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P11137

- MTAP2_HUMAN

UniProt

P11137 - MTAP2_HUMAN

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Protein

Microtubule-associated protein 2

Gene
MAP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

GO - Molecular functioni

  1. dystroglycan binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. structural molecule activity Source: ProtInc

GO - Biological processi

  1. axonogenesis Source: Ensembl
  2. cellular response to organic substance Source: Ensembl
  3. central nervous system neuron development Source: DFLAT
  4. dendrite morphogenesis Source: DFLAT
  5. microtubule bundle formation Source: Ensembl
  6. neuron projection development Source: DFLAT
  7. peptidyl-threonine phosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
Gene namesi
Name:MAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6839. MAP2.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. dendritic shaft Source: Ensembl
  3. microtubule Source: UniProtKB-KW
  4. microtubule associated complex Source: ProtInc
  5. neuronal cell body Source: Ensembl
  6. nuclear periphery Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18271827Microtubule-associated protein 2PRO_0000072747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei725 – 7251Phosphoserine By similarity
Modified residuei1347 – 13471Phosphoserine1 Publication
Modified residuei1353 – 13531Phosphoserine1 Publication
Modified residuei1602 – 16021Phosphothreonine By similarity
Modified residuei1605 – 16051Phosphothreonine By similarity
Modified residuei1679 – 16791Phosphoserine; by MARK1 By similarity

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly By similarity. Isoform 2/MAP2c is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11137.
PaxDbiP11137.
PRIDEiP11137.

PTM databases

PhosphoSiteiP11137.

Expressioni

Gene expression databases

ArrayExpressiP11137.
BgeeiP11137.
CleanExiHS_MAP2.
GenevestigatoriP11137.

Organism-specific databases

HPAiCAB001984.
HPA008273.
HPA012828.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CBFBQ139512EBI-2682460,EBI-718750

Protein-protein interaction databases

BioGridi110305. 37 interactions.
DIPiDIP-577N.
IntActiP11137. 7 interactions.
MINTiMINT-1210186.
STRINGi9606.ENSP00000353508.

Structurei

3D structure databases

ProteinModelPortaliP11137.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1661 – 169131Tau/MAP 1Add
BLAST
Repeati1692 – 172231Tau/MAP 2Add
BLAST
Repeati1723 – 175432Tau/MAP 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1447 – 146721Calmodulin-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 3 Tau/MAP repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG148882.
HOGENOMiHOG000113477.
HOVERGENiHBG000991.
InParanoidiP11137.
KOiK10430.
OMAiTEFREQP.
OrthoDBiEOG75XGKK.
PhylomeDBiP11137.
TreeFamiTF316358.

Family and domain databases

InterProiIPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 1 hit.
PfamiPF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 3 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 2 hits.
PS51491. TAU_MAP_2. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P11137-1) [UniParc]FASTAAdd to Basket

Also known as: MAP2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY     50
REDEEGAFGE HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA 100
EAVAVLKGEQ EKEAQHKDQT AALPLAAEET ANLPPSPPPS PASEQTVTVE 150
EDLLTASKME FHDQQELTPS TAEPSDQKEK ESEKQSKPGE DLKHAALVSQ 200
PETTKTYPDK KDMQGTEEEK APLALFGHTL VASLEDMKQK TEPSLVVPGI 250
DLPKEPPTPK EQKDWFIEMP TEAKKDEWGL VAPISPGPLT PMREKDVFDD 300
IPKWEGKQFD SPMPSPFQGG SFTLPLDVMK NEIVTETSPF APAFLQPDDK 350
KSLQQTSGPA TAKDSFKIEE PHEAKPDKMA EAPPSEAMTL PKDAHIPVVE 400
EHVMGKVLEE EKEAINQETV QQRDTFTPSG QEPILTEKET ELKLEEKTTI 450
SDKEAVPKES KPPKPADEEI GIIQTSTEHT FSEQKDQEPT TDMLKQDSFP 500
VSLEQAVTDS AMTSKTLEKA MTEPSALIEK SSIQELFEMR VDDKDKIEGV 550
GAATSAELDM PFYEDKSGMS KYFETSALKE EATKSIEPGS DYYELSDTRE 600
SVHESIDTMS PMHKNGDKEF QTGKESQPSP PAQEAGYSTL AQSYPSDLPE 650
EPSSPQERMF TIDPKVYGEK RDLHSKNKDD LTLSRSLGLG GRSAIEQRSM 700
SINLPMSCLD SIALGFNFGR GHDLSPLASD ILTNTSGSMD EGDDYLPATT 750
PALEKAPCFP VESKEEEQIE KVKATGEEST QAEISCESPF LAKDFYKNGT 800
VMAPDLPEML DLAGTRSRLA SVSADAEVAR RKSVPSETVV EDSRTGLPPV 850
TDENHVIVKT DSQLEDLGYC VFNKYTVPLP SPVQDSENLS GESGTFYEGT 900
DDKVRRDLAT DLSLIEVKLA AAGRVKDEFS VDKEASAHIS GDKSGLSKEF 950
DQEKKANDRL DTVLEKSEEH ADSKEHAKKT EEAGDEIETF GLGVTYEQAL 1000
AKDLSIPTDA SSEKAEKGLS SVPEIAEVEP SKKVEQGLDF AVQGQLDVKI 1050
SDFGQMASGL NIDDRRATEL KLEATQDMTP SSKAPQEADA FMGVESGHMK 1100
EGTKVSETEV KEKVAKPDLV HQEAVDKEES YESSGEHESL TMESLKADEG 1150
KKETSPESSL IQDEIAVKLS VEIPCPPAVS EADLATDERA DVQMEFIQGP 1200
KEESKETPDI SITPSDVAEP LHETIVSEPA EIQSEEEEIE AQGEYDKLLF 1250
RSDTLQITDL GVSGAREEFV ETCPSEHKGV IESVVTIEDD FITVVQTTTD 1300
EGESGSHSVR FAALEQPEVE RRPSPHDEEE FEVEEAAEAQ AEPKDGSPEA 1350
PASPEREEVA LSEYKTETYD DYKDETTIDD SIMDADSLWV DTQDDDRSIM 1400
TEQLETIPKE EKAEKEARRS SLEKHRKEKP FKTGRGRIST PERKVAKKEP 1450
STVSRDEVRR KKAVYKKAEL AKKTEVQAHS PSRKFILKPA IKYTRPTHLS 1500
CVKRKTTAAG GESALAPSVF KQAKDKVSDG VTKSPEKRSS LPRPSSILPP 1550
RRGVSGDRDE NSFSLNSSIS SSARRTTRSE PIRRAGKSGT STPTTPGSTA 1600
ITPGTPPSYS SRTPGTPGTP SYPRTPHTPG TPKSAILVPS EKKVAIIRTP 1650
PKSPATPKQL RLINQPLPDL KNVKSKIGST DNIKYQPKGG QVQIVTKKID 1700
LSHVTSKCGS LKNIRHRPGG GRVKIESVKL DFKEKAQAKV GSLDNAHHVP 1750
GGGNVKIDSQ KLNFREHAKA RVDHGAEIIT QSPGRSSVAS PRRLSNVSSS 1800
GSINLLESPQ LATLAEDVTA ALAKQGL 1827
Length:1,827
Mass (Da):199,526
Last modified:November 25, 2008 - v4
Checksum:i2C4801C589086603
GO
Isoform 2 (identifier: P11137-2) [UniParc]FASTAAdd to Basket

Also known as: MAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     152-1507: Missing.

Note: Contains a phosphoserine at position 323 (By similarity). Contains a phosphoserine at position 354 (By similarity). Contains a phosphoserine at position 386 (By similarity). Contains a phosphotyrosine at position 67.

Show »
Length:471
Mass (Da):49,640
Checksum:iCE8BB23BCD16A159
GO
Isoform 3 (identifier: P11137-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-155: Missing.

Show »
Length:1,823
Mass (Da):199,084
Checksum:i7E474A0F3B691188
GO
Isoform 4 (identifier: P11137-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-229: DLLTASKMEF...KAPLALFGHT → AAGGESALAP...RLPYSKSGNK
     230-1528: Missing.
     1691-1691: Q → QVRILNKKIDFSKVQSRCGSKDNIKHSAGGGN

Note: No experimental confirmation available.

Show »
Length:559
Mass (Da):58,954
Checksum:i2A4E43681AE8C196
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821A → G.
Corresponds to variant rs2271251 [ dbSNP | Ensembl ].
VAR_019612
Natural varianti179 – 1791E → G.
Corresponds to variant rs6749066 [ dbSNP | Ensembl ].
VAR_050019
Natural varianti277 – 2771E → D in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036014
Natural varianti423 – 4231R → K.
Corresponds to variant rs741006 [ dbSNP | Ensembl ].
VAR_019613
Natural varianti705 – 7051P → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036015
Natural varianti976 – 9761H → L.
Corresponds to variant rs13425372 [ dbSNP | Ensembl ].
VAR_050020
Natural varianti991 – 9911G → R.
Corresponds to variant rs35927101 [ dbSNP | Ensembl ].
VAR_050021
Natural varianti1099 – 10991M → V.
Corresponds to variant rs17745550 [ dbSNP | Ensembl ].
VAR_050022

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei152 – 15071356Missing in isoform 2. VSP_003197Add
BLAST
Alternative sequencei152 – 22978DLLTA…LFGHT → AAGGESALAPSVFKQAKDKV SNSTLSKIPALQGSTKSPRY SSACPSTTKRATFSDSLLIQ PTSAGSTDRLPYSKSGNK in isoform 4. VSP_043596Add
BLAST
Alternative sequencei152 – 1554Missing in isoform 3. VSP_011302
Alternative sequencei230 – 15281299Missing in isoform 4. VSP_043597Add
BLAST
Alternative sequencei1691 – 16911Q → QVRILNKKIDFSKVQSRCGS KDNIKHSAGGGN in isoform 4. VSP_043598

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → G in AAB48098. 1 Publication
Sequence conflicti9 – 91A → G in AAB48097. 1 Publication
Sequence conflicti37 – 371A → R in AAA03354. 1 Publication
Sequence conflicti108 – 1081G → A in AAA03354. 1 Publication
Sequence conflicti187 – 1871K → S in AAA03354. 1 Publication
Sequence conflicti1112 – 11121E → Q in AAA03354. 1 Publication
Sequence conflicti1112 – 11121E → Q in AAB48098. 1 Publication
Sequence conflicti1112 – 11121E → Q in AAA59552. 1 Publication
Sequence conflicti1655 – 16551A → GL in AAB48098. 1 Publication
Sequence conflicti1655 – 16551A → GL in AAB48097. 1 Publication
Sequence conflicti1715 – 17162RH → D in AAA03354. 1 Publication
Sequence conflicti1736 – 17361A → V in AAA03354. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01828 mRNA. Translation: AAA03354.1.
U89330 mRNA. Translation: AAB48098.1.
U89329 mRNA. Translation: AAB48097.1.
AC006385 Genomic DNA. No translation available.
AC019106 Genomic DNA. No translation available.
AC079833 Genomic DNA. No translation available.
AC108072 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70459.1.
BC038857 mRNA. Translation: AAH38857.1.
BC110423 mRNA. Translation: AAI10424.1.
BC117123 mRNA. Translation: AAI17124.1.
BC143245 mRNA. Translation: AAI43246.1.
M25668 mRNA. Translation: AAA59552.1.
CCDSiCCDS2384.1. [P11137-1]
CCDS2385.1. [P11137-2]
CCDS33369.1. [P11137-4]
PIRiI53693. QRHUMT.
I67793.
RefSeqiNP_001034627.1. NM_001039538.1. [P11137-4]
NP_002365.3. NM_002374.3. [P11137-1]
NP_114033.2. NM_031845.2. [P11137-2]
NP_114035.2. NM_031847.2.
XP_005246620.1. XM_005246563.1. [P11137-1]
XP_005246621.1. XM_005246564.1. [P11137-3]
UniGeneiHs.368281.

Genome annotation databases

EnsembliENST00000199940; ENSP00000199940; ENSG00000078018. [P11137-4]
ENST00000360351; ENSP00000353508; ENSG00000078018. [P11137-1]
ENST00000361559; ENSP00000355290; ENSG00000078018. [P11137-2]
ENST00000392194; ENSP00000376032; ENSG00000078018. [P11137-2]
ENST00000447185; ENSP00000392164; ENSG00000078018. [P11137-3]
GeneIDi4133.
KEGGihsa:4133.
UCSCiuc002vdc.1. human. [P11137-1]
uc002vdd.1. human. [P11137-4]
uc002vdg.1. human. [P11137-2]
uc002vdi.1. human. [P11137-3]

Polymorphism databases

DMDMi215274255.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01828 mRNA. Translation: AAA03354.1 .
U89330 mRNA. Translation: AAB48098.1 .
U89329 mRNA. Translation: AAB48097.1 .
AC006385 Genomic DNA. No translation available.
AC019106 Genomic DNA. No translation available.
AC079833 Genomic DNA. No translation available.
AC108072 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70459.1 .
BC038857 mRNA. Translation: AAH38857.1 .
BC110423 mRNA. Translation: AAI10424.1 .
BC117123 mRNA. Translation: AAI17124.1 .
BC143245 mRNA. Translation: AAI43246.1 .
M25668 mRNA. Translation: AAA59552.1 .
CCDSi CCDS2384.1. [P11137-1 ]
CCDS2385.1. [P11137-2 ]
CCDS33369.1. [P11137-4 ]
PIRi I53693. QRHUMT.
I67793.
RefSeqi NP_001034627.1. NM_001039538.1. [P11137-4 ]
NP_002365.3. NM_002374.3. [P11137-1 ]
NP_114033.2. NM_031845.2. [P11137-2 ]
NP_114035.2. NM_031847.2.
XP_005246620.1. XM_005246563.1. [P11137-1 ]
XP_005246621.1. XM_005246564.1. [P11137-3 ]
UniGenei Hs.368281.

3D structure databases

ProteinModelPortali P11137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110305. 37 interactions.
DIPi DIP-577N.
IntActi P11137. 7 interactions.
MINTi MINT-1210186.
STRINGi 9606.ENSP00000353508.

Chemistry

ChEMBLi CHEMBL2390810.
DrugBanki DB01196. Estramustine.

PTM databases

PhosphoSitei P11137.

Polymorphism databases

DMDMi 215274255.

Proteomic databases

MaxQBi P11137.
PaxDbi P11137.
PRIDEi P11137.

Protocols and materials databases

DNASUi 4133.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000199940 ; ENSP00000199940 ; ENSG00000078018 . [P11137-4 ]
ENST00000360351 ; ENSP00000353508 ; ENSG00000078018 . [P11137-1 ]
ENST00000361559 ; ENSP00000355290 ; ENSG00000078018 . [P11137-2 ]
ENST00000392194 ; ENSP00000376032 ; ENSG00000078018 . [P11137-2 ]
ENST00000447185 ; ENSP00000392164 ; ENSG00000078018 . [P11137-3 ]
GeneIDi 4133.
KEGGi hsa:4133.
UCSCi uc002vdc.1. human. [P11137-1 ]
uc002vdd.1. human. [P11137-4 ]
uc002vdg.1. human. [P11137-2 ]
uc002vdi.1. human. [P11137-3 ]

Organism-specific databases

CTDi 4133.
GeneCardsi GC02P210252.
HGNCi HGNC:6839. MAP2.
HPAi CAB001984.
HPA008273.
HPA012828.
MIMi 157130. gene.
neXtProti NX_P11137.
PharmGKBi PA30583.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148882.
HOGENOMi HOG000113477.
HOVERGENi HBG000991.
InParanoidi P11137.
KOi K10430.
OMAi TEFREQP.
OrthoDBi EOG75XGKK.
PhylomeDBi P11137.
TreeFami TF316358.

Miscellaneous databases

ChiTaRSi MAP2. human.
GeneWikii MAP2.
GenomeRNAii 4133.
NextBioi 16222.
PROi P11137.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11137.
Bgeei P11137.
CleanExi HS_MAP2.
Genevestigatori P11137.

Family and domain databases

InterProi IPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view ]
PANTHERi PTHR11501. PTHR11501. 1 hit.
Pfami PF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 3 hits.
[Graphical view ]
PROSITEi PS00229. TAU_MAP_1. 2 hits.
PS51491. TAU_MAP_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete cDNA of human MAP2 gene and a profile of two RFLPs for BglII/BclI."
    Price R.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)."
    Albala J.S., Kalcheva N., Shafit-Zagardo B.
    Gene 136:377-378(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain and Pancreas.
  6. "Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles."
    Dammerman M., Yen S.H., Shafit-Zagardo B.
    J. Neurosci. Res. 24:487-495(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-649 (ISOFORM 1).
  7. "Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles."
    Kosik K.S., Orecchio L.D., Bakalis S., Duffy L., Neve R.L.
    J. Neurochem. 51:587-598(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 494-1562 (ISOFORM 1).
  8. Cited for: PHOSPHORYLATION AT TYR-67 (ISOFORM 2) BY FYN.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1347 AND SER-1353, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-277 AND LEU-705.

Entry informationi

Entry nameiMTAP2_HUMAN
AccessioniPrimary (citable) accession number: P11137
Secondary accession number(s): Q17S04
, Q8IUX2, Q99975, Q99976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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