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P11001

- GTF1_STRDO

UniProt

P11001 - GTF1_STRDO

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Protein

Glucosyltransferase-I

Gene

gtfI

Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-I (EC:2.4.1.5)
Short name:
GTF-I
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
Gene namesi
Name:gtfI
OrganismiStreptococcus downei (Streptococcus sobrinus)
Taxonomic identifieri1317 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 15971559Glucosyltransferase-IPRO_0000021383Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP11001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati157 – 17620Cell wall-binding 1Add
BLAST
Repeati178 – 19720Cell wall-binding 2Add
BLAST
Repeati1089 – 110820Cell wall-binding 3Add
BLAST
Repeati1109 – 112820Cell wall-binding 4Add
BLAST
Repeati1130 – 115021Cell wall-binding 5Add
BLAST
Repeati1152 – 117221Cell wall-binding 6Add
BLAST
Repeati1173 – 119119Cell wall-binding 7Add
BLAST
Repeati1193 – 121422Cell wall-binding 8Add
BLAST
Repeati1216 – 123621Cell wall-binding 9Add
BLAST
Repeati1237 – 125620Cell wall-binding 10Add
BLAST
Repeati1258 – 127922Cell wall-binding 11Add
BLAST
Repeati1281 – 130121Cell wall-binding 12Add
BLAST
Repeati1302 – 132120Cell wall-binding 13Add
BLAST
Repeati1323 – 134321Cell wall-binding 14Add
BLAST
Repeati1344 – 136522Cell wall-binding 15Add
BLAST
Repeati1366 – 138015Cell wall-binding 16Add
BLAST
Repeati1415 – 143420Cell wall-binding 17Add
BLAST
Repeati1436 – 145722Cell wall-binding 18Add
BLAST
Repeati1459 – 147820Cell wall-binding 19Add
BLAST
Repeati1485 – 150521Cell wall-binding 20Add
BLAST
Repeati1508 – 152720Cell wall-binding 21Add
BLAST
Repeati1528 – 154720Cell wall-binding 22Add
BLAST
Repeati1549 – 157022Cell wall-binding 23Add
BLAST
Repeati1572 – 159120Cell wall-binding 24Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 1050851Catalytic; approximateAdd
BLAST
Regioni1099 – 1597499Glucan-binding; approximateAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 70 family.Curated
Contains 24 cell wall-binding repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di3.20.20.80. 3 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 6 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 4 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11001-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKNERFKMH KVKKRWVTIS VASATMLASA LGASVASADT ETVSEDSNQA
60 70 80 90 100
VLTADQTTTN QDTEQTSVAA TATSEQSAST DAATDQASAT DQASAAEQTQ
110 120 130 140 150
GTTASTDTAA QTTTNANEAK WVPTENENQV FTDEMLAEAK NVATAESNSI
160 170 180 190 200
PSDLAKMSNV KQVDGKYYYY DQDGNVKKNF AVSVGEKIYY FDETGAYKDT
210 220 230 240 250
SKVEADKSGS DISKEETTFA ANNRAYSTSA ENFEAIDNYL TADSWYRPKS
260 270 280 290 300
ILKDGKTWTE SSKDDFRPLL MAWWPDTETK RNYVNYMNKV VGIDKTYTAE
310 320 330 340 350
TSQADLTAAA ELVQARIEQK ITTEQNTKWL REAISAFVKT QPQWNGESEK
360 370 380 390 400
PYDDHLQNGA LKFDNQSDLT PDTQSNYRLL NRTPTNQTGS LDSRFTYNAN
410 420 430 440 450
DPLGGYELLL ANDVDNSNPI VQAEQLNWLH YLLNFGTIYA KDADANFDSI
460 470 480 490 500
RVDAVDNVDA DLLQISSDYL KAAYGIDKNN KNANNHVSIV EAWSDNDTPY
510 520 530 540 550
LHDDGDNLMN MDNKFRLSML WSLAKPLDKR SGLNPLIHNS LVDREVDDRE
560 570 580 590 600
VETVPSYSFA RAHDSEVQDL IRDIIKAEIN PNAFGYSFTQ DEIDQAFKIY
610 620 630 640 650
NEDLKKTDKK YTHYNVPLSY TLLLTNKGSI PRVYYGDMFT DDGQYMANKT
660 670 680 690 700
VNYDAIESLL KARMKYVAGG QAMQNYQIGN GEILTSVRYG KGALKQSDKG
710 720 730 740 750
DATTRTSGVG VVMGNQPNFS LDGKVVALNM GAAHANQEYR ALMVSTKDGV
760 770 780 790 800
ATYATDADAS KAGLVKRTDE NGYLYFLNDD LKGVANPQVS GFLQVWVPVG
810 820 830 840 850
AADDQDIRVA ASDTASTDGK SLHQDAAMDS RVMFEGFSNF QSFATKEEEY
860 870 880 890 900
TNVVIANNVD KFVSWGITDF EMAPQYVSST DGQFLDSVIQ NGYAFTDRYD
910 920 930 940 950
LGMSKANKYG TADQLVKAIK ALHAKGLKVM ADWVPDQMYT FPKQEVVTVT
960 970 980 990 1000
RTDKFGKPIA GSQINHSLYV TDTKSSGDDY QAKYGGAFLD ELKEKYPELF
1010 1020 1030 1040 1050
TKKQISTGQA IDPSVKIKQW SAKYFNGSNI LGRGADYVLS DQASNKYLNV
1060 1070 1080 1090 1100
SDDKLFLPKT LLGQVVESGI RFDGTGYVYN SSTTGEKVTD SFITEAGNLY
1110 1120 1130 1140 1150
YFGQDGYMVT GAQNIKGSNY YFLANGAALR NTVYTDAQGQ NHYYGNDGKR
1160 1170 1180 1190 1200
YENGYQQFGN DSWRYFKNGV MALGLTTVDG HVQYFDKDGV QAKDKIIVTR
1210 1220 1230 1240 1250
DGKVRYFDQH NGNAVTNTFV ADKTGHWYYL GKDGVAVTGA QTVGKQHLYF
1260 1270 1280 1290 1300
EANGQQVKGD FVTAKDGKLY FYDVDSGDMW TNTFIEDKAG NWFYLGKDGA
1310 1320 1330 1340 1350
AVTGAQTIKG QKLYFKANGQ QVKGDIVKDA DGKIRYYDAQ TGEQVFNKSV
1360 1370 1380 1390 1400
SVNGKTYYFG SDGTAQTQAN PKGQTFKDGS GVLRFYNLEG QYVSGSGWYE
1410 1420 1430 1440 1450
TAEHEWVYVK SGKVLTGAQT IGNQRVYFKD NGHQVKGQLV TGNDGKLRYY
1460 1470 1480 1490 1500
DANSGDQAFN KSVTVNGKTY YFGSDGTAQT QANPKGQTFK DGSGVLRFYN
1510 1520 1530 1540 1550
LEGQYVSGSG WYKNAQGQWL YVKDGKVLTG LQTVGNQKVY FDKNGIQAKG
1560 1570 1580 1590
KAVRTSDGKV RYFDENSGSM ITNQWKFVYG QYYYFGSDGA AVYRGWN
Length:1,597
Mass (Da):177,080
Last modified:July 1, 1989 - v1
Checksum:iB9E86A200868798E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17391 Genomic DNA. Translation: AAC63063.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17391 Genomic DNA. Translation: AAC63063.1 .

3D structure databases

ProteinModelPortali P11001.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 3 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 6 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 4 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a glucosyltransferase gene from Streptococcus sobrinus MFe28."
    Ferretti J.J., Gilpin M.L., Russell R.R.B.
    J. Bacteriol. 169:4271-4278(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MFE28.

Entry informationi

Entry nameiGTF1_STRDO
AccessioniPrimary (citable) accession number: P11001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3