P10986 (ACT4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-4

Gene names

Name:	act-4
ORF Names:	M03F4.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Ref.1
Subcellular location	Cytoplasm › cytoskeleton Ref.1.
Miscellaneous	In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from mutant phenotype. Source: WormBase cytokinesis Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase inductive cell migration Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase receptor-mediated endocytosis Inferred from mutant phenotype. Source: WormBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 2	2	Removed in mature form By similarity		PRO_0000000654
	Chain	3 – 376	374	Actin-4		PRO_0000000655
Amino acid modifications
	Modified residue	3	1	N-acetylaspartate By similarity
Experimental info
	Sequence conflict	5	1	E → D in AAA27890. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P10986 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 4DF86D2E14623560	FASTA	376	41,778
	10 20 30 40 50 60 MCDDEVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ 70 80 90 100 110 120 SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM 130 140 150 160 170 180 TQIMFETFNT PAMYVAIQAV LSLYASGRTT GVVLDSGDGV THTVPIYEGY ALPHAILRLD 190 200 210 220 230 240 LAGRDLTDYL MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS 250 260 270 280 290 300 YELPDGQVIT VGNERFRCPE ALFQPSFLGM ESAGIHETSY NSIMKCDIDI RKDLYANTVL 310 320 330 340 350 360 SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK 370 QEYDESGPSI VHRKCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Wild-type and mutant actin genes in Caenorhabditis elegans." Krause M., Wild M., Rosenzweig B., Hirsh D. J. Mol. Biol. 208:381-392(1989) [PubMed: 2795655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Actin gene family of Caenorhabditis elegans." Files J.G., Carr S., Hirsh D. J. Mol. Biol. 164:355-375(1983) [PubMed: 6302275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-86.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16799, X16800 Genomic DNA. Translation: CAA34720.1. FO081654 Genomic DNA. Translation: CCD83476.1. J01046, J01045 Genomic DNA. Translation: AAA27890.1.
PIR	S27135.
RefSeq	NP_508841.1. NM_076440.5.
UniGene	Cel.17615.
3D structure databases
ProteinModelPortal	P10986.
SMR	P10986. Positions 5-376.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27204N.
IntAct	P10986. 7 interactions.
MINT	MINT-1062174.
STRING	P10986.
Proteomic databases
PRIDE	P10986.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	M03F4.2a; M03F4.2a; M03F4.2.
GeneID	180767.
KEGG	cel:M03F4.2.
UCSC	M03F4.2a. c. elegans.
Organism-specific databases
CTD	180767.
WormBase	M03F4.2a; CE12358; WBGene00000066; act-4.
Phylogenomic databases
eggNOG	meNOG06733.
HOGENOM	HBG559892.
InParanoid	P10986.
OMA	IAMEEEI.
PhylomeDB	P10986.
Gene expression databases
ArrayExpress	P10986.
Family and domain databases
InterPro	IPR004000. Actin-like. IPR020902. Actin/actin-like_CS. IPR004001. Actin_CS. [Graphical view]
KO	K05692.
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	910856.

Entry information

Entry name

ACT4_CAEEL

Accession

Primary (citable) accession number: P10986
Secondary accession number(s): Q7YSY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project