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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei349MonosaccharideBy similarity1
Binding sitei420MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • glucose transport Source: Reactome
  • hexose transport Source: Reactome
  • regulation of insulin secretion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163581-MONOMER.
ReactomeiR-HSA-189200. Hexose transport.
R-HSA-210745. Regulation of gene expression in beta cells.
R-HSA-422356. Regulation of insulin secretion.
R-HSA-428790. Facilitative Na+-independent glucose transporters.
R-HSA-70153. Glucose transport.
SIGNORiP11168.

Protein family/group databases

TCDBi2.A.1.1.29. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:SLC2A2
Synonyms:GLUT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11006. SLC2A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 98ExtracellularSequence analysisAdd BLAST67
Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini120 – 127CytoplasmicSequence analysis8
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 158ExtracellularSequence analysis10
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 187CytoplasmicSequence analysis8
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 217ExtracellularSequence analysis9
Transmembranei218 – 238Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini239 – 303CytoplasmicSequence analysisAdd BLAST65
Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini325 – 338ExtracellularSequence analysisAdd BLAST14
Transmembranei339 – 359Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini360 – 368CytoplasmicSequence analysis9
Transmembranei369 – 389Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini390 – 400ExtracellularSequence analysisAdd BLAST11
Transmembranei401 – 421Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini422 – 433CytoplasmicSequence analysisAdd BLAST12
Transmembranei434 – 454Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini455 – 461ExtracellularSequence analysis7
Transmembranei462 – 482Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini483 – 524CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • brush border Source: Ensembl
  • cell-cell junction Source: Ensembl
  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Fanconi-Bickel syndrome (FBS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
See also OMIM:227810
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant rs121909747dbSNPEnsembl.1
Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant rs121909744dbSNPEnsembl.1
Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant rs28928874dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6514.
MalaCardsiSLC2A2.
MIMi227810. phenotype.
OpenTargetsiENSG00000163581.
Orphaneti2088. Glycogen storage disease due to GLUT2 deficiency.
PharmGKBiPA35876.

Chemistry databases

ChEMBLiCHEMBL5873.
DrugBankiDB00428. Streptozocin.

Polymorphism and mutation databases

BioMutaiSLC2A2.
DMDMi121756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503461 – 524Solute carrier family 2, facilitated glucose transporter member 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Modified residuei523PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP11168.
MaxQBiP11168.
PaxDbiP11168.
PeptideAtlasiP11168.
PRIDEiP11168.

PTM databases

iPTMnetiP11168.
PhosphoSitePlusiP11168.

Expressioni

Tissue specificityi

Liver, insulin-producing beta cell, small intestine and kidney.

Gene expression databases

BgeeiENSG00000163581.
CleanExiHS_SLC2A2.
ExpressionAtlasiP11168. baseline and differential.
GenevisibleiP11168. HS.

Organism-specific databases

HPAiCAB010444.
HPA028997.

Interactioni

Protein-protein interaction databases

BioGridi112405. 4 interactors.
STRINGi9606.ENSP00000323568.

Chemistry databases

BindingDBiP11168.

Structurei

3D structure databases

ProteinModelPortaliP11168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni314 – 320Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP11168.
KOiK07593.
OMAiYDLWHIL.
OrthoDBiEOG091G0A9K.
PhylomeDBiP11168.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11168-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL
60 70 80 90 100
DDRKAINNYV INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS
110 120 130 140 150
VSSFAVGGMT ASFFGGWLGD TLGRIKAMLV ANILSLVGAL LMGFSKLGPS
160 170 180 190 200
HILIIAGRSI SGLYCGLISG LVPMYIGEIA PTALRGALGT FHQLAIVTGI
210 220 230 240 250
LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP ESPRYLYIKL
260 270 280 290 300
DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY
310 320 330 340 350
RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM
360 370 380 390 400
VFTAVSVFLV EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS
410 420 430 440 450
MIAIFLFVSF FEIGPGPIPW FMVAEFFSQG PRPAALAIAA FSNWTCNFIV
460 470 480 490 500
ALCFQYIADF CGPYVFFLFA GVLLAFTLFT FFKVPETKGK SFEEIAAEFQ
510 520
KKSGSAHRPK AAVEMKFLGA TETV
Length:524
Mass (Da):57,490
Last modified:July 1, 1989 - v1
Checksum:iDA600577207EC083
GO
Isoform 2 (identifier: P11168-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: MTEDKVTGTL...FGGWLGDTLG → MHLN

Show »
Length:405
Mass (Da):44,702
Checksum:i41F3A2ADC187753A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183A → S in BAF83535 (PubMed:14702039).Curated1
Sequence conflicti269V → I in BAH12783 (PubMed:14702039).Curated1
Sequence conflicti374S → N in BAF83535 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00716968P → L.2 PublicationsCorresponds to variant rs7637863dbSNPEnsembl.1
Natural variantiVAR_014718101V → I.Corresponds to variant rs1800572dbSNPEnsembl.1
Natural variantiVAR_014719110T → I.3 PublicationsCorresponds to variant rs5400dbSNPEnsembl.1
Natural variantiVAR_018650197V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. 2 PublicationsCorresponds to variant rs121909741dbSNPEnsembl.1
Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant rs121909747dbSNPEnsembl.1
Natural variantiVAR_052501404I → T.Corresponds to variant rs2229608dbSNPEnsembl.1
Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant rs121909744dbSNPEnsembl.1
Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant rs28928874dbSNPEnsembl.1
Natural variantiVAR_014720478L → V.Corresponds to variant rs5397dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0548351 – 123MTEDK…GDTLG → MHLN in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03810 mRNA. Translation: AAA59514.1.
AK290846 mRNA. Translation: BAF83535.1.
AK298418 mRNA. Translation: BAH12783.1.
AK313622 mRNA. Translation: BAG36383.1.
AC061708 Genomic DNA. No translation available.
AC092918 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78499.1.
CCDSiCCDS3215.1. [P11168-1]
PIRiA31318.
RefSeqiNP_000331.1. NM_000340.1. [P11168-1]
NP_001265587.1. NM_001278658.1. [P11168-2]
NP_001265588.1. NM_001278659.1.
UniGeneiHs.167584.

Genome annotation databases

EnsembliENST00000314251; ENSP00000323568; ENSG00000163581. [P11168-1]
GeneIDi6514.
KEGGihsa:6514.
UCSCiuc003fhe.2. human. [P11168-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

GLUT2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03810 mRNA. Translation: AAA59514.1.
AK290846 mRNA. Translation: BAF83535.1.
AK298418 mRNA. Translation: BAH12783.1.
AK313622 mRNA. Translation: BAG36383.1.
AC061708 Genomic DNA. No translation available.
AC092918 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78499.1.
CCDSiCCDS3215.1. [P11168-1]
PIRiA31318.
RefSeqiNP_000331.1. NM_000340.1. [P11168-1]
NP_001265587.1. NM_001278658.1. [P11168-2]
NP_001265588.1. NM_001278659.1.
UniGeneiHs.167584.

3D structure databases

ProteinModelPortaliP11168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112405. 4 interactors.
STRINGi9606.ENSP00000323568.

Chemistry databases

BindingDBiP11168.
ChEMBLiCHEMBL5873.
DrugBankiDB00428. Streptozocin.

Protein family/group databases

TCDBi2.A.1.1.29. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP11168.
PhosphoSitePlusiP11168.

Polymorphism and mutation databases

BioMutaiSLC2A2.
DMDMi121756.

Proteomic databases

EPDiP11168.
MaxQBiP11168.
PaxDbiP11168.
PeptideAtlasiP11168.
PRIDEiP11168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314251; ENSP00000323568; ENSG00000163581. [P11168-1]
GeneIDi6514.
KEGGihsa:6514.
UCSCiuc003fhe.2. human. [P11168-1]

Organism-specific databases

CTDi6514.
DisGeNETi6514.
GeneCardsiSLC2A2.
HGNCiHGNC:11006. SLC2A2.
HPAiCAB010444.
HPA028997.
MalaCardsiSLC2A2.
MIMi138160. gene.
227810. phenotype.
neXtProtiNX_P11168.
OpenTargetsiENSG00000163581.
Orphaneti2088. Glycogen storage disease due to GLUT2 deficiency.
PharmGKBiPA35876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP11168.
KOiK07593.
OMAiYDLWHIL.
OrthoDBiEOG091G0A9K.
PhylomeDBiP11168.
TreeFamiTF313762.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163581-MONOMER.
ReactomeiR-HSA-189200. Hexose transport.
R-HSA-210745. Regulation of gene expression in beta cells.
R-HSA-422356. Regulation of insulin secretion.
R-HSA-428790. Facilitative Na+-independent glucose transporters.
R-HSA-70153. Glucose transport.
SIGNORiP11168.

Miscellaneous databases

GenomeRNAii6514.
PROiP11168.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163581.
CleanExiHS_SLC2A2.
ExpressionAtlasiP11168. baseline and differential.
GenevisibleiP11168. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR2_HUMAN
AccessioniPrimary (citable) accession number: P11168
Secondary accession number(s): A8K481
, B2R936, B7Z547, F8W8V8, Q9UCW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.