Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock 70 kDa protein cognate 2

Gene

Hsc70-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein cognate 2
Alternative name(s):
Heat shock 70 kDa protein 87D
Gene namesi
Name:Hsc70-2
Synonyms:Hsc2
ORF Names:CG7756
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001217. Hsc70-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783391 – 633Heat shock 70 kDa protein cognate 2Add BLAST633

Proteomic databases

PaxDbiP11146.
PRIDEiP11146.

Expressioni

Developmental stagei

Heat shock cognate proteins are expressed constitutively during normal development.

Gene expression databases

BgeeiFBgn0001217.
GenevisibleiP11146. DM.

Interactioni

Protein-protein interaction databases

BioGridi66696. 10 interactors.
IntActiP11146. 1 interactor.
STRINGi7227.FBpp0082175.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B26X-ray3.20D626-632[»]
ProteinModelPortaliP11146.
SMRiP11146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11146.

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
InParanoidiP11146.
KOiK03283.
OMAiYEHHLKD.
OrthoDBiEOG091G03SF.
PhylomeDBiP11146.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIPAIGID LGTTYSCVGV WQNSKVEIIA NDQGNRTTPS YVAFNETERL
60 70 80 90 100
IGDPAKNQVA MNAKNTVFDA KRLIGRKFDD KKIQEDLKLW PFKVINEKGK
110 120 130 140 150
PKIEVEFKGE RKRFAPEEIS SMVLTKMREI AEVYLGGKVK DAVVTVPAYF
160 170 180 190 200
NDSQRQATKD AGSIAGLNVL RIINEPTAAA LAYGLDKNLK GERNVLIFDL
210 220 230 240 250
GGGTFDVSVL SIDEGSLFEV KATAGDTHLG GEDFDNRLVN HFAEEFKRKH
260 270 280 290 300
KSDIKGNARA LRRLRTACER AKRTLSSSTE ASLEIDALHE GIDFYSKISR
310 320 330 340 350
ARFEELNMDL FRSTMQPVER ALSDAKMDKK AIHDVVLVGG STRIPKIQKL
360 370 380 390 400
LQDLFGGKQL NLSINPDEAV AYGAAVQAAI LTGVGSSQIQ DLLLVDVAPL
410 420 430 440 450
SLGIETAGGV MTNLVERNAR IPCKQQQIFT TYSDNQNAVT IQVYEGERAM
460 470 480 490 500
TKDNNLLGTF NLTGIPPAPR GVPQIEVAFD LNADGILNVN AKDNSTGKSE
510 520 530 540 550
KITISNDKGR LSKAEIDRML SEAEKYKVED DRQRERVQSK NNLEAYIYAC
560 570 580 590 600
RQAVDDAPSG VLSETERSKV RDKCSSEASW LDKNSLAEKE EFESHLKECQ
610 620 630
RICTPIMSKI HGGKKGKSSM GKGSHPTVEE VDG
Length:633
Mass (Da):69,722
Last modified:February 21, 2001 - v2
Checksum:i851D3FBEDB227F08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54899.1.
BT016141 mRNA. Translation: AAV37026.1.
K01297, K01296 Genomic DNA. Translation: AAA28630.1.
RefSeqiNP_524339.1. NM_079615.4.
UniGeneiDm.2434.

Genome annotation databases

EnsemblMetazoaiFBtr0082707; FBpp0082175; FBgn0001217.
GeneIDi41609.
KEGGidme:Dmel_CG7756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54899.1.
BT016141 mRNA. Translation: AAV37026.1.
K01297, K01296 Genomic DNA. Translation: AAA28630.1.
RefSeqiNP_524339.1. NM_079615.4.
UniGeneiDm.2434.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B26X-ray3.20D626-632[»]
ProteinModelPortaliP11146.
SMRiP11146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66696. 10 interactors.
IntActiP11146. 1 interactor.
STRINGi7227.FBpp0082175.

Proteomic databases

PaxDbiP11146.
PRIDEiP11146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082707; FBpp0082175; FBgn0001217.
GeneIDi41609.
KEGGidme:Dmel_CG7756.

Organism-specific databases

CTDi41609.
FlyBaseiFBgn0001217. Hsc70-2.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
InParanoidiP11146.
KOiK03283.
OMAiYEHHLKD.
OrthoDBiEOG091G03SF.
PhylomeDBiP11146.

Miscellaneous databases

ChiTaRSiHsc70-2. fly.
EvolutionaryTraceiP11146.
GenomeRNAii41609.
PROiP11146.

Gene expression databases

BgeeiFBgn0001217.
GenevisibleiP11146. DM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP7B_DROME
AccessioniPrimary (citable) accession number: P11146
Secondary accession number(s): Q5U0V1, Q9VFZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 21, 2001
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.