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Protein

Granzyme D

Gene

Gzmd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Active sitei113Charge relay systemBy similarity1
Active sitei208Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCytolysis

Enzyme and pathway databases

ReactomeiR-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiS01.398

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme D (EC:3.4.21.-)
Gene namesi
Name:Gzmd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109255 Gzmd

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000002740519 – 201 Publication2
ChainiPRO_000002740621 – 252Granzyme DAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 214PROSITE-ProRule annotation
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi179 ↔ 193PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP11033
PaxDbiP11033
PeptideAtlasiP11033
PRIDEiP11033

Expressioni

Gene expression databases

BgeeiENSMUSG00000059256
CleanExiMM_GZMD
GenevisibleiP11033 MM

Interactioni

Protein-protein interaction databases

IntActiP11033, 1 interactor
MINTiP11033
STRINGi10090.ENSMUSP00000080742

Structurei

3D structure databases

ProteinModelPortaliP11033
SMRiP11033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 250Peptidase S1PROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP11033
OMAiWDTVNPG
OrthoDBiEOG091G0G5F
PhylomeDBiP11033
TreeFamiTF333630

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPILILLTL LLPLRAGAEE IIGGHVVKPH SRPYMAFVMS VDIKGNRIYC
60 70 80 90 100
GGFLIQDDFV LTAAHCKNSS VQSSMTVTLG AHNITAKEET QQIIPVAKDI
110 120 130 140 150
PHPDYNATIF YSDIMLLKLE SKAKRTKAVR PLKLPRSNAR VKPGDVCSVA
160 170 180 190 200
GWGSRSINDT KASARLREVQ LVIQEDEECK KRFRYYTETT EICAGDLKKI
210 220 230 240 250
KTPFKGDSGG PLVCDNQAYG LFAYAKNGTI SSGIFTKVVH FLPWISWNMK

LL
Length:252
Mass (Da):27,955
Last modified:October 3, 2012 - v4
Checksum:i0A6DDF6459410142
GO

Sequence cautioni

The sequence AAB19190 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215D → H in AAA37736 (PubMed:3260382).Curated1
Sequence conflicti215D → H in AAB19190 (PubMed:8917549).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03255 mRNA Translation: AAA37736.1
U66472 Genomic DNA Translation: AAB19190.1 Sequence problems.
AK131671 mRNA Translation: BAE20756.1
AC091783 Genomic DNA No translation available.
BC141122 mRNA Translation: AAI41123.1
CCDSiCCDS49502.1
PIRiA36172
RefSeqiNP_034502.2, NM_010372.2
UniGeneiMm.482071

Genome annotation databases

EnsembliENSMUST00000082093; ENSMUSP00000080742; ENSMUSG00000059256
GeneIDi14941
KEGGimmu:14941
UCSCiuc007ubp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGRAD_MOUSE
AccessioniPrimary (citable) accession number: P11033
Secondary accession number(s): P97387, Q3V2P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health