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Protein

Colipase

Gene

CLPS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Digestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›34›34ColipasePRO_0000144831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ 23PROSITE-ProRule annotation
Disulfide bondi18 ↔ 34PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP11148.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001320.

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG42456.
HOGENOMiHOG000059253.
InParanoidiP11148.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017913. Colipase_N.
[Graphical view]
PfamiPF01114. Colipase. 1 hit.
[Graphical view]
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P11148-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC
Length:34
Mass (Da):3,591
Last modified:December 1, 1992 - v2
Checksum:i4A646B55FCB83BEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence uncertaintyi12 – 121
Non-terminal residuei34 – 341

Sequence databases

PIRiA05330.
UniGeneiGga.6607.

Cross-referencesi

Sequence databases

PIRiA05330.
UniGeneiGga.6607.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001320.

Proteomic databases

PaxDbiP11148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG42456.
HOGENOMiHOG000059253.
InParanoidiP11148.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017913. Colipase_N.
[Graphical view]
PfamiPF01114. Colipase. 1 hit.
[Graphical view]
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence for the existence of procolipase in chicken pancreas and pancreatic juice."
    Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L.
    Biochimie 66:413-416(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Pancreas.
  2. "Isolation and partial structural characterization of chicken pancreatic colipase."
    Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G., Gregorie J., Rochat H., Sarda L.
    Biochim. Biophys. Acta 667:225-232(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Pancreas.

Entry informationi

Entry nameiCOL_CHICK
AccessioniPrimary (citable) accession number: P11148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: February 4, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.