ID   LAML3_XENLA             Reviewed;         583 AA.
AC   P10999; P23420; Q6AZG7;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 2.
DT   22-SEP-2009, entry version 75.
DE   RecName: Full=Lamin-L(III);
DE   AltName: Full=Lamin-B3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   MEDLINE=91065338; PubMed=2249665;
RA   Doering V., Stick R.;
RT   "Gene structure of nuclear lamin LIII of Xenopus laevis; a model for
RT   the evolution of IF proteins from a lamin-like ancestor.";
RL   EMBO J. 9:4073-4081(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Ovary;
RX   MEDLINE=89030615; PubMed=3181134;
RA   Stick R.;
RT   "cDNA cloning of the developmentally regulated lamin LIII of Xenopus
RT   laevis.";
RL   EMBO J. 7:3189-3197(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lamins are components of the nuclear lamina, a fibrous
CC       layer on the nucleoplasmic side of the inner nuclear membrane,
CC       which is thought to provide a framework for the nuclear envelope
CC       and may also interact with chromatin.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane; Lipid-anchor;
CC       Nucleoplasmic side.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=B3A;
CC         IsoId=P10999-1; Sequence=Displayed;
CC       Name=2; Synonyms=B3B;
CC         IsoId=P10999-2; Sequence=VSP_002473;
CC   -!- DEVELOPMENTAL STAGE: Expressed in oocytes.
CC   -!- MISCELLANEOUS: There are at least five different lamins in
CC       Xenopus: the somatic lamins L(I), L(II), and A; the oocyte
CC       germinal vesicle lamin L(III); and the male germ cells lamin
CC       l(IV).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
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DR   EMBL; X13169; CAA31567.1; -; mRNA.
DR   EMBL; BC078034; AAH78034.1; -; mRNA.
DR   PIR; S01301; S01301.
DR   RefSeq; NP_001081545.1; -.
DR   UniGene; Xl.1238; -.
DR   HSSP; P02545; 1IVT.
DR   GeneID; 397910; -.
DR   KEGG; xla:397910; -.
DR   CTD; 397910; -.
DR   Xenbase; XB-FEAT-920612; lmnb3.
DR   HOVERGEN; P10999; -.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR016044; F.
DR   InterPro; IPR001664; IF.
DR   InterPro; IPR001322; IF_tail_C.
DR   InterPro; IPR018039; Intermediate_filament_CS.
DR   PANTHER; PTHR23239; IF; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF00932; IF_tail; 1.
DR   PROSITE; PS00226; IF; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Intermediate filament; Lipoprotein;
KW   Membrane; Nucleus; Phosphoprotein; Prenylation.
FT   CHAIN         1    583       Lamin-L(III).
FT                                /FTId=PRO_0000063825.
FT   REGION        1     32       Head.
FT   REGION       33    384       Rod.
FT   REGION       33     67       Coil 1A.
FT   REGION       68     79       Linker 1.
FT   REGION       80    215       Coil 1B.
FT   REGION      216    242       Linker 2.
FT   REGION      243    384       Coil 2.
FT   REGION      385    583       Tail.
FT   COMPBIAS    550    565       Asp/Glu-rich (highly acidic; could be
FT                                involved in chromatin binding).
FT   LIPID       580    580       S-farnesyl cysteine (By similarity).
FT   VAR_SEQ     572    583       SHQSVDPSCSIM -> TKRRKKKCCSVS (in isoform
FT                                2).
FT                                /FTId=VSP_002473.
FT   CONFLICT    349    349       Q -> H (in Ref. 2; CAA31567).
SQ   SEQUENCE   583 AA;  67291 MW;  6BDBD1CF25ACEE92 CRC64;
     MATSTPSRAR EHASAAQSPG SPTRISRMQE KEDLRHLNDR LAAYIERVRS LEADKSLLKI
     QLEEREEVSS REVTNLRQLY ETELADARKL LDQTANERAR LQVELGKVRE EYRQLQARNS
     KKENDLSLAQ NQLRDLESKL NTKEAELATA LSGKRGLEEQ LQEQRAQIAG LESSLRDTTK
     QLHDEMLWRV DLENKMQTIR EQLDFQKNIH TQEVKEIKKR HDTRIVEIDS GRRVEFESKL
     AEALQELRRD HEQQILEYKE HLEKNFSAKL ENAQLAAAKN SDYASATREE IMATKLRVDT
     LSSQLNHYQK QNSALEAKVR DLQDMLDRAH DMHRRQMTEK DREVTEIRQT LQGQLEEYEQ
     LLDVKLALDM EINAYRKMLE GEEQRLKLSP SPSQRSTVSR ASTSQTSRLL RGKKRKLDET
     GRSVTKRSYK VVQQASSTGP VSVEDIDPEG NYVRLLNNTE EDFSLHGWVV KRMHMSLPEI
     AFKLPCRFIL KSSQRVTIWA AGAGAVHSPP TDLVWKSQKT WGTGDNIKIT LLDSTGEECA
     ERTLYRVIGE EGETDEDFVE EEELERQFRS QSHQSVDPSC SIM
//