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Protein

50S ribosomal protein L22

Gene

rpl22

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.UniRule annotation
Contacts all 6 domains of the 23S rRNA, helping stabilize their relative orientation. An extended beta-hairpin in the C-terminus forms part of the polypeptide exit tunnel, in which it helps forms a bend with protein L4, while most of the rest of the protein is located at the polypeptide exit tunnel on the outside of the subunit.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1462-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L22UniRule annotation
Alternative name(s):
Hl23
Hmal22
Gene namesi
Name:rpl22UniRule annotation
Ordered Locus Names:rrnAC1606
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 15515450S ribosomal protein L22PRO_0000125272Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Contacts the macrolide antibiotic tylosin in the polypeptide exit tunnel.UniRule annotation2 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1606.

Structurei

Secondary structure

1
155
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 133Combined sources
Beta strandi14 – 229Combined sources
Helixi26 – 3611Combined sources
Helixi41 – 5212Combined sources
Beta strandi61 – 633Combined sources
Beta strandi74 – 807Combined sources
Helixi83 – 10220Combined sources
Helixi107 – 1093Combined sources
Beta strandi110 – 12314Combined sources
Beta strandi126 – 1283Combined sources
Helixi130 – 1323Combined sources
Beta strandi134 – 1363Combined sources
Beta strandi139 – 14911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40O2-155[»]
1JJ2X-ray2.40Q2-155[»]
1K73X-ray3.01S2-155[»]
1K8AX-ray3.00S2-155[»]
1K9MX-ray3.00S2-155[»]
1KC8X-ray3.01S2-155[»]
1KD1X-ray3.00S2-155[»]
1KQSX-ray3.10Q2-155[»]
1M1KX-ray3.20S2-155[»]
1M90X-ray2.80S2-155[»]
1N8RX-ray3.00S2-155[»]
1NJIX-ray3.00S2-155[»]
1Q7YX-ray3.20S2-155[»]
1Q81X-ray2.95S2-155[»]
1Q82X-ray2.98S2-155[»]
1Q86X-ray3.00S2-155[»]
1QVFX-ray3.10Q2-155[»]
1QVGX-ray2.90Q2-155[»]
1S72X-ray2.40R1-155[»]
1VQ4X-ray2.70R1-155[»]
1VQ5X-ray2.60R1-155[»]
1VQ6X-ray2.70R1-155[»]
1VQ7X-ray2.50R1-155[»]
1VQ8X-ray2.20R1-155[»]
1VQ9X-ray2.40R1-155[»]
1VQKX-ray2.30R1-155[»]
1VQLX-ray2.30R1-155[»]
1VQMX-ray2.30R1-155[»]
1VQNX-ray2.40R1-155[»]
1VQOX-ray2.20R1-155[»]
1VQPX-ray2.25R1-155[»]
1W2BX-ray3.50Q2-155[»]
1YHQX-ray2.40R1-155[»]
1YI2X-ray2.65R1-155[»]
1YIJX-ray2.60R1-155[»]
1YITX-ray2.80R1-155[»]
1YJ9X-ray2.80R1-152[»]
1YJNX-ray3.00R1-155[»]
1YJWX-ray2.90R1-155[»]
2OTJX-ray2.90R1-155[»]
2OTLX-ray2.70R1-155[»]
2QA4X-ray3.00R1-155[»]
2QEXX-ray2.90R1-155[»]
3CC2X-ray2.40R1-155[»]
3CC4X-ray2.70R1-155[»]
3CC7X-ray2.70R1-155[»]
3CCEX-ray2.75R1-155[»]
3CCJX-ray2.70R1-155[»]
3CCLX-ray2.90R1-155[»]
3CCMX-ray2.55R1-155[»]
3CCQX-ray2.90R1-155[»]
3CCRX-ray3.00R1-155[»]
3CCSX-ray2.95R1-155[»]
3CCUX-ray2.80R1-155[»]
3CCVX-ray2.90R1-155[»]
3CD6X-ray2.75R1-155[»]
3CMAX-ray2.80R1-155[»]
3CMEX-ray2.95R1-155[»]
3CPWX-ray2.70Q1-155[»]
3CXCX-ray3.00Q2-155[»]
3G4SX-ray3.20R2-151[»]
3G6EX-ray2.70R2-151[»]
3G71X-ray2.85R2-151[»]
3I55X-ray3.11R1-155[»]
3I56X-ray2.90R1-155[»]
3OW2X-ray2.70Q2-151[»]
4ADXelectron microscopy6.60R1-155[»]
4V9FX-ray2.40R1-155[»]
ProteinModelPortaliP10970.
SMRiP10970. Positions 2-151.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10970.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L22P family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04098. Archaea.
COG0091. LUCA.
HOGENOMiHOG000205045.
KOiK02890.
OMAiMHIRKAN.

Family and domain databases

CDDicd00336. Ribosomal_L22. 1 hit.
Gene3Di3.90.470.10. 1 hit.
HAMAPiMF_01331_A. Ribosomal_L22_A. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005721. Ribosomal_L22/L17_euk/arc.
[Graphical view]
PANTHERiPTHR11593. PTHR11593. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
TIGRFAMsiTIGR01038. uL22_arch_euk. 1 hit.
PROSITEiPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISYSVEAD PDTTAKAMLR ERQMSFKHSK AIAREIKGKT AGEAVDYLEA
60 70 80 90 100
VIEGDQPVPF KQHNSGVGHK SKVDGWDAGR YPEKASKAFL DLLENAVGNA
110 120 130 140 150
DHQGFDGEAM TIKHVAAHKV GEQQGRKPRA MGRASAWNSP QVDVELILEE

PEVED
Length:155
Mass (Da):16,941
Last modified:January 23, 2007 - v2
Checksum:iE6730272296C0D7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05222 Genomic DNA. Translation: AAA86864.1.
AY596297 Genomic DNA. Translation: AAV46523.1.
PIRiH35063. R5HS22.
RefSeqiWP_011223742.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46523; AAV46523; rrnAC1606.
GeneIDi3128443.
KEGGihma:rrnAC1606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05222 Genomic DNA. Translation: AAA86864.1.
AY596297 Genomic DNA. Translation: AAV46523.1.
PIRiH35063. R5HS22.
RefSeqiWP_011223742.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40O2-155[»]
1JJ2X-ray2.40Q2-155[»]
1K73X-ray3.01S2-155[»]
1K8AX-ray3.00S2-155[»]
1K9MX-ray3.00S2-155[»]
1KC8X-ray3.01S2-155[»]
1KD1X-ray3.00S2-155[»]
1KQSX-ray3.10Q2-155[»]
1M1KX-ray3.20S2-155[»]
1M90X-ray2.80S2-155[»]
1N8RX-ray3.00S2-155[»]
1NJIX-ray3.00S2-155[»]
1Q7YX-ray3.20S2-155[»]
1Q81X-ray2.95S2-155[»]
1Q82X-ray2.98S2-155[»]
1Q86X-ray3.00S2-155[»]
1QVFX-ray3.10Q2-155[»]
1QVGX-ray2.90Q2-155[»]
1S72X-ray2.40R1-155[»]
1VQ4X-ray2.70R1-155[»]
1VQ5X-ray2.60R1-155[»]
1VQ6X-ray2.70R1-155[»]
1VQ7X-ray2.50R1-155[»]
1VQ8X-ray2.20R1-155[»]
1VQ9X-ray2.40R1-155[»]
1VQKX-ray2.30R1-155[»]
1VQLX-ray2.30R1-155[»]
1VQMX-ray2.30R1-155[»]
1VQNX-ray2.40R1-155[»]
1VQOX-ray2.20R1-155[»]
1VQPX-ray2.25R1-155[»]
1W2BX-ray3.50Q2-155[»]
1YHQX-ray2.40R1-155[»]
1YI2X-ray2.65R1-155[»]
1YIJX-ray2.60R1-155[»]
1YITX-ray2.80R1-155[»]
1YJ9X-ray2.80R1-152[»]
1YJNX-ray3.00R1-155[»]
1YJWX-ray2.90R1-155[»]
2OTJX-ray2.90R1-155[»]
2OTLX-ray2.70R1-155[»]
2QA4X-ray3.00R1-155[»]
2QEXX-ray2.90R1-155[»]
3CC2X-ray2.40R1-155[»]
3CC4X-ray2.70R1-155[»]
3CC7X-ray2.70R1-155[»]
3CCEX-ray2.75R1-155[»]
3CCJX-ray2.70R1-155[»]
3CCLX-ray2.90R1-155[»]
3CCMX-ray2.55R1-155[»]
3CCQX-ray2.90R1-155[»]
3CCRX-ray3.00R1-155[»]
3CCSX-ray2.95R1-155[»]
3CCUX-ray2.80R1-155[»]
3CCVX-ray2.90R1-155[»]
3CD6X-ray2.75R1-155[»]
3CMAX-ray2.80R1-155[»]
3CMEX-ray2.95R1-155[»]
3CPWX-ray2.70Q1-155[»]
3CXCX-ray3.00Q2-155[»]
3G4SX-ray3.20R2-151[»]
3G6EX-ray2.70R2-151[»]
3G71X-ray2.85R2-151[»]
3I55X-ray3.11R1-155[»]
3I56X-ray2.90R1-155[»]
3OW2X-ray2.70Q2-151[»]
4ADXelectron microscopy6.60R1-155[»]
4V9FX-ray2.40R1-155[»]
ProteinModelPortaliP10970.
SMRiP10970. Positions 2-151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC1606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46523; AAV46523; rrnAC1606.
GeneIDi3128443.
KEGGihma:rrnAC1606.

Phylogenomic databases

eggNOGiarCOG04098. Archaea.
COG0091. LUCA.
HOGENOMiHOG000205045.
KOiK02890.
OMAiMHIRKAN.

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1462-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP10970.

Family and domain databases

CDDicd00336. Ribosomal_L22. 1 hit.
Gene3Di3.90.470.10. 1 hit.
HAMAPiMF_01331_A. Ribosomal_L22_A. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005721. Ribosomal_L22/L17_euk/arc.
[Graphical view]
PANTHERiPTHR11593. PTHR11593. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
TIGRFAMsiTIGR01038. uL22_arch_euk. 1 hit.
PROSITEiPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL22_HALMA
AccessioniPrimary (citable) accession number: P10970
Secondary accession number(s): Q5V1S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.