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Protein

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168NucleophileBy similarity1
Active sitei194Charge relay systemPROSITE-ProRule annotation1
Active sitei279Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • apolipoprotein binding Source: BHF-UCL
  • heparin binding Source: UniProtKB-KW
  • low-density lipoprotein particle binding Source: BHF-UCL
  • phospholipase activity Source: BHF-UCL
  • triglyceride lipase activity Source: BHF-UCL

GO - Biological processi

  • cholesterol homeostasis Source: BHF-UCL
  • cholesterol metabolic process Source: Ensembl
  • chylomicron remnant clearance Source: BHF-UCL
  • fatty acid biosynthetic process Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • intermediate-density lipoprotein particle remodeling Source: BHF-UCL
  • lipid digestion Source: Reactome
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • phosphatidylcholine catabolic process Source: BHF-UCL
  • reverse cholesterol transport Source: BHF-UCL
  • triglyceride catabolic process Source: BHF-UCL
  • triglyceride homeostasis Source: BHF-UCL
  • very-low-density lipoprotein particle remodeling Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:HS09323-MONOMER.
ReactomeiR-HSA-174800. Chylomicron-mediated lipid transport.
R-HSA-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERihuman-LIPC. Hepatic_Lipase.

Chemistry databases

SwissLipidsiSLP:000000569.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
Gene namesi
Name:LIPC
Synonyms:HTGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:6619. LIPC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Hepatic lipase deficiency (HL deficiency)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins.
See also OMIM:614025
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004207134V → VHYTVAV in HL deficiency. 1 Publication1
Natural variantiVAR_004209289S → F in HL deficiency. 2 PublicationsCorresponds to variant rs121912502dbSNPEnsembl.1
Natural variantiVAR_004210405T → M in HL deficiency. 2 PublicationsCorresponds to variant rs113298164dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3990.
MalaCardsiLIPC.
MIMi125853. phenotype.
612797. phenotype.
614025. phenotype.
OpenTargetsiENSG00000166035.
Orphaneti140905. Hyperlipidemia due to hepatic triglyceride lipase deficiency.
PharmGKBiPA230.

Chemistry databases

ChEMBLiCHEMBL2127.

Polymorphism and mutation databases

BioMutaiLIPC.
DMDMi317373430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001776923 – 499Hepatic triacylglycerol lipaseAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP11150.
PeptideAtlasiP11150.
PRIDEiP11150.

PTM databases

iPTMnetiP11150.
PhosphoSitePlusiP11150.

Expressioni

Gene expression databases

BgeeiENSG00000166035.
CleanExiHS_LIPC.
ExpressionAtlasiP11150. baseline and differential.
GenevisibleiP11150. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110178. 6 interactors.
IntActiP11150. 1 interactor.
STRINGi9606.ENSP00000299022.

Chemistry databases

BindingDBiP11150.

Structurei

3D structure databases

ProteinModelPortaliP11150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 486PLATPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 193Heparin-bindingSequence analysisAdd BLAST13

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIHP. Eukaryota.
ENOG4110MCZ. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038553.
HOVERGENiHBG002259.
InParanoidiP11150.
KOiK01046.
OrthoDBiEOG091G052B.
PhylomeDBiP11150.
TreeFamiTF324997.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR002333. Lipase_hep.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 2 hits.
PTHR11610:SF2. PTHR11610:SF2. 2 hits.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT
60 70 80 90 100
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI
110 120 130 140 150
WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW
160 170 180 190 200
LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF
210 220 230 240 250
EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF
260 270 280 290 300
QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY
310 320 330 340 350
PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK
360 370 380 390 400
VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY
410 420 430 440 450
SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL
460 470 480 490
KTIRVKAGET QQRMTFCSEN TDDLLLRPTQ EKIFVKCEIK SKTSKRKIR
Length:499
Mass (Da):55,914
Last modified:January 11, 2011 - v3
Checksum:i1FC7567CAE3E514B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti256F → S in AAA61165 (PubMed:2828141).Curated1

Polymorphismi

Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIMi:612797].1 Publication
Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIMi:125853].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00420695V → M.2 PublicationsCorresponds to variant rs6078dbSNPEnsembl.1
Natural variantiVAR_004207134V → VHYTVAV in HL deficiency. 1 Publication1
Natural variantiVAR_004208215N → S.6 PublicationsCorresponds to variant rs6083dbSNPEnsembl.1
Natural variantiVAR_004209289S → F in HL deficiency. 2 PublicationsCorresponds to variant rs121912502dbSNPEnsembl.1
Natural variantiVAR_017024342V → I.1 PublicationCorresponds to variant rs145811475dbSNPEnsembl.1
Natural variantiVAR_017025356F → L.8 PublicationsCorresponds to variant rs3829462dbSNPEnsembl.1
Natural variantiVAR_004210405T → M in HL deficiency. 2 PublicationsCorresponds to variant rs113298164dbSNPEnsembl.1
Natural variantiVAR_017026409D → A.1 PublicationCorresponds to variant rs142036980dbSNPEnsembl.1
Natural variantiVAR_014179440S → N.1 PublicationCorresponds to variant rs6079dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83548 mRNA. Translation: BAA12014.1.
X07228 mRNA. Translation: CAA30188.1.
J03540 mRNA. Translation: AAA59520.1.
J03895 mRNA. Translation: AAA61165.1.
M29194
, M29186, M29187, M29188, M29189, M29190, M29191, M29192, M29193 Genomic DNA. Translation: AAB60702.1.
D83062 Genomic DNA. Translation: BAA11760.1.
M35433
, M35425, M35426, M35427, M35429, M35430, M35431, M35432 Genomic DNA. Translation: AAA59521.1.
AK292631 mRNA. Translation: BAF85320.1.
AK315306 mRNA. Translation: BAG37710.1.
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.
BC132825 mRNA. Translation: AAI32826.1.
BC136495 mRNA. Translation: AAI36496.1.
AF037404 Genomic DNA. Translation: AAC34206.1.
CCDSiCCDS10166.1.
PIRiA28997.
RefSeqiNP_000227.2. NM_000236.2.
XP_005254429.1. XM_005254372.1.
UniGeneiHs.654472.

Genome annotation databases

EnsembliENST00000299022; ENSP00000299022; ENSG00000166035.
ENST00000356113; ENSP00000348425; ENSG00000166035.
GeneIDi3990.
KEGGihsa:3990.
UCSCiuc002afa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83548 mRNA. Translation: BAA12014.1.
X07228 mRNA. Translation: CAA30188.1.
J03540 mRNA. Translation: AAA59520.1.
J03895 mRNA. Translation: AAA61165.1.
M29194
, M29186, M29187, M29188, M29189, M29190, M29191, M29192, M29193 Genomic DNA. Translation: AAB60702.1.
D83062 Genomic DNA. Translation: BAA11760.1.
M35433
, M35425, M35426, M35427, M35429, M35430, M35431, M35432 Genomic DNA. Translation: AAA59521.1.
AK292631 mRNA. Translation: BAF85320.1.
AK315306 mRNA. Translation: BAG37710.1.
AC018904 Genomic DNA. No translation available.
AC084781 Genomic DNA. No translation available.
BC132825 mRNA. Translation: AAI32826.1.
BC136495 mRNA. Translation: AAI36496.1.
AF037404 Genomic DNA. Translation: AAC34206.1.
CCDSiCCDS10166.1.
PIRiA28997.
RefSeqiNP_000227.2. NM_000236.2.
XP_005254429.1. XM_005254372.1.
UniGeneiHs.654472.

3D structure databases

ProteinModelPortaliP11150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110178. 6 interactors.
IntActiP11150. 1 interactor.
STRINGi9606.ENSP00000299022.

Chemistry databases

BindingDBiP11150.
ChEMBLiCHEMBL2127.
SwissLipidsiSLP:000000569.

Protein family/group databases

ESTHERihuman-LIPC. Hepatic_Lipase.

PTM databases

iPTMnetiP11150.
PhosphoSitePlusiP11150.

Polymorphism and mutation databases

BioMutaiLIPC.
DMDMi317373430.

Proteomic databases

PaxDbiP11150.
PeptideAtlasiP11150.
PRIDEiP11150.

Protocols and materials databases

DNASUi3990.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299022; ENSP00000299022; ENSG00000166035.
ENST00000356113; ENSP00000348425; ENSG00000166035.
GeneIDi3990.
KEGGihsa:3990.
UCSCiuc002afa.3. human.

Organism-specific databases

CTDi3990.
DisGeNETi3990.
GeneCardsiLIPC.
H-InvDBHIX0038150.
HGNCiHGNC:6619. LIPC.
MalaCardsiLIPC.
MIMi125853. phenotype.
151670. gene.
612797. phenotype.
614025. phenotype.
neXtProtiNX_P11150.
OpenTargetsiENSG00000166035.
Orphaneti140905. Hyperlipidemia due to hepatic triglyceride lipase deficiency.
PharmGKBiPA230.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIHP. Eukaryota.
ENOG4110MCZ. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038553.
HOVERGENiHBG002259.
InParanoidiP11150.
KOiK01046.
OrthoDBiEOG091G052B.
PhylomeDBiP11150.
TreeFamiTF324997.

Enzyme and pathway databases

BioCyciZFISH:HS09323-MONOMER.
ReactomeiR-HSA-174800. Chylomicron-mediated lipid transport.
R-HSA-192456. Digestion of dietary lipid.

Miscellaneous databases

ChiTaRSiLIPC. human.
GeneWikiiHepatic_lipase.
GenomeRNAii3990.
PROiP11150.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166035.
CleanExiHS_LIPC.
ExpressionAtlasiP11150. baseline and differential.
GenevisibleiP11150. HS.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR002333. Lipase_hep.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 2 hits.
PTHR11610:SF2. PTHR11610:SF2. 2 hits.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPC_HUMAN
AccessioniPrimary (citable) accession number: P11150
Secondary accession number(s): A2RUB4
, A8K9B6, O43571, P78529, Q99465
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 184 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.