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Reviewed, UniProtKB/Swiss-Prot P11049 (CD37_HUMAN)

Last modified November 24, 2009. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Leukocyte antigen CD37
Alternative name(s):
    Tetraspanin-26
      Short name=Tspan-26
    CD_antigen=CD37
Gene names
Name: CD37
Synonyms: TSPAN26
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

B-lymphocytes.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein amino acid N-linked glycosylation Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Leukocyte antigen CD37
PRO_0000219209

Regions

Topological domain1 – 1717Cytoplasmic Potential
Transmembrane18 – 3821 Potential
Topological domain39 – 5921Extracellular Potential
Transmembrane60 – 7415 Potential
Topological domain75 – 8511Cytoplasmic Potential
Transmembrane86 – 11126 Potential
Topological domain112 – 241130Extracellular Potential
Transmembrane242 – 26625 Potential
Topological domain267 – 28115Cytoplasmic Potential

Amino acid modifications

Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P11049-1 [UniParc].

Last modified November 1, 1990. Version 2.
Checksum: 4342C5FB4479FDC8

FASTA28131,703
        10         20         30         40         50         60 
MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV 

        70         80         90        100        110        120 
LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR 

       130        140        150        160        170        180 
DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS 

       190        200        210        220        230        240 
CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN 

       250        260        270        280 
NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen."
Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.
J. Exp. Med. 169:1497-1502(1989) [PubMed: 2466944] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Erratum
Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.
J. Exp. Med. 172:1007-1007(1990) [PubMed: 2388030] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

X14046 mRNA. Translation: CAA32204.1.
CR541877 mRNA. Translation: CAG46675.1.
BT019851 mRNA. Translation: AAV38654.1.
BC106752 mRNA. Translation: AAI06753.1.
BC110379 mRNA. Translation: AAI10380.1.
IPIIPI00003400.
PIRA47629.
RefSeqNP_001765.1.
UniGeneHs.166556

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP11049.

Proteomic databases

PRIDEP11049.

Genome annotation databases

EnsemblENST00000323906; ENSP00000325708; ENSG00000104894; Homo sapiens. [Genome view]
GeneID951.
UCSCuc002pnd.1. human.

Organism-specific databases

CTD951.
GeneCardsGC19P054533.
HGNCHGNC:1666. CD37.
HPACAB002492.
MIM151523. gene.
PharmGKBPA26213.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP11049.
HOVERGENP11049.
OMAQFQLRCC

Gene expression databases

ArrayExpressP11049.
BgeeP11049.
CleanExHS_CD37.
GenevestigatorP11049.
GermOnlineENSG00000104894. Homo sapiens.

Family and domain databases

InterProIPR018499. Tetraspanin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
IPR000301. Tetraspanin_sub.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSPR00259. TMFOUR.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio3956.
SOURCESearch...

Entry information

Entry nameCD37_HUMAN
AccessionPrimary (citable) accession number: P11049
Secondary accession number(s): Q3KPF9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: November 24, 2009
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents