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Protein

Low molecular weight phosphotyrosine protein phosphatase

Gene

ACP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Enzyme regulationi

Inhibited by sulfhydryl reagents.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13Nucleophile1 Publication1
Active sitei191
Active sitei130Proton donor1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SABIO-RKP11064.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase (EC:3.1.3.48)
Short name:
LMW-PTP
Short name:
LMW-PTPase
Alternative name(s):
Low molecular weight cytosolic acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:ACP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi13C → A or S: Inactive. 1 Publication1
Mutagenesisi18C → S: Greatly decreases activity. 1 Publication1
Mutagenesisi63C → S: 2.5-fold increase in activity. 1 Publication1
Mutagenesisi67H → E: Decreased activity. 2 Publications1
Mutagenesisi73H → E: Decreased activity. 2 Publications1
Mutagenesisi146C → S: No effect on activity. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL1075054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000465572 – 158Low molecular weight phosphotyrosine protein phosphataseAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei132PhosphotyrosineBy similarity1
Modified residuei133PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP11064.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020498.

Interactioni

Subunit structurei

Interacts with the SH3 domain of SPTAN1. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 (By similarity).By similarity

Chemistry databases

BindingDBiP11064.

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 18Combined sources12
Helixi19 – 33Combined sources15
Helixi37 – 39Combined sources3
Beta strandi40 – 47Combined sources8
Turni50 – 53Combined sources4
Helixi58 – 66Combined sources9
Helixi82 – 85Combined sources4
Beta strandi87 – 93Combined sources7
Helixi94 – 104Combined sources11
Beta strandi113 – 116Combined sources4
Helixi117 – 120Combined sources4
Helixi136 – 157Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BVHNMR-A2-158[»]
1C0EX-ray2.20A/B2-158[»]
1DG9X-ray1.90A2-158[»]
1PHRX-ray2.10A2-158[»]
1PNTX-ray2.20A2-158[»]
1Z12X-ray2.20A2-158[»]
1Z13X-ray2.20A2-158[»]
ProteinModelPortaliP11064.
SMRiP11064.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11064.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
HOVERGENiHBG007540.
InParanoidiP11064.
KOiK14394.
OMAiCEIAPEM.
OrthoDBiEOG091G0P0O.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQVTKSVL FVCLGNICRS PIAEAVFRKL VTDQNISDNW VIDSGAVSDW
60 70 80 90 100
NVGRSPDPRA VSCLRNHGIN TAHKARQVTK EDFVTFDYIL CMDESNLRDL
110 120 130 140 150
NRKSNQVKNC RAKIELLGSY DPQKQLIIED PYYGNDADFE TVYQQCVRCC

RAFLEKVR
Length:158
Mass (Da):18,055
Last modified:January 23, 2007 - v3
Checksum:i5925D5048C42BE02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57D → N AA sequence (PubMed:2644264).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83656 mRNA. Translation: AAC37328.1.
PIRiA42082.
RefSeqiNP_776403.1. NM_173978.2.
UniGeneiBt.9965.

Genome annotation databases

EnsembliENSBTAT00000027314; ENSBTAP00000027314; ENSBTAG00000020498.
GeneIDi280977.
KEGGibta:280977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83656 mRNA. Translation: AAC37328.1.
PIRiA42082.
RefSeqiNP_776403.1. NM_173978.2.
UniGeneiBt.9965.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BVHNMR-A2-158[»]
1C0EX-ray2.20A/B2-158[»]
1DG9X-ray1.90A2-158[»]
1PHRX-ray2.10A2-158[»]
1PNTX-ray2.20A2-158[»]
1Z12X-ray2.20A2-158[»]
1Z13X-ray2.20A2-158[»]
ProteinModelPortaliP11064.
SMRiP11064.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP11064.
ChEMBLiCHEMBL1075054.

Proteomic databases

PRIDEiP11064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027314; ENSBTAP00000027314; ENSBTAG00000020498.
GeneIDi280977.
KEGGibta:280977.

Organism-specific databases

CTDi52.

Phylogenomic databases

GeneTreeiENSGT00500000044891.
HOGENOMiHOG000273094.
HOVERGENiHBG007540.
InParanoidiP11064.
KOiK14394.
OMAiCEIAPEM.
OrthoDBiEOG091G0P0O.

Enzyme and pathway databases

SABIO-RKP11064.

Miscellaneous databases

EvolutionaryTraceiP11064.
PROiP11064.

Gene expression databases

BgeeiENSBTAG00000020498.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_BOVIN
AccessioniPrimary (citable) accession number: P11064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.