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Protein

Granzyme D

Gene

Gzmd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei113 – 1131Charge relay systemBy similarity
Active sitei208 – 2081Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Cytolysis

Protein family/group databases

MEROPSiS01.398.

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme D (EC:3.4.21.-)
Gene namesi
Name:Gzmd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109255. Gzmd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Propeptidei19 – 2021 PublicationPRO_0000027405
Chaini21 – 252232Granzyme DPRO_0000027406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi147 ↔ 214PROSITE-ProRule annotation
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi179 ↔ 193PROSITE-ProRule annotation
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP11033.
PaxDbiP11033.
PeptideAtlasiP11033.
PRIDEiP11033.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059256.
CleanExiMM_GZMD.
GenevisibleiP11033. MM.

Interactioni

Protein-protein interaction databases

IntActiP11033. 1 interaction.
MINTiMINT-4096686.
STRINGi10090.ENSMUSP00000080742.

Structurei

3D structure databases

ProteinModelPortaliP11033.
SMRiP11033. Positions 21-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 250230Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP11033.
OMAiYNATIFY.
OrthoDBiEOG091G0G5F.
PhylomeDBiP11033.
TreeFamiTF333630.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPILILLTL LLPLRAGAEE IIGGHVVKPH SRPYMAFVMS VDIKGNRIYC
60 70 80 90 100
GGFLIQDDFV LTAAHCKNSS VQSSMTVTLG AHNITAKEET QQIIPVAKDI
110 120 130 140 150
PHPDYNATIF YSDIMLLKLE SKAKRTKAVR PLKLPRSNAR VKPGDVCSVA
160 170 180 190 200
GWGSRSINDT KASARLREVQ LVIQEDEECK KRFRYYTETT EICAGDLKKI
210 220 230 240 250
KTPFKGDSGG PLVCDNQAYG LFAYAKNGTI SSGIFTKVVH FLPWISWNMK

LL
Length:252
Mass (Da):27,955
Last modified:October 3, 2012 - v4
Checksum:i0A6DDF6459410142
GO

Sequence cautioni

The sequence AAB19190 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2151D → H in AAA37736 (PubMed:3260382).Curated
Sequence conflicti215 – 2151D → H in AAB19190 (PubMed:8917549).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03255 mRNA. Translation: AAA37736.1.
U66472 Genomic DNA. Translation: AAB19190.1. Sequence problems.
AK131671 mRNA. Translation: BAE20756.1.
AC091783 Genomic DNA. No translation available.
BC141122 mRNA. Translation: AAI41123.1.
CCDSiCCDS49502.1.
PIRiA36172.
RefSeqiNP_034502.2. NM_010372.2.
UniGeneiMm.482071.

Genome annotation databases

EnsembliENSMUST00000082093; ENSMUSP00000080742; ENSMUSG00000059256.
GeneIDi14941.
KEGGimmu:14941.
UCSCiuc007ubp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03255 mRNA. Translation: AAA37736.1.
U66472 Genomic DNA. Translation: AAB19190.1. Sequence problems.
AK131671 mRNA. Translation: BAE20756.1.
AC091783 Genomic DNA. No translation available.
BC141122 mRNA. Translation: AAI41123.1.
CCDSiCCDS49502.1.
PIRiA36172.
RefSeqiNP_034502.2. NM_010372.2.
UniGeneiMm.482071.

3D structure databases

ProteinModelPortaliP11033.
SMRiP11033. Positions 21-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11033. 1 interaction.
MINTiMINT-4096686.
STRINGi10090.ENSMUSP00000080742.

Protein family/group databases

MEROPSiS01.398.

Proteomic databases

EPDiP11033.
PaxDbiP11033.
PeptideAtlasiP11033.
PRIDEiP11033.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082093; ENSMUSP00000080742; ENSMUSG00000059256.
GeneIDi14941.
KEGGimmu:14941.
UCSCiuc007ubp.1. mouse.

Organism-specific databases

CTDi14941.
MGIiMGI:109255. Gzmd.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP11033.
OMAiYNATIFY.
OrthoDBiEOG091G0G5F.
PhylomeDBiP11033.
TreeFamiTF333630.

Miscellaneous databases

PROiP11033.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059256.
CleanExiMM_GZMD.
GenevisibleiP11033. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRAD_MOUSE
AccessioniPrimary (citable) accession number: P11033
Secondary accession number(s): P97387, Q3V2P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 132 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.