P11049 (CD37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte antigen CD37

Alternative name(s):
Tetraspanin-26
Short name=Tspan-26
CD_antigen=CD37

Gene names

Name:	CD37
Synonyms:	TSPAN26

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with SCIMP.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	B-lymphocytes.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Leukocyte antigen CD37		PRO_0000219209
Regions
	Topological domain	1 – 17	17	Cytoplasmic Potential
	Transmembrane	18 – 38	21	Helical; Potential
	Topological domain	39 – 59	21	Extracellular Potential
	Transmembrane	60 – 74	15	Helical; Potential
	Topological domain	75 – 85	11	Cytoplasmic Potential
	Transmembrane	86 – 111	26	Helical; Potential
	Topological domain	112 – 241	130	Extracellular Potential
	Transmembrane	242 – 266	25	Helical; Potential
	Topological domain	267 – 281	15	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P11049 [UniParc]. Last modified November 1, 1990. Version 2. Checksum: 4342C5FB4479FDC8	FASTA	281	31,703
	10 20 30 40 50 60 MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV 70 80 90 100 110 120 LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR 130 140 150 160 170 180 DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS 190 200 210 220 230 240 CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN 250 260 270 280 NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen." Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I. J. Exp. Med. 169:1497-1502(1989) [PubMed: 2466944] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Erratum Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I. J. Exp. Med. 172:1007-1007(1990) [PubMed: 2388030] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling." Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T. Mol. Cell. Biol. 31:4550-4562(2011) [PubMed: 21930792] [Abstract] Cited for: INTERACTION WITH SCIMP.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14046 mRNA. Translation: CAA32204.1. CR541877 mRNA. Translation: CAG46675.1. BT019851 mRNA. Translation: AAV38654.1. BC106752 mRNA. Translation: AAI06753.1. BC110379 mRNA. Translation: AAI10380.1.
IPI	IPI00003400.
PIR	A47629.
RefSeq	NP_001765.1. NM_001774.2.
UniGene	Hs.166556.
3D structure databases
ProteinModelPortal	P11049.
ModBase	Search...
Protein-protein interaction databases
STRING	P11049.
PTM databases
PhosphoSite	P11049.
Polymorphism databases
DMDM	115983.
Proteomic databases
PRIDE	P11049.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323906; ENSP00000325708; ENSG00000104894.
GeneID	951.
KEGG	hsa:951.
UCSC	uc002pnd.1. human.
Organism-specific databases
CTD	951.
GeneCards	GC19P049838.
HGNC	HGNC:1666. CD37.
HPA	CAB002492.
MIM	151523. gene.
neXtProt	NX_P11049.
PharmGKB	PA26213.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12577.
GeneTree	ENSGT00590000082836.
HOGENOM	HBG716506.
HOVERGEN	HBG002324.
InParanoid	P11049.
OMA	QFQLRCC.
OrthoDB	EOG4T7841.
PhylomeDB	P11049.
Gene expression databases
ArrayExpress	P11049.
Bgee	P11049.
CleanEx	HS_CD37.
Genevestigator	P11049.
GermOnline	ENSG00000104894. Homo sapiens.
Family and domain databases
InterPro	IPR018499. Tetraspanin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. IPR000301. Tetraspanin_subgr. [Graphical view]
KO	K06475.
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PRINTS	PR00259. TMFOUR.
SUPFAM	SSF48652. Tetraspanin. 1 hit.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	3956.
SOURCE	Search...

Entry information

Entry name

CD37_HUMAN

Accession

Primary (citable) accession number: P11049
Secondary accession number(s): Q3KPF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1990
Last modified:	January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.