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Protein

Heat shock 70 kDa protein F, mitochondrial

Gene

hsp-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • mitochondrial unfolded protein response Source: WormBase
  • protein folding Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein F, mitochondrial
Gene namesi
Name:hsp-6
Synonyms:hsp70f
ORF Names:C37H5.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC37H5.8; CE08631; WBGene00002010; hsp-6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionSequence analysisAdd
BLAST
Chaini28 – 657630Heat shock 70 kDa protein F, mitochondrialPRO_0000013543Add
BLAST

Proteomic databases

EPDiP11141.
PaxDbiP11141.
PRIDEiP11141.

2D gel databases

World-2DPAGE0020:P11141.

Interactioni

Protein-protein interaction databases

BioGridi43923. 2 interactions.
IntActiP11141. 2 interactions.
STRINGi6239.C37H5.8.

Structurei

Secondary structure

1
657
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi424 – 4285Combined sources
Turni429 – 4313Combined sources
Beta strandi432 – 4376Combined sources
Beta strandi442 – 45514Combined sources
Beta strandi460 – 46910Combined sources
Helixi473 – 4753Combined sources
Beta strandi476 – 48510Combined sources
Beta strandi497 – 5037Combined sources
Beta strandi507 – 5159Combined sources
Turni516 – 5183Combined sources
Beta strandi521 – 5277Combined sources
Beta strandi529 – 5324Combined sources
Helixi534 – 55118Combined sources
Beta strandi557 – 5593Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DQGX-ray1.72A/B/C/D418-565[»]
ProteinModelPortaliP11141.
SMRiP11141. Positions 33-630.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11141.

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00800000124275.
HOGENOMiHOG000228135.
InParanoidiP11141.
KOiK04043.
OMAiKVYEKRS.
OrthoDBiEOG715Q3K.
PhylomeDBiP11141.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSARSFLSS ARTIARSSLM SARSLSDKPK GHVIGIDLGT TNSCVSIMEG
60 70 80 90 100
KTPKVIENAE GVRTTPSTVA FTADGERLVG APAKRQAVTN SANTLFATKR
110 120 130 140 150
LIGRRYEDPE VQKDLKVVPY KIVKASNGDA WVEAQGKVYS PSQVGAFVLM
160 170 180 190 200
KMKETAESYL GTTVNNAVVT VPAYFNDSQR QATKDAGQIS GLNVLRVINE
210 220 230 240 250
PTAAALAYGL DKDAGDKIIA VYDLGGGTFD VSILEIQKGV FEVKSTNGDT
260 270 280 290 300
FLGGEDFDHA LVHHLVGEFK KEQGVDLTKD PQAMQRLREA AEKAKCELSS
310 320 330 340 350
TTQTDINLPY ITMDQSGPKH LNLKLTRAKF EQIVGDLIKR TIEPCRKALH
360 370 380 390 400
DAEVKSSQIA DVLLVGGMSR MPKVQATVQE IFGKVPSKAV NPDEAVAMGA
410 420 430 440 450
AIQGAVLAGD VTDVLLLDVT PLSLGIETLG GIMTKLITRN TTIPTKKSQV
460 470 480 490 500
FSTAADGQTQ VQIKVFQGER EMATSNKLLG QFSLVGIPPA PRGVPQVEVT
510 520 530 540 550
FDIDANGIVN VSARDRGTGK EQQIVIQSSG GLSKDQIENM IKEAEKNAAE
560 570 580 590 600
DAKRKELVEV INQAEGIIHD TEAKMTEFAD QLPKDECEAL RTKIADTKKI
610 620 630 640 650
LDNKDNETPE AIKEACNTLQ QQSLKLFEAA YKNMAAKNSG GDAQEAKTAE

EPKKEQN
Length:657
Mass (Da):70,845
Last modified:July 15, 1998 - v2
Checksum:i637A1636B6ABB836
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381V → E in CAA30525 (PubMed:2766926).Curated
Sequence conflicti140 – 1401S → P in CAA30525 (PubMed:2766926).Curated
Sequence conflicti167 – 1671A → P in CAA30525 (PubMed:2766926).Curated
Sequence conflicti347 – 3482KA → NV in CAA30525 (PubMed:2766926).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080813 Genomic DNA. Translation: CCD66987.1.
X07678 Genomic DNA. Translation: CAA30525.1.
PIRiB32475.
T25613.
RefSeqiNP_504291.1. NM_071890.4.
UniGeneiCel.38712.

Genome annotation databases

EnsemblMetazoaiC37H5.8; C37H5.8; WBGene00002010.
GeneIDi178873.
KEGGicel:CELE_C37H5.8.
UCSCiC37H5.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080813 Genomic DNA. Translation: CCD66987.1.
X07678 Genomic DNA. Translation: CAA30525.1.
PIRiB32475.
T25613.
RefSeqiNP_504291.1. NM_071890.4.
UniGeneiCel.38712.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DQGX-ray1.72A/B/C/D418-565[»]
ProteinModelPortaliP11141.
SMRiP11141. Positions 33-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43923. 2 interactions.
IntActiP11141. 2 interactions.
STRINGi6239.C37H5.8.

2D gel databases

World-2DPAGE0020:P11141.

Proteomic databases

EPDiP11141.
PaxDbiP11141.
PRIDEiP11141.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC37H5.8; C37H5.8; WBGene00002010.
GeneIDi178873.
KEGGicel:CELE_C37H5.8.
UCSCiC37H5.8. c. elegans.

Organism-specific databases

CTDi178873.
WormBaseiC37H5.8; CE08631; WBGene00002010; hsp-6.

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00800000124275.
HOGENOMiHOG000228135.
InParanoidiP11141.
KOiK04043.
OMAiKVYEKRS.
OrthoDBiEOG715Q3K.
PhylomeDBiP11141.

Miscellaneous databases

EvolutionaryTraceiP11141.
NextBioi902922.
PROiP11141.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Characterization of the hsp70 multigene family of Caenorhabditis elegans."
    Heschl M.F.P., Baillie D.L.
    DNA 8:233-243(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-487.
    Strain: Bristol N2.

Entry informationi

Entry nameiHSP7F_CAEEL
AccessioniPrimary (citable) accession number: P11141
Secondary accession number(s): P91135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 15, 1998
Last modified: May 11, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.