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P10972

- RL24_HALMA

UniProt

P10972 - RL24_HALMA

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Protein

50S ribosomal protein L24P

Gene

rpl24p

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.By similarity
Stabilizes the tertiary rRNA structure within the 23S rRNA domain (domain I) to which it binds. Located at the polypeptide exit tunnel on the outside of the subunit.

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L24P
Alternative name(s):
Hl15
Hl16
Hmal24
Gene namesi
Name:rpl24p
Ordered Locus Names:rrnAC1601
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 12011950S ribosomal protein L24PPRO_0000130767Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts weakly with protein L4.2 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1601.

Structurei

Secondary structure

1
120
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 139Combined sources
Helixi17 – 193Combined sources
Helixi21 – 244Combined sources
Beta strandi25 – 284Combined sources
Helixi30 – 367Combined sources
Beta strandi39 – 424Combined sources
Beta strandi48 – 514Combined sources
Turni55 – 584Combined sources
Beta strandi60 – 678Combined sources
Turni68 – 714Combined sources
Beta strandi72 – 754Combined sources
Beta strandi79 – 813Combined sources
Beta strandi83 – 853Combined sources
Beta strandi87 – 893Combined sources
Helixi94 – 963Combined sources
Beta strandi97 – 1015Combined sources
Helixi107 – 1148Combined sources
Beta strandi116 – 1183Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40Q2-120[»]
1JJ2X-ray2.40S2-120[»]
1K73X-ray3.01U2-120[»]
1K8AX-ray3.00U2-120[»]
1K9MX-ray3.00U2-120[»]
1KC8X-ray3.01U2-120[»]
1KD1X-ray3.00U2-120[»]
1KQSX-ray3.10S2-120[»]
1M1KX-ray3.20U2-120[»]
1M90X-ray2.80U2-120[»]
1N8RX-ray3.00U2-120[»]
1NJIX-ray3.00U2-120[»]
1Q7YX-ray3.20U2-120[»]
1Q81X-ray2.95U2-120[»]
1Q82X-ray2.98U2-120[»]
1Q86X-ray3.00U2-120[»]
1QVFX-ray3.10S2-120[»]
1QVGX-ray2.90S2-120[»]
1S72X-ray2.40T1-120[»]
1VQ4X-ray2.70T1-120[»]
1VQ5X-ray2.60T1-120[»]
1VQ6X-ray2.70T1-120[»]
1VQ7X-ray2.50T1-120[»]
1VQ8X-ray2.20T1-120[»]
1VQ9X-ray2.40T1-120[»]
1VQKX-ray2.30T1-120[»]
1VQLX-ray2.30T1-120[»]
1VQMX-ray2.30T1-120[»]
1VQNX-ray2.40T1-120[»]
1VQOX-ray2.20T1-120[»]
1VQPX-ray2.25T1-120[»]
1W2BX-ray3.50S2-120[»]
1YHQX-ray2.40T1-120[»]
1YI2X-ray2.65T1-120[»]
1YIJX-ray2.60T1-120[»]
1YITX-ray2.80T1-120[»]
1YJ9X-ray2.90T1-120[»]
1YJNX-ray3.00T1-120[»]
1YJWX-ray2.90T1-120[»]
2B66X-ray5.90Y2-120[»]
2B9PX-ray6.46Y2-120[»]
2OTJX-ray2.90T1-120[»]
2OTLX-ray2.70T1-120[»]
2QA4X-ray3.00T1-120[»]
2QEXX-ray2.90T1-120[»]
3CC2X-ray2.40T1-120[»]
3CC4X-ray2.70T1-120[»]
3CC7X-ray2.70T1-120[»]
3CCEX-ray2.75T1-120[»]
3CCJX-ray2.70T1-120[»]
3CCLX-ray2.90T1-120[»]
3CCMX-ray2.55T1-120[»]
3CCQX-ray2.90T1-120[»]
3CCRX-ray3.00T1-120[»]
3CCSX-ray2.95T1-120[»]
3CCUX-ray2.80T1-120[»]
3CCVX-ray2.90T1-120[»]
3CD6X-ray2.75T1-120[»]
3CMAX-ray2.80T1-120[»]
3CMEX-ray2.95T1-120[»]
3CPWX-ray2.70S1-120[»]
3CXCX-ray3.00S2-120[»]
3G4SX-ray3.20T2-120[»]
3G6EX-ray2.70T2-120[»]
3G71X-ray2.85T2-120[»]
3I55X-ray3.11T1-120[»]
3I56X-ray2.90T1-120[»]
3OW2X-ray2.70S2-120[»]
4ADXelectron microscopy6.60T1-120[»]
4HUBX-ray2.40T1-120[»]
ProteinModelPortaliP10972.
SMRiP10972. Positions 2-120.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10972.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24P family.Curated

Phylogenomic databases

eggNOGiCOG0198.
HOGENOMiHOG000216571.
KOiK02895.
OMAiHKIMSAT.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10972-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQPDKQRK SQRRAPLHER HKQVRATLSA DLREEYGQRN VRVNAGDTVE
60 70 80 90 100
VLRGDFAGEE GEVINVDLDK AVIHVEDVTL EKTDGEEVPR PLDTSNVRVT
110 120
DLDLEDEKRE ARLESEDDSA
Length:120
Mass (Da):13,648
Last modified:January 23, 2007 - v3
Checksum:iBDEEF21DE1587096
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211H → R AA sequence (PubMed:3191994)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55311 Genomic DNA. Translation: CAA39019.1.
AY596297 Genomic DNA. Translation: AAV46518.1.
PIRiS10735. R5HS24.
RefSeqiYP_136224.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46518; AAV46518; rrnAC1601.
GeneIDi3128440.
KEGGihma:rrnAC1601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55311 Genomic DNA. Translation: CAA39019.1 .
AY596297 Genomic DNA. Translation: AAV46518.1 .
PIRi S10735. R5HS24.
RefSeqi YP_136224.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 Q 2-120 [» ]
1JJ2 X-ray 2.40 S 2-120 [» ]
1K73 X-ray 3.01 U 2-120 [» ]
1K8A X-ray 3.00 U 2-120 [» ]
1K9M X-ray 3.00 U 2-120 [» ]
1KC8 X-ray 3.01 U 2-120 [» ]
1KD1 X-ray 3.00 U 2-120 [» ]
1KQS X-ray 3.10 S 2-120 [» ]
1M1K X-ray 3.20 U 2-120 [» ]
1M90 X-ray 2.80 U 2-120 [» ]
1N8R X-ray 3.00 U 2-120 [» ]
1NJI X-ray 3.00 U 2-120 [» ]
1Q7Y X-ray 3.20 U 2-120 [» ]
1Q81 X-ray 2.95 U 2-120 [» ]
1Q82 X-ray 2.98 U 2-120 [» ]
1Q86 X-ray 3.00 U 2-120 [» ]
1QVF X-ray 3.10 S 2-120 [» ]
1QVG X-ray 2.90 S 2-120 [» ]
1S72 X-ray 2.40 T 1-120 [» ]
1VQ4 X-ray 2.70 T 1-120 [» ]
1VQ5 X-ray 2.60 T 1-120 [» ]
1VQ6 X-ray 2.70 T 1-120 [» ]
1VQ7 X-ray 2.50 T 1-120 [» ]
1VQ8 X-ray 2.20 T 1-120 [» ]
1VQ9 X-ray 2.40 T 1-120 [» ]
1VQK X-ray 2.30 T 1-120 [» ]
1VQL X-ray 2.30 T 1-120 [» ]
1VQM X-ray 2.30 T 1-120 [» ]
1VQN X-ray 2.40 T 1-120 [» ]
1VQO X-ray 2.20 T 1-120 [» ]
1VQP X-ray 2.25 T 1-120 [» ]
1W2B X-ray 3.50 S 2-120 [» ]
1YHQ X-ray 2.40 T 1-120 [» ]
1YI2 X-ray 2.65 T 1-120 [» ]
1YIJ X-ray 2.60 T 1-120 [» ]
1YIT X-ray 2.80 T 1-120 [» ]
1YJ9 X-ray 2.90 T 1-120 [» ]
1YJN X-ray 3.00 T 1-120 [» ]
1YJW X-ray 2.90 T 1-120 [» ]
2B66 X-ray 5.90 Y 2-120 [» ]
2B9P X-ray 6.46 Y 2-120 [» ]
2OTJ X-ray 2.90 T 1-120 [» ]
2OTL X-ray 2.70 T 1-120 [» ]
2QA4 X-ray 3.00 T 1-120 [» ]
2QEX X-ray 2.90 T 1-120 [» ]
3CC2 X-ray 2.40 T 1-120 [» ]
3CC4 X-ray 2.70 T 1-120 [» ]
3CC7 X-ray 2.70 T 1-120 [» ]
3CCE X-ray 2.75 T 1-120 [» ]
3CCJ X-ray 2.70 T 1-120 [» ]
3CCL X-ray 2.90 T 1-120 [» ]
3CCM X-ray 2.55 T 1-120 [» ]
3CCQ X-ray 2.90 T 1-120 [» ]
3CCR X-ray 3.00 T 1-120 [» ]
3CCS X-ray 2.95 T 1-120 [» ]
3CCU X-ray 2.80 T 1-120 [» ]
3CCV X-ray 2.90 T 1-120 [» ]
3CD6 X-ray 2.75 T 1-120 [» ]
3CMA X-ray 2.80 T 1-120 [» ]
3CME X-ray 2.95 T 1-120 [» ]
3CPW X-ray 2.70 S 1-120 [» ]
3CXC X-ray 3.00 S 2-120 [» ]
3G4S X-ray 3.20 T 2-120 [» ]
3G6E X-ray 2.70 T 2-120 [» ]
3G71 X-ray 2.85 T 2-120 [» ]
3I55 X-ray 3.11 T 1-120 [» ]
3I56 X-ray 2.90 T 1-120 [» ]
3OW2 X-ray 2.70 S 2-120 [» ]
4ADX electron microscopy 6.60 T 1-120 [» ]
4HUB X-ray 2.40 T 1-120 [» ]
ProteinModelPortali P10972.
SMRi P10972. Positions 2-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46518 ; AAV46518 ; rrnAC1601 .
GeneIDi 3128440.
KEGGi hma:rrnAC1601.

Phylogenomic databases

eggNOGi COG0198.
HOGENOMi HOG000216571.
KOi K02895.
OMAi HKIMSAT.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1457-MONOMER.

Miscellaneous databases

EvolutionaryTracei P10972.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
HAMAPi MF_01326_A. Ribosomal_L24_A.
InterProi IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR11143. PTHR11143. 1 hit.
Pfami PF00467. KOW. 1 hit.
[Graphical view ]
SMARTi SM00739. KOW. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
TIGRFAMsi TIGR01080. rplX_A_E. 1 hit.
PROSITEi PS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of four genes encoding ribosomal proteins from the 'S10 and spectinomycin' operon equivalent region in the archaebacterium Halobacterium marismortui."
    Arndt E.
    FEBS Lett. 267:193-198(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "The primary structures of ribosomal proteins L16, L23 and L33 from the archaebacterium Halobacterium marismortui."
    Hatakeyama T., Hatakeyama T., Kimura M.
    FEBS Lett. 240:21-28(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-120.
  4. "Extended N-terminal sequencing of proteins of archaebacterial ribosomes blotted from two-dimensional gels onto glass fiber and poly(vinylidene difluoride) membrane."
    Walsh M.J., McDougall J., Wittmann-Liebold B.
    Biochemistry 27:6867-6876(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-18.
  5. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  11. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  12. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  13. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL24_HALMA
AccessioniPrimary (citable) accession number: P10972
Secondary accession number(s): Q5V1T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3