Reviewed,
UniProtKB/Swiss-Prot P10999 (LAML3_XENLA)
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September 22, 2009.
Version 75.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Lamin-L(III) Alternative name(s): Lamin-B3 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic identifier | 8355 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 583 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. |
| Subcellular location | |
| Developmental stage | Expressed in oocytes. |
| Miscellaneous | There are at least five different lamins in Xenopus: the somatic lamins L(I), L(II), and A; the oocyte germinal vesicle lamin L(III); and the male germ cells lamin l(IV). |
| Sequence similarities | Belongs to the intermediate filament family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Intermediate filament Membrane Nucleus |
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil |
| PTM | Lipoprotein Phosphoprotein Prenylation |
| Gene Ontology (GO) | |
| Cellular component | intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW membraneInferred from electronic annotation. Source: UniProtKB-KW nucleusInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | structural molecule activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P10999-1) Also known as: B3A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P10999-2) Also known as: B3B; The sequence of this isoform differs from the canonical sequence as follows: 572-583: SHQSVDPSCSIM → TKRRKKKCCSVS |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 583 | 583 | Lamin-L(III) | PRO_0000063825 | |||||
Regions | |||||||||
| Region | 1 – 32 | 32 | Head | ||||||
| Region | 33 – 384 | 352 | Rod | ||||||
| Region | 33 – 67 | 35 | Coil 1A | ||||||
| Region | 68 – 79 | 12 | Linker 1 | ||||||
| Region | 80 – 215 | 136 | Coil 1B | ||||||
| Region | 216 – 242 | 27 | Linker 2 | ||||||
| Region | 243 – 384 | 142 | Coil 2 | ||||||
| Region | 385 – 583 | 199 | Tail | ||||||
| Compositional bias | 550 – 565 | 16 | Asp/Glu-rich (highly acidic; could be involved in chromatin binding) | ||||||
Amino acid modifications | |||||||||
| Lipidation | 580 | 1 | S-farnesyl cysteine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 572 – 583 | 12 | SHQSV…SCSIM → TKRRKKKCCSVS in isoform 2. | VSP_002473 | |||||
Experimental info | |||||||||
| Sequence conflict | 349 | 1 | Q → H in CAA31567. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Gene structure of nuclear lamin LIII of Xenopus laevis; a model for the evolution of IF proteins from a lamin-like ancestor." Doering V., Stick R. EMBO J. 9:4073-4081(1990) [PubMed: 2249665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). |
| [2] | "cDNA cloning of the developmentally regulated lamin LIII of Xenopus laevis." Stick R. EMBO J. 7:3189-3197(1988) [PubMed: 3181134] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Ovary. |
| [3] | NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| X13169 mRNA. Translation: CAA31567.1. BC078034 mRNA. Translation: AAH78034.1. | |
| PIR | S01301. |
| RefSeq | NP_001081545.1. |
| UniGene | Xl.1238 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IVT based on UniProtKB P02545. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 397910. |
| KEGG | xla:397910. |
Organism-specific databases | |
| CTD | 397910. |
| Xenbase | XB-FEAT-920612. lmnb3. |
Phylogenomic databases | |
| HOVERGEN | P10999. |
Family and domain databases | |
| InterPro | IPR016044. F. IPR001664. IF. IPR001322. IF_tail_C. IPR018039. Intermediate_filament_CS. [Graphical view] |
| PANTHER | PTHR23239. IF. 1 hit. |
| Pfam | PF00038. Filament. 1 hit. PF00932. IF_tail. 1 hit. [Graphical view] |
| PROSITE | PS00226. IF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LAML3_XENLA | ||||||||
| Accession | Primary (citable) accession number: P10999 Secondary accession number(s): P23420, Q6AZG7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||
