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P11058 (TXMG2_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mu-agatoxin-Aa1b

Short name=Mu-AGTX-Aa1b
Alternative name(s):
Mu-agatoxin II
Mu-agatoxin-2
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

Toxic dose

Lethal dose is 75 +-27 mg/kg into third stadium larvae of M.sexta. Ref.1

Sequence similarities

Belongs to the beta/delta-agatoxin family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Mu-agatoxin-Aa1b
PRO_0000044954

Amino acid modifications

Modified residue371Serine amide Probable
Disulfide bond2 ↔ 18 By similarity
Disulfide bond9 ↔ 23 By similarity
Disulfide bond17 ↔ 33 By similarity
Disulfide bond25 ↔ 31 By similarity

Sequences

Sequence LengthMass (Da)Tools
P11058 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 8900D367B4F096CD

FASTA374,110
        10         20         30 
ECATKNKRCA DWAGPWCCDG LYCSCRSYPG CMCRPSS 

« Hide

References

[1]"Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
Tissue: Venom.
[2]"Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
Adams M.E.
Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

PIRB32038.

3D structure databases

ProteinModelPortalP11058.
SMRP11058. Positions 1-37.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB8.B.6.1.2. the ca(2+) channel-targeting spider toxin (cst) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000377. mu-agatoxin-Aa1b.

Family and domain databases

InterProIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFPIRSF001882. Curtatoxin. 1 hit.
PROSITEPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTXMG2_AGEAP
AccessionPrimary (citable) accession number: P11058
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families