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P11057

- TXMG1_AGEAP

UniProt

P11057 - TXMG1_AGEAP

Protein

Mu-agatoxin-Aa1a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mu-agatoxin-Aa1a
    Short name:
    Mu-AGTX-Aa1a
    Alternative name(s):
    Mu-agatoxin I
    Mu-agatoxin-1
    OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
    Taxonomic identifieri6908 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

    Organism-specific databases

    ArachnoServeriAS000375. mu-agatoxin-Aa1a.

    Subcellular locationi

    GO - Cellular componenti

    1. other organism presynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Toxic dosei

    Lethal dose is 28 +-7 mg/kg into third stadium larvae of M.sexta.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3636Mu-agatoxin-Aa1aPRO_0000044952Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 171 Publication
    Disulfide bondi9 ↔ 221 Publication
    Disulfide bondi16 ↔ 321 Publication
    Disulfide bondi24 ↔ 301 Publication
    Modified residuei36 – 361Asparagine amide2 Publications

    Keywords - PTMi

    Amidation, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    Secondary structure

    1
    36
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi11 – 144
    Beta strandi20 – 267
    Beta strandi29 – 346

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EITNMR-A1-36[»]
    ProteinModelPortaliP11057.
    SMRiP11057. Positions 1-36.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11057.

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

    Sequence similaritiesi

    Belongs to the beta/delta-agatoxin family.Curated

    Keywords - Domaini

    Knottin

    Family and domain databases

    InterProiIPR016328. Curtatoxin.
    IPR009243. Toxin_7.
    [Graphical view]
    PIRSFiPIRSF001882. Curtatoxin. 1 hit.
    PROSITEiPS60015. MU_AGATOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P11057-1 [UniParc]FASTAAdd to Basket

    « Hide

    ECVPENGHCR DWYDECCEGF YCSCRQPPKC ICRNNN                  36
    Length:36
    Mass (Da):4,273
    Last modified:July 1, 1989 - v1
    Checksum:i3B973A605B90DE85
    GO

    Sequence databases

    PIRiA32038.

    Cross-referencesi

    Sequence databases

    PIRi A32038.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EIT NMR - A 1-36 [» ]
    ProteinModelPortali P11057.
    SMRi P11057. Positions 1-36.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ArachnoServeri AS000375. mu-agatoxin-Aa1a.

    Miscellaneous databases

    EvolutionaryTracei P11057.

    Family and domain databases

    InterProi IPR016328. Curtatoxin.
    IPR009243. Toxin_7.
    [Graphical view ]
    PIRSFi PIRSF001882. Curtatoxin. 1 hit.
    PROSITEi PS60015. MU_AGATOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
      Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
      J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
      Tissue: Venom.
    2. "Three-dimensional structure analysis of mu-agatoxins: further evidence for common motifs among neurotoxins with diverse ion channel specificities."
      Omecinsky D.O., Holub K.E., Adams M.E., Reily M.D.
      Biochemistry 35:2836-2844(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, AMIDATION AT ASN-36, DISULFIDE BONDS.
    3. "Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
      Adams M.E.
      Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiTXMG1_AGEAP
    AccessioniPrimary (citable) accession number: P11057
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3