P11148 (COL_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Colipase

Gene names

Name:

CLPS

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	34 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Subunit structure	Forms a 1:1 stoichiometric complex with pancreatic lipase.
Subcellular location	Secreted.
Tissue specificity	Expressed by the pancreas.
Sequence similarities	Belongs to the colipase family.

Ontologies

Keywords
Biological process	Digestion Lipid degradation
Cellular component	Secreted
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	digestion Inferred from electronic annotation. Source: UniProtKB-KW lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	enzyme activator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›34	›34	Colipase		PRO_0000144831
Amino acid modifications
	Disulfide bond	12 ↔ 23		By similarity
	Disulfide bond	18 ↔ 34		By similarity
Experimental info
	Sequence uncertainty	12	1
	Non-terminal residue	34	1

Sequences

	Sequence		Length	Mass (Da)
	P11148 [UniParc]. Last modified December 1, 1992. Version 2. Checksum: 4A646B55FCB83BEB	FASTA	34	3,591
	10 20 30 GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC

References

[1]	"Evidence for the existence of procolipase in chicken pancreas and pancreatic juice." Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L. Biochimie 66:413-416(1984) [PubMed: 6547861] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pancreas.
[2]	"Isolation and partial structural characterization of chicken pancreatic colipase." Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G., Gregorie J., Rochat H., Sarda L. Biochim. Biophys. Acta 667:225-232(1981) [PubMed: 7213802] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
IPI	IPI00814483.
PIR	A05330.
UniGene	Gga.6607.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P11148.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	veNOG21204.
GeneTree	ENSGT00390000012644.
HOGENOM	HBG125595.
InParanoid	P11148.
OrthoDB	EOG498V28.
Family and domain databases
InterPro	IPR001981. Colipase. IPR017913. Colipase_N. [Graphical view]
PANTHER	PTHR10041. PTHR10041. 1 hit.
Pfam	PF01114. Colipase. 1 hit. [Graphical view]
PROSITE	PS00121. COLIPASE_1. Partial match. PS51342. COLIPASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COL_CHICK

Accession

Primary (citable) accession number: P11148

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	December 1, 1992
Last modified:	October 19, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program