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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

NRDB

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Iron 1PROSITE-ProRule annotation1
Metal bindingi115Iron 1PROSITE-ProRule annotation1
Metal bindingi115Iron 2By similarity1
Metal bindingi118Iron 1PROSITE-ProRule annotation1
Active sitei122PROSITE-ProRule annotation1
Metal bindingi212Iron 2By similarity1
Metal bindingi247Iron 2By similarity1
Metal bindingi250Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Protein B2
Ribonucleotide reductase
Gene namesi
Name:NRDB
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904901 – 388Ribonucleoside-diphosphate reductase subunit betaAdd BLAST388

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Structurei

3D structure databases

ProteinModelPortaliP11156
SMRiP11156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000AF

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR012348 RNR-like
IPR033909 RNR_small
IPR030475 RNR_small_AS
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00368 RIBORED_SMALL, 1 hit

Sequencei

Sequence statusi: Complete.

P11156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVFNTNPV DVLNEPMFFG SGLGLARYDI QRHRVFEELI ERQISFFWRP
60 70 80 90 100
EEVNLMMDAA QFNKLPQYQQ NIFTNNLKYQ SLLDSIQGRA PSAVLMSLIS
110 120 130 140 150
DPSLDTWVAT WTFSETIHSR SYTHIMRNLY TDPSKVFDEI VLDEAIMKRA
160 170 180 190 200
ESIGRYYDDV LVKTREWENA KDMVEYYKDQ GLILADKDVE QRAKRDLMKS
210 220 230 240 250
LYLCLHVINA LEAIRFYVSF ACTFNFHKNM EIMEGNAKIM KFIARDEQLH
260 270 280 290 300
LKGTQYIIRQ LQSGTDGDEW VKIAQECEQE AVDIFMEVNR QEKDWAVHLF
310 320 330 340 350
KDGDVPGLNT NSMWSFIDYL TVSRMKQCGL PCPITDAPVK HPYPWIREYL
360 370 380
NSDNVQSAPQ EVELSSYLVA QIDNDVDDKV MMSFKKYF
Length:388
Mass (Da):45,354
Last modified:November 1, 1995 - v2
Checksum:iE08F021DEF7DFB30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04140 Genomic DNA Translation: CAA27757.1
AF158101 Genomic DNA Translation: AAD42624.1
PIRiS07190 RDBP24
RefSeqiNP_049841.1, NC_000866.4

Genome annotation databases

GeneIDi1258601
KEGGivg:1258601

Similar proteinsi

Entry informationi

Entry nameiRIR2_BPT4
AccessioniPrimary (citable) accession number: P11156
Secondary accession number(s): Q96211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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