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P11137

- MTAP2_HUMAN

UniProt

P11137 - MTAP2_HUMAN

Protein

Microtubule-associated protein 2

Gene

MAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • Format
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 4 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

    GO - Molecular functioni

    1. dystroglycan binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. structural molecule activity Source: ProtInc

    GO - Biological processi

    1. axonogenesis Source: Ensembl
    2. cellular response to organic substance Source: Ensembl
    3. central nervous system neuron development Source: DFLAT
    4. dendrite morphogenesis Source: DFLAT
    5. microtubule bundle formation Source: Ensembl
    6. neuron projection development Source: DFLAT
    7. peptidyl-threonine phosphorylation Source: Ensembl

    Keywords - Ligandi

    Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microtubule-associated protein 2
    Short name:
    MAP-2
    Gene namesi
    Name:MAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6839. MAP2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. dendritic shaft Source: Ensembl
    3. microtubule Source: UniProtKB-KW
    4. microtubule associated complex Source: ProtInc
    5. neuronal cell body Source: Ensembl
    6. nuclear periphery Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30583.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18271827Microtubule-associated protein 2PRO_0000072747Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei725 – 7251PhosphoserineBy similarity
    Modified residuei1347 – 13471Phosphoserine1 Publication
    Modified residuei1353 – 13531Phosphoserine1 Publication
    Modified residuei1602 – 16021PhosphothreonineBy similarity
    Modified residuei1605 – 16051PhosphothreonineBy similarity
    Modified residuei1679 – 16791Phosphoserine; by MARK1By similarity

    Post-translational modificationi

    Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly By similarity. Isoform 2/MAP2c is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP11137.
    PaxDbiP11137.
    PRIDEiP11137.

    PTM databases

    PhosphoSiteiP11137.

    Expressioni

    Gene expression databases

    ArrayExpressiP11137.
    BgeeiP11137.
    CleanExiHS_MAP2.
    GenevestigatoriP11137.

    Organism-specific databases

    HPAiCAB001984.
    HPA008273.
    HPA012828.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CBFBQ139512EBI-2682460,EBI-718750

    Protein-protein interaction databases

    BioGridi110305. 37 interactions.
    DIPiDIP-577N.
    IntActiP11137. 7 interactions.
    MINTiMINT-1210186.
    STRINGi9606.ENSP00000353508.

    Structurei

    3D structure databases

    ProteinModelPortaliP11137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1661 – 169131Tau/MAP 1Add
    BLAST
    Repeati1692 – 172231Tau/MAP 2Add
    BLAST
    Repeati1723 – 175432Tau/MAP 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1447 – 146721Calmodulin-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Tau/MAP repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG148882.
    HOGENOMiHOG000113477.
    HOVERGENiHBG000991.
    InParanoidiP11137.
    KOiK10430.
    OMAiTEFREQP.
    OrthoDBiEOG75XGKK.
    PhylomeDBiP11137.
    TreeFamiTF316358.

    Family and domain databases

    InterProiIPR027324. MAP2/MAP4/Tau.
    IPR013588. MAP2_projctn.
    IPR001084. MAP_tubulin-bd_rpt.
    [Graphical view]
    PANTHERiPTHR11501. PTHR11501. 1 hit.
    PfamiPF08377. MAP2_projctn. 1 hit.
    PF00418. Tubulin-binding. 3 hits.
    [Graphical view]
    PROSITEiPS00229. TAU_MAP_1. 2 hits.
    PS51491. TAU_MAP_2. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P11137-1) [UniParc]FASTAAdd to Basket

    Also known as: MAP2b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY     50
    REDEEGAFGE HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA 100
    EAVAVLKGEQ EKEAQHKDQT AALPLAAEET ANLPPSPPPS PASEQTVTVE 150
    EDLLTASKME FHDQQELTPS TAEPSDQKEK ESEKQSKPGE DLKHAALVSQ 200
    PETTKTYPDK KDMQGTEEEK APLALFGHTL VASLEDMKQK TEPSLVVPGI 250
    DLPKEPPTPK EQKDWFIEMP TEAKKDEWGL VAPISPGPLT PMREKDVFDD 300
    IPKWEGKQFD SPMPSPFQGG SFTLPLDVMK NEIVTETSPF APAFLQPDDK 350
    KSLQQTSGPA TAKDSFKIEE PHEAKPDKMA EAPPSEAMTL PKDAHIPVVE 400
    EHVMGKVLEE EKEAINQETV QQRDTFTPSG QEPILTEKET ELKLEEKTTI 450
    SDKEAVPKES KPPKPADEEI GIIQTSTEHT FSEQKDQEPT TDMLKQDSFP 500
    VSLEQAVTDS AMTSKTLEKA MTEPSALIEK SSIQELFEMR VDDKDKIEGV 550
    GAATSAELDM PFYEDKSGMS KYFETSALKE EATKSIEPGS DYYELSDTRE 600
    SVHESIDTMS PMHKNGDKEF QTGKESQPSP PAQEAGYSTL AQSYPSDLPE 650
    EPSSPQERMF TIDPKVYGEK RDLHSKNKDD LTLSRSLGLG GRSAIEQRSM 700
    SINLPMSCLD SIALGFNFGR GHDLSPLASD ILTNTSGSMD EGDDYLPATT 750
    PALEKAPCFP VESKEEEQIE KVKATGEEST QAEISCESPF LAKDFYKNGT 800
    VMAPDLPEML DLAGTRSRLA SVSADAEVAR RKSVPSETVV EDSRTGLPPV 850
    TDENHVIVKT DSQLEDLGYC VFNKYTVPLP SPVQDSENLS GESGTFYEGT 900
    DDKVRRDLAT DLSLIEVKLA AAGRVKDEFS VDKEASAHIS GDKSGLSKEF 950
    DQEKKANDRL DTVLEKSEEH ADSKEHAKKT EEAGDEIETF GLGVTYEQAL 1000
    AKDLSIPTDA SSEKAEKGLS SVPEIAEVEP SKKVEQGLDF AVQGQLDVKI 1050
    SDFGQMASGL NIDDRRATEL KLEATQDMTP SSKAPQEADA FMGVESGHMK 1100
    EGTKVSETEV KEKVAKPDLV HQEAVDKEES YESSGEHESL TMESLKADEG 1150
    KKETSPESSL IQDEIAVKLS VEIPCPPAVS EADLATDERA DVQMEFIQGP 1200
    KEESKETPDI SITPSDVAEP LHETIVSEPA EIQSEEEEIE AQGEYDKLLF 1250
    RSDTLQITDL GVSGAREEFV ETCPSEHKGV IESVVTIEDD FITVVQTTTD 1300
    EGESGSHSVR FAALEQPEVE RRPSPHDEEE FEVEEAAEAQ AEPKDGSPEA 1350
    PASPEREEVA LSEYKTETYD DYKDETTIDD SIMDADSLWV DTQDDDRSIM 1400
    TEQLETIPKE EKAEKEARRS SLEKHRKEKP FKTGRGRIST PERKVAKKEP 1450
    STVSRDEVRR KKAVYKKAEL AKKTEVQAHS PSRKFILKPA IKYTRPTHLS 1500
    CVKRKTTAAG GESALAPSVF KQAKDKVSDG VTKSPEKRSS LPRPSSILPP 1550
    RRGVSGDRDE NSFSLNSSIS SSARRTTRSE PIRRAGKSGT STPTTPGSTA 1600
    ITPGTPPSYS SRTPGTPGTP SYPRTPHTPG TPKSAILVPS EKKVAIIRTP 1650
    PKSPATPKQL RLINQPLPDL KNVKSKIGST DNIKYQPKGG QVQIVTKKID 1700
    LSHVTSKCGS LKNIRHRPGG GRVKIESVKL DFKEKAQAKV GSLDNAHHVP 1750
    GGGNVKIDSQ KLNFREHAKA RVDHGAEIIT QSPGRSSVAS PRRLSNVSSS 1800
    GSINLLESPQ LATLAEDVTA ALAKQGL 1827
    Length:1,827
    Mass (Da):199,526
    Last modified:November 25, 2008 - v4
    Checksum:i2C4801C589086603
    GO
    Isoform 2 (identifier: P11137-2) [UniParc]FASTAAdd to Basket

    Also known as: MAP2c

    The sequence of this isoform differs from the canonical sequence as follows:
         152-1507: Missing.

    Note: Contains a phosphoserine at position 323 (By similarity). Contains a phosphoserine at position 354 (By similarity). Contains a phosphoserine at position 386 (By similarity). Contains a phosphotyrosine at position 67.By similarity

    Show »
    Length:471
    Mass (Da):49,640
    Checksum:iCE8BB23BCD16A159
    GO
    Isoform 3 (identifier: P11137-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         152-155: Missing.

    Show »
    Length:1,823
    Mass (Da):199,084
    Checksum:i7E474A0F3B691188
    GO
    Isoform 4 (identifier: P11137-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         152-229: DLLTASKMEF...KAPLALFGHT → AAGGESALAP...RLPYSKSGNK
         230-1528: Missing.
         1691-1691: Q → QVRILNKKIDFSKVQSRCGSKDNIKHSAGGGN

    Note: No experimental confirmation available.

    Show »
    Length:559
    Mass (Da):58,954
    Checksum:i2A4E43681AE8C196
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91A → G in AAB48098. (PubMed:8294038)Curated
    Sequence conflicti9 – 91A → G in AAB48097. (PubMed:8294038)Curated
    Sequence conflicti37 – 371A → R in AAA03354. 1 PublicationCurated
    Sequence conflicti108 – 1081G → A in AAA03354. 1 PublicationCurated
    Sequence conflicti187 – 1871K → S in AAA03354. 1 PublicationCurated
    Sequence conflicti1112 – 11121E → Q in AAA03354. 1 PublicationCurated
    Sequence conflicti1112 – 11121E → Q in AAB48098. (PubMed:8294038)Curated
    Sequence conflicti1112 – 11121E → Q in AAA59552. (PubMed:15489334)Curated
    Sequence conflicti1655 – 16551A → GL in AAB48098. (PubMed:8294038)Curated
    Sequence conflicti1655 – 16551A → GL in AAB48097. (PubMed:8294038)Curated
    Sequence conflicti1715 – 17162RH → D in AAA03354. 1 PublicationCurated
    Sequence conflicti1736 – 17361A → V in AAA03354. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821A → G.
    Corresponds to variant rs2271251 [ dbSNP | Ensembl ].
    VAR_019612
    Natural varianti179 – 1791E → G.
    Corresponds to variant rs6749066 [ dbSNP | Ensembl ].
    VAR_050019
    Natural varianti277 – 2771E → D in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036014
    Natural varianti423 – 4231R → K.
    Corresponds to variant rs741006 [ dbSNP | Ensembl ].
    VAR_019613
    Natural varianti705 – 7051P → L in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036015
    Natural varianti976 – 9761H → L.
    Corresponds to variant rs13425372 [ dbSNP | Ensembl ].
    VAR_050020
    Natural varianti991 – 9911G → R.
    Corresponds to variant rs35927101 [ dbSNP | Ensembl ].
    VAR_050021
    Natural varianti1099 – 10991M → V.
    Corresponds to variant rs17745550 [ dbSNP | Ensembl ].
    VAR_050022

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei152 – 15071356Missing in isoform 2. 2 PublicationsVSP_003197Add
    BLAST
    Alternative sequencei152 – 22978DLLTA…LFGHT → AAGGESALAPSVFKQAKDKV SNSTLSKIPALQGSTKSPRY SSACPSTTKRATFSDSLLIQ PTSAGSTDRLPYSKSGNK in isoform 4. 1 PublicationVSP_043596Add
    BLAST
    Alternative sequencei152 – 1554Missing in isoform 3. 1 PublicationVSP_011302
    Alternative sequencei230 – 15281299Missing in isoform 4. 1 PublicationVSP_043597Add
    BLAST
    Alternative sequencei1691 – 16911Q → QVRILNKKIDFSKVQSRCGS KDNIKHSAGGGN in isoform 4. 1 PublicationVSP_043598

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01828 mRNA. Translation: AAA03354.1.
    U89330 mRNA. Translation: AAB48098.1.
    U89329 mRNA. Translation: AAB48097.1.
    AC006385 Genomic DNA. No translation available.
    AC019106 Genomic DNA. No translation available.
    AC079833 Genomic DNA. No translation available.
    AC108072 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70459.1.
    BC038857 mRNA. Translation: AAH38857.1.
    BC110423 mRNA. Translation: AAI10424.1.
    BC117123 mRNA. Translation: AAI17124.1.
    BC143245 mRNA. Translation: AAI43246.1.
    M25668 mRNA. Translation: AAA59552.1.
    CCDSiCCDS2384.1. [P11137-1]
    CCDS2385.1. [P11137-2]
    CCDS33369.1. [P11137-4]
    PIRiI53693. QRHUMT.
    I67793.
    RefSeqiNP_001034627.1. NM_001039538.1. [P11137-4]
    NP_002365.3. NM_002374.3. [P11137-1]
    NP_114033.2. NM_031845.2. [P11137-2]
    NP_114035.2. NM_031847.2.
    XP_005246620.1. XM_005246563.1. [P11137-1]
    XP_005246621.1. XM_005246564.1. [P11137-3]
    UniGeneiHs.368281.

    Genome annotation databases

    EnsembliENST00000199940; ENSP00000199940; ENSG00000078018. [P11137-4]
    ENST00000360351; ENSP00000353508; ENSG00000078018. [P11137-1]
    ENST00000361559; ENSP00000355290; ENSG00000078018. [P11137-2]
    ENST00000392194; ENSP00000376032; ENSG00000078018. [P11137-2]
    ENST00000447185; ENSP00000392164; ENSG00000078018. [P11137-3]
    GeneIDi4133.
    KEGGihsa:4133.
    UCSCiuc002vdc.1. human. [P11137-1]
    uc002vdd.1. human. [P11137-4]
    uc002vdg.1. human. [P11137-2]
    uc002vdi.1. human. [P11137-3]

    Polymorphism databases

    DMDMi215274255.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01828 mRNA. Translation: AAA03354.1 .
    U89330 mRNA. Translation: AAB48098.1 .
    U89329 mRNA. Translation: AAB48097.1 .
    AC006385 Genomic DNA. No translation available.
    AC019106 Genomic DNA. No translation available.
    AC079833 Genomic DNA. No translation available.
    AC108072 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70459.1 .
    BC038857 mRNA. Translation: AAH38857.1 .
    BC110423 mRNA. Translation: AAI10424.1 .
    BC117123 mRNA. Translation: AAI17124.1 .
    BC143245 mRNA. Translation: AAI43246.1 .
    M25668 mRNA. Translation: AAA59552.1 .
    CCDSi CCDS2384.1. [P11137-1 ]
    CCDS2385.1. [P11137-2 ]
    CCDS33369.1. [P11137-4 ]
    PIRi I53693. QRHUMT.
    I67793.
    RefSeqi NP_001034627.1. NM_001039538.1. [P11137-4 ]
    NP_002365.3. NM_002374.3. [P11137-1 ]
    NP_114033.2. NM_031845.2. [P11137-2 ]
    NP_114035.2. NM_031847.2.
    XP_005246620.1. XM_005246563.1. [P11137-1 ]
    XP_005246621.1. XM_005246564.1. [P11137-3 ]
    UniGenei Hs.368281.

    3D structure databases

    ProteinModelPortali P11137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110305. 37 interactions.
    DIPi DIP-577N.
    IntActi P11137. 7 interactions.
    MINTi MINT-1210186.
    STRINGi 9606.ENSP00000353508.

    Chemistry

    ChEMBLi CHEMBL2390810.
    DrugBanki DB01196. Estramustine.

    PTM databases

    PhosphoSitei P11137.

    Polymorphism databases

    DMDMi 215274255.

    Proteomic databases

    MaxQBi P11137.
    PaxDbi P11137.
    PRIDEi P11137.

    Protocols and materials databases

    DNASUi 4133.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000199940 ; ENSP00000199940 ; ENSG00000078018 . [P11137-4 ]
    ENST00000360351 ; ENSP00000353508 ; ENSG00000078018 . [P11137-1 ]
    ENST00000361559 ; ENSP00000355290 ; ENSG00000078018 . [P11137-2 ]
    ENST00000392194 ; ENSP00000376032 ; ENSG00000078018 . [P11137-2 ]
    ENST00000447185 ; ENSP00000392164 ; ENSG00000078018 . [P11137-3 ]
    GeneIDi 4133.
    KEGGi hsa:4133.
    UCSCi uc002vdc.1. human. [P11137-1 ]
    uc002vdd.1. human. [P11137-4 ]
    uc002vdg.1. human. [P11137-2 ]
    uc002vdi.1. human. [P11137-3 ]

    Organism-specific databases

    CTDi 4133.
    GeneCardsi GC02P210252.
    HGNCi HGNC:6839. MAP2.
    HPAi CAB001984.
    HPA008273.
    HPA012828.
    MIMi 157130. gene.
    neXtProti NX_P11137.
    PharmGKBi PA30583.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148882.
    HOGENOMi HOG000113477.
    HOVERGENi HBG000991.
    InParanoidi P11137.
    KOi K10430.
    OMAi TEFREQP.
    OrthoDBi EOG75XGKK.
    PhylomeDBi P11137.
    TreeFami TF316358.

    Miscellaneous databases

    ChiTaRSi MAP2. human.
    GeneWikii MAP2.
    GenomeRNAii 4133.
    NextBioi 16222.
    PROi P11137.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11137.
    Bgeei P11137.
    CleanExi HS_MAP2.
    Genevestigatori P11137.

    Family and domain databases

    InterProi IPR027324. MAP2/MAP4/Tau.
    IPR013588. MAP2_projctn.
    IPR001084. MAP_tubulin-bd_rpt.
    [Graphical view ]
    PANTHERi PTHR11501. PTHR11501. 1 hit.
    Pfami PF08377. MAP2_projctn. 1 hit.
    PF00418. Tubulin-binding. 3 hits.
    [Graphical view ]
    PROSITEi PS00229. TAU_MAP_1. 2 hits.
    PS51491. TAU_MAP_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete cDNA of human MAP2 gene and a profile of two RFLPs for BglII/BclI."
      Price R.
      Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)."
      Albala J.S., Kalcheva N., Shafit-Zagardo B.
      Gene 136:377-378(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Brain and Pancreas.
    6. "Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles."
      Dammerman M., Yen S.H., Shafit-Zagardo B.
      J. Neurosci. Res. 24:487-495(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-649 (ISOFORM 1).
    7. "Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles."
      Kosik K.S., Orecchio L.D., Bakalis S., Duffy L., Neve R.L.
      J. Neurochem. 51:587-598(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 494-1562 (ISOFORM 1).
    8. Cited for: PHOSPHORYLATION AT TYR-67 (ISOFORM 2) BY FYN.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1347 AND SER-1353, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-277 AND LEU-705.

    Entry informationi

    Entry nameiMTAP2_HUMAN
    AccessioniPrimary (citable) accession number: P11137
    Secondary accession number(s): Q17S04
    , Q8IUX2, Q99975, Q99976
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 146 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3