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Protein

Actin-2

Gene

act-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Miscellaneous

In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.

GO - Molecular functioni

  • ATP binding Source: WormBase

GO - Biological processi

  • cortical actin cytoskeleton organization Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • locomotion Source: WormBase
  • meiosis II cytokinesis Source: WormBase
  • mitotic cytokinesis Source: WormBase

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP10984

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-2
Gene namesi
Name:act-2
ORF Names:T04C12.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT04C12.5 ; CE13150 ; WBGene00000064 ; act-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000006521 – 2Removed in mature formBy similarity2
ChainiPRO_00000006533 – 376Actin-2Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N-acetylaspartateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP10984
PaxDbiP10984
PeptideAtlasiP10984
PRIDEiP10984

Expressioni

Gene expression databases

BgeeiWBGene00000064

Interactioni

Protein-protein interaction databases

BioGridi44561, 5 interactors
DIPiDIP-25116N
IntActiP10984, 5 interactors
STRINGi6239.T04C12.5.2

Structurei

3D structure databases

ProteinModelPortaliP10984
SMRiP10984
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
InParanoidiP10984
KOiK05692
OMAiMERGYPF
OrthoDBiEOG091G08LD
PhylomeDBiP10984

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDDVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV THTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS YELPDGQVIT
260 270 280 290 300
VGNERFRCPE ALFQPSFLGM ESAGIHETSY NSIMKCDIDI RKDLYANTVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDESGPSI VHRKCF
Length:376
Mass (Da):41,778
Last modified:May 27, 2002 - v3
Checksum:i69D9209F0D5C3190
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 11VV → IL in CAA34718 (PubMed:2795655).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16797 Genomic DNA Translation: CAA34718.1
Z81584 Genomic DNA Translation: CAB04675.1
J01043 Genomic DNA Translation: AAA27888.1
PIRiS16709
T24448
RefSeqiNP_505818.1, NM_073417.5
UniGeneiCel.30587

Genome annotation databases

EnsemblMetazoaiT04C12.5.1; T04C12.5.1; WBGene00000064
T04C12.5.2; T04C12.5.2; WBGene00000064
T04C12.5.3; T04C12.5.3; WBGene00000064
GeneIDi179534
KEGGicel:CELE_T04C12.5
UCSCiT04C12.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiACT2_CAEEL
AccessioniPrimary (citable) accession number: P10984
Secondary accession number(s): O45744
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 27, 2002
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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