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P11156

- RIR2_BPT4

UniProt

P11156 - RIR2_BPT4

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

NRDB

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Iron 1PROSITE-ProRule annotation
    Metal bindingi115 – 1151Iron 1PROSITE-ProRule annotation
    Metal bindingi115 – 1151Iron 2By similarity
    Metal bindingi118 – 1181Iron 1PROSITE-ProRule annotation
    Active sitei122 – 1221PROSITE-ProRule annotation
    Metal bindingi212 – 2121Iron 2By similarity
    Metal bindingi247 – 2471Iron 2By similarity
    Metal bindingi250 – 2501Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Protein B2
    Ribonucleotide reductase
    Gene namesi
    Name:NRDB
    OrganismiEnterobacteria phage T4 (Bacteriophage T4)
    Taxonomic identifieri10665 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
    Virus hostiEscherichia coli [TaxID: 562]
    ProteomesiUP000009087: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Ribonucleoside-diphosphate reductase subunit betaPRO_0000190490Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliP11156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11156-1 [UniParc]FASTAAdd to Basket

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    MSTVFNTNPV DVLNEPMFFG SGLGLARYDI QRHRVFEELI ERQISFFWRP    50
    EEVNLMMDAA QFNKLPQYQQ NIFTNNLKYQ SLLDSIQGRA PSAVLMSLIS 100
    DPSLDTWVAT WTFSETIHSR SYTHIMRNLY TDPSKVFDEI VLDEAIMKRA 150
    ESIGRYYDDV LVKTREWENA KDMVEYYKDQ GLILADKDVE QRAKRDLMKS 200
    LYLCLHVINA LEAIRFYVSF ACTFNFHKNM EIMEGNAKIM KFIARDEQLH 250
    LKGTQYIIRQ LQSGTDGDEW VKIAQECEQE AVDIFMEVNR QEKDWAVHLF 300
    KDGDVPGLNT NSMWSFIDYL TVSRMKQCGL PCPITDAPVK HPYPWIREYL 350
    NSDNVQSAPQ EVELSSYLVA QIDNDVDDKV MMSFKKYF 388
    Length:388
    Mass (Da):45,354
    Last modified:November 1, 1995 - v2
    Checksum:iE08F021DEF7DFB30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04140 Genomic DNA. Translation: CAA27757.1.
    AF158101 Genomic DNA. Translation: AAD42624.1.
    PIRiS07190. RDBP24.
    RefSeqiNP_049841.1. NC_000866.4.

    Genome annotation databases

    GeneIDi1258601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04140 Genomic DNA. Translation: CAA27757.1 .
    AF158101 Genomic DNA. Translation: AAD42624.1 .
    PIRi S07190. RDBP24.
    RefSeqi NP_049841.1. NC_000866.4.

    3D structure databases

    ProteinModelPortali P11156.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1258601.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The bacteriophage T4 gene for the small subunit of ribonucleotide reductase contains an intron."
      Sjoeberg B.-M., Hahne S., Mathews C.Z., Mathews C.K., Rand K.N., Gait M.J.
      EMBO J. 5:2031-2036(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR2_BPT4
    AccessioniPrimary (citable) accession number: P11156
    Secondary accession number(s): Q96211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3