P11148 (COL_CHICK) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 67.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Colipase | ||
| Gene names |
| ||
| Organism | Gallus gallus (Chicken) [Reference proteome] | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 34 AA. |
| Sequence status | Fragment. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. |
| Subunit structure | Forms a 1:1 stoichiometric complex with pancreatic lipase. |
| Subcellular location | |
| Tissue specificity | Expressed by the pancreas. |
| Sequence similarities | Belongs to the colipase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Digestion Lipid degradation Lipid metabolism |
| Cellular component | Secreted |
| PTM | Disulfide bond |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | digestion Inferred from electronic annotation. Source: UniProtKB-KW lipid catabolic processInferred from electronic annotation. Source: UniProtKB-KW positive regulation of catalytic activityInferred from electronic annotation. Source: GOC |
| Cellular_component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | enzyme activator activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Evidence for the existence of procolipase in chicken pancreas and pancreatic juice." Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L. Biochimie 66:413-416(1984) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pancreas. |
| [2] | "Isolation and partial structural characterization of chicken pancreatic colipase." Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G., Gregorie J., Rochat H., Sarda L. Biochim. Biophys. Acta 667:225-232(1981) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pancreas. |
Cross-references
Sequence databases | |
|---|---|
| IPI | IPI00814483. |
| PIR | A05330. |
| UniGene | Gga.6607. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9031.ENSGALP00000001320. |
Proteomic databases | |
| PaxDb | P11148. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| eggNOG | NOG42456. |
| HOGENOM | HOG000059253. |
| InParanoid | P11148. |
| OrthoDB | EOG498V28. |
Family and domain databases | |
| InterPro | IPR001981. Colipase. IPR017913. Colipase_N. [Graphical view] |
| PANTHER | PTHR10041. PTHR10041. 1 hit. |
| Pfam | PF01114. Colipase. 1 hit. [Graphical view] |
| PROSITE | PS00121. COLIPASE_1. Partial match. PS51342. COLIPASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COL_CHICK | ||||||||
| Accession | Primary (citable) accession number: P11148 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |