Reviewed, UniProtKB/Swiss-Prot P10984 (ACT2_CAEEL)

Names and origin

Protein names

Recommended name:
    Actin-2

Gene names

Name:	act-2
ORF Names:	T04C12.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location	Cytoplasm › cytoskeleton.
Miscellaneous	In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.
Sequence similarities	Belongs to the actin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	ATP-binding Nucleotide-binding
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytokinesis Inferred from mutant phenotype. Source: WormBase embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 2	2	Removed in mature form By similarity		PRO_0000000652
	Chain	3 – 376	374	Actin-2		PRO_0000000653
Amino acid modifications
	Modified residue	3	1	N-acetylaspartate By similarity
Experimental info
	Sequence conflict	10 – 11	2	VV → IL in CAA34718. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P10984-1 [UniParc]. Last modified May 27, 2002. Version 3. Checksum: 69D9209F0D5C3190	FASTA	376	41,778
	10 20 30 40 50 60 MCDDDVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ 70 80 90 100 110 120 SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM 130 140 150 160 170 180 TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THTVPIYEGY ALPHAILRLD 190 200 210 220 230 240 LAGRDLTDYL MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS 250 260 270 280 290 300 YELPDGQVIT VGNERFRCPE ALFQPSFLGM ESAGIHETSY NSIMKCDIDI RKDLYANTVL 310 320 330 340 350 360 SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK 370 QEYDESGPSI VHRKCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Wild-type and mutant actin genes in Caenorhabditis elegans." Krause M., Wild M., Rosenzweig B., Hirsh D. J. Mol. Biol. 208:381-392(1989) [PubMed: 2795655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Actin gene family of Caenorhabditis elegans." Files J.G., Carr S., Hirsh D. J. Mol. Biol. 164:355-375(1983) [PubMed: 6302275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-83.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16797 Genomic DNA. Translation: CAA34718.1. Z81584 Genomic DNA. Translation: CAB04675.1. J01043 Genomic DNA. Translation: AAA27888.1.
PIR	S16709. T24448.
RefSeq	NP_505818.1.
UniGene	Cel.34750
3D structure databases
SMR	P10984. Positions 5-372.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25116N.
IntAct	P10984. 5 interactions.
STRING	P10984.
Genome annotation databases
Ensembl	T04C12.5; T04C12.5; T04C12.5; Caenorhabditis elegans. [Genome view]
GeneID	179534.
KEGG	cel:T04C12.5.
UCSC	T04C12.5. c. elegans.
Organism-specific databases
CTD	179534.
WormBase	WBGene00000064. act-2.
WormPep	T04C12.5. CE13150. [WorfDB]
Phylogenomic databases
OMA	EKMTQIL
Gene expression databases
ArrayExpress	P10984.
Family and domain databases
InterPro	IPR004000. Actin-like. IPR004001. Actin_CS. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
PRINTS	PR00190. ACTIN.
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
PROSITE	PS00406. ACTINS_1. 1 hit. PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	905824.

Entry information

Entry name

ACT2_CAEEL

Accession

Primary (citable) accession number: P10984
Secondary accession number(s): O45744

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	May 27, 2002
Last modified:	November 24, 2009
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project