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Protein

Colipase

Gene

CLPS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448311 – ›34ColipaseAdd BLAST›34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi12 ↔ 23PROSITE-ProRule annotation
Disulfide bondi18 ↔ 34PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000059253.
InParanoidiP11148.

Family and domain databases

InterProiView protein in InterPro
IPR001981. Colipase.
IPR017913. Colipase_N.
PfamiView protein in Pfam
PF01114. Colipase. 1 hit.
PROSITEiView protein in PROSITE
PS51342. COLIPASE_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

P11148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC
Length:34
Mass (Da):3,591
Last modified:December 1, 1992 - v2
Checksum:i4A646B55FCB83BEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi121
Non-terminal residuei341

Sequence databases

PIRiA05330.
UniGeneiGga.6607.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOL_CHICK
AccessioniPrimary (citable) accession number: P11148
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: November 11, 2015
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families