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Protein

Tubulin alpha-1 chain

Gene

TUBA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Miscellaneous

There are six genes coding for alpha-tubulin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei450Involved in polymerization1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

  • microtubule-based process Source: TAIR

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-114608 Platelet degranulation
R-ATH-5617833 Cilium Assembly
R-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-ATH-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha-1 chain
Gene namesi
Name:TUBA1
Synonyms:TUA1
Ordered Locus Names:At1g64740
ORF Names:F13O11.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G64740
TAIRilocus:2010846 AT1G64740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000481361 – 450Tubulin alpha-1 chainAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphothreonineBy similarity1

Post-translational modificationi

Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP11139
PRIDEiP11139

PTM databases

iPTMnetiP11139

Expressioni

Gene expression databases

ExpressionAtlasiP11139 baseline and differential
GenevisibleiP11139 AT

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

BioGridi28003, 2 interactors
STRINGi3702.AT1G64740.1

Structurei

3D structure databases

ProteinModelPortaliP11139
SMRiP11139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1376 Eukaryota
COG5023 LUCA
HOGENOMiHOG000165711
InParanoidiP11139
KOiK07374
OMAiNQRECIS
OrthoDBiEOG0936135G
PhylomeDBiP11139

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR013838 Beta-tubulin_BS
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

P11139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIISIHIG QAGIQVGNSC WELYCLEHGI QPDGTMPSDS TVGACHDAFN
60 70 80 90 100
TFFSETSSGQ HVPRAVFLDL EPTVIDEVRT GTYRQLFHPE QLISGKEDAA
110 120 130 140 150
NNFARGHYTV GREIVDTCLE RLRKLADNCT GLQGFLVFNA VGGGTGSGLG
160 170 180 190 200
SLLLERLSVD FGKKSKLGFT IYPSPQVSTA VVEPYNSVLS THSLLEHTDV
210 220 230 240 250
VVLLDNEAIY DICRRSLDIE RPTYSNLNRL ISQTISSLTT SLRFDGAINV
260 270 280 290 300
DITEFQTNLV PYPRIHFMLS SYAPVISSAK AYHEQFSVPE ITTSVFEPSN
310 320 330 340 350
MMAKCDPRHG KYMACCLMYR GDVVPKDVNT AVAAIKAKRT IQFVDWCPTG
360 370 380 390 400
FKCGINYQPP SVVPGGDLAK VQRAVCMISN NTAVAEVFSR IDHKFDLMYS
410 420 430 440 450
KRAFVHWYVG EGMEEGEFSE AREDLAALEK DYEEVGGEGA EDDDEEGDEY
Length:450
Mass (Da):49,800
Last modified:July 1, 1989 - v1
Checksum:i08B11BA5CD3DB072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21414 Genomic DNA Translation: AAA32880.1
AC006193 Genomic DNA Translation: AAD38249.1
CP002684 Genomic DNA Translation: AEE34279.1
AY059728 mRNA Translation: AAL24085.1
AY091372 mRNA Translation: AAM14311.1
PIRiJA0062 UBMUAM
RefSeqiNP_176654.1, NM_105148.3
UniGeneiAt.27012
At.328

Genome annotation databases

EnsemblPlantsiAT1G64740.1; AT1G64740.1; AT1G64740
GeneIDi842782
GrameneiAT1G64740.1; AT1G64740.1; AT1G64740
KEGGiath:AT1G64740

Similar proteinsi

Entry informationi

Entry nameiTBA1_ARATH
AccessioniPrimary (citable) accession number: P11139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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