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Protein

Mu-agatoxin-Aa1f

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-agatoxin-Aa1f
Short name:
Mu-AGTX-Aa1f
Alternative name(s):
Mu-agatoxin VI1 Publication
Mu-agatoxin-6
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000385. mu-agatoxin-Aa1f.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Lethal dose is 38 +-12 mg/kg into third stadium larvae of M.sexta.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449601 – 37Mu-agatoxin-Aa1fAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 18By similarity
Disulfide bondi9 ↔ 23By similarity
Disulfide bondi17 ↔ 33By similarity
Disulfide bondi25 ↔ 31By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP11062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR016328. Curtatoxin.
IPR009243. Mu-agatoxin.
[Graphical view]
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
DCVGESQQCA DWAGPHCCDG YYCTCRYFPK CICVNNN
Length:37
Mass (Da):4,168
Last modified:July 1, 1989 - v1
Checksum:iB2AC03A74B5ED028
GO

Sequence databases

PIRiF32038.

Cross-referencesi

Sequence databases

PIRiF32038.

3D structure databases

ProteinModelPortaliP11062.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000385. mu-agatoxin-Aa1f.

Family and domain databases

InterProiIPR016328. Curtatoxin.
IPR009243. Mu-agatoxin.
[Graphical view]
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT4G1F_AGEAP
AccessioniPrimary (citable) accession number: P11062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.