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Protein

Cell death peptidase

Gene

lit

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Interacts with a short DNA sequence about one-quarter of the way into the major capsid protein gene 23 of T4; general translation inhibition occurs when this late gene of the virus is expressed.1 Publication

GO - Molecular functioni

  • peptidase activity Source: EcoCyc

GO - Biological processi

  • regulation of translational elongation Source: EcoCyc

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BioCyciEcoCyc:EG10535-MONOMER.

Protein family/group databases

MEROPSiU49.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death peptidaseCurated
Alternative name(s):
Bacteriophage T4 late gene expression-blocking protein
GpLit
Gene namesi
Name:lit
Ordered Locus Names:b1139, JW1125
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10535. lit.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 82HelicalSequence analysisAdd BLAST22
Transmembranei149 – 178HelicalSequence analysisAdd BLAST30

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844461 – 297Cell death peptidaseAdd BLAST297

Proteomic databases

PaxDbiP11072.
PRIDEiP11072.

Interactioni

Protein-protein interaction databases

BioGridi4263099. 10 interactors.
STRINGi316407.1651567.

Structurei

3D structure databases

ProteinModelPortaliP11072.
SMRiP11072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase U49 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106VW7. Bacteria.
ENOG410YPG7. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR019504. Peptidase_U49_Lit_pept.
PfamiView protein in Pfam
PF10463. Peptidase_U49. 1 hit.

Sequencei

Sequence statusi: Complete.

P11072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSPICHLFS AINSSPFKIA PEKEQDLKTI VDDKKIIISV VSEPGFNIRV
60 70 80 90 100
RKNESNNSHE IVLTVASLEY IWAFSNFFWV FTQEYSKSQK NNDEHFDLTG
110 120 130 140 150
KNRLKKSDEL LKWARKNLQT TGCESWPKKC PKPEAYLQGS EDSQVASEIF
160 170 180 190 200
LCAIAWILHH EISHVVLQHP LVTTAFSTQE EREADSHATK WILGNLYESA
210 220 230 240 250
PELKKRALGI ATAVLCIQSL EVENYFCLQN THPAAYERIY SNISCYPVGN
260 270 280 290
EELIEALCTV MLQYLFHGKN INVNLDGESF SSILGDLLCD ISRLTSN
Length:297
Mass (Da):33,762
Last modified:November 1, 1997 - v2
Checksum:i8A06C0EB82FBB1AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121 – 135TGCES…PKPEA → QVANHGLKNVPSQKH in AAA24074 (PubMed:2452152).CuratedAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19634 Genomic DNA. Translation: AAA24074.1.
U00096 Genomic DNA. Translation: AAC74223.1.
AP009048 Genomic DNA. Translation: BAA35968.1.
PIRiH64858. BVECLT.
RefSeqiNP_415657.1. NC_000913.3.
WP_001257372.1. NZ_CP010440.1.

Genome annotation databases

EnsemblBacteriaiAAC74223; AAC74223; b1139.
BAA35968; BAA35968; BAA35968.
GeneIDi948421.
KEGGiecj:JW1125.
eco:b1139.
PATRICifig|511145.12.peg.1185.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLIT_ECOLI
AccessioniPrimary (citable) accession number: P11072
Secondary accession number(s): P77283
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families