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Protein

Solute carrier family 2, facilitated glucose transporter member 1

Gene

Slc2a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei317MonosaccharideBy similarity1
Binding sitei388MonosaccharideBy similarity1

GO - Molecular functioni

  • dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
  • D-glucose transmembrane transporter activity Source: UniProtKB
  • glucose transmembrane transporter activity Source: RGD
  • identical protein binding Source: Ensembl
  • kinase binding Source: RGD
  • protein self-association Source: UniProtKB
  • xenobiotic transmembrane transporter activity Source: RGD

GO - Biological processi

  • cellular hyperosmotic response Source: RGD
  • cellular response to glucose starvation Source: Ensembl
  • cellular response to mechanical stimulus Source: RGD
  • cerebral cortex development Source: RGD
  • dehydroascorbic acid transport Source: UniProtKB
  • female pregnancy Source: RGD
  • glucose transmembrane transport Source: UniProtKB
  • protein-containing complex assembly Source: UniProtKB
  • response to insulin Source: RGD
  • response to osmotic stress Source: RGD
  • response to Thyroglobulin triiodothyronine Source: RGD
  • xenobiotic transport Source: RGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-189200 Cellular hexose transport
R-RNO-196836 Vitamin C (ascorbate) metabolism
R-RNO-422356 Regulation of insulin secretion
R-RNO-5653890 Lactose synthesis
SABIO-RKiP11167

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 1
Alternative name(s):
Glucose transporter type 1, erythrocyte/brain
Short name:
GLUT-1
Gene namesi
Name:Slc2a1
Synonyms:Glut-1, Glut1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3704 Slc2a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicBy similarityAdd BLAST11
Transmembranei12 – 33Helical; Name=1By similarityAdd BLAST22
Topological domaini34 – 66ExtracellularBy similarityAdd BLAST33
Transmembranei67 – 87Helical; Name=2By similarityAdd BLAST21
Topological domaini88 – 90CytoplasmicBy similarity3
Transmembranei91 – 112Helical; Name=3By similarityAdd BLAST22
Topological domaini113 – 120ExtracellularBy similarity8
Transmembranei121 – 144Helical; Name=4By similarityAdd BLAST24
Topological domaini145 – 155CytoplasmicBy similarityAdd BLAST11
Transmembranei156 – 176Helical; Name=5By similarityAdd BLAST21
Topological domaini177 – 185ExtracellularBy similarity9
Transmembranei186 – 206Helical; Name=6By similarityAdd BLAST21
Topological domaini207 – 271CytoplasmicBy similarityAdd BLAST65
Transmembranei272 – 293Helical; Name=7By similarityAdd BLAST22
Topological domaini294 – 306ExtracellularBy similarityAdd BLAST13
Transmembranei307 – 328Helical; Name=8By similarityAdd BLAST22
Topological domaini329 – 334CytoplasmicBy similarity6
Transmembranei335 – 355Helical; Name=9By similarityAdd BLAST21
Topological domaini356 – 365ExtracellularBy similarity10
Transmembranei366 – 388Helical; Name=10By similarityAdd BLAST23
Topological domaini389 – 401CytoplasmicBy similarityAdd BLAST13
Transmembranei402 – 422Helical; Name=11By similarityAdd BLAST21
Topological domaini423 – 429ExtracellularBy similarity7
Transmembranei430 – 450Helical; Name=12By similarityAdd BLAST21
Topological domaini451 – 492CytoplasmicBy similarityAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5214

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503421 – 492Solute carrier family 2, facilitated glucose transporter member 1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei465PhosphoserineBy similarity1
Modified residuei478PhosphothreonineCombined sources1
Modified residuei490PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP11167
PRIDEiP11167

PTM databases

iPTMnetiP11167
PhosphoSitePlusiP11167
SwissPalmiP11167

Expressioni

Tissue specificityi

Detected in osteoblastic cells (at protein level). Detected in brain, and at lower levels in kidney, heart and lung.4 Publications

Gene expression databases

BgeeiENSRNOG00000007284
ExpressionAtlasiP11167 baseline and differential
GenevisibleiP11167 RN

Interactioni

Subunit structurei

Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with STOM (By similarity). Interacts with GIPC (via PDZ domain) (PubMed:10198040). Interacts with SGTA (via Gln-rich region) (PubMed:15708368).By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: Ensembl
  • kinase binding Source: RGD
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi246902, 1 interactor
ComplexPortaliCPX-3113 Glucose transporter complex 1
STRINGi10116.ENSRNOP00000061340

Chemistry databases

BindingDBiP11167

Structurei

3D structure databases

ProteinModelPortaliP11167
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni282 – 288Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP11167
KOiK07299
OMAiAFAMFYI
OrthoDBiEOG091G0A9K
PhylomeDBiP11167
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002439 Glu_transpt_1
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01190 GLUCTRSPORT1
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P11167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSSKKVTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWNH
60 70 80 90 100
RYGESIPSTT LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN
110 120 130 140 150
LLAFVSAVLM GFSKLGKSFE MLILGRFIIG VYCGLTTGFV PMYVGEVSPT
160 170 180 190 200
ALRGALGTLH QLGIVVGILI AQVFGLDSIM GNADLWPLLL SVIFIPALLQ
210 220 230 240 250
CILLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTRD LQEMKEEGRQ
260 270 280 290 300
MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK
310 320 330 340 350
AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAVL
360 370 380 390 400
MTIALALLEQ LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR
410 420 430 440 450
PAAVAVAGFS NWTSNFIVGM CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF
460 470 480 490
KVPETKGRTF DEIASGFRQG GASQSDKTPE ELFHPLGADS QV
Length:492
Mass (Da):53,963
Last modified:July 1, 1989 - v1
Checksum:i05719AB061D0F67C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13979 mRNA Translation: AAA41248.1
M22063, M22061, M22062 Genomic DNA Translation: AAA41297.1
BC061873 mRNA Translation: AAH61873.1
PIRiA25949
RefSeqiNP_620182.1, NM_138827.1
UniGeneiRn.3205

Genome annotation databases

EnsembliENSRNOT00000064452; ENSRNOP00000061340; ENSRNOG00000007284
GeneIDi24778
KEGGirno:24778

Similar proteinsi

Entry informationi

Entry nameiGTR1_RAT
AccessioniPrimary (citable) accession number: P11167
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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