ACP2

Functionⁱ

Catalytic activityⁱ

A phosphate monoester + H₂O = an alcohol + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	42	NucleophileBy similarity		1
Active siteⁱ	287	Proton donorBy similarity		1

GO - Molecular functionⁱ

acid phosphatase activity
Source: ProtInc
Traceable author statementⁱ
- 3191910

Complete GO annotation...

GO - Biological processⁱ

lysosome organization Source: Ensembl
skeletal system development Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysosomal acid phosphatase (EC:3.1.3.2) Short name: LAP
Gene namesⁱ	Name:ACP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:123. ACP2.

HGNCⁱ

HGNC:123. ACP2.

Subcellular locationⁱ

Lysosome membrane
2 Publications
Manual assertion based on experiment inⁱ
- Ref.6
  "Sequential processing of lysosomal acid phosphatase by a cytoplasmic thiol proteinase and a lysosomal aspartyl proteinase."
  Gottschalk S., Waheed A., Schmidt B., Laidler P., von Figura K.
  EMBO J. 8:3215-3219(1989) [PubMed] [Europe PMC] [Abstract]
  Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
- Ref.8
  "Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells."
  Waheed A., Gottschalk S., Hille A., Krentler C., Pohlmann R., Braulke T., Hauser H., Geuze H., von Figura K.
  EMBO J. 7:2351-2358(1988) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION, MEMBRANE TOPOLOGY, PROTEOLYTIC PROCESSING.
; Single-pass membrane protein Sequence analysis; Lumenal side
2 Publications
Manual assertion inferred by curator fromⁱ
- Ref.6
  "Sequential processing of lysosomal acid phosphatase by a cytoplasmic thiol proteinase and a lysosomal aspartyl proteinase."
  Gottschalk S., Waheed A., Schmidt B., Laidler P., von Figura K.
  EMBO J. 8:3215-3219(1989) [PubMed] [Europe PMC] [Abstract]
  Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
- Ref.8
  "Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells."
  Waheed A., Gottschalk S., Hille A., Krentler C., Pohlmann R., Braulke T., Hauser H., Geuze H., von Figura K.
  EMBO J. 7:2351-2358(1988) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION, MEMBRANE TOPOLOGY, PROTEOLYTIC PROCESSING.
Lysosome lumen

Note:

The soluble form arises by proteolytic processing of the membrane-bound form.2 Publications

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	31 – 380	LumenalSequence analysisAdd BLAST	350
Transmembraneⁱ	381 – 401	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	402 – 423	CytoplasmicSequence analysisAdd BLAST	22

GO - Cellular componentⁱ

extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
integral component of membrane
Source: ProtInc
Traceable author statementⁱ
- 2776754
lysosomal lumen Source: UniProtKB-SubCell
lysosomal membrane Source: UniProtKB-SubCell
lysosome
Source: MGI
Inferred from direct assayⁱ
- 3160696
membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 19946888

Complete GO annotation...

Keywords - Cellular componentⁱ

Lysosome, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Lysosomal acid phosphatase has been shown to be deficient in cultured fibroblasts from patients manifesting intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding and death in early infancy.1 Publication

Organism-specific databases

DisGeNET More...DisGeNETⁱ	53.
MalaCards human disease database More...MalaCardsⁱ	ACP2.
Open Targets More...OpenTargetsⁱ	ENSG00000134575.
Orphanetⁱ	35121. Acid phosphatase deficiency.
PharmGKBⁱ	PA24447.

Polymorphism and mutation databases

BioMutaⁱ	ACP2.
DMDMⁱ	115502439.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 30	Add BLAST		30
ChainⁱPRO_0000023960	31 – 423	Lysosomal acid phosphataseAdd BLAST		393

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	92	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	133	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	159 ↔ 370	By similarity
Glycosylationⁱ	167	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	177	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	191	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	212 ↔ 310	By similarity
Glycosylationⁱ	267	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	322	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	331	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	345 ↔ 349	By similarity

Post-translational modificationⁱ

The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.2 Publications

N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted N-glycosylation sites are used.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P11117.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11117.
PaxDbⁱ	P11117.
PeptideAtlas More...PeptideAtlasⁱ	P11117.
PRIDEⁱ	P11117.
TopDownProteomicsⁱ	P11117-1. [P11117-1]

PTM databases

DEPODⁱ	P11117.
iPTMnetⁱ	P11117.
PhosphoSitePlusⁱ	P11117.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134575.
CleanExⁱ	HS_ACP2.
ExpressionAtlasⁱ	P11117. baseline and differential.
Genevisibleⁱ	P11117. HS.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	106569. 36 interactors.
IntActⁱ	P11117. 2 interactors.
STRINGⁱ	9606.ENSP00000256997.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P11117.
SMRⁱ	P11117.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3720. Eukaryota. ENOG410ZVBQ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062956.
HOGENOMⁱ	HOG000231439.
HOVERGENⁱ	HBG002203.
InParanoidⁱ	P11117.
KEGG Orthology (KO) More...KOⁱ	K14410.
OMAⁱ	FLHLTEP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09FA.
PhylomeDBⁱ	P11117.
TreeFamⁱ	TF312893.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07061. HP_HAP_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
InterProⁱ	View protein in InterPro IPR033379. Acid_Pase_AS. IPR000560. His_Pase_clade-2. IPR029033. His_PPase_superfam.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00328. His_Phos_2. 1 hit.
SUPFAMⁱ	SSF53254. SSF53254. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P11117-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT 
        60         70         80         90        100
YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV 
       110        120        130        140        150
YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR 
       160        170        180        190        200
LLKFPLGPCP RYEQLQNETR QTPEYQNESS RNAQFLDMVA NETGLTDLTL 
       210        220        230        240        250
ETVWNVYDTL FCEQTHGLRL PPWASPQTMQ RLSRLKDFSF RFLFGIYQQA 
       260        270        280        290        300
EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY 
       310        320        330        340        350
NGEQAPYASC HIFELYQEDS GNFSVEMYFR NESDKAPWPL SLPGCPHRCP 
       360        370        380        390        400
LQDFLRLTEP VVPKDWQQEC QLASGPADTE VIVALAVCGS ILFLLIVLLL 
       410        420 
TVLFRMQAQP PGYRHVADGE DHA

Length:423

Mass (Da):48,344

Last modified:October 3, 2006 - v3

Checksum:ⁱ3431A30B83A1E2B4

GO

Isoform 2 (identifier: P11117-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
151-160: LLKFPLGPCP → VRVASPSLGW
161-423: Missing.

« Hide

        10         20         30         40         50
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLLY RHGDRSPVKT 
        60         70         80         90        100
YPKDPYQEEE WPQGFGQLTK EGMLQHWELG QALRQRYHGF LNTSYHRQEV 
       110        120        130        140        150
YVRSTDFDRT LMSAEANLAG LFPPNGMQRF NPNISWQPIP VHTVPITEDR 
       160
VRVASPSLGW

Note: No experimental confirmation available.

Show »

Length:160

Mass (Da):18,417

Checksum:ⁱ18EA6F3F31278714

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_027801	29	R → Q2 PublicationsCorresponds to variant dbSNP:rs2167079Ensembl.	1
Natural variantⁱVAR_034394	320	S → F. Corresponds to variant dbSNP:rs34425282Ensembl.	1
Natural variantⁱVAR_050519	402	V → I. Corresponds to variant dbSNP:rs4647764Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045629	151 – 160	LLKFPLGPCP → VRVASPSLGW in isoform 2. 1 Publication		10
Alternative sequenceⁱVSP_045630	161 – 423	Missing in isoform 2. 1 PublicationAdd BLAST		263

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12548 mRNA. Translation: CAA31064.1. X15525 X15535 Genomic DNA. Translation: CAA33542.1. DA382854 mRNA. No translation available. AC018410 Genomic DNA. No translation available. BC003160 mRNA. Translation: AAH03160.1. BC093010 mRNA. Translation: AAH93010.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7928.1. [P11117-1]
PIRⁱ	S06167.
NCBI Reference Sequences More...RefSeqⁱ	NP_001289418.1. NM_001302489.1. NP_001289419.1. NM_001302490.1. NP_001289420.1. NM_001302491.1. NP_001289421.1. NM_001302492.1. NP_001601.1. NM_001610.3. [P11117-1]
UniGeneⁱ	Hs.532492.

Genome annotation databases

Ensemblⁱ	ENST00000256997; ENSP00000256997; ENSG00000134575. [P11117-1]
GeneIDⁱ	53.
KEGGⁱ	hsa:53.
UCSC genome browser More...UCSCⁱ	uc001nei.3. human. [P11117-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12548 mRNA. Translation: CAA31064.1. X15525 X15535 Genomic DNA. Translation: CAA33542.1. DA382854 mRNA. No translation available. AC018410 Genomic DNA. No translation available. BC003160 mRNA. Translation: AAH03160.1. BC093010 mRNA. Translation: AAH93010.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7928.1. [P11117-1]
PIRⁱ	S06167.
NCBI Reference Sequences More...RefSeqⁱ	NP_001289418.1. NM_001302489.1. NP_001289419.1. NM_001302490.1. NP_001289420.1. NM_001302491.1. NP_001289421.1. NM_001302492.1. NP_001601.1. NM_001610.3. [P11117-1]
UniGeneⁱ	Hs.532492.

3D structure databases

ProteinModelPortalⁱ	P11117.
SMRⁱ	P11117.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106569. 36 interactors.
IntActⁱ	P11117. 2 interactors.
STRINGⁱ	9606.ENSP00000256997.

PTM databases

DEPODⁱ	P11117.
iPTMnetⁱ	P11117.
PhosphoSitePlusⁱ	P11117.

Polymorphism and mutation databases

BioMutaⁱ	ACP2.
DMDMⁱ	115502439.

Proteomic databases

EPDⁱ	P11117.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11117.
PaxDbⁱ	P11117.
PeptideAtlas More...PeptideAtlasⁱ	P11117.
PRIDEⁱ	P11117.
TopDownProteomicsⁱ	P11117-1. [P11117-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	53.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000256997; ENSP00000256997; ENSG00000134575. [P11117-1]
GeneIDⁱ	53.
KEGGⁱ	hsa:53.
UCSC genome browser More...UCSCⁱ	uc001nei.3. human. [P11117-1]

Organism-specific databases

CTDⁱ	53.
DisGeNET More...DisGeNETⁱ	53.
GeneCardsⁱ	ACP2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:123. ACP2.
MalaCards human disease database More...MalaCardsⁱ	ACP2.
MIMⁱ	171650. gene.
neXtProtⁱ	NX_P11117.
Open Targets More...OpenTargetsⁱ	ENSG00000134575.
Orphanetⁱ	35121. Acid phosphatase deficiency.
PharmGKBⁱ	PA24447.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3720. Eukaryota. ENOG410ZVBQ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062956.
HOGENOMⁱ	HOG000231439.
HOVERGENⁱ	HBG002203.
InParanoidⁱ	P11117.
KEGG Orthology (KO) More...KOⁱ	K14410.
OMAⁱ	FLHLTEP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09FA.
PhylomeDBⁱ	P11117.
TreeFamⁱ	TF312893.

Miscellaneous databases

ChiTaRSⁱ	ACP2. human.
GeneWikiⁱ	ACP2.
GenomeRNAiⁱ	53.
Protein Ontology More...PROⁱ	PR:P11117.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134575.
CleanExⁱ	HS_ACP2.
ExpressionAtlasⁱ	P11117. baseline and differential.
Genevisibleⁱ	P11117. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07061. HP_HAP_like. 1 hit.
Gene3Dⁱ	3.40.50.1240. 1 hit.
InterProⁱ	View protein in InterPro IPR033379. Acid_Pase_AS. IPR000560. His_Pase_clade-2. IPR029033. His_PPase_superfam.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00328. His_Phos_2. 1 hit.
SUPFAMⁱ	SSF53254. SSF53254. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPAL_HUMAN
Accessionⁱ	P11117Primary (citable) accession number: P11117 Secondary accession number(s): E9PCI1, Q561W5, Q9BTU7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	October 3, 2006
	Last modified:	May 10, 2017
	This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P11117 (PPAL_HUMAN)

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Lysosomal acid phosphatase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ