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P11057 (TXMG1_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mu-agatoxin-Aa1a

Short name=Mu-AGTX-Aa1a
Alternative name(s):
Mu-agatoxin I
Mu-agatoxin-1
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length36 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Toxic dose

Lethal dose is 28 +-7 mg/kg into third stadium larvae of M.sexta. Ref.1

Sequence similarities

Belongs to the beta/delta-agatoxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3636Mu-agatoxin-Aa1a
PRO_0000044952

Amino acid modifications

Modified residue361Asparagine amide Ref.1 Ref.2
Disulfide bond2 ↔ 17 Ref.2
Disulfide bond9 ↔ 22 Ref.2
Disulfide bond16 ↔ 32 Ref.2
Disulfide bond24 ↔ 30 Ref.2

Secondary structure

....... 36
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P11057 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 3B973A605B90DE85

FASTA364,273
        10         20         30 
ECVPENGHCR DWYDECCEGF YCSCRQPPKC ICRNNN 

« Hide

References

[1]"Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
Tissue: Venom.
[2]"Three-dimensional structure analysis of mu-agatoxins: further evidence for common motifs among neurotoxins with diverse ion channel specificities."
Omecinsky D.O., Holub K.E., Adams M.E., Reily M.D.
Biochemistry 35:2836-2844(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, AMIDATION AT ASN-36, DISULFIDE BONDS.
[3]"Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
Adams M.E.
Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

PIRA32038.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EITNMR-A1-36[»]
ProteinModelPortalP11057.
SMRP11057. Positions 1-36.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000375. mu-agatoxin-Aa1a.

Family and domain databases

InterProIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFPIRSF001882. Curtatoxin. 1 hit.
PROSITEPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP11057.

Entry information

Entry nameTXMG1_AGEAP
AccessionPrimary (citable) accession number: P11057
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references