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P11146 (HSP7B_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock 70 kDa protein cognate 2
Alternative name(s):
Heat shock 70 kDa protein 87D
Gene names
Name:Hsc70-2
Synonyms:Hsc2
ORF Names:CG7756
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Developmental stage

Heat shock cognate proteins are expressed constitutively during normal development.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   LigandATP-binding
Nucleotide-binding
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 633633Heat shock 70 kDa protein cognate 2
PRO_0000078339

Sequences

Sequence LengthMass (Da)Tools
P11146 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 851D3FBEDB227F08

FASTA63369,722
        10         20         30         40         50         60 
MGKIPAIGID LGTTYSCVGV WQNSKVEIIA NDQGNRTTPS YVAFNETERL IGDPAKNQVA 

        70         80         90        100        110        120 
MNAKNTVFDA KRLIGRKFDD KKIQEDLKLW PFKVINEKGK PKIEVEFKGE RKRFAPEEIS 

       130        140        150        160        170        180 
SMVLTKMREI AEVYLGGKVK DAVVTVPAYF NDSQRQATKD AGSIAGLNVL RIINEPTAAA 

       190        200        210        220        230        240 
LAYGLDKNLK GERNVLIFDL GGGTFDVSVL SIDEGSLFEV KATAGDTHLG GEDFDNRLVN 

       250        260        270        280        290        300 
HFAEEFKRKH KSDIKGNARA LRRLRTACER AKRTLSSSTE ASLEIDALHE GIDFYSKISR 

       310        320        330        340        350        360 
ARFEELNMDL FRSTMQPVER ALSDAKMDKK AIHDVVLVGG STRIPKIQKL LQDLFGGKQL 

       370        380        390        400        410        420 
NLSINPDEAV AYGAAVQAAI LTGVGSSQIQ DLLLVDVAPL SLGIETAGGV MTNLVERNAR 

       430        440        450        460        470        480 
IPCKQQQIFT TYSDNQNAVT IQVYEGERAM TKDNNLLGTF NLTGIPPAPR GVPQIEVAFD 

       490        500        510        520        530        540 
LNADGILNVN AKDNSTGKSE KITISNDKGR LSKAEIDRML SEAEKYKVED DRQRERVQSK 

       550        560        570        580        590        600 
NNLEAYIYAC RQAVDDAPSG VLSETERSKV RDKCSSEASW LDKNSLAEKE EFESHLKECQ 

       610        620        630 
RICTPIMSKI HGGKKGKSSM GKGSHPTVEE VDG

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Testis.
[4]"Expression of Drosophila heat-shock cognate genes during heat shock and development."
Craig E.A., Ingolia T.D., Manseau L.J.
Dev. Biol. 99:418-426(1983) [PubMed: 6311649] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014297 Genomic DNA. Translation: AAF54899.1.
BT016141 mRNA. Translation: AAV37026.1.
K01297, K01296 Genomic DNA. Translation: AAA28630.1.
RefSeqNP_524339.1. NM_079615.3.
UniGeneDm.2434.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B26X-ray3.20D626-632[»]
ProteinModelPortalP11146.
SMRP11146. Positions 3-617.
ModBaseSearch...

Protein-protein interaction databases

IntActP11146. 1 interaction.
STRINGP11146.

Proteomic databases

PRIDEP11146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0082707; FBpp0082175; FBgn0001217.
GeneID41609.
KEGGdme:Dmel_CG7756.

Organism-specific databases

CTD41609.
FlyBaseFBgn0001217. Hsc70-2.

Phylogenomic databases

eggNOGmeNOG13955.
GeneTreeEMGT00050000004323.
InParanoidP11146.
OMARIPCKQQ.
OrthoDBEOG4547DP.
PhylomeDBP11146.

Gene expression databases

ArrayExpressP11146.
BgeeP11146.
GermOnlineCG7756. Drosophila melanogaster.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR001023. Hsp70.
IPR013126. Hsp_70.
[Graphical view]
KOK03283.
PANTHERPTHR19375. Hsp70. 1 hit.
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio824632.

Entry information

Entry nameHSP7B_DROME
AccessionPrimary (citable) accession number: P11146
Secondary accession number(s): Q5U0V1, Q9VFZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 21, 2001
Last modified: January 25, 2012
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents