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Protein

Actin-87E

Gene

Act87E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.1 Publication
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.1 Publication

Miscellaneous

In Drosophila there are 6 closely related actin genes.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  • cytoskeleton organization Source: FlyBase
  • histone acetylation Source: FlyBase
  • histone exchange Source: FlyBase

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-190873. Gap junction degradation.
R-DME-196025. Formation of annular gap junctions.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-437239. Recycling pathway of L1.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-5689603. UCH proteinases.
R-DME-5696394. DNA Damage Recognition in GG-NER.
R-DME-8856828. Clathrin-mediated endocytosis.
SignaLinkiP10981.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-87E
Gene namesi
Name:Act87E
ORF Names:CG18290
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000046. Act87E.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000006641 – 2Removed in mature formBy similarity2
ChainiPRO_00000006653 – 376Actin-87EAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N-acetylaspartateBy similarity1
Modified residuei45Methionine sulfoxide1 Publication1
Modified residuei48Methionine sulfoxide1 Publication1

Post-translational modificationi

Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.1 Publication

Keywords - PTMi

Acetylation, Oxidation

Proteomic databases

PaxDbiP10981.
PRIDEiP10981.

Expressioni

Gene expression databases

BgeeiFBgn0000046.
ExpressionAtlasiP10981. differential.
GenevisibleiP10981. DM.

Interactioni

Subunit structurei

Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.1 Publication

Protein-protein interaction databases

BioGridi71541. 16 interactors.
DIPiDIP-18091N.
IntActiP10981. 14 interactors.
MINTiMINT-899452.
STRINGi7227.FBpp0082253.

Structurei

3D structure databases

ProteinModelPortaliP10981.
SMRiP10981.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
InParanoidiP10981.
KOiK05692.
OMAiAMCEEED.
OrthoDBiEOG091G08LD.
PhylomeDBiP10981.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDDEVAALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNA PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV SHTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AAASTSLEKS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE SLFQPSFLGM ESCGIHETVY NSIMKCDVDI RKDLYANIVM
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTIKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDESGPGI VHRKCF
Length:376
Mass (Da):41,802
Last modified:July 1, 1989 - v1
Checksum:i60252541882B0A7F
GO

Sequence cautioni

The sequence AAM29410 differs from that shown. Reason: Erroneous translation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12452 Genomic DNA. Translation: CAA30982.1.
K00674 Genomic DNA. Translation: AAA28320.1.
AE014297 Genomic DNA. Translation: AAF54950.2.
AE014297 Genomic DNA. Translation: AAN13567.1.
AY089587 mRNA. Translation: AAL90325.1.
AY113405 mRNA. Translation: AAM29410.1. Sequence problems.
BT016152 mRNA. Translation: AAV37037.1.
PIRiS04538.
RefSeqiNP_001287314.1. NM_001300385.1.
NP_477091.1. NM_057743.5.
NP_731812.1. NM_169525.2.
UniGeneiDm.4869.

Genome annotation databases

EnsemblMetazoaiFBtr0082785; FBpp0082253; FBgn0000046.
FBtr0082786; FBpp0082254; FBgn0000046.
FBtr0346242; FBpp0312019; FBgn0000046.
GeneIDi48632.
KEGGidme:Dmel_CG18290.

Similar proteinsi

Entry informationi

Entry nameiACT5_DROME
AccessioniPrimary (citable) accession number: P10981
Secondary accession number(s): A4V2T6
, Q5U0U0, Q8MZ23, Q9VFU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 27, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families