Solute carrier family 2, facilitated glucose transporter member 2

Names and origin

Protein names

Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
    Glucose transporter type 2, liver
      Short name=GLUT-2

Gene names

Name:	SLC2A2
Synonyms:	GLUT2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na⁺/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Liver, insulin-producing beta cell, small intestine and kidney.
Post-translational modification	N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells By similarity.
Involvement in disease	Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS) [MIM:227810]. FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. Ref.7 Ref.8
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

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Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Ref.6 Traceable author statement. Source: ProtInc glucose transport Ref.6 Traceable author statement. Source: ProtInc transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Ref.6 Traceable author statement. Source: ProtInc membrane fraction Ref.6 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 524

524

Solute carrier family 2, facilitated glucose transporter member 2

PRO_0000050346

Regions

Topological domain

1 – 10

10

Cytoplasmic Potential

Transmembrane

11 – 31

21

1 Potential

Topological domain

32 – 98

67

Extracellular Potential

Transmembrane

99 – 119

21

2 Potential

Topological domain

120 – 127

8

Cytoplasmic Potential

Transmembrane

128 – 148

21

3 Potential

Topological domain

149 – 158

10

Extracellular Potential

Transmembrane

159 – 179

21

4 Potential

Topological domain

180 – 187

8

Cytoplasmic Potential

Transmembrane

188 – 208

21

5 Potential

Topological domain

209 – 217

9

Extracellular Potential

Transmembrane

218 – 238

21

6 Potential

Topological domain

239 – 303

65

Cytoplasmic Potential

Transmembrane

304 – 324

21

7 Potential

Topological domain

325 – 338

14

Extracellular Potential

Transmembrane

339 – 359

21

8 Potential

Topological domain

360 – 368

9

Cytoplasmic Potential

Transmembrane

369 – 389

21

9 Potential

Topological domain

390 – 400

11

Extracellular Potential

Transmembrane

401 – 421

21

10 Potential

Topological domain

422 – 433

12

Cytoplasmic Potential

Transmembrane

434 – 454

21

11 Potential

Topological domain

455 – 461

7

Extracellular Potential

Transmembrane

462 – 482

21

12 Potential

Topological domain

483 – 524

42

Cytoplasmic Potential

Amino acid modifications

Glycosylation

62

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

68

1

P → L: dbSNP rs7637863. Ref.1 Ref.4

VAR_007169

Natural variant

101

1

V → I: dbSNP rs1800572.

VAR_014718

Natural variant

110

1

T → I: dbSNP rs5400. Ref.4 Ref.5 Ref.6

VAR_014719

Natural variant

197

1

V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. Ref.5 Ref.6

VAR_018650

Natural variant

389

1

L → P in FBS. Ref.8

VAR_018651

Natural variant

404

1

I → T: dbSNP rs2229608.

VAR_052501

Natural variant

417

1

P → L in FBS. Ref.7

VAR_018652

Natural variant

423

1

V → E in FBS. dbSNP rs28928874. Ref.8

VAR_018653

Natural variant

478

1

L → V: dbSNP rs5397.

VAR_014720

Experimental info

Sequence conflict

183

1

A → S in BAF83535. Ref.2

Sequence conflict

374

1

S → N in BAF83535. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

P11168-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: DA600577207EC083
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FASTA

524

57,490

        10         20         30         40         50         60 
MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL DDRKAINNYV 

        70         80         90        100        110        120 
INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS VSSFAVGGMT ASFFGGWLGD 

       130        140        150        160        170        180 
TLGRIKAMLV ANILSLVGAL LMGFSKLGPS HILIIAGRSI SGLYCGLISG LVPMYIGEIA 

       190        200        210        220        230        240 
PTALRGALGT FHQLAIVTGI LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP 

       250        260        270        280        290        300 
ESPRYLYIKL DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 

       310        320        330        340        350        360 
RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM VFTAVSVFLV 

       370        380        390        400        410        420 
EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS MIAIFLFVSF FEIGPGPIPW 

       430        440        450        460        470        480 
FMVAEFFSQG PRPAALAIAA FSNWTCNFIV ALCFQYIADF CGPYVFFLFA GVLLAFTLFT 

       490        500        510        520 
FFKVPETKGK SFEEIAAEFQ KKSGSAHRPK AAVEMKFLGA TETV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein." Fukumoto H., Seino S., Imura H., Sieno Y., Eddy R.L., Fukushima Y., Byers M.G., Shows T.B., Bell G.I. Proc. Natl. Acad. Sci. U.S.A. 85:5434-5438(1988) [PubMed: 3399500] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-68. Tissue: Kidney and Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus." Matsubara A., Tanizawa Y., Matsutani A., Kaneko T., Kaku K. J. Clin. Endocrinol. Metab. 80:3131-3135(1995) [PubMed: 7593414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-100, VARIANTS LEU-68 AND ILE-110. Tissue: Peripheral blood.
[5]	"Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients." Tanizawa Y., Riggs A.C., Chiu K.C., Janssen R.C., Bell D.S.H., Go R.P.C., Roseman J.M., Acton R.T., Permutt M.A. Diabetologia 37:420-427(1994) [PubMed: 8063045] [Abstract] Cited for: VARIANT NIDDM ILE-197, VARIANT ILE-110.
[6]	"A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity." Mueckler M., Kruse M., Strube M., Riggs A.C., Chiu K.C., Permutt M.A. J. Biol. Chem. 269:17765-17767(1994) [PubMed: 8027028] [Abstract] Cited for: CHARACTERIZATION OF VARIANT NIDDM ILE-197, CHARACTERIZATION OF VARIANT ILE-110.
[7]	"A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity." Burwinkel B., Sanjad S.A., Al-Sabban E., Al-Abbad A., Kilimann M.W. Hum. Genet. 105:240-243(1999) [PubMed: 10987651] [Abstract] Cited for: VARIANT FBS LEU-417.
[8]	"Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome." Sakamoto O., Ogawa E., Ohura T., Igarashi Y., Matsubara Y., Narisawa K., Iinuma K. Pediatr. Res. 48:586-589(2000) [PubMed: 11044475] [Abstract] Cited for: VARIANTS FBS PRO-389 AND GLU-423.
+	Additional computationally mapped references.

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Web resources

GeneReviews

Wikipedia

GLUT2 entry

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Cross-references

Sequence databases
EMBL GenBank DDBJ	J03810 mRNA. Translation: AAA59514.1. AK290846 mRNA. Translation: BAF83535.1. AK313622 mRNA. Translation: BAG36383.1. CH471052 Genomic DNA. Translation: EAW78499.1.
IPI	IPI00003905.
PIR	A31318.
RefSeq	NP_000331.1.
UniGene	Hs.167584
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P11168.
Protein family/group databases
TCDB	2.A.1.1.29. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	P11168.
Proteomic databases
PRIDE	P11168.
Genome annotation databases
Ensembl	ENST00000314251; ENSP00000323568; ENSG00000163581; Homo sapiens. [Genome view]
GeneID	6514.
KEGG	hsa:6514.
UCSC	uc003fhe.1. human.
Organism-specific databases
CTD	6514.
GeneCards	GC03M172196.
H-InvDB	HIX0030837.
HGNC	HGNC:11006. SLC2A2.
HPA	CAB010444.
MIM	138160. gene. 227810. phenotype.
Orphanet	2088. Bickel-Fanconi glycogenosis.
PharmGKB	PA35876.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04098.
HOGENOM	HBG744444.
HOVERGEN	P11168.
InParanoid	P11168.
OrthoDB	EOG9F4VWG.
PhylomeDB	P11168.
Enzyme and pathway databases
Pathway_Interaction_DB	hnf3bpathway. FOXA2 and FOXA3 transcription factor networks.
Reactome	REACT_13698. Regulation of beta-cell development. REACT_1505. Integration of energy metabolism. REACT_15380. Diabetes pathways. REACT_15518. Transmembrane transport of small molecules. REACT_474. Metabolism of carbohydrates. REACT_602. Metabolism of lipids and lipoproteins.
Gene expression databases
ArrayExpress	P11168.
Bgee	P11168.
CleanEx	HS_SLC2A2.
Genevestigator	P11168.
GermOnline	ENSG00000163581. Homo sapiens.
Family and domain databases
InterPro	IPR002440. Glc_transpt_2. IPR016196. MFS_general_subst_transpt. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
PRINTS	PR01191. GLUCTRSPORT2. PR00171. SUGRTRNSPORT.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25331.
SOURCE	Search...

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Entry information

Entry name

GTR2_HUMAN

Accession

Primary (citable) accession number: P11168
Secondary accession number(s): A8K481, B2R936, Q9UCW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	February 9, 2010
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents