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P11062

- TXMG6_AGEAP

UniProt

P11062 - TXMG6_AGEAP

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Protein

Mu-agatoxin-Aa1f

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-agatoxin-Aa1f
Short name:
Mu-AGTX-Aa1f
Alternative name(s):
Mu-agatoxin VI
Mu-agatoxin-6
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000385. mu-agatoxin-Aa1f.

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Lethal dose is 38 +-12 mg/kg into third stadium larvae of M.sexta.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3737Mu-agatoxin-Aa1fPRO_0000044960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 18 By similarity
Disulfide bondi9 ↔ 23 By similarity
Disulfide bondi17 ↔ 33 By similarity
Disulfide bondi25 ↔ 31 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP11062.
SMRiP11062. Positions 1-37.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11062-1 [UniParc]FASTAAdd to Basket

« Hide

DCVGESQQCA DWAGPHCCDG YYCTCRYFPK CICVNNN                 37
Length:37
Mass (Da):4,168
Last modified:July 1, 1989 - v1
Checksum:iB2AC03A74B5ED028
GO

Sequence databases

PIRiF32038.

Cross-referencesi

Sequence databases

PIRi F32038.

3D structure databases

ProteinModelPortali P11062.
SMRi P11062. Positions 1-37.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000385. mu-agatoxin-Aa1f.

Family and domain databases

InterProi IPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view ]
PIRSFi PIRSF001882. Curtatoxin. 1 hit.
PROSITEi PS60015. MU_AGATOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
    Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
    J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
    Tissue: Venom.
  2. "Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
    Adams M.E.
    Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTXMG6_AGEAP
AccessioniPrimary (citable) accession number: P11062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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