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P11001

- GTF1_STRDO

UniProt

P11001 - GTF1_STRDO

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Protein
Glucosyltransferase-I
Gene
gtfI
Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-I (EC:2.4.1.5)
Short name:
GTF-I
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
Gene namesi
Name:gtfI
OrganismiStreptococcus downei (Streptococcus sobrinus)
Taxonomic identifieri1317 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed prediction
Add
BLAST
Chaini39 – 15971559Glucosyltransferase-I
PRO_0000021383Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP11001.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati157 – 17620Cell wall-binding 1
Add
BLAST
Repeati178 – 19720Cell wall-binding 2
Add
BLAST
Repeati1089 – 110820Cell wall-binding 3
Add
BLAST
Repeati1109 – 112820Cell wall-binding 4
Add
BLAST
Repeati1130 – 115021Cell wall-binding 5
Add
BLAST
Repeati1152 – 117221Cell wall-binding 6
Add
BLAST
Repeati1173 – 119119Cell wall-binding 7
Add
BLAST
Repeati1193 – 121422Cell wall-binding 8
Add
BLAST
Repeati1216 – 123621Cell wall-binding 9
Add
BLAST
Repeati1237 – 125620Cell wall-binding 10
Add
BLAST
Repeati1258 – 127922Cell wall-binding 11
Add
BLAST
Repeati1281 – 130121Cell wall-binding 12
Add
BLAST
Repeati1302 – 132120Cell wall-binding 13
Add
BLAST
Repeati1323 – 134321Cell wall-binding 14
Add
BLAST
Repeati1344 – 136522Cell wall-binding 15
Add
BLAST
Repeati1366 – 138015Cell wall-binding 16
Add
BLAST
Repeati1415 – 143420Cell wall-binding 17
Add
BLAST
Repeati1436 – 145722Cell wall-binding 18
Add
BLAST
Repeati1459 – 147820Cell wall-binding 19
Add
BLAST
Repeati1485 – 150521Cell wall-binding 20
Add
BLAST
Repeati1508 – 152720Cell wall-binding 21
Add
BLAST
Repeati1528 – 154720Cell wall-binding 22
Add
BLAST
Repeati1549 – 157022Cell wall-binding 23
Add
BLAST
Repeati1572 – 159120Cell wall-binding 24
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 1050851Catalytic; approximate
Add
BLAST
Regioni1099 – 1597499Glucan-binding; approximate
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di3.20.20.80. 3 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 6 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 4 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11001-1 [UniParc]FASTAAdd to Basket

« Hide

MEKNERFKMH KVKKRWVTIS VASATMLASA LGASVASADT ETVSEDSNQA     50
VLTADQTTTN QDTEQTSVAA TATSEQSAST DAATDQASAT DQASAAEQTQ 100
GTTASTDTAA QTTTNANEAK WVPTENENQV FTDEMLAEAK NVATAESNSI 150
PSDLAKMSNV KQVDGKYYYY DQDGNVKKNF AVSVGEKIYY FDETGAYKDT 200
SKVEADKSGS DISKEETTFA ANNRAYSTSA ENFEAIDNYL TADSWYRPKS 250
ILKDGKTWTE SSKDDFRPLL MAWWPDTETK RNYVNYMNKV VGIDKTYTAE 300
TSQADLTAAA ELVQARIEQK ITTEQNTKWL REAISAFVKT QPQWNGESEK 350
PYDDHLQNGA LKFDNQSDLT PDTQSNYRLL NRTPTNQTGS LDSRFTYNAN 400
DPLGGYELLL ANDVDNSNPI VQAEQLNWLH YLLNFGTIYA KDADANFDSI 450
RVDAVDNVDA DLLQISSDYL KAAYGIDKNN KNANNHVSIV EAWSDNDTPY 500
LHDDGDNLMN MDNKFRLSML WSLAKPLDKR SGLNPLIHNS LVDREVDDRE 550
VETVPSYSFA RAHDSEVQDL IRDIIKAEIN PNAFGYSFTQ DEIDQAFKIY 600
NEDLKKTDKK YTHYNVPLSY TLLLTNKGSI PRVYYGDMFT DDGQYMANKT 650
VNYDAIESLL KARMKYVAGG QAMQNYQIGN GEILTSVRYG KGALKQSDKG 700
DATTRTSGVG VVMGNQPNFS LDGKVVALNM GAAHANQEYR ALMVSTKDGV 750
ATYATDADAS KAGLVKRTDE NGYLYFLNDD LKGVANPQVS GFLQVWVPVG 800
AADDQDIRVA ASDTASTDGK SLHQDAAMDS RVMFEGFSNF QSFATKEEEY 850
TNVVIANNVD KFVSWGITDF EMAPQYVSST DGQFLDSVIQ NGYAFTDRYD 900
LGMSKANKYG TADQLVKAIK ALHAKGLKVM ADWVPDQMYT FPKQEVVTVT 950
RTDKFGKPIA GSQINHSLYV TDTKSSGDDY QAKYGGAFLD ELKEKYPELF 1000
TKKQISTGQA IDPSVKIKQW SAKYFNGSNI LGRGADYVLS DQASNKYLNV 1050
SDDKLFLPKT LLGQVVESGI RFDGTGYVYN SSTTGEKVTD SFITEAGNLY 1100
YFGQDGYMVT GAQNIKGSNY YFLANGAALR NTVYTDAQGQ NHYYGNDGKR 1150
YENGYQQFGN DSWRYFKNGV MALGLTTVDG HVQYFDKDGV QAKDKIIVTR 1200
DGKVRYFDQH NGNAVTNTFV ADKTGHWYYL GKDGVAVTGA QTVGKQHLYF 1250
EANGQQVKGD FVTAKDGKLY FYDVDSGDMW TNTFIEDKAG NWFYLGKDGA 1300
AVTGAQTIKG QKLYFKANGQ QVKGDIVKDA DGKIRYYDAQ TGEQVFNKSV 1350
SVNGKTYYFG SDGTAQTQAN PKGQTFKDGS GVLRFYNLEG QYVSGSGWYE 1400
TAEHEWVYVK SGKVLTGAQT IGNQRVYFKD NGHQVKGQLV TGNDGKLRYY 1450
DANSGDQAFN KSVTVNGKTY YFGSDGTAQT QANPKGQTFK DGSGVLRFYN 1500
LEGQYVSGSG WYKNAQGQWL YVKDGKVLTG LQTVGNQKVY FDKNGIQAKG 1550
KAVRTSDGKV RYFDENSGSM ITNQWKFVYG QYYYFGSDGA AVYRGWN 1597
Length:1,597
Mass (Da):177,080
Last modified:July 1, 1989 - v1
Checksum:iB9E86A200868798E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17391 Genomic DNA. Translation: AAC63063.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17391 Genomic DNA. Translation: AAC63063.1 .

3D structure databases

ProteinModelPortali P11001.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 3 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 6 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 4 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a glucosyltransferase gene from Streptococcus sobrinus MFe28."
    Ferretti J.J., Gilpin M.L., Russell R.R.B.
    J. Bacteriol. 169:4271-4278(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MFE28.

Entry informationi

Entry nameiGTF1_STRDO
AccessioniPrimary (citable) accession number: P11001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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