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Protein

Colipase

Gene

CLPS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Digestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›34›34ColipasePRO_0000144831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ 23PROSITE-ProRule annotation
Disulfide bondi18 ↔ 34PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP11148.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG42456.
HOGENOMiHOG000059253.
InParanoidiP11148.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017913. Colipase_N.
[Graphical view]
PfamiPF01114. Colipase. 1 hit.
[Graphical view]
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P11148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC
Length:34
Mass (Da):3,591
Last modified:December 1, 1992 - v2
Checksum:i4A646B55FCB83BEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence uncertaintyi12 – 121
Non-terminal residuei34 – 341

Sequence databases

PIRiA05330.
UniGeneiGga.6607.

Cross-referencesi

Sequence databases

PIRiA05330.
UniGeneiGga.6607.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP11148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG42456.
HOGENOMiHOG000059253.
InParanoidiP11148.

Family and domain databases

InterProiIPR001981. Colipase.
IPR017913. Colipase_N.
[Graphical view]
PfamiPF01114. Colipase. 1 hit.
[Graphical view]
PROSITEiPS51342. COLIPASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence for the existence of procolipase in chicken pancreas and pancreatic juice."
    Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L.
    Biochimie 66:413-416(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Pancreas.
  2. "Isolation and partial structural characterization of chicken pancreatic colipase."
    Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G., Gregorie J., Rochat H., Sarda L.
    Biochim. Biophys. Acta 667:225-232(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Pancreas.

Entry informationi

Entry nameiCOL_CHICK
AccessioniPrimary (citable) accession number: P11148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: July 22, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.