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P11156

- RIR2_BPT4

UniProt

P11156 - RIR2_BPT4

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

NRDB

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Iron 1PROSITE-ProRule annotation
Metal bindingi115 – 1151Iron 1PROSITE-ProRule annotation
Metal bindingi115 – 1151Iron 2By similarity
Metal bindingi118 – 1181Iron 1PROSITE-ProRule annotation
Active sitei122 – 1221PROSITE-ProRule annotation
Metal bindingi212 – 2121Iron 2By similarity
Metal bindingi247 – 2471Iron 2By similarity
Metal bindingi250 – 2501Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Protein B2
Ribonucleotide reductase
Gene namesi
Name:NRDB
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000009087: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Ribonucleoside-diphosphate reductase subunit betaPRO_0000190490Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Structurei

3D structure databases

ProteinModelPortaliP11156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11156-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVFNTNPV DVLNEPMFFG SGLGLARYDI QRHRVFEELI ERQISFFWRP
60 70 80 90 100
EEVNLMMDAA QFNKLPQYQQ NIFTNNLKYQ SLLDSIQGRA PSAVLMSLIS
110 120 130 140 150
DPSLDTWVAT WTFSETIHSR SYTHIMRNLY TDPSKVFDEI VLDEAIMKRA
160 170 180 190 200
ESIGRYYDDV LVKTREWENA KDMVEYYKDQ GLILADKDVE QRAKRDLMKS
210 220 230 240 250
LYLCLHVINA LEAIRFYVSF ACTFNFHKNM EIMEGNAKIM KFIARDEQLH
260 270 280 290 300
LKGTQYIIRQ LQSGTDGDEW VKIAQECEQE AVDIFMEVNR QEKDWAVHLF
310 320 330 340 350
KDGDVPGLNT NSMWSFIDYL TVSRMKQCGL PCPITDAPVK HPYPWIREYL
360 370 380
NSDNVQSAPQ EVELSSYLVA QIDNDVDDKV MMSFKKYF
Length:388
Mass (Da):45,354
Last modified:November 1, 1995 - v2
Checksum:iE08F021DEF7DFB30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04140 Genomic DNA. Translation: CAA27757.1.
AF158101 Genomic DNA. Translation: AAD42624.1.
PIRiS07190. RDBP24.
RefSeqiNP_049841.1. NC_000866.4.

Genome annotation databases

GeneIDi1258601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04140 Genomic DNA. Translation: CAA27757.1 .
AF158101 Genomic DNA. Translation: AAD42624.1 .
PIRi S07190. RDBP24.
RefSeqi NP_049841.1. NC_000866.4.

3D structure databases

ProteinModelPortali P11156.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1258601.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 2 hits.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The bacteriophage T4 gene for the small subunit of ribonucleotide reductase contains an intron."
    Sjoeberg B.-M., Hahne S., Mathews C.Z., Mathews C.K., Rand K.N., Gait M.J.
    EMBO J. 5:2031-2036(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_BPT4
AccessioniPrimary (citable) accession number: P11156
Secondary accession number(s): Q96211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3