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P11058

- TXMG2_AGEAP

UniProt

P11058 - TXMG2_AGEAP

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Protein
Mu-agatoxin-Aa1b
Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Protein family/group databases

TCDBi8.B.6.1.2. the ca(2+) channel-targeting spider toxin (cst) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-agatoxin-Aa1b
Short name:
Mu-AGTX-Aa1b
Alternative name(s):
Mu-agatoxin II
Mu-agatoxin-2
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000377. mu-agatoxin-Aa1b.

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Lethal dose is 75 +-27 mg/kg into third stadium larvae of M.sexta.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3737Mu-agatoxin-Aa1b
PRO_0000044954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 18 By similarity
Disulfide bondi9 ↔ 23 By similarity
Disulfide bondi17 ↔ 33 By similarity
Disulfide bondi25 ↔ 31 By similarity
Modified residuei37 – 371Serine amide Inferred

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP11058.
SMRiP11058. Positions 1-37.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11058-1 [UniParc]FASTAAdd to Basket

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ECATKNKRCA DWAGPWCCDG LYCSCRSYPG CMCRPSS                 37
Length:37
Mass (Da):4,110
Last modified:July 1, 1989 - v1
Checksum:i8900D367B4F096CD
GO

Sequence databases

PIRiB32038.

Cross-referencesi

Sequence databases

PIRi B32038.

3D structure databases

ProteinModelPortali P11058.
SMRi P11058. Positions 1-37.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 8.B.6.1.2. the ca(2+) channel-targeting spider toxin (cst) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000377. mu-agatoxin-Aa1b.

Family and domain databases

InterProi IPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view ]
PIRSFi PIRSF001882. Curtatoxin. 1 hit.
PROSITEi PS60015. MU_AGATOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
    Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
    J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
    Tissue: Venom.
  2. "Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
    Adams M.E.
    Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTXMG2_AGEAP
AccessioniPrimary (citable) accession number: P11058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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