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P11148

- COL_CHICK

UniProt

P11148 - COL_CHICK

Protein

Colipase

Gene

CLPS

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

    GO - Molecular functioni

    1. enzyme activator activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Biological processi

    Digestion, Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Colipase
    Gene namesi
    Name:CLPS
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›34›34ColipasePRO_0000144831Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi12 ↔ 23PROSITE-ProRule annotation
    Disulfide bondi18 ↔ 34PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP11148.

    Expressioni

    Tissue specificityi

    Expressed by the pancreas.

    Interactioni

    Subunit structurei

    Forms a 1:1 stoichiometric complex with pancreatic lipase.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000001320.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the colipase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG42456.
    HOGENOMiHOG000059253.
    InParanoidiP11148.

    Family and domain databases

    InterProiIPR001981. Colipase.
    IPR017913. Colipase_N.
    [Graphical view]
    PfamiPF01114. Colipase. 1 hit.
    [Graphical view]
    PROSITEiPS51342. COLIPASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P11148-1 [UniParc]FASTAAdd to Basket

    « Hide

    GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC                    34
    Length:34
    Mass (Da):3,591
    Last modified:December 1, 1992 - v2
    Checksum:i4A646B55FCB83BEB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence uncertaintyi12 – 121
    Non-terminal residuei34 – 341

    Sequence databases

    PIRiA05330.
    UniGeneiGga.6607.

    Cross-referencesi

    Sequence databases

    PIRi A05330.
    UniGenei Gga.6607.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000001320.

    Proteomic databases

    PaxDbi P11148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG42456.
    HOGENOMi HOG000059253.
    InParanoidi P11148.

    Family and domain databases

    InterProi IPR001981. Colipase.
    IPR017913. Colipase_N.
    [Graphical view ]
    Pfami PF01114. Colipase. 1 hit.
    [Graphical view ]
    PROSITEi PS51342. COLIPASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for the existence of procolipase in chicken pancreas and pancreatic juice."
      Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L.
      Biochimie 66:413-416(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Pancreas.
    2. "Isolation and partial structural characterization of chicken pancreatic colipase."
      Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G., Gregorie J., Rochat H., Sarda L.
      Biochim. Biophys. Acta 667:225-232(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiCOL_CHICK
    AccessioniPrimary (citable) accession number: P11148
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3