Reviewed,
UniProtKB/Swiss-Prot P11003 (METF_SALTY)
Last modified
June 16, 2009.
Version 63.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: 5,10-methylenetetrahydrofolate reductase EC=1.5.1.20 | ||||
| Gene names |
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| Organism | Salmonella typhimurium [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 90371 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 296 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. |
| Cofactor | FAD. |
| Pathway | |
| Sequence similarities | Belongs to the methylenetetrahydrofolate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Methionine biosynthesis |
| Ligand | FAD Flavoprotein NAD NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and nucleotide sequence of the Salmonella typhimurium LT2 metF gene and its homology with the corresponding sequence of Escherichia coli." Stauffer G.V., Stauffer L.T. Mol. Gen. Genet. 212:246-251(1988) [PubMed: 2841568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2. |
| [2] | "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. Wilson R.K.Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720. |
Cross-references
Sequence databases | |
|---|---|
| X07689 Genomic DNA. Translation: CAA30531.1. AE008891 Genomic DNA. Translation: AAL22945.1. | |
| PIR | S03169. |
| RefSeq | NP_462986.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B5T based on UniProtKB P00394. |
| SMR | P11003. Positions 3-294. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1255632. |
| GenomeReviews | Gene locus STM4105 in contig AE006468_GR. |
| KEGG | stm:STM4105. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P11003. |
| OMA | P11003. FFPPKTP. |
Enzyme and pathway databases | |
| BioCyc | STYP99287:STM4105-MON. |
| BRENDA | 1.5.1.20. 2. |
Family and domain databases | |
| InterPro | IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view] |
| Pfam | PF02219. MTHFR. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00676. fadh2. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | METF_SALTY | ||||||||
| Accession | Primary (citable) accession number: P11003 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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