P11049 (CD37_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 101.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Leukocyte antigen CD37 Alternative name(s): Tetraspanin-26 Short name=Tspan-26 CD_antigen=CD37 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 281 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subunit structure | Interacts with SCIMP. |
| Subcellular location | |
| Tissue specificity | B-lymphocytes. |
| Sequence similarities | Belongs to the tetraspanin (TM4SF) family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 281 | 281 | Leukocyte antigen CD37 | PRO_0000219209 | |||||
Regions | |||||||||
| Topological domain | 1 – 17 | 17 | Cytoplasmic Potential | ||||||
| Transmembrane | 18 – 38 | 21 | Helical; Potential | ||||||
| Topological domain | 39 – 59 | 21 | Extracellular Potential | ||||||
| Transmembrane | 60 – 74 | 15 | Helical; Potential | ||||||
| Topological domain | 75 – 85 | 11 | Cytoplasmic Potential | ||||||
| Transmembrane | 86 – 111 | 26 | Helical; Potential | ||||||
| Topological domain | 112 – 241 | 130 | Extracellular Potential | ||||||
| Transmembrane | 242 – 266 | 25 | Helical; Potential | ||||||
| Topological domain | 267 – 281 | 15 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 170 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 183 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 188 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen." Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I. J. Exp. Med. 169:1497-1502(1989) [PubMed: 2466944] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Erratum Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I. J. Exp. Med. 172:1007-1007(1990) [PubMed: 2388030] [Abstract] Cited for: SEQUENCE REVISION. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling." Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T. Mol. Cell. Biol. 31:4550-4562(2011) [PubMed: 21930792] [Abstract] Cited for: INTERACTION WITH SCIMP. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X14046 mRNA. Translation: CAA32204.1. CR541877 mRNA. Translation: CAG46675.1. BT019851 mRNA. Translation: AAV38654.1. BC106752 mRNA. Translation: AAI06753.1. BC110379 mRNA. Translation: AAI10380.1. |
| IPI | IPI00003400. |
| PIR | A47629. |
| RefSeq | NP_001765.1. NM_001774.2. |
| UniGene | Hs.166556. |
3D structure databases | |
| ProteinModelPortal | P11049. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P11049. |
PTM databases | |
| PhosphoSite | P11049. |
Polymorphism databases | |
| DMDM | 115983. |
Proteomic databases | |
| PRIDE | P11049. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000323906; ENSP00000325708; ENSG00000104894. |
| GeneID | 951. |
| KEGG | hsa:951. |
| UCSC | uc002pnd.1. human. |
Organism-specific databases | |
| CTD | 951. |
| GeneCards | GC19P049838. |
| HGNC | HGNC:1666. CD37. |
| HPA | CAB002492. |
| MIM | 151523. gene. |
| neXtProt | NX_P11049. |
| PharmGKB | PA26213. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG12577. |
| GeneTree | ENSGT00590000082836. |
| HOGENOM | HBG716506. |
| HOVERGEN | HBG002324. |
| InParanoid | P11049. |
| OMA | QFQLRCC. |
| OrthoDB | EOG4T7841. |
| PhylomeDB | P11049. |
Gene expression databases | |
| ArrayExpress | P11049. |
| Bgee | P11049. |
| CleanEx | HS_CD37. |
| Genevestigator | P11049. |
| GermOnline | ENSG00000104894. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018499. Tetraspanin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. IPR000301. Tetraspanin_subgr. [Graphical view] |
| KO | K06475. |
| Pfam | PF00335. Tetraspannin. 1 hit. [Graphical view] |
| PRINTS | PR00259. TMFOUR. |
| SUPFAM | SSF48652. Tetraspanin. 1 hit. |
| PROSITE | PS00421. TM4_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 3956. |
| SOURCE | Search... |
Entry information
| Entry name | CD37_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P11049 Secondary accession number(s): Q3KPF9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with