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P11006

- MAGA_XENLA

UniProt

P11006 - MAGA_XENLA

Protein

Magainins

Gene

magainins

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents.

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. defense response to fungus Source: UniProtKB-KW
    3. hemolysis in other organism Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide

    Keywords - Biological processi

    Cytolysis, Hemolysis

    Protein family/group databases

    TCDBi1.C.16.1.1. the magainin (magainin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Magainins
    Cleaved into the following 5 chains:
    Alternative name(s):
    Magainin I
    Alternative name(s):
    Magainin II
    Gene namesi
    Name:magainins
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252596. magainins.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 268PRO_0000010677
    Peptidei27 – 326Small acidic peptide 1PRO_0000010678
    Propeptidei33 – 364PRO_0000010679
    Peptidei37 – 5923Magainin-1PRO_0000010680Add
    BLAST
    Propeptidei62 – 7211PRO_0000010681Add
    BLAST
    Peptidei73 – 786Small acidic peptide 2PRO_0000010682
    Propeptidei79 – 824PRO_0000010683
    Peptidei83 – 10523Magainin-2PRO_0000010684Add
    BLAST
    Propeptidei108 – 11811PRO_0000010685Add
    BLAST
    Peptidei119 – 1246Small acidic peptide 2PRO_0000010686
    Propeptidei125 – 1284PRO_0000010687
    Peptidei129 – 15123Magainin-2PRO_0000010688Add
    BLAST
    Propeptidei154 – 16411PRO_0000010689Add
    BLAST
    Peptidei165 – 1706Small acidic peptide 2PRO_0000010690
    Propeptidei171 – 1744PRO_0000010691
    Peptidei175 – 19723Magainin-2PRO_0000010692Add
    BLAST
    Propeptidei200 – 21011PRO_0000010693Add
    BLAST
    Peptidei211 – 2166Small acidic peptide 3PRO_0000010694
    Propeptidei217 – 2204PRO_0000010695
    Peptidei221 – 24323Magainin-2PRO_0000010696Add
    BLAST
    Propeptidei246 – 25611PRO_0000010697Add
    BLAST
    Peptidei257 – 2626Small acidic peptide 2PRO_0000010698
    Propeptidei263 – 2664PRO_0000010699
    Peptidei267 – 28923Magainin-2PRO_0000010700Add
    BLAST
    Propeptidei292 – 30312PRO_0000010701Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Expressioni

    Tissue specificityi

    Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin.

    Structurei

    Secondary structure

    1
    303
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi268 – 28619

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D9JNMR-A267-278[»]
    1D9LNMR-A270-278[»]
    1D9MNMR-A270-278[»]
    1D9ONMR-A267-278[»]
    1D9PNMR-A267-278[»]
    1DUMNMR-A/B267-289[»]
    1F0DNMR-A267-278[»]
    1F0ENMR-A269-278[»]
    1F0FNMR-A270-278[»]
    1F0GNMR-A267-278[»]
    1F0HNMR-A267-278[»]
    2LSANMR-A267-289[»]
    2MAGNMR-A267-289[»]
    4MGPX-ray1.75A267-289[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP11006.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11006-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKGLFICSL IAVICANALP QPEASADEDM DEREVRGIGK FLHSAGKFGK    50
    AFVGEIMKSK RDAEAVGPEA FADEDLDERE VRGIGKFLHS AKKFGKAFVG 100
    EIMNSKRDAE AVGPEAFADE DLDEREVRGI GKFLHSAKKF GKAFVGEIMN 150
    SKRDAEAVGP EAFADEDLDE REVRGIGKFL HSAKKFGKAF VGEIMNSKRD 200
    AEAVGPEAFA DEDFDEREVR GIGKFLHSAK KFGKAFVGEI MNSKRDAEAV 250
    GPEAFADEDL DEREVRGIGK FLHSAKKFGK AFVGEIMNSK RDAEAVDDRR 300
    WVE 303
    Length:303
    Mass (Da):33,380
    Last modified:July 1, 1989 - v1
    Checksum:iE369B0DBB033EA80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 741E → Q AA sequence (PubMed:3299384)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03193 mRNA. Translation: AAA49930.1.
    PIRiA28620.
    RefSeqiNP_001081306.1. NM_001087837.1.
    UniGeneiXl.843.

    Genome annotation databases

    GeneIDi397766.
    KEGGixla:397766.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    When a frog swallows a fly - Issue 7 of February 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03193 mRNA. Translation: AAA49930.1 .
    PIRi A28620.
    RefSeqi NP_001081306.1. NM_001087837.1.
    UniGenei Xl.843.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D9J NMR - A 267-278 [» ]
    1D9L NMR - A 270-278 [» ]
    1D9M NMR - A 270-278 [» ]
    1D9O NMR - A 267-278 [» ]
    1D9P NMR - A 267-278 [» ]
    1DUM NMR - A/B 267-289 [» ]
    1F0D NMR - A 267-278 [» ]
    1F0E NMR - A 269-278 [» ]
    1F0F NMR - A 270-278 [» ]
    1F0G NMR - A 267-278 [» ]
    1F0H NMR - A 267-278 [» ]
    2LSA NMR - A 267-289 [» ]
    2MAG NMR - A 267-289 [» ]
    4MGP X-ray 1.75 A 267-289 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.C.16.1.1. the magainin (magainin) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397766.
    KEGGi xla:397766.

    Organism-specific databases

    Xenbasei XB-GENE-6252596. magainins.

    Miscellaneous databases

    EvolutionaryTracei P11006.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide."
      Terry A.S., Poulter L., Williams D.H., Nutkins J.C., Giovannini M.G., Moore C.H., Gibson B.W.
      J. Biol. Chem. 263:5745-5751(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor."
      Zasloff M.
      Proc. Natl. Acad. Sci. U.S.A. 84:5449-5453(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-158 AND 297-303, PARTIAL PROTEIN SEQUENCE.
      Tissue: Skin and Skin secretion.
    3. "Antimicrobial peptides in the stomach of Xenopus laevis."
      Moore K.S., Bevins C.L., Brasseur M.M., Tomassini N., Turner K., Eck H., Zasloff M.
      J. Biol. Chem. 266:19851-19857(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (MAGAININ-1 AND MAGAININ-2).
      Tissue: Stomach.
    4. "Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy."
      Bechinger B., Zasloff M., Opella S.J.
      Protein Sci. 2:2077-2084(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF MAGAININ-2.

    Entry informationi

    Entry nameiMAGA_XENLA
    AccessioniPrimary (citable) accession number: P11006
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3