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Protein

Actin-2

Gene

act-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

GO - Molecular functioni

  • ATP binding Source: WormBase

GO - Biological processi

  • cortical actin cytoskeleton organization Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • locomotion Source: WormBase
  • meiosis II cytokinesis Source: WormBase
  • mitotic cytokinesis Source: WormBase
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP10984.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-2
Gene namesi
Name:act-2
ORF Names:T04C12.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT04C12.5; CE13150; WBGene00000064; act-2.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: WormBase
  • cell cortex Source: WormBase
  • cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000006521 – 2Removed in mature formBy similarity2
ChainiPRO_00000006533 – 376Actin-2Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N-acetylaspartateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP10984.
PaxDbiP10984.
PeptideAtlasiP10984.
PRIDEiP10984.

Expressioni

Gene expression databases

BgeeiWBGene00000064.

Interactioni

Protein-protein interaction databases

BioGridi44561. 5 interactors.
DIPiDIP-25116N.
IntActiP10984. 5 interactors.
MINTiMINT-1100945.
STRINGi6239.T04C12.5.2.

Structurei

3D structure databases

ProteinModelPortaliP10984.
SMRiP10984.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
InParanoidiP10984.
KOiK05692.
OMAiTFQQART.
OrthoDBiEOG091G08LD.
PhylomeDBiP10984.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDDVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV THTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS YELPDGQVIT
260 270 280 290 300
VGNERFRCPE ALFQPSFLGM ESAGIHETSY NSIMKCDIDI RKDLYANTVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDESGPSI VHRKCF
Length:376
Mass (Da):41,778
Last modified:May 27, 2002 - v3
Checksum:i69D9209F0D5C3190
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 11VV → IL in CAA34718 (PubMed:2795655).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16797 Genomic DNA. Translation: CAA34718.1.
Z81584 Genomic DNA. Translation: CAB04675.1.
J01043 Genomic DNA. Translation: AAA27888.1.
PIRiS16709.
T24448.
RefSeqiNP_505818.1. NM_073417.5.
UniGeneiCel.30587.

Genome annotation databases

EnsemblMetazoaiT04C12.5.1; T04C12.5.1; WBGene00000064.
T04C12.5.2; T04C12.5.2; WBGene00000064.
GeneIDi179534.
KEGGicel:CELE_T04C12.5.
UCSCiT04C12.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16797 Genomic DNA. Translation: CAA34718.1.
Z81584 Genomic DNA. Translation: CAB04675.1.
J01043 Genomic DNA. Translation: AAA27888.1.
PIRiS16709.
T24448.
RefSeqiNP_505818.1. NM_073417.5.
UniGeneiCel.30587.

3D structure databases

ProteinModelPortaliP10984.
SMRiP10984.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44561. 5 interactors.
DIPiDIP-25116N.
IntActiP10984. 5 interactors.
MINTiMINT-1100945.
STRINGi6239.T04C12.5.2.

Proteomic databases

EPDiP10984.
PaxDbiP10984.
PeptideAtlasiP10984.
PRIDEiP10984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04C12.5.1; T04C12.5.1; WBGene00000064.
T04C12.5.2; T04C12.5.2; WBGene00000064.
GeneIDi179534.
KEGGicel:CELE_T04C12.5.
UCSCiT04C12.5. c. elegans.

Organism-specific databases

CTDi179534.
WormBaseiT04C12.5; CE13150; WBGene00000064; act-2.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
InParanoidiP10984.
KOiK05692.
OMAiTFQQART.
OrthoDBiEOG091G08LD.
PhylomeDBiP10984.

Enzyme and pathway databases

SignaLinkiP10984.

Miscellaneous databases

PROiP10984.

Gene expression databases

BgeeiWBGene00000064.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACT2_CAEEL
AccessioniPrimary (citable) accession number: P10984
Secondary accession number(s): O45744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 27, 2002
Last modified: November 30, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.