P11137 (MAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated protein 2
Short name=MAP-2

Gene names

Name:

MAP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1827 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Post-translational modification	Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly By similarity. MAP2A/c is phosphorylated. Isoform MAP2c is phosphorylated by FYN at Tyr-67. Ref.8
Sequence similarities	Contains 3 Tau/MAP repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	Calmodulin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from electronic annotation. Source: Compara cellular response to organic substance Inferred from electronic annotation. Source: Compara central nervous system neuron development Inferred from expression pattern PubMed 20846339. Source: DFLAT dendrite morphogenesis Inferred from expression pattern PubMed 20846339. Source: DFLAT microtubule bundle formation Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW dendritic shaft Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Traceable author statement PubMed 9588626. Source: ProtInc neuronal cell body Inferred from electronic annotation. Source: Compara nuclear periphery Inferred from electronic annotation. Source: Compara
Molecular_function	structural molecule activity Non-traceable author statement PubMed 9588626. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CBFB	Q13951	2	EBI-2682460,EBI-718750

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P11137-1)

Also known as: MAP2b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P11137-2)

Also known as: MAP2c;

The sequence of this isoform differs from the canonical sequence as follows:
     152-1507: Missing.

Note: Phosphorylated on Tyr-67 by FYN.

Isoform 3 (identifier: P11137-3)

The sequence of this isoform differs from the canonical sequence as follows:
     152-155: Missing.

Isoform 4 (identifier: P11137-4)

The sequence of this isoform differs from the canonical sequence as follows:
     152-229: DLLTASKMEF...KAPLALFGHT → AAGGESALAP...RLPYSKSGNK
     230-1528: Missing.
     1691-1691: Q → QVRILNKKIDFSKVQSRCGSKDNIKHSAGGGN

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1827	1827	Microtubule-associated protein 2		PRO_0000072747
Regions
	Repeat	1661 – 1691	31	Tau/MAP 1
	Repeat	1692 – 1722	31	Tau/MAP 2
	Repeat	1723 – 1754	32	Tau/MAP 3
	Region	1447 – 1467	21	Calmodulin-binding Potential
Amino acid modifications
	Modified residue	610	1	Phosphoserine By similarity
	Modified residue	629	1	Phosphoserine By similarity
	Modified residue	654	1	Phosphoserine By similarity
	Modified residue	729	1	Phosphoserine By similarity
	Modified residue	736	1	Phosphoserine By similarity
	Modified residue	745	1	Phosphotyrosine By similarity
	Modified residue	821	1	Phosphoserine By similarity
	Modified residue	1155	1	Phosphoserine By similarity
	Modified residue	1347	1	Phosphoserine Ref.11
	Modified residue	1353	1	Phosphoserine Ref.11
	Modified residue	1421	1	Phosphoserine By similarity
	Modified residue	1440	1	Phosphothreonine By similarity
	Modified residue	1480	1	Phosphoserine By similarity
	Modified residue	1534	1	Phosphoserine By similarity
	Modified residue	1591	1	Phosphoserine By similarity
	Modified residue	1594	1	Phosphothreonine By similarity
	Modified residue	1595	1	Phosphothreonine By similarity
	Modified residue	1602	1	Phosphothreonine By similarity
	Modified residue	1605	1	Phosphothreonine By similarity
	Modified residue	1608	1	Phosphoserine By similarity
	Modified residue	1611	1	Phosphoserine By similarity
	Modified residue	1613	1	Phosphothreonine By similarity
	Modified residue	1616	1	Phosphothreonine By similarity
	Modified residue	1649	1	Phosphothreonine By similarity
	Modified residue	1656	1	Phosphothreonine By similarity
	Modified residue	1679	1	Phosphoserine; by MARK1 By similarity
	Modified residue	1710	1	Phosphoserine By similarity
	Modified residue	1742	1	Phosphoserine By similarity
	Modified residue	1782	1	Phosphoserine By similarity
	Modified residue	1790	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	152 – 1507	1356	Missing in isoform 2.		VSP_003197
	Alternative sequence	152 – 229	78	DLLTA…LFGHT → AAGGESALAPSVFKQAKDKV SNSTLSKIPALQGSTKSPRY SSACPSTTKRATFSDSLLIQ PTSAGSTDRLPYSKSGNK in isoform 4.		VSP_043596
	Alternative sequence	152 – 155	4	Missing in isoform 3.		VSP_011302
	Alternative sequence	230 – 1528	1299	Missing in isoform 4.		VSP_043597
	Alternative sequence	1691	1	Q → QVRILNKKIDFSKVQSRCGS KDNIKHSAGGGN in isoform 4.		VSP_043598
	Natural variant	82	1	A → G. Corresponds to variant rs2271251 [ dbSNP | Ensembl ].		VAR_019612
	Natural variant	179	1	E → G. Corresponds to variant rs6749066 [ dbSNP | Ensembl ].		VAR_050019
	Natural variant	277	1	E → D in a colorectal cancer sample; somatic mutation. Ref.12		VAR_036014
	Natural variant	423	1	R → K. Corresponds to variant rs741006 [ dbSNP | Ensembl ].		VAR_019613
	Natural variant	705	1	P → L in a colorectal cancer sample; somatic mutation. Ref.12		VAR_036015
	Natural variant	976	1	H → L. Corresponds to variant rs13425372 [ dbSNP | Ensembl ].		VAR_050020
	Natural variant	991	1	G → R. Corresponds to variant rs35927101 [ dbSNP | Ensembl ].		VAR_050021
	Natural variant	1099	1	M → V. Corresponds to variant rs17745550 [ dbSNP | Ensembl ].		VAR_050022
Experimental info
	Sequence conflict	9	1	A → G in AAB48098. Ref.2
	Sequence conflict	9	1	A → G in AAB48097. Ref.2
	Sequence conflict	37	1	A → R in AAA03354. Ref.1
	Sequence conflict	108	1	G → A in AAA03354. Ref.1
	Sequence conflict	187	1	K → S in AAA03354. Ref.1
	Sequence conflict	1112	1	E → Q in AAA03354. Ref.1
	Sequence conflict	1112	1	E → Q in AAB48098. Ref.2
	Sequence conflict	1112	1	E → Q in AAA59552. Ref.5
	Sequence conflict	1655	1	A → GL in AAB48098. Ref.2
	Sequence conflict	1655	1	A → GL in AAB48097. Ref.2
	Sequence conflict	1715 – 1716	2	RH → D in AAA03354. Ref.1
	Sequence conflict	1736	1	A → V in AAA03354. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MAP2b) [UniParc]. Last modified November 25, 2008. Version 4. Checksum: 2C4801C589086603	FASTA	1,827	199,526
	10 20 30 40 50 60 MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY REDEEGAFGE 70 80 90 100 110 120 HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQT 130 140 150 160 170 180 AALPLAAEET ANLPPSPPPS PASEQTVTVE EDLLTASKME FHDQQELTPS TAEPSDQKEK 190 200 210 220 230 240 ESEKQSKPGE DLKHAALVSQ PETTKTYPDK KDMQGTEEEK APLALFGHTL VASLEDMKQK 250 260 270 280 290 300 TEPSLVVPGI DLPKEPPTPK EQKDWFIEMP TEAKKDEWGL VAPISPGPLT PMREKDVFDD 310 320 330 340 350 360 IPKWEGKQFD SPMPSPFQGG SFTLPLDVMK NEIVTETSPF APAFLQPDDK KSLQQTSGPA 370 380 390 400 410 420 TAKDSFKIEE PHEAKPDKMA EAPPSEAMTL PKDAHIPVVE EHVMGKVLEE EKEAINQETV 430 440 450 460 470 480 QQRDTFTPSG QEPILTEKET ELKLEEKTTI SDKEAVPKES KPPKPADEEI GIIQTSTEHT 490 500 510 520 530 540 FSEQKDQEPT TDMLKQDSFP VSLEQAVTDS AMTSKTLEKA MTEPSALIEK SSIQELFEMR 550 560 570 580 590 600 VDDKDKIEGV GAATSAELDM PFYEDKSGMS KYFETSALKE EATKSIEPGS DYYELSDTRE 610 620 630 640 650 660 SVHESIDTMS PMHKNGDKEF QTGKESQPSP PAQEAGYSTL AQSYPSDLPE EPSSPQERMF 670 680 690 700 710 720 TIDPKVYGEK RDLHSKNKDD LTLSRSLGLG GRSAIEQRSM SINLPMSCLD SIALGFNFGR 730 740 750 760 770 780 GHDLSPLASD ILTNTSGSMD EGDDYLPATT PALEKAPCFP VESKEEEQIE KVKATGEEST 790 800 810 820 830 840 QAEISCESPF LAKDFYKNGT VMAPDLPEML DLAGTRSRLA SVSADAEVAR RKSVPSETVV 850 860 870 880 890 900 EDSRTGLPPV TDENHVIVKT DSQLEDLGYC VFNKYTVPLP SPVQDSENLS GESGTFYEGT 910 920 930 940 950 960 DDKVRRDLAT DLSLIEVKLA AAGRVKDEFS VDKEASAHIS GDKSGLSKEF DQEKKANDRL 970 980 990 1000 1010 1020 DTVLEKSEEH ADSKEHAKKT EEAGDEIETF GLGVTYEQAL AKDLSIPTDA SSEKAEKGLS 1030 1040 1050 1060 1070 1080 SVPEIAEVEP SKKVEQGLDF AVQGQLDVKI SDFGQMASGL NIDDRRATEL KLEATQDMTP 1090 1100 1110 1120 1130 1140 SSKAPQEADA FMGVESGHMK EGTKVSETEV KEKVAKPDLV HQEAVDKEES YESSGEHESL 1150 1160 1170 1180 1190 1200 TMESLKADEG KKETSPESSL IQDEIAVKLS VEIPCPPAVS EADLATDERA DVQMEFIQGP 1210 1220 1230 1240 1250 1260 KEESKETPDI SITPSDVAEP LHETIVSEPA EIQSEEEEIE AQGEYDKLLF RSDTLQITDL 1270 1280 1290 1300 1310 1320 GVSGAREEFV ETCPSEHKGV IESVVTIEDD FITVVQTTTD EGESGSHSVR FAALEQPEVE 1330 1340 1350 1360 1370 1380 RRPSPHDEEE FEVEEAAEAQ AEPKDGSPEA PASPEREEVA LSEYKTETYD DYKDETTIDD 1390 1400 1410 1420 1430 1440 SIMDADSLWV DTQDDDRSIM TEQLETIPKE EKAEKEARRS SLEKHRKEKP FKTGRGRIST 1450 1460 1470 1480 1490 1500 PERKVAKKEP STVSRDEVRR KKAVYKKAEL AKKTEVQAHS PSRKFILKPA IKYTRPTHLS 1510 1520 1530 1540 1550 1560 CVKRKTTAAG GESALAPSVF KQAKDKVSDG VTKSPEKRSS LPRPSSILPP RRGVSGDRDE 1570 1580 1590 1600 1610 1620 NSFSLNSSIS SSARRTTRSE PIRRAGKSGT STPTTPGSTA ITPGTPPSYS SRTPGTPGTP 1630 1640 1650 1660 1670 1680 SYPRTPHTPG TPKSAILVPS EKKVAIIRTP PKSPATPKQL RLINQPLPDL KNVKSKIGST 1690 1700 1710 1720 1730 1740 DNIKYQPKGG QVQIVTKKID LSHVTSKCGS LKNIRHRPGG GRVKIESVKL DFKEKAQAKV 1750 1760 1770 1780 1790 1800 GSLDNAHHVP GGGNVKIDSQ KLNFREHAKA RVDHGAEIIT QSPGRSSVAS PRRLSNVSSS 1810 1820 GSINLLESPQ LATLAEDVTA ALAKQGL
	Isoform 2 (MAP2c) [UniParc]. Checksum: CE8BB23BCD16A159	FASTA	471	49,640
	10 20 30 40 50 60 MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY REDEEGAFGE 70 80 90 100 110 120 HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQT 130 140 150 160 170 180 AALPLAAEET ANLPPSPPPS PASEQTVTVE EAAGGESALA PSVFKQAKDK VSDGVTKSPE 190 200 210 220 230 240 KRSSLPRPSS ILPPRRGVSG DRDENSFSLN SSISSSARRT TRSEPIRRAG KSGTSTPTTP 250 260 270 280 290 300 GSTAITPGTP PSYSSRTPGT PGTPSYPRTP HTPGTPKSAI LVPSEKKVAI IRTPPKSPAT 310 320 330 340 350 360 PKQLRLINQP LPDLKNVKSK IGSTDNIKYQ PKGGQVQIVT KKIDLSHVTS KCGSLKNIRH 370 380 390 400 410 420 RPGGGRVKIE SVKLDFKEKA QAKVGSLDNA HHVPGGGNVK IDSQKLNFRE HAKARVDHGA 430 440 450 460 470 EIITQSPGRS SVASPRRLSN VSSSGSINLL ESPQLATLAE DVTAALAKQG L
	Isoform 3 [UniParc]. Checksum: 7E474A0F3B691188	FASTA	1,823	199,084
	10 20 30 40 50 60 MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY REDEEGAFGE 70 80 90 100 110 120 HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQT 130 140 150 160 170 180 AALPLAAEET ANLPPSPPPS PASEQTVTVE EASKMEFHDQ QELTPSTAEP SDQKEKESEK 190 200 210 220 230 240 QSKPGEDLKH AALVSQPETT KTYPDKKDMQ GTEEEKAPLA LFGHTLVASL EDMKQKTEPS 250 260 270 280 290 300 LVVPGIDLPK EPPTPKEQKD WFIEMPTEAK KDEWGLVAPI SPGPLTPMRE KDVFDDIPKW 310 320 330 340 350 360 EGKQFDSPMP SPFQGGSFTL PLDVMKNEIV TETSPFAPAF LQPDDKKSLQ QTSGPATAKD 370 380 390 400 410 420 SFKIEEPHEA KPDKMAEAPP SEAMTLPKDA HIPVVEEHVM GKVLEEEKEA INQETVQQRD 430 440 450 460 470 480 TFTPSGQEPI LTEKETELKL EEKTTISDKE AVPKESKPPK PADEEIGIIQ TSTEHTFSEQ 490 500 510 520 530 540 KDQEPTTDML KQDSFPVSLE QAVTDSAMTS KTLEKAMTEP SALIEKSSIQ ELFEMRVDDK 550 560 570 580 590 600 DKIEGVGAAT SAELDMPFYE DKSGMSKYFE TSALKEEATK SIEPGSDYYE LSDTRESVHE 610 620 630 640 650 660 SIDTMSPMHK NGDKEFQTGK ESQPSPPAQE AGYSTLAQSY PSDLPEEPSS PQERMFTIDP 670 680 690 700 710 720 KVYGEKRDLH SKNKDDLTLS RSLGLGGRSA IEQRSMSINL PMSCLDSIAL GFNFGRGHDL 730 740 750 760 770 780 SPLASDILTN TSGSMDEGDD YLPATTPALE KAPCFPVESK EEEQIEKVKA TGEESTQAEI 790 800 810 820 830 840 SCESPFLAKD FYKNGTVMAP DLPEMLDLAG TRSRLASVSA DAEVARRKSV PSETVVEDSR 850 860 870 880 890 900 TGLPPVTDEN HVIVKTDSQL EDLGYCVFNK YTVPLPSPVQ DSENLSGESG TFYEGTDDKV 910 920 930 940 950 960 RRDLATDLSL IEVKLAAAGR VKDEFSVDKE ASAHISGDKS GLSKEFDQEK KANDRLDTVL 970 980 990 1000 1010 1020 EKSEEHADSK EHAKKTEEAG DEIETFGLGV TYEQALAKDL SIPTDASSEK AEKGLSSVPE 1030 1040 1050 1060 1070 1080 IAEVEPSKKV EQGLDFAVQG QLDVKISDFG QMASGLNIDD RRATELKLEA TQDMTPSSKA 1090 1100 1110 1120 1130 1140 PQEADAFMGV ESGHMKEGTK VSETEVKEKV AKPDLVHQEA VDKEESYESS GEHESLTMES 1150 1160 1170 1180 1190 1200 LKADEGKKET SPESSLIQDE IAVKLSVEIP CPPAVSEADL ATDERADVQM EFIQGPKEES 1210 1220 1230 1240 1250 1260 KETPDISITP SDVAEPLHET IVSEPAEIQS EEEEIEAQGE YDKLLFRSDT LQITDLGVSG 1270 1280 1290 1300 1310 1320 AREEFVETCP SEHKGVIESV VTIEDDFITV VQTTTDEGES GSHSVRFAAL EQPEVERRPS 1330 1340 1350 1360 1370 1380 PHDEEEFEVE EAAEAQAEPK DGSPEAPASP EREEVALSEY KTETYDDYKD ETTIDDSIMD 1390 1400 1410 1420 1430 1440 ADSLWVDTQD DDRSIMTEQL ETIPKEEKAE KEARRSSLEK HRKEKPFKTG RGRISTPERK 1450 1460 1470 1480 1490 1500 VAKKEPSTVS RDEVRRKKAV YKKAELAKKT EVQAHSPSRK FILKPAIKYT RPTHLSCVKR 1510 1520 1530 1540 1550 1560 KTTAAGGESA LAPSVFKQAK DKVSDGVTKS PEKRSSLPRP SSILPPRRGV SGDRDENSFS 1570 1580 1590 1600 1610 1620 LNSSISSSAR RTTRSEPIRR AGKSGTSTPT TPGSTAITPG TPPSYSSRTP GTPGTPSYPR 1630 1640 1650 1660 1670 1680 TPHTPGTPKS AILVPSEKKV AIIRTPPKSP ATPKQLRLIN QPLPDLKNVK SKIGSTDNIK 1690 1700 1710 1720 1730 1740 YQPKGGQVQI VTKKIDLSHV TSKCGSLKNI RHRPGGGRVK IESVKLDFKE KAQAKVGSLD 1750 1760 1770 1780 1790 1800 NAHHVPGGGN VKIDSQKLNF REHAKARVDH GAEIITQSPG RSSVASPRRL SNVSSSGSIN 1810 1820 LLESPQLATL AEDVTAALAK QGL
	Isoform 4 [UniParc]. Checksum: 2A4E43681AE8C196	FASTA	559	58,954
	10 20 30 40 50 60 MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY REDEEGAFGE 70 80 90 100 110 120 HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA EAVAVLKGEQ EKEAQHKDQT 130 140 150 160 170 180 AALPLAAEET ANLPPSPPPS PASEQTVTVE EAAGGESALA PSVFKQAKDK VSNSTLSKIP 190 200 210 220 230 240 ALQGSTKSPR YSSACPSTTK RATFSDSLLI QPTSAGSTDR LPYSKSGNKD GVTKSPEKRS 250 260 270 280 290 300 SLPRPSSILP PRRGVSGDRD ENSFSLNSSI SSSARRTTRS EPIRRAGKSG TSTPTTPGST 310 320 330 340 350 360 AITPGTPPSY SSRTPGTPGT PSYPRTPHTP GTPKSAILVP SEKKVAIIRT PPKSPATPKQ 370 380 390 400 410 420 LRLINQPLPD LKNVKSKIGS TDNIKYQPKG GQVRILNKKI DFSKVQSRCG SKDNIKHSAG 430 440 450 460 470 480 GGNVQIVTKK IDLSHVTSKC GSLKNIRHRP GGGRVKIESV KLDFKEKAQA KVGSLDNAHH 490 500 510 520 530 540 VPGGGNVKID SQKLNFREHA KARVDHGAEI ITQSPGRSSV ASPRRLSNVS SSGSINLLES 550 PQLATLAEDV TAALAKQGL

References

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[1]	"Complete cDNA of human MAP2 gene and a profile of two RFLPs for BglII/BclI." Price R. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)." Albala J.S., Kalcheva N., Shafit-Zagardo B. Gene 136:377-378(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Brain and Pancreas.
[6]	"Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles." Dammerman M., Yen S.H., Shafit-Zagardo B. J. Neurosci. Res. 24:487-495(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-649 (ISOFORM 1).
[7]	"Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles." Kosik K.S., Orecchio L.D., Bakalis S., Duffy L., Neve R.L. J. Neurochem. 51:587-598(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 494-1562 (ISOFORM 1).
[8]	"Fyn phosphorylates human MAP-2c on tyrosine 67." Zamora-Leon S.P., Bresnick A., Backer J.M., Shafit-Zagardo B. J. Biol. Chem. 280:1962-1970(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION BY FYN.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1347 AND SER-1353, MASS SPECTROMETRY.
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-277 AND LEU-705.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U01828 mRNA. Translation: AAA03354.1. U89330 mRNA. Translation: AAB48098.1. U89329 mRNA. Translation: AAB48097.1. AC006385 Genomic DNA. No translation available. AC019106 Genomic DNA. No translation available. AC079833 Genomic DNA. No translation available. AC108072 Genomic DNA. No translation available. CH471063 Genomic DNA. Translation: EAW70459.1. BC038857 mRNA. Translation: AAH38857.1. BC110423 mRNA. Translation: AAI10424.1. BC117123 mRNA. Translation: AAI17124.1. BC143245 mRNA. Translation: AAI43246.1. M25668 mRNA. Translation: AAA59552.1.
IPI	IPI00003842. IPI00293579. IPI00472094. IPI00735732.
PIR	QRHUMT. I53693. I67793.
RefSeq	NP_001034627.1. NM_001039538.1. NP_002365.3. NM_002374.3. NP_114033.2. NM_031845.2. NP_114035.2. NM_031847.2.
UniGene	Hs.368281.
3D structure databases
ProteinModelPortal	P11137.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-577N.
IntAct	P11137. 4 interactions.
MINT	MINT-1210186.
STRING	9606.ENSP00000353508.
PTM databases
PhosphoSite	P11137.
Polymorphism databases
DMDM	215274255.
Proteomic databases
PaxDb	P11137.
PRIDE	P11137.
Protocols and materials databases
DNASU	4133.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000199940; ENSP00000199940; ENSG00000078018. ENST00000360351; ENSP00000353508; ENSG00000078018. ENST00000361559; ENSP00000355290; ENSG00000078018. ENST00000392194; ENSP00000376032; ENSG00000078018. ENST00000447185; ENSP00000392164; ENSG00000078018.
GeneID	4133.
KEGG	hsa:4133.
UCSC	uc002vdc.1. human. uc002vdg.1. human. uc002vdi.1. human.
Organism-specific databases
CTD	4133.
GeneCards	GC02P210252.
HGNC	HGNC:6839. MAP2.
HPA	CAB001984. HPA008273. HPA012828.
MIM	157130. gene.
neXtProt	NX_P11137.
PharmGKB	PA30583.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148882.
HOGENOM	HOG000113477.
HOVERGEN	HBG000991.
InParanoid	P11137.
KO	K10430.
OMA	QMEFIQL.
Gene expression databases
ArrayExpress	P11137.
Bgee	P11137.
CleanEx	HS_MAP2.
Genevestigator	P11137.
GermOnline	ENSG00000078018. Homo sapiens.
Family and domain databases
InterPro	IPR027324. MAP2/MAP4/Tau. IPR013588. MAP2_projctn. IPR001084. Tau/MAP_tubulin-bd_rpt. [Graphical view]
PANTHER	PTHR11501. PTHR11501. 1 hit.
Pfam	PF08377. MAP2_projctn. 1 hit. PF00418. Tubulin-binding. 3 hits. [Graphical view]
PROSITE	PS00229. TAU_MAP_1. 2 hits. PS51491. TAU_MAP_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MAP2. human.
DrugBank	DB01196. Estramustine.
GenomeRNAi	4133.
NextBio	16222.
SOURCE	Search...

Entry information

Entry name

MAP2_HUMAN

Accession

Primary (citable) accession number: P11137
Secondary accession number(s): Q17S04 , Q8IUX2, Q99975, Q99976

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 133 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.