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P11062 (TXMG6_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mu-agatoxin-Aa1f

Short name=Mu-AGTX-Aa1f
Alternative name(s):
Mu-agatoxin VI
Mu-agatoxin-6
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Toxic dose

Lethal dose is 38 +-12 mg/kg into third stadium larvae of M.sexta. Ref.1

Sequence similarities

Belongs to the beta/delta-agatoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainKnottin
   Molecular functionIon channel impairing toxin
Neurotoxin
Presynaptic neurotoxin
Toxin
Voltage-gated sodium channel impairing toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentother organism presynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Mu-agatoxin-Aa1f
PRO_0000044960

Amino acid modifications

Disulfide bond2 ↔ 18 By similarity
Disulfide bond9 ↔ 23 By similarity
Disulfide bond17 ↔ 33 By similarity
Disulfide bond25 ↔ 31 By similarity

Sequences

Sequence LengthMass (Da)Tools
P11062 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: B2AC03A74B5ED028

FASTA374,168
        10         20         30 
DCVGESQQCA DWAGPHCCDG YYCTCRYFPK CICVNNN 

« Hide

References

[1]"Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
Tissue: Venom.
[2]"Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
Adams M.E.
Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

PIRF32038.

3D structure databases

ProteinModelPortalP11062.
SMRP11062. Positions 1-37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000385. mu-agatoxin-Aa1f.

Family and domain databases

InterProIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFPIRSF001882. Curtatoxin. 1 hit.
PROSITEPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTXMG6_AGEAP
AccessionPrimary (citable) accession number: P11062
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families