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P11034

- MCPT1_MOUSE

UniProt

P11034 - MCPT1_MOUSE

Protein

Mast cell protease 1

Gene

Mcpt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Has a chymotrypsin-like activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei109 – 1091Charge relay systemBy similarity
    Active sitei202 – 2021Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.458.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mast cell protease 1 (EC:3.4.21.-)
    Short name:
    mMCP-1
    Gene namesi
    Name:Mcpt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:96937. Mcpt1.

    Subcellular locationi

    Secreted. Cytoplasmic granule
    Note: Secretory granules.

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. intracellular Source: MGI
    3. secretory granule Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Propeptidei19 – 202Activation peptide2 PublicationsPRO_0000027449
    Chaini21 – 246226Mast cell protease 1PRO_0000027450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
    Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
    Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP11034.
    PaxDbiP11034.
    PRIDEiP11034.

    Expressioni

    Tissue specificityi

    Mucosal mast cells.

    Gene expression databases

    ArrayExpressiP11034.
    BgeeiP11034.
    CleanExiMM_MCPT1.
    GenevestigatoriP11034.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022836.

    Structurei

    3D structure databases

    ProteinModelPortaliP11034.
    SMRiP11034. Positions 21-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 244224Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP11034.
    KOiK08661.
    OMAiSKDHNNG.
    OrthoDBiEOG7RRF7Z.
    PhylomeDBiP11034.
    TreeFamiTF333630.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11034-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQALLFLMAL LLPSGAGAEE IIGGVEARPH SRPYMAHLKI ITDRGSEDRC    50
    GGFLIAPQFV LTAAHCKGRE ITVTLGAHDV SKSESTQQRI KVEKQIIHKN 100
    YNVSFNLYDI MLLKLEEKAE LTPTVDVIPL PGPSDFIDPG KMCWTAGWGK 150
    TGEKEPTSET LREVELRIMD KEACKMYKHY DYNFQVCVGS STKLKTAYMG 200
    DSGGPLLCAG VAHGIVSYGD SHGKPPAVFT RISAYVPWIK TVINGK 246
    Length:246
    Mass (Da):27,013
    Last modified:December 1, 1992 - v2
    Checksum:i26E112E8C580154B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S44609 mRNA. Translation: AAB23194.1.
    X68803 Genomic DNA. Translation: CAA48703.1.
    CCDSiCCDS27137.1.
    PIRiA46504.
    RefSeqiNP_032596.1. NM_008570.1.
    UniGeneiMm.201549.

    Genome annotation databases

    EnsembliENSMUST00000022836; ENSMUSP00000022836; ENSMUSG00000022227.
    GeneIDi17224.
    KEGGimmu:17224.
    UCSCiuc007ubi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S44609 mRNA. Translation: AAB23194.1 .
    X68803 Genomic DNA. Translation: CAA48703.1 .
    CCDSi CCDS27137.1.
    PIRi A46504.
    RefSeqi NP_032596.1. NM_008570.1.
    UniGenei Mm.201549.

    3D structure databases

    ProteinModelPortali P11034.
    SMRi P11034. Positions 21-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022836.

    Protein family/group databases

    MEROPSi S01.458.

    Proteomic databases

    MaxQBi P11034.
    PaxDbi P11034.
    PRIDEi P11034.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022836 ; ENSMUSP00000022836 ; ENSMUSG00000022227 .
    GeneIDi 17224.
    KEGGi mmu:17224.
    UCSCi uc007ubi.1. mouse.

    Organism-specific databases

    CTDi 17224.
    MGIi MGI:96937. Mcpt1.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P11034.
    KOi K08661.
    OMAi SKDHNNG.
    OrthoDBi EOG7RRF7Z.
    PhylomeDBi P11034.
    TreeFami TF333630.

    Miscellaneous databases

    NextBioi 291636.
    PROi P11034.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P11034.
    Bgeei P11034.
    CleanExi MM_MCPT1.
    Genevestigatori P11034.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice."
      Ghildyal N., McNeil H.P., Stechschulte S., Austen K.F., Silberstein D., Gurish M.F., Somerville L.L., Stevens R.L.
      J. Immunol. 149:2123-2129(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases."
      Huang R., Blom T., Hellman L.
      Eur. J. Immunol. 21:1611-1621(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
      Tissue: Liver.
    3. Cited for: PROTEIN SEQUENCE OF 21-246.
    4. "Biochemical and immunological characterization of multiple glycoforms of mouse mast cell protease 1: comparison with an isolated murine serosal mast cell protease (MMCP-4)."
      Newlands G.F.J., Knox D.P., Pirie-Shepherd S.R., Miller H.R.P.
      Biochem. J. 294:127-135(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-49.

    Entry informationi

    Entry nameiMCPT1_MOUSE
    AccessioniPrimary (citable) accession number: P11034
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3