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Protein

Magainins

Gene

magainins

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide

Keywords - Biological processi

Cytolysis, Hemolysis

Protein family/group databases

TCDBi1.C.16.1.1. the magainin (magainin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Magainins
Cleaved into the following 5 chains:
Alternative name(s):
Magainin I
Alternative name(s):
Magainin II
Gene namesi
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252596. magainins.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001067719 – 268
PeptideiPRO_000001067827 – 32Small acidic peptide 16
PropeptideiPRO_000001067933 – 364
PeptideiPRO_000001068037 – 59Magainin-1Add BLAST23
PropeptideiPRO_000001068162 – 72Add BLAST11
PeptideiPRO_000001068273 – 78Small acidic peptide 26
PropeptideiPRO_000001068379 – 824
PeptideiPRO_000001068483 – 105Magainin-2Add BLAST23
PropeptideiPRO_0000010685108 – 118Add BLAST11
PeptideiPRO_0000010686119 – 124Small acidic peptide 26
PropeptideiPRO_0000010687125 – 1284
PeptideiPRO_0000010688129 – 151Magainin-2Add BLAST23
PropeptideiPRO_0000010689154 – 164Add BLAST11
PeptideiPRO_0000010690165 – 170Small acidic peptide 26
PropeptideiPRO_0000010691171 – 1744
PeptideiPRO_0000010692175 – 197Magainin-2Add BLAST23
PropeptideiPRO_0000010693200 – 210Add BLAST11
PeptideiPRO_0000010694211 – 216Small acidic peptide 36
PropeptideiPRO_0000010695217 – 2204
PeptideiPRO_0000010696221 – 243Magainin-2Add BLAST23
PropeptideiPRO_0000010697246 – 256Add BLAST11
PeptideiPRO_0000010698257 – 262Small acidic peptide 26
PropeptideiPRO_0000010699263 – 2664
PeptideiPRO_0000010700267 – 289Magainin-2Add BLAST23
PropeptideiPRO_0000010701292 – 303Add BLAST12

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi269 – 287Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9JNMR-A267-278[»]
1D9LNMR-A270-278[»]
1D9MNMR-A270-278[»]
1D9ONMR-A267-278[»]
1D9PNMR-A267-278[»]
1DUMNMR-A/B267-289[»]
1F0DNMR-A267-278[»]
1F0ENMR-A269-278[»]
1F0FNMR-A270-278[»]
1F0GNMR-A267-278[»]
1F0HNMR-A267-278[»]
2LSANMR-A267-289[»]
2MAGNMR-A267-289[»]
4MGPX-ray1.75A267-289[»]
5CGNX-ray2.20E/F/G/H267-289[»]
5CGOX-ray1.50A/B267-289[»]
SMRiP11006.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11006.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKGLFICSL IAVICANALP QPEASADEDM DEREVRGIGK FLHSAGKFGK
60 70 80 90 100
AFVGEIMKSK RDAEAVGPEA FADEDLDERE VRGIGKFLHS AKKFGKAFVG
110 120 130 140 150
EIMNSKRDAE AVGPEAFADE DLDEREVRGI GKFLHSAKKF GKAFVGEIMN
160 170 180 190 200
SKRDAEAVGP EAFADEDLDE REVRGIGKFL HSAKKFGKAF VGEIMNSKRD
210 220 230 240 250
AEAVGPEAFA DEDFDEREVR GIGKFLHSAK KFGKAFVGEI MNSKRDAEAV
260 270 280 290 300
GPEAFADEDL DEREVRGIGK FLHSAKKFGK AFVGEIMNSK RDAEAVDDRR

WVE
Length:303
Mass (Da):33,380
Last modified:July 1, 1989 - v1
Checksum:iE369B0DBB033EA80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74E → Q AA sequence (PubMed:3299384).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03193 mRNA. Translation: AAA49930.1.
PIRiA28620.
RefSeqiNP_001081306.1. NM_001087837.1.
UniGeneiXl.843.

Genome annotation databases

GeneIDi397766.
KEGGixla:397766.

Cross-referencesi

Web resourcesi

Protein Spotlight

When a frog swallows a fly - Issue 7 of February 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03193 mRNA. Translation: AAA49930.1.
PIRiA28620.
RefSeqiNP_001081306.1. NM_001087837.1.
UniGeneiXl.843.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9JNMR-A267-278[»]
1D9LNMR-A270-278[»]
1D9MNMR-A270-278[»]
1D9ONMR-A267-278[»]
1D9PNMR-A267-278[»]
1DUMNMR-A/B267-289[»]
1F0DNMR-A267-278[»]
1F0ENMR-A269-278[»]
1F0FNMR-A270-278[»]
1F0GNMR-A267-278[»]
1F0HNMR-A267-278[»]
2LSANMR-A267-289[»]
2MAGNMR-A267-289[»]
4MGPX-ray1.75A267-289[»]
5CGNX-ray2.20E/F/G/H267-289[»]
5CGOX-ray1.50A/B267-289[»]
SMRiP11006.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.16.1.1. the magainin (magainin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397766.
KEGGixla:397766.

Organism-specific databases

XenbaseiXB-GENE-6252596. magainins.

Miscellaneous databases

EvolutionaryTraceiP11006.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMAGA_XENLA
AccessioniPrimary (citable) accession number: P11006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.