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P11034

- MCPT1_MOUSE

UniProt

P11034 - MCPT1_MOUSE

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Protein

Mast cell protease 1

Gene
Mcpt1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has a chymotrypsin-like activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system By similarity
Active sitei109 – 1091Charge relay system By similarity
Active sitei202 – 2021Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.458.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 1 (EC:3.4.21.-)
Short name:
mMCP-1
Gene namesi
Name:Mcpt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:96937. Mcpt1.

Subcellular locationi

Secreted. Cytoplasmic granule
Note: Secretory granules.

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. intracellular Source: MGI
  3. secretory granule Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Propeptidei19 – 202Activation peptidePRO_0000027449
Chaini21 – 246226Mast cell protease 1PRO_0000027450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66 By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...) Inferred
Disulfide bondi143 ↔ 208 By similarity
Disulfide bondi174 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP11034.
PaxDbiP11034.
PRIDEiP11034.

Expressioni

Tissue specificityi

Mucosal mast cells.

Gene expression databases

ArrayExpressiP11034.
BgeeiP11034.
CleanExiMM_MCPT1.
GenevestigatoriP11034.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022836.

Structurei

3D structure databases

ProteinModelPortaliP11034.
SMRiP11034. Positions 21-244.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 244224Peptidase S1Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP11034.
KOiK08661.
OMAiSKDHNNG.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP11034.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11034-1 [UniParc]FASTAAdd to Basket

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MQALLFLMAL LLPSGAGAEE IIGGVEARPH SRPYMAHLKI ITDRGSEDRC    50
GGFLIAPQFV LTAAHCKGRE ITVTLGAHDV SKSESTQQRI KVEKQIIHKN 100
YNVSFNLYDI MLLKLEEKAE LTPTVDVIPL PGPSDFIDPG KMCWTAGWGK 150
TGEKEPTSET LREVELRIMD KEACKMYKHY DYNFQVCVGS STKLKTAYMG 200
DSGGPLLCAG VAHGIVSYGD SHGKPPAVFT RISAYVPWIK TVINGK 246
Length:246
Mass (Da):27,013
Last modified:December 1, 1992 - v2
Checksum:i26E112E8C580154B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S44609 mRNA. Translation: AAB23194.1.
X68803 Genomic DNA. Translation: CAA48703.1.
CCDSiCCDS27137.1.
PIRiA46504.
RefSeqiNP_032596.1. NM_008570.1.
UniGeneiMm.201549.

Genome annotation databases

EnsembliENSMUST00000022836; ENSMUSP00000022836; ENSMUSG00000022227.
GeneIDi17224.
KEGGimmu:17224.
UCSCiuc007ubi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S44609 mRNA. Translation: AAB23194.1 .
X68803 Genomic DNA. Translation: CAA48703.1 .
CCDSi CCDS27137.1.
PIRi A46504.
RefSeqi NP_032596.1. NM_008570.1.
UniGenei Mm.201549.

3D structure databases

ProteinModelPortali P11034.
SMRi P11034. Positions 21-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022836.

Protein family/group databases

MEROPSi S01.458.

Proteomic databases

MaxQBi P11034.
PaxDbi P11034.
PRIDEi P11034.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022836 ; ENSMUSP00000022836 ; ENSMUSG00000022227 .
GeneIDi 17224.
KEGGi mmu:17224.
UCSCi uc007ubi.1. mouse.

Organism-specific databases

CTDi 17224.
MGIi MGI:96937. Mcpt1.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P11034.
KOi K08661.
OMAi SKDHNNG.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P11034.
TreeFami TF333630.

Miscellaneous databases

NextBioi 291636.
PROi P11034.
SOURCEi Search...

Gene expression databases

ArrayExpressi P11034.
Bgeei P11034.
CleanExi MM_MCPT1.
Genevestigatori P11034.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice."
    Ghildyal N., McNeil H.P., Stechschulte S., Austen K.F., Silberstein D., Gurish M.F., Somerville L.L., Stevens R.L.
    J. Immunol. 149:2123-2129(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases."
    Huang R., Blom T., Hellman L.
    Eur. J. Immunol. 21:1611-1621(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
    Tissue: Liver.
  3. Cited for: PROTEIN SEQUENCE OF 21-246.
  4. "Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4)."
    Newlands G.F.J., Knox D.P., Pirie-Shepherd S.R., Miller H.R.P.
    Biochem. J. 294:127-135(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-49.

Entry informationi

Entry nameiMCPT1_MOUSE
AccessioniPrimary (citable) accession number: P11034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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