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Protein

Galectin-1

Gene

LGALS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin that binds beta-galactoside and a wide array of complex carbohydrates (PubMed:1900835, PubMed:8108426, PubMed:7773775). Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Beta-galactosideBy similarity1
Binding sitei62Beta-galactosideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Enzyme and pathway databases

ReactomeiR-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
S-Lac lectin 1
Gene namesi
Name:LGALS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:30850 LGALS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi69W → F: Reduced carbohydrate binding. 1 Publication1
Mutagenesisi69W → L: No carbohydrate binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000769152 – 135Galectin-1Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei29N6-acetyllysineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei108N6-acetyllysine; alternateBy similarity1
Modified residuei108N6-succinyllysine; alternateBy similarity1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11116
PeptideAtlasiP11116
PRIDEiP11116

Expressioni

Gene expression databases

BgeeiENSBTAG00000015089

Interactioni

Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020080

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi17 – 24Combined sources8
Beta strandi30 – 38Combined sources9
Beta strandi41 – 52Combined sources12
Beta strandi55 – 65Combined sources11
Beta strandi73 – 75Combined sources3
Beta strandi85 – 92Combined sources8
Beta strandi94 – 100Combined sources7
Helixi102 – 104Combined sources3
Beta strandi106 – 110Combined sources5
Beta strandi120 – 135Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SLAX-ray2.45A/B2-135[»]
1SLBX-ray2.30A/B/C/D2-135[»]
1SLCX-ray2.15A/B/C/D2-135[»]
1SLTX-ray1.90A/B2-135[»]
ProteinModelPortaliP11116
SMRiP11116
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11116

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 135GalectinPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 49Beta-galactoside bindingBy similarity5
Regioni69 – 72Beta-galactoside bindingBy similarity4

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOGENOMiHOG000059539
HOVERGENiHBG006255
InParanoidiP11116
KOiK06830
OMAiCNSKEDG
OrthoDBiEOG091G0S7H
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGLVASNL NLKPGECLRV RGEVAADAKS FLLNLGKDDN NLCLHFNPRF
60 70 80 90 100
NAHGDVNTIV CNSKDAGAWG AEQRESAFPF QPGSVVEVCI SFNQTDLTIK
110 120 130
LPDGYEFKFP NRLNLEAINY LSAGGDFKIK CVAFE
Length:135
Mass (Da):14,744
Last modified:January 23, 2007 - v2
Checksum:i77FE0F95C67317BC
GO

Mass spectrometryi

Molecular mass is 14654.6±0.9 Da from positions 2 - 135. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14330 mRNA Translation: CAA32508.1
AB099039 mRNA Translation: BAC56529.1
BC103156 mRNA Translation: AAI03157.1
PIRiS03865 LNBOGB
RefSeqiNP_786976.1, NM_175782.1
UniGeneiBt.5472

Genome annotation databases

EnsembliENSBTAT00000020080; ENSBTAP00000020080; ENSBTAG00000015089
GeneIDi326598
KEGGibta:326598

Similar proteinsi

Entry informationi

Entry nameiLEG1_BOVIN
AccessioniPrimary (citable) accession number: P11116
Secondary accession number(s): P11945, Q54A27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health