    Topological domaini483 – 52442CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei462 – 48221Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni314 – 3207Monosaccharide bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000202871.
    HOVERGENiHBG014816.
    InParanoidiP11168.
    KOiK07593.
    OMAiMKFLGAT.
    OrthoDBiEOG7QVM2R.
    PhylomeDBiP11168.
    TreeFamiTF313762.

    Family and domain databases

    InterProiIPR002440. Glc_transpt_2.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR01191. GLUCTRSPORT2.
    PR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P11168-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL    50
    DDRKAINNYV INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS 100
    VSSFAVGGMT ASFFGGWLGD TLGRIKAMLV ANILSLVGAL LMGFSKLGPS 150
    HILIIAGRSI SGLYCGLISG LVPMYIGEIA PTALRGALGT FHQLAIVTGI 200
    LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP ESPRYLYIKL 250
    DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 300
    RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM 350
    VFTAVSVFLV EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS 400
    MIAIFLFVSF FEIGPGPIPW FMVAEFFSQG PRPAALAIAA FSNWTCNFIV 450
    ALCFQYIADF CGPYVFFLFA GVLLAFTLFT FFKVPETKGK SFEEIAAEFQ 500
    KKSGSAHRPK AAVEMKFLGA TETV 524
    Length:524
    Mass (Da):57,490
    Last modified:July 1, 1989 - v1
    Checksum:iDA600577207EC083
    GO
    Isoform 2 (identifier: P11168-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: MTEDKVTGTL...FGGWLGDTLG → MHLN

    Show »
    Length:405
    Mass (Da):44,702
    Checksum:i41F3A2ADC187753A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1831A → S in BAF83535. (PubMed:14702039)Curated
    Sequence conflicti269 – 2691V → I in BAH12783. (PubMed:14702039)Curated
    Sequence conflicti374 – 3741S → N in BAF83535. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681P → L.2 Publications
    Corresponds to variant rs7637863 [ dbSNP | Ensembl ].
    VAR_007169
    Natural varianti101 – 1011V → I.
    Corresponds to variant rs1800572 [ dbSNP | Ensembl ].
    VAR_014718
    Natural varianti110 – 1101T → I.2 Publications
    Corresponds to variant rs5400 [ dbSNP | Ensembl ].
    VAR_014719
    Natural varianti197 – 1971V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. 1 Publication
    VAR_018650
    Natural varianti389 – 3891L → P in FBS. 1 Publication
    VAR_018651
    Natural varianti404 – 4041I → T.
    Corresponds to variant rs2229608 [ dbSNP | Ensembl ].
    VAR_052501
    Natural varianti417 – 4171P → L in FBS. 1 Publication
    VAR_018652
    Natural varianti423 – 4231V → E in FBS. 1 Publication
    Corresponds to variant rs28928874 [ dbSNP | Ensembl ].
    VAR_018653
    Natural varianti478 – 4781L → V.
    Corresponds to variant rs5397 [ dbSNP | Ensembl ].
    VAR_014720

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 123123MTEDK…GDTLG → MHLN in isoform 2. 1 PublicationVSP_054835Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03810 mRNA. Translation: AAA59514.1.
    AK290846 mRNA. Translation: BAF83535.1.
    AK298418 mRNA. Translation: BAH12783.1.
    AK313622 mRNA. Translation: BAG36383.1.
    AC061708 Genomic DNA. No translation available.
    AC092918 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78499.1.
    CCDSiCCDS3215.1. [P11168-1]
    CCDS63837.1. [P11168-2]
    PIRiA31318.
    RefSeqiNP_000331.1. NM_000340.1. [P11168-1]
    NP_001265587.1. NM_001278658.1. [P11168-2]
    NP_001265588.1. NM_001278659.1.
    UniGeneiHs.167584.

    Genome annotation databases

    EnsembliENST00000314251; ENSP00000323568; ENSG00000163581. [P11168-1]
    GeneIDi6514.
    KEGGihsa:6514.
    UCSCiuc003fhe.1. human. [P11168-1]

    Polymorphism databases

    DMDMi121756.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    GLUT2 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03810 mRNA. Translation: AAA59514.1 .
    AK290846 mRNA. Translation: BAF83535.1 .
    AK298418 mRNA. Translation: BAH12783.1 .
    AK313622 mRNA. Translation: BAG36383.1 .
    AC061708 Genomic DNA. No translation available.
    AC092918 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78499.1 .
    CCDSi CCDS3215.1. [P11168-1 ]
    CCDS63837.1. [P11168-2 ]
    PIRi A31318.
    RefSeqi NP_000331.1. NM_000340.1. [P11168-1 ]
    NP_001265587.1. NM_001278658.1. [P11168-2 ]
    NP_001265588.1. NM_001278659.1.
    UniGenei Hs.167584.

    3D structure databases

    ProteinModelPortali P11168.
    SMRi P11168. Positions 101-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112405. 2 interactions.
    STRINGi 9606.ENSP00000323568.

    Chemistry

    BindingDBi P11168.
    ChEMBLi CHEMBL5873.
    GuidetoPHARMACOLOGYi 876.

    Protein family/group databases

    TCDBi 2.A.1.1.29. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei P11168.

    Polymorphism databases

    DMDMi 121756.

    Proteomic databases

    MaxQBi P11168.
    PaxDbi P11168.
    PRIDEi P11168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314251 ; ENSP00000323568 ; ENSG00000163581 . [P11168-1 ]
    GeneIDi 6514.
    KEGGi hsa:6514.
    UCSCi uc003fhe.1. human. [P11168-1 ]

    Organism-specific databases

    CTDi 6514.
    GeneCardsi GC03M170714.
    HGNCi HGNC:11006. SLC2A2.
    HPAi CAB010444.
    HPA028997.
    MIMi 138160. gene.
    227810. phenotype.
    neXtProti NX_P11168.
    Orphaneti 2088. Glycogen storage disease due to GLUT2 deficiency.
    PharmGKBi PA35876.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000202871.
    HOVERGENi HBG014816.
    InParanoidi P11168.
    KOi K07593.
    OMAi MKFLGAT.
    OrthoDBi EOG7QVM2R.
    PhylomeDBi P11168.
    TreeFami TF313762.

    Enzyme and pathway databases

    Reactomei REACT_13819. Regulation of gene expression in beta cells.
    REACT_18325. Regulation of insulin secretion.
    REACT_19343. Facilitative Na+-independent glucose transporters.
    REACT_212. Glucose transport.
    REACT_9441. Hexose transport.

    Miscellaneous databases

    GenomeRNAii 6514.
    NextBioi 25331.
    PROi P11168.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11168.
    Bgeei P11168.
    CleanExi HS_SLC2A2.
    Genevestigatori P11168.

    Family and domain databases

    InterProi IPR002440. Glc_transpt_2.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR01191. GLUCTRSPORT2.
    PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein."
      Fukumoto H., Seino S., Imura H., Sieno Y., Eddy R.L., Fukushima Y., Byers M.G., Shows T.B., Bell G.I.
      Proc. Natl. Acad. Sci. U.S.A. 85:5434-5438(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-68.
      Tissue: Kidney and Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Liver.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus."
      Matsubara A., Tanizawa Y., Matsutani A., Kaneko T., Kaku K.
      J. Clin. Endocrinol. Metab. 80:3131-3135(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-100 (ISOFORM 1), VARIANTS LEU-68 AND ILE-110.
      Tissue: Peripheral blood.
    6. "Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients."
      Tanizawa Y., Riggs A.C., Chiu K.C., Janssen R.C., Bell D.S.H., Go R.P.C., Roseman J.M., Acton R.T., Permutt M.A.
      Diabetologia 37:420-427(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NIDDM ILE-197, VARIANT ILE-110.
    7. "A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity."
      Mueckler M., Kruse M., Strube M., Riggs A.C., Chiu K.C., Permutt M.A.
      J. Biol. Chem. 269:17765-17767(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT NIDDM ILE-197, CHARACTERIZATION OF VARIANT ILE-110.
    8. "A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity."
      Burwinkel B., Sanjad S.A., Al-Sabban E., Al-Abbad A., Kilimann M.W.
      Hum. Genet. 105:240-243(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT FBS LEU-417.
    9. "Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome."
      Sakamoto O., Ogawa E., Ohura T., Igarashi Y., Matsubara Y., Narisawa K., Iinuma K.
      Pediatr. Res. 48:586-589(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS FBS PRO-389 AND GLU-423.

    Entry informationi

    Entry nameiGTR2_HUMAN
    AccessioniPrimary (citable) accession number: P11168
    Secondary accession number(s): A8K481
    , B2R936, B7Z547, F8W8V8, Q9UCW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3