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Protein

Retrovirus-related Pol polyprotein from transposon TNT 1-94

Gene
N/A
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei297 – 2971For protease activityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 24718CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiA11.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Retrovirus-related Pol polyprotein from transposon TNT 1-94
Including the following 3 domains:
Protease (EC:3.4.23.-)
Reverse transcriptase (EC:2.7.7.49)
Endonuclease
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13281328Retrovirus-related Pol polyprotein from transposon TNT 1-94PRO_0000199561Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini473 – 642170Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
Contains 1 peptidase A11 domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri230 – 24718CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR025724. GAG-pre-integrase_dom.
IPR001584. Integrase_cat-core.
IPR012337. RNaseH-like_dom.
IPR013103. RVT_2.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF13976. gag_pre-integrs. 1 hit.
PF00665. rve. 1 hit.
PF07727. RVT_2. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVKYEVAK FNGDNGFSTW QRRMRDLLIQ QGLHKVLDVD SKKPDTMKAE
60 70 80 90 100
DWADLDERAA SAIRLHLSDD VVNNIIDEDT ARGIWTRLES LYMSKTLTNK
110 120 130 140 150
LYLKKQLYAL HMSEGTNFLS HLNVFNGLIT QLANLGVKIE EEDKAILLLN
160 170 180 190 200
SLPSSYDNLA TTILHGKTTI ELKDVTSALL LNEKMRKKPE NQGQALITEG
210 220 230 240 250
RGRSYQRSSN NYGRSGARGK SKNRSKSRVR NCYNCNQPGH FKRDCPNPRK
260 270 280 290 300
GKGETSGQKN DDNTAAMVQN NDNVVLFINE EEECMHLSGP ESEWVVDTAA
310 320 330 340 350
SHHATPVRDL FCRYVAGDFG TVKMGNTSYS KIAGIGDICI KTNVGCTLVL
360 370 380 390 400
KDVRHVPDLR MNLISGIALD RDGYESYFAN QKWRLTKGSL VIAKGVARGT
410 420 430 440 450
LYRTNAEICQ GELNAAQDEI SVDLWHKRMG HMSEKGLQIL AKKSLISYAK
460 470 480 490 500
GTTVKPCDYC LFGKQHRVSF QTSSERKLNI LDLVYSDVCG PMEIESMGGN
510 520 530 540 550
KYFVTFIDDA SRKLWVYILK TKDQVFQVFQ KFHALVERET GRKLKRLRSD
560 570 580 590 600
NGGEYTSREF EEYCSSHGIR HEKTVPGTPQ HNGVAERMNR TIVEKVRSML
610 620 630 640 650
RMAKLPKSFW GEAVQTACYL INRSPSVPLA FEIPERVWTN KEVSYSHLKV
660 670 680 690 700
FGCRAFAHVP KEQRTKLDDK SIPCIFIGYG DEEFGYRLWD PVKKKVIRSR
710 720 730 740 750
DVVFRESEVR TAADMSEKVK NGIIPNFVTI PSTSNNPTSA ESTTDEVSEQ
760 770 780 790 800
GEQPGEVIEQ GEQLDEGVEE VEHPTQGEEQ HQPLRRSERP RVESRRYPST
810 820 830 840 850
EYVLISDDRE PESLKEVLSH PEKNQLMKAM QEEMESLQKN GTYKLVELPK
860 870 880 890 900
GKRPLKCKWV FKLKKDGDCK LVRYKARLVV KGFEQKKGID FDEIFSPVVK
910 920 930 940 950
MTSIRTILSL AASLDLEVEQ LDVKTAFLHG DLEEEIYMEQ PEGFEVAGKK
960 970 980 990 1000
HMVCKLNKSL YGLKQAPRQW YMKFDSFMKS QTYLKTYSDP CVYFKRFSEN
1010 1020 1030 1040 1050
NFIILLLYVD DMLIVGKDKG LIAKLKGDLS KSFDMKDLGP AQQILGMKIV
1060 1070 1080 1090 1100
RERTSRKLWL SQEKYIERVL ERFNMKNAKP VSTPLAGHLK LSKKMCPTTV
1110 1120 1130 1140 1150
EEKGNMAKVP YSSAVGSLMY AMVCTRPDIA HAVGVVSRFL ENPGKEHWEA
1160 1170 1180 1190 1200
VKWILRYLRG TTGDCLCFGG SDPILKGYTD ADMAGDIDNR KSSTGYLFTF
1210 1220 1230 1240 1250
SGGAISWQSK LQKCVALSTT EAEYIAATET GKEMIWLKRF LQELGLHQKE
1260 1270 1280 1290 1300
YVVYCDSQSA IDLSKNSMYH ARTKHIDVRY HWIREMVDDE SLKVLKISTN
1310 1320
ENPADMLTKV VPRNKFELCK ELVGMHSN
Length:1,328
Mass (Da):151,077
Last modified:July 1, 1989 - v1
Checksum:iF27E76C504B19B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13777 Genomic DNA. Translation: CAA32025.1.
PIRiS04273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13777 Genomic DNA. Translation: CAA32025.1.
PIRiS04273.

3D structure databases

ProteinModelPortaliP10978.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA11.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR025724. GAG-pre-integrase_dom.
IPR001584. Integrase_cat-core.
IPR012337. RNaseH-like_dom.
IPR013103. RVT_2.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF13976. gag_pre-integrs. 1 hit.
PF00665. rve. 1 hit.
PF07727. RVT_2. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tnt1, a mobile retroviral-like transposable element of tobacco isolated by plant cell genetics."
    Grandbastien M.-A., Spielmann A., Caboche M.
    Nature 337:376-380(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPOLX_TOBAC
AccessioniPrimary (citable) accession number: P10978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 16, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.