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P11150

- LIPC_HUMAN

UniProt

P11150 - LIPC_HUMAN

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Protein

Hepatic triacylglycerol lipase

Gene
LIPC, HTGL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681Nucleophile By similarity
Active sitei194 – 1941Charge relay system By similarity
Active sitei279 – 2791Charge relay system By similarity

GO - Molecular functioni

  1. apolipoprotein binding Source: BHF-UCL
  2. heparin binding Source: UniProtKB-KW
  3. low-density lipoprotein particle binding Source: BHF-UCL
  4. phospholipase activity Source: BHF-UCL
  5. triglyceride lipase activity Source: BHF-UCL

GO - Biological processi

  1. cholesterol homeostasis Source: BHF-UCL
  2. cholesterol metabolic process Source: Ensembl
  3. chylomicron remnant clearance Source: BHF-UCL
  4. fatty acid biosynthetic process Source: BHF-UCL
  5. high-density lipoprotein particle remodeling Source: BHF-UCL
  6. intermediate-density lipoprotein particle remodeling Source: BHF-UCL
  7. low-density lipoprotein particle remodeling Source: BHF-UCL
  8. phosphatidylcholine catabolic process Source: BHF-UCL
  9. reverse cholesterol transport Source: BHF-UCL
  10. triglyceride catabolic process Source: BHF-UCL
  11. triglyceride homeostasis Source: BHF-UCL
  12. very-low-density lipoprotein particle remodeling Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
Gene namesi
Name:LIPC
Synonyms:HTGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:6619. LIPC.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
  2. high-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Hepatic lipase deficiency (HL deficiency) [MIM:614025]: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins.
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341V → VHYTVAV in HL deficiency.
VAR_004207
Natural varianti289 – 2891S → F in HL deficiency. 2 Publications
Corresponds to variant rs121912502 [ dbSNP | Ensembl ].
VAR_004209
Natural varianti405 – 4051T → M in HL deficiency. 2 Publications
Corresponds to variant rs28933094 [ dbSNP | Ensembl ].
VAR_004210

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi125853. phenotype.
612797. phenotype.
614025. phenotype.
Orphaneti140905. Hyperlipidemia due to hepatic triglyceride lipase deficiency.
PharmGKBiPA230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 499477Hepatic triacylglycerol lipasePRO_0000017769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi362 – 3621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP11150.
PRIDEiP11150.

PTM databases

PhosphoSiteiP11150.

Expressioni

Gene expression databases

ArrayExpressiP11150.
BgeeiP11150.
CleanExiHS_LIPC.
GenevestigatoriP11150.

Organism-specific databases

HPAiCAB016141.

Interactioni

Protein-protein interaction databases

BioGridi110178. 4 interactions.
IntActiP11150. 1 interaction.
STRINGi9606.ENSP00000299022.

Structurei

3D structure databases

ProteinModelPortaliP11150.
SMRiP11150. Positions 47-425.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini352 – 486135PLATAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni181 – 19313Heparin-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 PLAT domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG81747.
HOGENOMiHOG000038553.
HOVERGENiHBG002259.
InParanoidiP11150.
KOiK01046.
OrthoDBiEOG757CX5.
PhylomeDBiP11150.
TreeFamiTF324997.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11150-1 [UniParc]FASTAAdd to Basket

« Hide

MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT    50
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI 100
WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW 150
LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF 200
EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF 250
QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY 300
PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK 350
VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY 400
SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL 450
KTIRVKAGET QQRMTFCSEN TDDLLLRPTQ EKIFVKCEIK SKTSKRKIR 499
Length:499
Mass (Da):55,914
Last modified:January 11, 2011 - v3
Checksum:i1FC7567CAE3E514B
GO

Polymorphismi

Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIMi:612797].
Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIMi:125853].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951V → M.2 Publications
Corresponds to variant rs6078 [ dbSNP | Ensembl ].
VAR_004206
Natural varianti134 – 1341V → VHYTVAV in HL deficiency.
VAR_004207
Natural varianti215 – 2151N → S.6 Publications
Corresponds to variant rs6083 [ dbSNP | Ensembl ].
VAR_004208
Natural varianti289 – 2891S → F in HL deficiency. 2 Publications
Corresponds to variant rs121912502 [ dbSNP | Ensembl ].
VAR_004209
Natural varianti342 – 3421V → I.1 Publication
Corresponds to variant rs145811475 [ dbSNP | Ensembl ].
VAR_017024
Natural varianti356 – 3561F → L.8 Publications
Corresponds to variant rs3829462 [ dbSNP | Ensembl ].
VAR_017025
Natural varianti405 – 4051T → M in HL deficiency. 2 Publications
Corresponds to variant rs28933094 [ dbSNP | Ensembl ].
VAR_004210
Natural varianti409 – 4091D → A.1 Publication
Corresponds to variant rs142036980 [ dbSNP | Ensembl ].
VAR_017026
Natural varianti440 – 4401S → N.1 Publication
Corresponds to variant rs6079 [ dbSNP | Ensembl ].
VAR_014179

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti256 – 2561F → S in AAA61165. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83548 mRNA. Translation: BAA12014.1.
X07228 mRNA. Translation: CAA30188.1.
J03540 mRNA. Translation: AAA59520.1.
J03895 mRNA. Translation: AAA61165.1.
M29194
, M29186, M29187, M29188, M29189, M29190, M29191, M29192, M29193 Genomic DNA. Translation: AAB60702.1.
D83062 Genomic DNA. Translation: BAA11760.1.
M35433
, M35425, M35426, M35427, M35429, M35430, M35431, M35432 Genomic DNA. Translation: AAA59521.1.
AK292631 mRNA. Translation: BAF85320.1.
AK315306 mRNA. Translation: BAG37710.1.
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.
BC132825 mRNA. Translation: AAI32826.1.
BC136495 mRNA. Translation: AAI36496.1.
AF037404 Genomic DNA. Translation: AAC34206.1.
CCDSiCCDS10166.1.
PIRiA28997.
RefSeqiNP_000227.2. NM_000236.2.
XP_005254429.1. XM_005254372.1.
XP_006720564.1. XM_006720501.1.
UniGeneiHs.654472.

Genome annotation databases

EnsembliENST00000299022; ENSP00000299022; ENSG00000166035.
ENST00000356113; ENSP00000348425; ENSG00000166035.
GeneIDi3990.
KEGGihsa:3990.
UCSCiuc002afa.2. human.

Polymorphism databases

DMDMi317373430.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83548 mRNA. Translation: BAA12014.1 .
X07228 mRNA. Translation: CAA30188.1 .
J03540 mRNA. Translation: AAA59520.1 .
J03895 mRNA. Translation: AAA61165.1 .
M29194
, M29186 , M29187 , M29188 , M29189 , M29190 , M29191 , M29192 , M29193 Genomic DNA. Translation: AAB60702.1 .
D83062 Genomic DNA. Translation: BAA11760.1 .
M35433
, M35425 , M35426 , M35427 , M35429 , M35430 , M35431 , M35432 Genomic DNA. Translation: AAA59521.1 .
AK292631 mRNA. Translation: BAF85320.1 .
AK315306 mRNA. Translation: BAG37710.1 .
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.
BC132825 mRNA. Translation: AAI32826.1 .
BC136495 mRNA. Translation: AAI36496.1 .
AF037404 Genomic DNA. Translation: AAC34206.1 .
CCDSi CCDS10166.1.
PIRi A28997.
RefSeqi NP_000227.2. NM_000236.2.
XP_005254429.1. XM_005254372.1.
XP_006720564.1. XM_006720501.1.
UniGenei Hs.654472.

3D structure databases

ProteinModelPortali P11150.
SMRi P11150. Positions 47-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110178. 4 interactions.
IntActi P11150. 1 interaction.
STRINGi 9606.ENSP00000299022.

Chemistry

BindingDBi P11150.
ChEMBLi CHEMBL2127.

PTM databases

PhosphoSitei P11150.

Polymorphism databases

DMDMi 317373430.

Proteomic databases

PaxDbi P11150.
PRIDEi P11150.

Protocols and materials databases

DNASUi 3990.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299022 ; ENSP00000299022 ; ENSG00000166035 .
ENST00000356113 ; ENSP00000348425 ; ENSG00000166035 .
GeneIDi 3990.
KEGGi hsa:3990.
UCSCi uc002afa.2. human.

Organism-specific databases

CTDi 3990.
GeneCardsi GC15P058702.
H-InvDB HIX0038150.
HGNCi HGNC:6619. LIPC.
HPAi CAB016141.
MIMi 125853. phenotype.
151670. gene.
612797. phenotype.
614025. phenotype.
neXtProti NX_P11150.
Orphaneti 140905. Hyperlipidemia due to hepatic triglyceride lipase deficiency.
PharmGKBi PA230.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81747.
HOGENOMi HOG000038553.
HOVERGENi HBG002259.
InParanoidi P11150.
KOi K01046.
OrthoDBi EOG757CX5.
PhylomeDBi P11150.
TreeFami TF324997.

Miscellaneous databases

ChiTaRSi LIPC. human.
GeneWikii Hepatic_lipase.
GenomeRNAii 3990.
NextBioi 15652.
PROi P11150.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11150.
Bgeei P11150.
CleanExi HS_LIPC.
Genevestigatori P11150.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
Pfami PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSi PR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line."
    Stahnke G., Sprengel R., Augustin J., Will H.
    Differentiation 35:45-52(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-215 AND LEU-356.
    Tissue: Liver.
  2. "Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase."
    Datta S., Luo C.C., Li W.H., VanTuinen P., Ledbetter D.H., Brown M.A., Chen S.H., Liu S., Chan L.
    J. Biol. Chem. 263:1107-1110(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-215 AND LEU-356.
    Tissue: Liver.
  3. "Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase."
    Martin G.A., Busch S.J., Meredith G.D., Cardin A.D., Blankenship D.T., Mao S.J.T., Rechtin A.E., Woods C.W., Racke M.M., Schafer M.P., Fitzgerald M.C., Burke D.M., Flanagan M.A., Jackson R.L.
    J. Biol. Chem. 263:10907-10914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT LEU-356.
    Tissue: Liver.
  4. "Structure of the human hepatic triglyceride lipase gene."
    Cai S.J., Wong D.M., Chen S.H., Chan L.
    Biochemistry 28:8966-8971(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-356.
  5. "Isolation and characterization of the human hepatic lipase gene."
    Ameis D., Stahnke G., Kobayashi J., McLean J., Lee G., Buscher M., Schotz M.C., Will H.
    J. Biol. Chem. 265:6552-6555(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-215 AND LEU-356.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-215 AND LEU-356.
    Tissue: Kidney and Thymus.
  7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-356.
  9. "18 bp insertion/duplication with internal missense mutation in human hepatic lipase gene exon 3."
    Tiebel O., Gehrisch S., Pietzsch J., Gromeier S., Jaross W.
    Hum. Mutat. 12:216-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 92-152, VARIANT HL DEFICIENCY HIS-TYR-THR-VAL-ALA-VAL-134 INS.
  10. "Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene."
    Takagi A., Ikeda Y., Mori A., Ashida Y., Yamamoto A.
    Mol. Cell. Probes 10:313-314(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 464-499.
  11. "The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish diabetes prevention study."
    Todorova B., Kubaszek A., Pihlajamaki J., Lindstrom J., Eriksson J., Valle T.T., Hamalainen H., Ilanne-Parikka P., Keinanen-Kiukaanniemi S., Tuomilehto J., Uusitupa M., Laakso M.
    J. Clin. Endocrinol. Metab. 89:2019-2023(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH NIDDM SUSCEPTIBILITY.
  12. "The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects."
    Grarup N., Andreasen C.H., Andersen M.K., Albrechtsen A., Sandbaek A., Lauritzen T., Borch-Johnsen K., Jorgensen T., Schmitz O., Hansen T., Pedersen O.
    J. Clin. Endocrinol. Metab. 93:2294-2299(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN HDLCQ12.
  13. "Human hepatic lipase mutations and polymorphisms."
    Hegele R.A., Tu L., Connelly P.W.
    Hum. Mutat. 1:320-324(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HL DEFICIENCY PHE-289 AND MET-405.
  14. "Genetic variants affecting human lipoprotein and hepatic lipases."
    Hayden M.R., Ma Y., Brunzell J., Henderson H.E.
    Curr. Opin. Lipidol. 2:104-109(1991)
    Cited for: REVIEW ON POLYMORPHISM.
  15. Cited for: VARIANTS MET-95; SER-215 AND ASN-440.
  16. "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
    Morabia A., Cayanis E., Costanza M.C., Ross B.M., Flaherty M.S., Alvin G.B., Das K., Gilliam T.C.
    Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MET-95; SER-215; PHE-289; ILE-342; LEU-356; MET-405 AND ALA-409.

Entry informationi

Entry nameiLIPC_HUMAN
AccessioniPrimary (citable) accession number: P11150
Secondary accession number(s): A2RUB4
, A8K9B6, O43571, P78529, Q99465
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 165 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi