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P11156 (RIR2_BPT4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Protein B2
Ribonucleotide reductase
Gene names
Name:NRDB
OrganismEnterobacteria phage T4 (Bacteriophage T4) [Reference proteome]
Taxonomic identifier10665 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190490

Sites

Active site1221 By similarity
Metal binding841Iron 1 By similarity
Metal binding1151Iron 1 By similarity
Metal binding1151Iron 2 By similarity
Metal binding1181Iron 1 By similarity
Metal binding2121Iron 2 By similarity
Metal binding2471Iron 2 By similarity
Metal binding2501Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P11156 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: E08F021DEF7DFB30

FASTA38845,354
        10         20         30         40         50         60 
MSTVFNTNPV DVLNEPMFFG SGLGLARYDI QRHRVFEELI ERQISFFWRP EEVNLMMDAA 

        70         80         90        100        110        120 
QFNKLPQYQQ NIFTNNLKYQ SLLDSIQGRA PSAVLMSLIS DPSLDTWVAT WTFSETIHSR 

       130        140        150        160        170        180 
SYTHIMRNLY TDPSKVFDEI VLDEAIMKRA ESIGRYYDDV LVKTREWENA KDMVEYYKDQ 

       190        200        210        220        230        240 
GLILADKDVE QRAKRDLMKS LYLCLHVINA LEAIRFYVSF ACTFNFHKNM EIMEGNAKIM 

       250        260        270        280        290        300 
KFIARDEQLH LKGTQYIIRQ LQSGTDGDEW VKIAQECEQE AVDIFMEVNR QEKDWAVHLF 

       310        320        330        340        350        360 
KDGDVPGLNT NSMWSFIDYL TVSRMKQCGL PCPITDAPVK HPYPWIREYL NSDNVQSAPQ 

       370        380 
EVELSSYLVA QIDNDVDDKV MMSFKKYF 

« Hide

References

« Hide 'large scale' references
[1]"The bacteriophage T4 gene for the small subunit of ribonucleotide reductase contains an intron."
Sjoeberg B.-M., Hahne S., Mathews C.Z., Mathews C.K., Rand K.N., Gait M.J.
EMBO J. 5:2031-2036(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Bacteriophage T4 genome."
Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.
Microbiol. Mol. Biol. Rev. 67:86-156(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04140 Genomic DNA. Translation: CAA27757.1.
AF158101 Genomic DNA. Translation: AAD42624.1.
PIRRDBP24. S07190.
RefSeqNP_049841.1. NC_000866.4.

3D structure databases

ProteinModelPortalP11156.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1258601.

Phylogenomic databases

ProtClustDBCLSP2343451.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_BPT4
AccessionPrimary (citable) accession number: P11156
Secondary accession number(s): Q96211
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: December 11, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways