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P11034 (MCPT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mast cell protease 1

Short name=mMCP-1
EC=3.4.21.-
Gene names
Name:Mcpt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a chymotrypsin-like activity.

Subcellular location

Secreted. Cytoplasmic granule. Note: Secretory granules.

Tissue specificity

Mucosal mast cells.

Sequence similarities

Belongs to the peptidase S1 family. Granzyme subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Propeptide19 – 202Activation peptide
PRO_0000027449
Chain21 – 246226Mast cell protease 1
PRO_0000027450

Regions

Domain21 – 244224Peptidase S1

Sites

Active site651Charge relay system By similarity
Active site1091Charge relay system By similarity
Active site2021Charge relay system By similarity

Amino acid modifications

Glycosylation1021N-linked (GlcNAc...) Probable
Disulfide bond50 ↔ 66 By similarity
Disulfide bond143 ↔ 208 By similarity
Disulfide bond174 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P11034 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: 26E112E8C580154B

FASTA24627,013
        10         20         30         40         50         60 
MQALLFLMAL LLPSGAGAEE IIGGVEARPH SRPYMAHLKI ITDRGSEDRC GGFLIAPQFV 

        70         80         90        100        110        120 
LTAAHCKGRE ITVTLGAHDV SKSESTQQRI KVEKQIIHKN YNVSFNLYDI MLLKLEEKAE 

       130        140        150        160        170        180 
LTPTVDVIPL PGPSDFIDPG KMCWTAGWGK TGEKEPTSET LREVELRIMD KEACKMYKHY 

       190        200        210        220        230        240 
DYNFQVCVGS STKLKTAYMG DSGGPLLCAG VAHGIVSYGD SHGKPPAVFT RISAYVPWIK 


TVINGK 

« Hide

References

[1]"IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice."
Ghildyal N., McNeil H.P., Stechschulte S., Austen K.F., Silberstein D., Gurish M.F., Somerville L.L., Stevens R.L.
J. Immunol. 149:2123-2129(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases."
Huang R., Blom T., Hellman L.
Eur. J. Immunol. 21:1611-1621(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c.
Tissue: Liver.
[3]"Amino acid sequence of a mouse mucosal mast cell protease."
le Trong H., Newlands G.F.J., Miller H.R.P., Charbonneau H., Neurath H., Woodbury R.G.
Biochemistry 28:391-395(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-246.
[4]"Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4)."
Newlands G.F.J., Knox D.P., Pirie-Shepherd S.R., Miller H.R.P.
Biochem. J. 294:127-135(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-49.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S44609 mRNA. Translation: AAB23194.1.
X68803 Genomic DNA. Translation: CAA48703.1.
CCDSCCDS27137.1.
PIRA46504.
RefSeqNP_032596.1. NM_008570.1.
UniGeneMm.201549.

3D structure databases

ProteinModelPortalP11034.
SMRP11034. Positions 21-244.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022836.

Protein family/group databases

MEROPSS01.458.

Proteomic databases

MaxQBP11034.
PaxDbP11034.
PRIDEP11034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022836; ENSMUSP00000022836; ENSMUSG00000022227.
GeneID17224.
KEGGmmu:17224.
UCSCuc007ubi.1. mouse.

Organism-specific databases

CTD17224.
MGIMGI:96937. Mcpt1.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP11034.
KOK08661.
OMASKDHNNG.
OrthoDBEOG7RRF7Z.
PhylomeDBP11034.
TreeFamTF333630.

Gene expression databases

ArrayExpressP11034.
BgeeP11034.
CleanExMM_MCPT1.
GenevestigatorP11034.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291636.
PROP11034.
SOURCESearch...

Entry information

Entry nameMCPT1_MOUSE
AccessionPrimary (citable) accession number: P11034
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot