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P11057

- TXMG1_AGEAP

UniProt

P11057 - TXMG1_AGEAP

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Protein

Mu-agatoxin-Aa1a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-agatoxin-Aa1a
Short name:
Mu-AGTX-Aa1a
Alternative name(s):
Mu-agatoxin I
Mu-agatoxin-1
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000375. mu-agatoxin-Aa1a.

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Lethal dose is 28 +-7 mg/kg into third stadium larvae of M.sexta.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3636Mu-agatoxin-Aa1aPRO_0000044952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 171 Publication
Disulfide bondi9 ↔ 221 Publication
Disulfide bondi16 ↔ 321 Publication
Disulfide bondi24 ↔ 301 Publication
Modified residuei36 – 361Asparagine amide2 Publications

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1
36
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 144
Beta strandi20 – 267
Beta strandi29 – 346

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EITNMR-A1-36[»]
ProteinModelPortaliP11057.
SMRiP11057. Positions 1-36.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11057.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the beta/delta-agatoxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view]
PIRSFiPIRSF001882. Curtatoxin. 1 hit.
PROSITEiPS60015. MU_AGATOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P11057-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
ECVPENGHCR DWYDECCEGF YCSCRQPPKC ICRNNN
Length:36
Mass (Da):4,273
Last modified:July 1, 1989 - v1
Checksum:i3B973A605B90DE85
GO

Sequence databases

PIRiA32038.

Cross-referencesi

Sequence databases

PIRi A32038.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EIT NMR - A 1-36 [» ]
ProteinModelPortali P11057.
SMRi P11057. Positions 1-36.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000375. mu-agatoxin-Aa1a.

Miscellaneous databases

EvolutionaryTracei P11057.

Family and domain databases

InterProi IPR016328. Curtatoxin.
IPR009243. Toxin_7.
[Graphical view ]
PIRSFi PIRSF001882. Curtatoxin. 1 hit.
PROSITEi PS60015. MU_AGATOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta."
    Skinner W.S., Adams M.E., Quistad G.B., Kataoka H., Cesarin B.J., Enderlin F.E., Schooley D.A.
    J. Biol. Chem. 264:2150-2155(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
    Tissue: Venom.
  2. "Three-dimensional structure analysis of mu-agatoxins: further evidence for common motifs among neurotoxins with diverse ion channel specificities."
    Omecinsky D.O., Holub K.E., Adams M.E., Reily M.D.
    Biochemistry 35:2836-2844(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, AMIDATION AT ASN-36, DISULFIDE BONDS.
  3. "Agatoxins: ion channel specific toxins from the American funnel web spider, Agelenopsis aperta."
    Adams M.E.
    Toxicon 43:509-525(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiTXMG1_AGEAP
AccessioniPrimary (citable) accession number: P11057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3