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Protein

Mu-agatoxin-Aa1a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-agatoxin-Aa1a
Short name:
Mu-AGTX-Aa1a
Alternative name(s):
Mu-agatoxin I1 Publication
Mu-agatoxin-1
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000375. mu-agatoxin-Aa1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Lethal dose is 28 +-7 mg/kg into third stadium larvae of M.sexta.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449521 – 36Mu-agatoxin-Aa1aAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 171 Publication
Disulfide bondi9 ↔ 221 Publication
Disulfide bondi16 ↔ 321 Publication
Disulfide bondi24 ↔ 301 Publication
Modified residuei36Asparagine amide2 Publications1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 14Combined sources4
Beta strandi20 – 26Combined sources7
Beta strandi29 – 34Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EITNMR-A1-36[»]
ProteinModelPortaliP11057.
SMRiP11057.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11057.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

CDDicd12960. Spider_toxin. 1 hit.
InterProiView protein in InterPro
IPR016328. Beta/delta-agatoxin_fam.
IPR004169. Spidertoxin.
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60015. MU_AGATOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P11057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
ECVPENGHCR DWYDECCEGF YCSCRQPPKC ICRNNN
Length:36
Mass (Da):4,273
Last modified:July 1, 1989 - v1
Checksum:i3B973A605B90DE85
GO

Sequence databases

PIRiA32038.

Entry informationi

Entry nameiT5G1A_AGEAP
AccessioniPrimary (citable) accession number: P11057
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 27, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families