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P11001

- GTF1_STRDO

UniProt

P11001 - GTF1_STRDO

Protein

Glucosyltransferase-I

Gene

gtfI

Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

    Catalytic activityi

    Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

    GO - Molecular functioni

    1. dextransucrase activity Source: UniProtKB-EC
    2. glucosyltransferase activity Source: InterPro

    GO - Biological processi

    1. glucan biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGH70. Glycoside Hydrolase Family 70.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucosyltransferase-I (EC:2.4.1.5)
    Short name:
    GTF-I
    Alternative name(s):
    Dextransucrase
    Sucrose 6-glucosyltransferase
    Gene namesi
    Name:gtfI
    OrganismiStreptococcus downei (Streptococcus sobrinus)
    Taxonomic identifieri1317 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Dental caries

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 15971559Glucosyltransferase-IPRO_0000021383Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP11001.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati157 – 17620Cell wall-binding 1Add
    BLAST
    Repeati178 – 19720Cell wall-binding 2Add
    BLAST
    Repeati1089 – 110820Cell wall-binding 3Add
    BLAST
    Repeati1109 – 112820Cell wall-binding 4Add
    BLAST
    Repeati1130 – 115021Cell wall-binding 5Add
    BLAST
    Repeati1152 – 117221Cell wall-binding 6Add
    BLAST
    Repeati1173 – 119119Cell wall-binding 7Add
    BLAST
    Repeati1193 – 121422Cell wall-binding 8Add
    BLAST
    Repeati1216 – 123621Cell wall-binding 9Add
    BLAST
    Repeati1237 – 125620Cell wall-binding 10Add
    BLAST
    Repeati1258 – 127922Cell wall-binding 11Add
    BLAST
    Repeati1281 – 130121Cell wall-binding 12Add
    BLAST
    Repeati1302 – 132120Cell wall-binding 13Add
    BLAST
    Repeati1323 – 134321Cell wall-binding 14Add
    BLAST
    Repeati1344 – 136522Cell wall-binding 15Add
    BLAST
    Repeati1366 – 138015Cell wall-binding 16Add
    BLAST
    Repeati1415 – 143420Cell wall-binding 17Add
    BLAST
    Repeati1436 – 145722Cell wall-binding 18Add
    BLAST
    Repeati1459 – 147820Cell wall-binding 19Add
    BLAST
    Repeati1485 – 150521Cell wall-binding 20Add
    BLAST
    Repeati1508 – 152720Cell wall-binding 21Add
    BLAST
    Repeati1528 – 154720Cell wall-binding 22Add
    BLAST
    Repeati1549 – 157022Cell wall-binding 23Add
    BLAST
    Repeati1572 – 159120Cell wall-binding 24Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni200 – 1050851Catalytic; approximateAdd
    BLAST
    Regioni1099 – 1597499Glucan-binding; approximateAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 70 family.Curated
    Contains 24 cell wall-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di3.20.20.80. 3 hits.
    InterProiIPR018337. Cell_wall/Cho-bd_repeat.
    IPR027636. Glucan-bd_rpt.
    IPR003318. Glyco_hydro70cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR022263. KxYKxGKxW.
    [Graphical view]
    PfamiPF01473. CW_binding_1. 6 hits.
    PF02324. Glyco_hydro_70. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 4 hits.
    TIGRFAMsiTIGR04035. glucan_65_rpt. 5 hits.
    TIGR03715. KxYKxGKxW. 1 hit.
    PROSITEiPS51170. CW. 15 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P11001-1 [UniParc]FASTAAdd to Basket

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    MEKNERFKMH KVKKRWVTIS VASATMLASA LGASVASADT ETVSEDSNQA     50
    VLTADQTTTN QDTEQTSVAA TATSEQSAST DAATDQASAT DQASAAEQTQ 100
    GTTASTDTAA QTTTNANEAK WVPTENENQV FTDEMLAEAK NVATAESNSI 150
    PSDLAKMSNV KQVDGKYYYY DQDGNVKKNF AVSVGEKIYY FDETGAYKDT 200
    SKVEADKSGS DISKEETTFA ANNRAYSTSA ENFEAIDNYL TADSWYRPKS 250
    ILKDGKTWTE SSKDDFRPLL MAWWPDTETK RNYVNYMNKV VGIDKTYTAE 300
    TSQADLTAAA ELVQARIEQK ITTEQNTKWL REAISAFVKT QPQWNGESEK 350
    PYDDHLQNGA LKFDNQSDLT PDTQSNYRLL NRTPTNQTGS LDSRFTYNAN 400
    DPLGGYELLL ANDVDNSNPI VQAEQLNWLH YLLNFGTIYA KDADANFDSI 450
    RVDAVDNVDA DLLQISSDYL KAAYGIDKNN KNANNHVSIV EAWSDNDTPY 500
    LHDDGDNLMN MDNKFRLSML WSLAKPLDKR SGLNPLIHNS LVDREVDDRE 550
    VETVPSYSFA RAHDSEVQDL IRDIIKAEIN PNAFGYSFTQ DEIDQAFKIY 600
    NEDLKKTDKK YTHYNVPLSY TLLLTNKGSI PRVYYGDMFT DDGQYMANKT 650
    VNYDAIESLL KARMKYVAGG QAMQNYQIGN GEILTSVRYG KGALKQSDKG 700
    DATTRTSGVG VVMGNQPNFS LDGKVVALNM GAAHANQEYR ALMVSTKDGV 750
    ATYATDADAS KAGLVKRTDE NGYLYFLNDD LKGVANPQVS GFLQVWVPVG 800
    AADDQDIRVA ASDTASTDGK SLHQDAAMDS RVMFEGFSNF QSFATKEEEY 850
    TNVVIANNVD KFVSWGITDF EMAPQYVSST DGQFLDSVIQ NGYAFTDRYD 900
    LGMSKANKYG TADQLVKAIK ALHAKGLKVM ADWVPDQMYT FPKQEVVTVT 950
    RTDKFGKPIA GSQINHSLYV TDTKSSGDDY QAKYGGAFLD ELKEKYPELF 1000
    TKKQISTGQA IDPSVKIKQW SAKYFNGSNI LGRGADYVLS DQASNKYLNV 1050
    SDDKLFLPKT LLGQVVESGI RFDGTGYVYN SSTTGEKVTD SFITEAGNLY 1100
    YFGQDGYMVT GAQNIKGSNY YFLANGAALR NTVYTDAQGQ NHYYGNDGKR 1150
    YENGYQQFGN DSWRYFKNGV MALGLTTVDG HVQYFDKDGV QAKDKIIVTR 1200
    DGKVRYFDQH NGNAVTNTFV ADKTGHWYYL GKDGVAVTGA QTVGKQHLYF 1250
    EANGQQVKGD FVTAKDGKLY FYDVDSGDMW TNTFIEDKAG NWFYLGKDGA 1300
    AVTGAQTIKG QKLYFKANGQ QVKGDIVKDA DGKIRYYDAQ TGEQVFNKSV 1350
    SVNGKTYYFG SDGTAQTQAN PKGQTFKDGS GVLRFYNLEG QYVSGSGWYE 1400
    TAEHEWVYVK SGKVLTGAQT IGNQRVYFKD NGHQVKGQLV TGNDGKLRYY 1450
    DANSGDQAFN KSVTVNGKTY YFGSDGTAQT QANPKGQTFK DGSGVLRFYN 1500
    LEGQYVSGSG WYKNAQGQWL YVKDGKVLTG LQTVGNQKVY FDKNGIQAKG 1550
    KAVRTSDGKV RYFDENSGSM ITNQWKFVYG QYYYFGSDGA AVYRGWN 1597
    Length:1,597
    Mass (Da):177,080
    Last modified:July 1, 1989 - v1
    Checksum:iB9E86A200868798E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17391 Genomic DNA. Translation: AAC63063.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17391 Genomic DNA. Translation: AAC63063.1 .

    3D structure databases

    ProteinModelPortali P11001.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH70. Glycoside Hydrolase Family 70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 3 hits.
    InterProi IPR018337. Cell_wall/Cho-bd_repeat.
    IPR027636. Glucan-bd_rpt.
    IPR003318. Glyco_hydro70cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR022263. KxYKxGKxW.
    [Graphical view ]
    Pfami PF01473. CW_binding_1. 6 hits.
    PF02324. Glyco_hydro_70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 4 hits.
    TIGRFAMsi TIGR04035. glucan_65_rpt. 5 hits.
    TIGR03715. KxYKxGKxW. 1 hit.
    PROSITEi PS51170. CW. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a glucosyltransferase gene from Streptococcus sobrinus MFe28."
      Ferretti J.J., Gilpin M.L., Russell R.R.B.
      J. Bacteriol. 169:4271-4278(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MFE28.

    Entry informationi

    Entry nameiGTF1_STRDO
    AccessioniPrimary (citable) accession number: P11001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3