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P11148

- COL_CHICK

UniProt

P11148 - COL_CHICK

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Protein

Colipase

Gene
CLPS
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Digestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›34›34ColipasePRO_0000144831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ 23 By similarity
Disulfide bondi18 ↔ 34 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP11148.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001320.

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.

Phylogenomic databases

eggNOGiNOG42456.
HOGENOMiHOG000059253.
InParanoidiP11148.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017913. Colipase_N.
[Graphical view]
PfamiPF01114. Colipase. 1 hit.
[Graphical view]
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P11148-1 [UniParc]FASTAAdd to Basket

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GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC                    34
Length:34
Mass (Da):3,591
Last modified:December 1, 1992 - v2
Checksum:i4A646B55FCB83BEB
GO

Sequence uncertainty

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence uncertaintyi12 – 121

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei34 – 341

Sequence databases

PIRiA05330.
UniGeneiGga.6607.

Cross-referencesi

Sequence databases

PIRi A05330.
UniGenei Gga.6607.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000001320.

Proteomic databases

PaxDbi P11148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG42456.
HOGENOMi HOG000059253.
InParanoidi P11148.

Family and domain databases

InterProi IPR001981. Colipase.
IPR017913. Colipase_N.
[Graphical view ]
Pfami PF01114. Colipase. 1 hit.
[Graphical view ]
PROSITEi PS51342. COLIPASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence for the existence of procolipase in chicken pancreas and pancreatic juice."
    Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L.
    Biochimie 66:413-416(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Pancreas.
  2. "Isolation and partial structural characterization of chicken pancreatic colipase."
    Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G., Gregorie J., Rochat H., Sarda L.
    Biochim. Biophys. Acta 667:225-232(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Pancreas.

Entry informationi

Entry nameiCOL_CHICK
AccessioniPrimary (citable) accession number: P11148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3