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Protein

Tubulin alpha-1 chain

Gene

TUBA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei450 – 4501Involved in polymerization

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1487GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • microtubule-based process Source: TAIR
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha-1 chain
Gene namesi
Name:TUBA1
Synonyms:TUA1
Ordered Locus Names:At1g64740
ORF Names:F13O11.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G64740.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • microtubule Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Tubulin alpha-1 chainPRO_0000048136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei349 – 3491PhosphothreonineBy similarity

Post-translational modificationi

Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP11139.
PRIDEiP11139.

PTM databases

iPTMnetiP11139.

Expressioni

Gene expression databases

GenevisibleiP11139. AT.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

BioGridi28003. 2 interactions.
STRINGi3702.AT1G64740.1.

Structurei

3D structure databases

ProteinModelPortaliP11139.
SMRiP11139. Positions 1-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1376. Eukaryota.
COG5023. LUCA.
HOGENOMiHOG000165711.
InParanoidiP11139.
KOiK07374.
OMAiRRMSDQC.
OrthoDBiEOG0936135G.
PhylomeDBiP11139.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002452. Alpha_tubulin.
IPR013838. Beta-tubulin_BS.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIISIHIG QAGIQVGNSC WELYCLEHGI QPDGTMPSDS TVGACHDAFN
60 70 80 90 100
TFFSETSSGQ HVPRAVFLDL EPTVIDEVRT GTYRQLFHPE QLISGKEDAA
110 120 130 140 150
NNFARGHYTV GREIVDTCLE RLRKLADNCT GLQGFLVFNA VGGGTGSGLG
160 170 180 190 200
SLLLERLSVD FGKKSKLGFT IYPSPQVSTA VVEPYNSVLS THSLLEHTDV
210 220 230 240 250
VVLLDNEAIY DICRRSLDIE RPTYSNLNRL ISQTISSLTT SLRFDGAINV
260 270 280 290 300
DITEFQTNLV PYPRIHFMLS SYAPVISSAK AYHEQFSVPE ITTSVFEPSN
310 320 330 340 350
MMAKCDPRHG KYMACCLMYR GDVVPKDVNT AVAAIKAKRT IQFVDWCPTG
360 370 380 390 400
FKCGINYQPP SVVPGGDLAK VQRAVCMISN NTAVAEVFSR IDHKFDLMYS
410 420 430 440 450
KRAFVHWYVG EGMEEGEFSE AREDLAALEK DYEEVGGEGA EDDDEEGDEY
Length:450
Mass (Da):49,800
Last modified:July 1, 1989 - v1
Checksum:i08B11BA5CD3DB072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21414 Genomic DNA. Translation: AAA32880.1.
AC006193 Genomic DNA. Translation: AAD38249.1.
CP002684 Genomic DNA. Translation: AEE34279.1.
AY059728 mRNA. Translation: AAL24085.1.
AY091372 mRNA. Translation: AAM14311.1.
PIRiJA0062. UBMUAM.
RefSeqiNP_176654.1. NM_105148.3.
UniGeneiAt.27012.
At.328.

Genome annotation databases

EnsemblPlantsiAT1G64740.1; AT1G64740.1; AT1G64740.
GeneIDi842782.
GrameneiAT1G64740.1; AT1G64740.1; AT1G64740.
KEGGiath:AT1G64740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21414 Genomic DNA. Translation: AAA32880.1.
AC006193 Genomic DNA. Translation: AAD38249.1.
CP002684 Genomic DNA. Translation: AEE34279.1.
AY059728 mRNA. Translation: AAL24085.1.
AY091372 mRNA. Translation: AAM14311.1.
PIRiJA0062. UBMUAM.
RefSeqiNP_176654.1. NM_105148.3.
UniGeneiAt.27012.
At.328.

3D structure databases

ProteinModelPortaliP11139.
SMRiP11139. Positions 1-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28003. 2 interactions.
STRINGi3702.AT1G64740.1.

PTM databases

iPTMnetiP11139.

Proteomic databases

PaxDbiP11139.
PRIDEiP11139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G64740.1; AT1G64740.1; AT1G64740.
GeneIDi842782.
GrameneiAT1G64740.1; AT1G64740.1; AT1G64740.
KEGGiath:AT1G64740.

Organism-specific databases

TAIRiAT1G64740.

Phylogenomic databases

eggNOGiKOG1376. Eukaryota.
COG5023. LUCA.
HOGENOMiHOG000165711.
InParanoidiP11139.
KOiK07374.
OMAiRRMSDQC.
OrthoDBiEOG0936135G.
PhylomeDBiP11139.

Miscellaneous databases

PROiP11139.

Gene expression databases

GenevisibleiP11139. AT.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002452. Alpha_tubulin.
IPR013838. Beta-tubulin_BS.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBA1_ARATH
AccessioniPrimary (citable) accession number: P11139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are six genes coding for alpha-tubulin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.