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Protein

Acyl-CoA-binding protein

Gene

Dbi

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoABy similarity1
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

  • benzodiazepine receptor binding Source: RGD
  • fatty-acyl-CoA binding Source: RGD
  • lipid binding Source: UniProtKB-KW
  • long-chain fatty acyl-CoA binding Source: RGD
  • protein dimerization activity Source: RGD

GO - Biological processi

  • acyl-CoA metabolic process Source: RGD
  • behavioral fear response Source: RGD
  • brain development Source: RGD
  • cellular response to nutrient Source: RGD
  • glial cell proliferation Source: RGD
  • hair follicle development Source: RGD
  • lateral ventricle development Source: RGD
  • learning or memory Source: RGD
  • long-term synaptic potentiation Source: RGD
  • negative regulation of fatty acid beta-oxidation Source: RGD
  • pancreatic juice secretion Source: RGD
  • phosphatidylcholine acyl-chain remodeling Source: RGD
  • positive regulation of lipid biosynthetic process Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • regulation of synaptic transmission, GABAergic Source: MGI
  • skin development Source: RGD
  • steroid biosynthetic process Source: RGD
  • triglyceride metabolic process Source: RGD

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Cleaved into the following 2 chains:
Gene namesi
Name:Dbi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2490. Dbi.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000452732 – 87Acyl-CoA-binding proteinAdd BLAST86
PeptideiPRO_000000028818 – 51Triakontatetraneuropeptide1 PublicationAdd BLAST34
PeptideiPRO_000000028934 – 51OctadecaneuropeptideAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei8N6-acetyllysine; alternateBy similarity1
Modified residuei8N6-succinyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysineBy similarity1
Modified residuei29PhosphotyrosineBy similarity1
Modified residuei51N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysine; alternateBy similarity1
Modified residuei55N6-malonyllysine; alternateBy similarity1
Modified residuei55N6-succinyllysine; alternateBy similarity1
Modified residuei77N6-acetyllysine; alternateBy similarity1
Modified residuei77N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11030.
PRIDEiP11030.

PTM databases

iPTMnetiP11030.
PhosphoSitePlusiP11030.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046889.
ExpressionAtlasiP11030. baseline and differential.
GenevisibleiP11030. RN.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • benzodiazepine receptor binding Source: RGD
  • protein dimerization activity Source: RGD

Protein-protein interaction databases

BioGridi247122. 1 interactor.
DIPiDIP-1164N.
MINTiMINT-4577042.
STRINGi10116.ENSRNOP00000066874.

Structurei

3D structure databases

ProteinModelPortaliP11030.
SMRiP11030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOVERGENiHBG000398.
InParanoidiP11030.
KOiK08762.
OMAiRYKFEAW.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiView protein in InterPro
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR035984. Acyl-CoA-binding_sf.
IPR014352. FERM/acyl-CoA-bd_prot_sf.
PfamiView protein in Pfam
PF00887. ACBP. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiView protein in PROSITE
PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQADFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTDRPGLLDL
60 70 80
KGKAKWDSWN KLKGTSKENA MKTYVEKVEE LKKKYGI
Length:87
Mass (Da):10,027
Last modified:January 23, 2007 - v3
Checksum:iC6B231C903098CDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14201 mRNA. Translation: AAA41078.1.
M20268 mRNA. Translation: AAA41079.1.
Z11991 Genomic DNA. No translation available.
S51442, S51427, S51426 Genomic DNA. Translation: AAA12824.1.
X96560 Genomic DNA. Translation: CAA65396.1.
BC084717 mRNA. Translation: AAH84717.1.
Z21846 Genomic DNA. Translation: CAA79894.1.
PIRiS27345. NZRT.
RefSeqiNP_114054.1. NM_031853.4.
UniGeneiRn.3285.

Genome annotation databases

EnsembliENSRNOT00000074685; ENSRNOP00000067623; ENSRNOG00000046889.
GeneIDi25045.
KEGGirno:25045.

Similar proteinsi

Entry informationi

Entry nameiACBP_RAT
AccessioniPrimary (citable) accession number: P11030
Secondary accession number(s): Q2V4X5, Q63160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families