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Protein

Leukocyte antigen CD37

Gene

CD37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte antigen CD37
Alternative name(s):
Tetraspanin-26
Short name:
Tspan-26
CD_antigen: CD37
Gene namesi
Name:CD37
Synonyms:TSPAN26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1666. CD37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Topological domaini39 – 5921ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 7415HelicalSequence analysisAdd
BLAST
Topological domaini75 – 8511CytoplasmicSequence analysisAdd
BLAST
Transmembranei86 – 11126HelicalSequence analysisAdd
BLAST
Topological domaini112 – 241130ExtracellularSequence analysisAdd
BLAST
Transmembranei242 – 26625HelicalSequence analysisAdd
BLAST
Topological domaini267 – 28115CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • immunological synapse Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26213.

Polymorphism and mutation databases

BioMutaiCD37.
DMDMi115983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Leukocyte antigen CD37PRO_0000219209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP11049.
PaxDbiP11049.
PeptideAtlasiP11049.
PRIDEiP11049.

PTM databases

iPTMnetiP11049.
PhosphoSiteiP11049.
SwissPalmiP11049.

Expressioni

Tissue specificityi

B-lymphocytes.

Gene expression databases

BgeeiENSG00000104894.
CleanExiHS_CD37.
ExpressionAtlasiP11049. baseline and differential.
GenevisibleiP11049. HS.

Organism-specific databases

HPAiCAB002492.
HPA032120.
HPA032121.

Interactioni

Subunit structurei

Interacts with SCIMP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LYNP079485EBI-6139068,EBI-79452
PTPN6P293504EBI-6139068,EBI-78260
SYKP434053EBI-6139068,EBI-78302

Protein-protein interaction databases

IntActiP11049. 6 interactions.
STRINGi9606.ENSP00000325708.

Structurei

3D structure databases

ProteinModelPortaliP11049.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP11049.
KOiK06475.
OMAiRCCGWHS.
OrthoDBiEOG091G0H71.
PhylomeDBiP11049.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11049-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA
60 70 80 90 100
FVPLQIWSKV LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT
110 120 130 140 150
QITLGILIST QRAQLERSLR DVVEKTIQKY GTNPEETAAE ESWDYVQFQL
160 170 180 190 200
RCCGWHYPQD WFQVLILRGN GSEAHRVPCS CYNLSATNDS TILDKVILPQ
210 220 230 240 250
LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN NLISIVGICL
260 270 280
GVGLLELGFM TLSIFLCRNL DHVYNRLARY R
Length:281
Mass (Da):31,703
Last modified:November 1, 1990 - v2
Checksum:i4342C5FB4479FDC8
GO
Isoform 2 (identifier: P11049-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: Gene prediction based on EST data.
Show »
Length:213
Mass (Da):23,996
Checksum:i7F046007C0A4F044
GO
Isoform 3 (identifier: P11049-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     257-281: LGFMTLSIFLCRNLDHVYNRLARYR → VIWPRPHPRSALNP

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,563
Checksum:iD3CDB33CF37804E9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6868Missing in isoform 2 and isoform 3. 1 PublicationVSP_047228Add
BLAST
Alternative sequencei257 – 28125LGFMT…LARYR → VIWPRPHPRSALNP in isoform 3. 1 PublicationVSP_047229Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14046 mRNA. Translation: CAA32204.1.
AK301016 mRNA. Translation: BAG62633.1.
CR541877 mRNA. Translation: CAG46675.1.
BT019851 mRNA. Translation: AAV38654.1.
AC010524 Genomic DNA. No translation available.
AC011450 Genomic DNA. No translation available.
BC106752 mRNA. Translation: AAI06753.1.
BC110379 mRNA. Translation: AAI10380.1.
CCDSiCCDS12760.1. [P11049-1]
CCDS46139.1. [P11049-2]
PIRiA47629.
RefSeqiNP_001035120.1. NM_001040031.1. [P11049-2]
NP_001765.1. NM_001774.2. [P11049-1]
XP_011525846.1. XM_011527544.2. [P11049-2]
UniGeneiHs.166556.

Genome annotation databases

EnsembliENST00000323906; ENSP00000325708; ENSG00000104894. [P11049-1]
ENST00000426897; ENSP00000413151; ENSG00000104894. [P11049-2]
ENST00000598095; ENSP00000470394; ENSG00000104894. [P11049-3]
GeneIDi951.
KEGGihsa:951.
UCSCiuc002pnd.4. human. [P11049-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14046 mRNA. Translation: CAA32204.1.
AK301016 mRNA. Translation: BAG62633.1.
CR541877 mRNA. Translation: CAG46675.1.
BT019851 mRNA. Translation: AAV38654.1.
AC010524 Genomic DNA. No translation available.
AC011450 Genomic DNA. No translation available.
BC106752 mRNA. Translation: AAI06753.1.
BC110379 mRNA. Translation: AAI10380.1.
CCDSiCCDS12760.1. [P11049-1]
CCDS46139.1. [P11049-2]
PIRiA47629.
RefSeqiNP_001035120.1. NM_001040031.1. [P11049-2]
NP_001765.1. NM_001774.2. [P11049-1]
XP_011525846.1. XM_011527544.2. [P11049-2]
UniGeneiHs.166556.

3D structure databases

ProteinModelPortaliP11049.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11049. 6 interactions.
STRINGi9606.ENSP00000325708.

PTM databases

iPTMnetiP11049.
PhosphoSiteiP11049.
SwissPalmiP11049.

Polymorphism and mutation databases

BioMutaiCD37.
DMDMi115983.

Proteomic databases

MaxQBiP11049.
PaxDbiP11049.
PeptideAtlasiP11049.
PRIDEiP11049.

Protocols and materials databases

DNASUi951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323906; ENSP00000325708; ENSG00000104894. [P11049-1]
ENST00000426897; ENSP00000413151; ENSG00000104894. [P11049-2]
ENST00000598095; ENSP00000470394; ENSG00000104894. [P11049-3]
GeneIDi951.
KEGGihsa:951.
UCSCiuc002pnd.4. human. [P11049-1]

Organism-specific databases

CTDi951.
GeneCardsiCD37.
HGNCiHGNC:1666. CD37.
HPAiCAB002492.
HPA032120.
HPA032121.
MIMi151523. gene.
neXtProtiNX_P11049.
PharmGKBiPA26213.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP11049.
KOiK06475.
OMAiRCCGWHS.
OrthoDBiEOG091G0H71.
PhylomeDBiP11049.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiCD37. human.
GeneWikiiCD37.
GenomeRNAii951.
PROiP11049.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104894.
CleanExiHS_CD37.
ExpressionAtlasiP11049. baseline and differential.
GenevisibleiP11049. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD37_HUMAN
AccessioniPrimary (citable) accession number: P11049
Secondary accession number(s): B4DVC1, Q3KPF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.