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P11061 (TXMG5_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mu-agatoxin-Aa1e

Short name=Mu-AGTX-Aa1e
Alternative name(s):
Mu-agatoxin V
Mu-agatoxin-5
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Toxic dose

Lethal dose is 48 +-11 mg/kg into third stadium larvae of M.sexta. Ref.1

Sequence similarities

Belongs to the beta/delta-agatoxin family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Mu-agatoxin-Aa1e
PRO_0000044959

Amino acid modifications

Modified residue371Asparagine amide Ref.1
Disulfide bond2 ↔ 18 Ref.1
Disulfide bond9 ↔ 23 Ref.1
Disulfide bond17 ↔ 33 Ref.1
Disulfide bond25 ↔ 31 Ref.1

Sequences

Sequence LengthMass (Da)Tools
P11061 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: E742F3A18C59BBE5

FASTA374,208
        10         20         30 
ACVGENKQCA DWAGPHCCDG YYCTCRYFPK CICRNNN 

« Hide

References

[1]"Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE, DISULFIDE BONDS.
Tissue: Venom.
[2]"Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
Adams M.E.
Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

PIRE32038.

3D structure databases

ProteinModelPortalP11061.
SMRP11061. Positions 1-37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000383. mu-agatoxin-Aa1e.

Family and domain databases

InterProIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFPIRSF001882. Curtatoxin. 1 hit.
PROSITEPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTXMG5_AGEAP
AccessionPrimary (citable) accession number: P11061
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families